Clinical trials: Respiratory Distress Syndrome, Adult
COVID-19, Acute Respiratory Distress Syndrome Due to COVID-19
Post-intensive Care Syndromes in Pregnant Patients With Respiratory Failure and COVID-19 Compared to Non-pregnant Patients With Respiratory Failure and COVID-19
The aim of this study is to characterize patients in the Post-Intensive-Care-Syndrome (PICS) outpatient clinic based on routine data and to evaluate their treatment outcome over the course of their treatment.
- Conditions
- COVID-19, Acute Respiratory Distress Syndrome Due to COVID-19, Pregnancy Related
- Trial name
- NCT07051967
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Prone Position, Severe Acute Respiratory Syndrome Coronavirus 2
Evaluation of Sedation in COVID-19 ARDS
This study focuses on the evaluation of various factors repeatedly discussed in relation to the impaired sedation of intubated ventilated COVID-19 patients.
- Conditions
- Prone Position, Severe Acute Respiratory Syndrome Coronavirus 2, Hypnotics and Sedatives, Pulmonary Ventilation
- Trial name
- NCT04667936
- Testing
- Treatment group
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- Goethe University
Dyspnea, Respiratory Distress Syndrome
LUng and Cardiac Ultrasound for REspiratory Distress in ElDerly
Prospective trial to evaluate the impact on the initial therapeutic inadequacy of a management strategy for acute dyspnea in the elderly based on the use of lung and cardiac ultrasonography.
- Trial name
- LUCREED (NCT06807983)
- Testing
- diagnostic strategy based on lung and cardiac ultrasonography
- Where
- France
- Volunteers
- 504 people
- Sponsor
- University Hospital, Toulouse
Prematurity, Respiratory Distress Syndrome, Infant
Weaning of Nasal Continuous Positive Airway Pressure (CPAP) in Premature Infants
The aim of this study is to investigate two different strategies for the withdrawal of CPAP in preterm infants born before 32 weeks of gestation.
- Trial name
- NCT01721629
- Testing
- Sudden wean of nasal CPAP, Gradual wean of nasal CPAP
- Where
- 6 sites in Denmark
- Volunteers
- 380 people
- Sponsor
- Aarhus University Hospital
Acute Respiratory Distress Syndrome
PEEP Test and Gas Exchange in ALI/ARDS Patients
The investigators aim to study the effect of different levels of PEEP in ALI/ARDS patients on gas exchange.
- Trial name
- NCT00284102
- Testing
- Mechanical ventilation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Policlinico Hospital
COVID-19
In Situ Thrombolysis With tPA and Inflow Perfusion Analysis in Patient With Severe Covid-19 Infection
To estimate the pulmonary response microvascular thrombosis in critical patients due to SARS-Cov-2., at the Hospital General de México "Dr.
- Trial name
- NCT04926428
- Testing
- tPA
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- Grupo Mexicano para el Estudio de la Medicina Intensiva
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in…
- Trial name
- WINDSURFER (NCT07558265)
- Testing
- Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen
- Where
- 6 sites in United States
- Volunteers
- 500 people
- Sponsor
- Ohio State University
Acute Respiratory Distress
the Effect of High Dose Ascorbic Acid on Critically Ill Patients With ARDS
1. To access role of vitamin C supplementation in ARDS patients on the following: Oxidants/ antioxidants imbalance Length of hospital stay Mortality rate Weaning from mechanical ventilator Incidence of adverse drug reaction 2.
- Trial name
- NCT03780933
- Testing
- vitamin c
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Misr International University
Bronchioalveolar Lavage
Cardiopulmonary Effects of Bronchoalveolar Wash on Patients With Acute Respiratory Distress Syndrome
The acute respiratory distress syndrome (ARDS) is a clinical syndrome characterized by an inflammatory pulmonary edema, severe hypoxia and endothelial and epithelial diffuse aggression.
- Trial name
- FLOOD (NCT02818049)
- Testing
- Bronchoalveolar Lavage
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Limoges
Acute Respiratory Distress Syndrome
Echocardiography Predictive of the Inefficacy and/or of the Unsafeness of Recruitment Maneuvers in Patients With Acute Respiratory Distress Syndrome.
The purpose of the study RVSTAR is to evaluate whether echocardiographic criteria exploring the right ventricle can predict the inefficacy and/or the unsafeness of recruitment maneuvers in patients suffering from acute…
- Trial name
- RV STAR (NCT01768949)
- Testing
- Echocardiography
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Respiratory Distress Syndrome
Efficacy and Safety of Goat Lung Surfactant for the Treatment of Respiratory Distress Syndrome in Preterm Neonates
The purpose of the study is to evaluate the efficacy and safety of Cadisurf (goat lung surfactant extract) as compared to Survanta (beractant) in the treatment of respiratory distress syndrome in preterm neonates (with gestation…
- Trial name
- NCT02774044
- Testing
- Cadisurf, Survanta
- Volunteers
- 900 people
- Sponsor
- Ramesh K Agarwal
ARDS (Acute Respiratory Distress Syndrome)
Physiological Effects of APRVplus and TCAV in ARDS
In previous studies, airway pressure release ventilation (APRV) has been proven to be an important respiratory support method for ARDS patients, and various APRV ventilation strategies have been proposed.
- Trial name
- NCT06748807
- Testing
- APRVplus, TCAV
- Where
- China
- Volunteers
- 20 people
- Sponsor
- West China Hospital
Acute Lung Injury
Incidence of Acute Lung Injury: The Alien Study
Acute lung injury is a clinical syndrome of rapid onset of acute respiratory failure. It represents a significant public health issue.
- Trial name
- ALIEN (NCT00736892)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Villar, Jesus, M.D.
Acute Respiratory Distress Syndrome
Effects of End-inspiratory Pause on Ventilation
This study aims to evaluate the effect of reducing tidal volume and respiratory rate together with an end-inspiratory pause setting on ventilatory efficiency and the distribution of inspired gas within the lungs in ARDS patients.
- Trial name
- NCT06692634
- Testing
- mechanical ventilation setting
- Where
- 2 sites in Chile
- Volunteers
- 20 people
- Sponsor
- Clinica las Condes, Chile
Acute Respiratory Distress Syndrome
Poractant Alfa (Curosurf®)) -- Effect in Adult Patients Diagnosed With 2019 Novel Coronavirus (SARS-COV-19; (Covid-19)) Acute Respiratory Distress Syndrome (ARDS)
The purpose of this study was to evaluate the efficacy and safety of poractant alfa (Curosurf®), administered by endotracheal (ET) instillation in hospitalized adult patients diagnosed with SARS-COV-19 acute respiratory distress…
- Trial name
- NCT04502433
- Testing
- CUROSURF® (poractant alfa)
- Where
- 6 sites in United States, Italy and 1 more
- Volunteers
- 22 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
COVID, ARDS, Human
Echocardiography in Patients With Covid-19
Prospective observational study of patients treated due to Covid-19 disease. Observation and analysis of echocardiographic studies performed in the intensive care setting.
- Trial name
- NCT04412460
- Where
- Germany
- Sponsor
- University Hospital Tuebingen
Respiratory Distress Syndrome, Lower Respiratory Tract Infection
A Low-Resource Oxygen Blender Prototype for Use in Modified Bubble CPAP Circuits
Purpose: Using a novel oxygen blender prototype with modified bCPAP to manage children 1 month to 5 years of age hospitalized with respiratory distress due to lower respiratory tract infection (LRTI) in low-resource settings is…
- Trial name
- NCT04311320
- Testing
- Low-Resource Oxygen Blender
- Where
- Cambodia
- Volunteers
- 33 people
- Sponsor
- University of Minnesota
COVID-19 Pneumonia, Covid19
A Randomized Controlled Trial to Investigate The Role of Adjuvant Inhalable Sodium Bicarbonate Solution 8.4% in Treatment of COVID-19
The aim of the study is to investigate the role of SB 8.4% as adjuvant therapy in the treatment of COVID- 19 patients proved to be RT-PCR positive (mild, moderate and severe).
- Conditions
- COVID-19 Pneumonia, Covid19, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05035524
- Testing
- Sodium Bicarbonate Solution
- Where
- Egypt
- Volunteers
- 340 people
- Sponsor
- Mansoura University
Medical Condition Requiring Extracorporeal Organ Support
The University of Freiburg Medical Center Extracorporeal Organ Support Device Registry
A prospective registry collecting pseudonymized clinical and treatment data from all patients treated with extracorporeal organ support (i.e., VV ECMO, VA ECMO, ECPR, Impella, IABP, and others) on the wards of the Department of…
- Trial name
- NCT05811780
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- University Hospital Freiburg
Respiratory Distress Syndrome, Adult
Effect of Positive Expiratory Pressure on Right Ventricular Function in Patients With Respiratory Distress Syndrome
The objective of this study is to analyze by trans-oesophageal echocardiography the effect on the right ventricle of positive expiratory pressure (PEP) level variations with constant plate pressure among patients with syndrome of…
- Trial name
- NCT00236262
- Testing
- ventilatory strategies with pressure
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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