Clinical trials: Respiratory Distress Syndrome, Adult
Critical Illness, Sleep
Sleep Intervention During Acute Lung Injury
The central purpose of this proposal is to study the short-term effects of sedation with sympatholysis, using α2 adrenergic agent Dexmedetomidine, on sleep and inflammation in critically ill patients with Acute Lung Injury and…
- Conditions
- Critical Illness, Sleep, Acute Lung Injury, Acute Respiratory Distress Syndrome
- Trial name
- NCT01050699
- Testing
- Dexmedetomidine, Midazolam and Fentanyl
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Arizona
Positive Expiratory Pressure, Acute Respiratory Distress Syndrome
Determination of the Best Positive End-expiratory Pressure (PEEP)
Determination of the best positive end-expiratory pressure (PEEP) based on oxygenation or driving pressure in patients with acute respiratory distress syndrome (ARDS) after cardiothoracic surgery The use of a positive…
- Trial name
- DROP (NCT03969407)
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Mechanical Ventilation Complication
Lowering PEEP: Weaning From High PEEP Setting
The perfusion of the deeply different areas coexisting in ARDS lung generates two type of venus-admixure : true shunt and shunt effect.
- Trial name
- NCT04429399
- Testing
- decrease the positive end expiratory pressure (PEEP), mechanical features assessment, shunt assessment
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Bari
Pulmonary Alveolar Proteinosis, COPD
Use of cSVF Via IV Deployment for Residual Lung Damage After Symptomatic COVID-19 Infection
COVID-19 Viral Global Pandemic resulting in post-infection pulmonary damage, including Fibrotic Lung Disease due to inflammatory and reactive protein secretions damaging pulmonary alveolar structure and functionality.
- Conditions
- Pulmonary Alveolar Proteinosis, COPD, Idiopathic Pulmonary Fibrosis, Viral Pneumonia
- Trial name
- GARM-COVID19 (NCT04326036)
- Testing
- Microcannula Harvest Adipose Derived tissue stromal vascular fraction (tSVF), Centricyte 1000, IV Deployment Of cSVF In Sterile Normal Saline IV Solution
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Black Tie Medical, Inc.
Acute Lung Injury(ALI)
Dexmedetomidine Dose-Dependent on Lung Function and AQP1 in One-Lung Ventilation Surgery
This randomized controlled trial evaluated the dose-dependent effects of dexmedetomidine (DEX) on pulmonary function and aquaporin-1 (AQP1) expression during one-lung ventilation (OLV) in thoracoscopic surgery.
- Trial name
- NCT07145814
- Testing
- dexmedetomidine 0.3 µg/kg/h, dexmedetomidine 0.5 µg/kg/h, 0.9 % saline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- People's Hospital of Guangxi Zhuang Autonomous Region
Acute Lung Injury, Sepsis
Extracardiac Complications After Cardiac Surgery
Hypothesis of the study is that patients undergoing major cardiac surgery can develop extracardiac complications correlated to cardiopulmonary by pass.
- Conditions
- Acute Lung Injury, Sepsis, Infections, Acute Kidney Injury
- Trial name
- NCT01187004
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- University of Turin, Italy
ICU Patients, Healthy Lung
Effects of End-expiratory Positive Pressure Optimization in Intubated Patients With Healthy Lung or Acute Respiratory Distress Syndrome
PEEP titration is a recommended during invasive mechanical ventilation of ICU patients. However, little is known about the right way to conduct this titration.
- Conditions
- ICU Patients, Healthy Lung, Positive End-Expiratory Pressure, ARDS
- Trial name
- PEEP-Réa (NCT04503876)
- Testing
- Increasing PEEP setting, Decreasing PEEP setting
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Respiratory Distress Syndrome
Effect of Prone Positioning on Mortality in Patients With Severe and Persistent Acute Respiratory Distress Syndrome
We project to test the effect of prone position on mortality in severe ARDS patients (PaO2/FiO2<150 with FiO2 > or = 0.6 and positive end-expiratory pressure > or = 5 cmH2O).
- Trial name
- Proseva (NCT00527813)
- Testing
- prone position
- Where
- France
- Volunteers
- 474 people
- Sponsor
- Hospices Civils de Lyon
Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
MicroRNA Diagnostics in Subarachnoid Hemorrhage 2
The purpose of this study is to validate results from a related trial (NCT01791257) and to compare the profile of microRNA in blood from patients suffering subarachnoid hemorrhage with and without systemic complications.
- Conditions
- Subarachnoid Hemorrhage, Delayed Cerebral Ischemia, Acute Lung Injury, Cardiac Dysfunction
- Trial name
- NCT02320539
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Respiratory Distress Syndrome, COVID-19
PRactice of VENTilation in Patients With ARDS Due to COVID-19 vs Pneumonia
This study aims to compare epidemiology, management of invasive ventilation and outcomes in critically ill patients with COVID-19 ARDS and ARDS from another pulmonary infection.
- Conditions
- Acute Respiratory Distress Syndrome, COVID-19, Pneumonia, Mechanical Ventilation Complication
- Trial name
- PRoVENT-COP (NCT05650957)
- Where
- 6 sites in Argentina, Brazil and 3 more
- Volunteers
- 7,145 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
ARDS (Acute Respiratory Distress Syndrome)
Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study
The goal of this clinical trial is to learn how low tidal volume ventilation (LTV) and airway pressure release ventilation (APRV) affect lung tissue mechanics in adults with ARDS.
- Trial name
- NCT06790875
- Testing
- Airway Pressure Release Ventilation (APRV)
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Acute Respiratory Distress Syndrome (ARDS)
Ultraprotective Lung Ventilation With Respiratory Extracorporeal Life Support for ARDS
Acute respiratory distress syndrome (ARDS) accounts for approximately 10% of all ICU admissions and 23% of patients requiring mechanical ventilation (MV).
- Trial name
- NOVAEOLIA (NCT07516665)
- Testing
- ECLS
- Volunteers
- 290 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Lung Injury
The Impact of Automatic Lung Recruitment Postoperative Pulmonary Complications
Study Background and Purpose As society ages, an increasing number of elderly patients undergo surgery. Following surgery, particularly abdominal procedures, patients are susceptible to lung-related issues such as atelectasis…
- Trial name
- lung (NCT07477951)
- Testing
- Automated recruitment maneuver (Auto-RM)
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Yongtao Sun
Respiratory Distress Syndrome
Comparing Weaning of Nasal Continuous Positive Airway Pressure (CPAP) From Preterm Infants
To compare the 2 methods of weaning of nasal continuous positive airway pressure (CPAP) in premature babies born between 26 and 32 weeks
- Trial name
- NCT02126501
- Testing
- Gradual pressure wean
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Maimonides Medical Center
Neonatal Acute Respiratory Distress Syndrome(ARDS)
Epidemiological Study of Neonatal Acute Respiratory Distress Syndrome (ARDS)
Neonatal acute respiratory distress syndrome(ARDS) is a rare but often severe respiratory disorder. The incidence remains unclear and mortality is about 30%-60%.
- Trial name
- NCT03311165
- Testing
- no intervention
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
COVID-19
Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19
The primary objectives are: Pooled Phase 3 (Cohort 1) and Phase 2 (Cohort 1A) To evaluate the virologic efficacy of REGN10933+REGN10987 compared to placebo in reducing viral load of SARS-CoV-2 To evaluate the clinical efficacy of…
- Trial name
- NCT04426695
- Testing
- REGN10933+REGN10987 combination therapy
- Where
- 123 sites in United States, Brazil and 4 more
- Volunteers
- 2,252 people
- Sponsor
- Regeneron Pharmaceuticals
Acute Lung Injury, Acute Respiratory Distress Syndrome
Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients
sRAGE, the soluble form of the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury, but is also involved in acute systemic inflammation.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Severe Sepsis, Septic Shock
- Trial name
- NCT00811629
- Testing
- sRAGE
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Premature Birth
Effects of L-Carnitine Supplementation on Respiratory Distress Syndrome
The aim of the present study was to investigate the efficacy of L-carnitine therapy on the occurrence and prognosis of respiratory distress syndrome
- Trial name
- NCT03630367
- Testing
- Dexamethasone, L-Carnitine 1G/5mL Injection
- Where
- Egypt
- Sponsor
- Assiut University
Respiratory Distress Syndrome, Newborn
Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress
Title of Study: A Prospective, Randomized, Multicenter Trial Comparing Synchronized Intermittent Mandatory Ventilation (SIMV) vs.
- Trial name
- NCT00486850
- Testing
- Extubation to Nasal IPPV
- Where
- 4 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Southern California
ARDS, Human, Mechanical Ventilation Pressure High
Lung Protection in ARDS Using Neurally Adjusted Ventilatory Assist
The aim of this study is to investigate the use neurally adjusted ventilatory assist (NAVA) as lung protective strategy in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- NAVA (NCT03868982)
- Testing
- Neurally adjusted ventilatory assist
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Fu Jen Catholic University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.