Clinical trials: Respiratory Distress Syndrome, Adult
Positive Expiratory Pressure, Acute Respiratory Distress Syndrome
Determination of the Best Positive End-expiratory Pressure (PEEP)
Determination of the best positive end-expiratory pressure (PEEP) based on oxygenation or driving pressure in patients with acute respiratory distress syndrome (ARDS) after cardiothoracic surgery The use of a positive…
- Trial name
- DROP (NCT03969407)
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Premature Birth, Respiratory Distress Syndrome, Newborn
Non-invasive Neurally Adjusted Ventilator Assist or Continuous Positive Airway Pressure in Preterm Infants
Strategies to prevent lung injury, facilitate lung development, and to support the preterm infant's capacity to breathe are decisive.
- Trial name
- NCT04333563
- Testing
- CPAP, NIV NAVA
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- St. Olavs Hospital
Acute Respiratory Distress Syndrome, Acute Lung Injury
Study of the Economics of Pulmonary Artery Catheter Use in Patients With Acute Respiratory Distress Syndrome (ARDS)
Study of the long term outcomes and economic impact of the pulmonary artery catheter in acute respiratory distress syndrome (ARDS/ALI) patients.
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Lung Diseases
- Trial name
- NCT00234767
- Testing
- Pulmonary Artery Catheter, Protocolized Fluid Management
- Volunteers
- 650 people
- Sponsor
- University of Pittsburgh
Corona Virus Infection, ARDS
Use of UC-MSCs for COVID-19 Patients
The purpose of this research study is to learn about the safety and efficacy of human umbilical cord derived Mesenchymal Stem Cells (UC-MSC) for treatment of COVID-19 Patients with Severe Complications of Acute Lung Injury/Acute…
- Conditions
- Corona Virus Infection, ARDS, ARDS, Human, Acute Respiratory Distress Syndrome
- Trial name
- NCT04355728
- Testing
- Umbilical Cord Mesenchymal Stem Cells + Heparin along with best supportive care., Vehicle + Heparin along with best supportive care
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Camillo Ricordi
Congenital Heart Disease, Postoperative Pulmonary Complications
Perioperative Lidocaine for Lung Protection in Infants Undergoing Cardiac Surgery
Cardiopulmonary bypass-associated pulmonary injury is a common complication after infant cardiac surgery and may contribute to impaired oxygenation, prolonged mechanical ventilation, and longer intensive care stay.
- Conditions
- Congenital Heart Disease, Postoperative Pulmonary Complications, Acute Lung Injury
- Trial name
- PLICS (NCT07499154)
- Testing
- Lidocaine %2 ampoule, Normal Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 320 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
COVID, Acute Respiratory Distress Syndrome
COVID-19 : Transcutaneous pO2 and pCO2 as Predictive Factors for Acute Respiratory Destress Syndrome in Patients Affected With SARS-Cov-2
The first case of a person infected with SARS-Cov-2 virus can be tracked back on November the 17th, 2019, in China. On March 11, 2020, the World Health Organization (WHO) declared COVID-19 outbreak a pandemic.
- Conditions
- COVID, Acute Respiratory Distress Syndrome, Endothelial Dysfunction
- Trial name
- COVID-pO2-RAAS (NCT04524156)
- Testing
- Physiology
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Erasme University Hospital
Respiratory Distress Syndrome, Adult
Evaluating a Web-Based Ventilator Management Educational Program for Clinicians (The Lung Injury Knowledge Network [LINK] Study)
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a severe lung condition that causes respiratory failure. Individuals with ALI/ARDS often require the use of a respirator or artificial breathing machine, known…
- Trial name
- LINK (NCT00542737)
- Testing
- Web-Based Educational Program
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Preterm Infants, Neonatal Respiratory Distress Syndrome
Comparison of the Need Of Mechanical Ventilation Between Less Invasive Surfactant Administration (LISA) and Conventional INSURE (Intubation-Surfactant Administration-Extubation) Methods in Spontaneously Breathing Preterm Infants With Respiratory Distress Syndrome
Brief Summary of the Study This randomized controlled trial aims to compare the need for mechanical ventilation between Less Invasive Surfactant Administration (LISA) and the conventional INSURE (Intubation, Surfactant…
- Conditions
- Preterm Infants, Neonatal Respiratory Distress Syndrome, Need for Mechanical Ventilation
- Trial name
- NCT07910539
- Testing
- Intervention Name: Poractant alfa (surfactant) administered by the INSURE method
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Fatima Jinnah Medical University
Respiratory Distress Syndrome, Newborn
Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study
The primary objective of this study is to compare two methods of post-delivery stabilization and subsequent early respiratory care for reducing the need for MV and related secondary complications, such as BPD, in premature babies…
- Trial name
- Curpap (NCT00501982)
- Testing
- Poractant alfa (Curosurf®)
- Where
- 5 sites in Czechia, France and 3 more
- Volunteers
- 208 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Pulmonary Edema
Power Spectral Analysis of Breath Sound in Pulmonary Edema
Pulmonary edema can be classified into "cardiogenic pulmonary edema" and "non-cardiogenic pulmonary edema" according to the underlying etiology.
- Trial name
- NCT00767195
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
ARDS
MultiStem Administration for COVID-19 Induced ARDS (MACoVIA)
Multicenter investigation featuring an open-label lead-in followed by a double blinded, randomized, placebo-controlled Phase 2/3 part to evaluate the safety and efficacy of MultiStem therapy in subjects with moderate to severe…
- Trial name
- MACoVIA (NCT04367077)
- Testing
- MultiStem
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Healios K.K.
Respiratory Distress Syndrome, Adult
Mesenchymal Stem Cell in Patients With Acute Severe Respiratory Failure
Although the advent of advanced medical support for respiratory failure, the mortality rate of acute severe respiratory failure is still high and the life quality is frequently compromised from pulmonary fibrosis.
- Trial name
- STELLAR (NCT02112500)
- Testing
- Mesenchymal Stem Cell
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Asan Medical Center
Pediatric Acute Respiratory Distress Syndrome
Comparison of Oxygenation Index and Oxygen Stretch Index
Pediatric acute respiratory distress syndrome (pARDS) is a heterogeneous clinical syndrome that causes high rates of mortality and morbidity.
- Trial name
- NCT06586411
- Where
- 7 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Acute Respiratory Distress Syndrome (ARDS)
Conventional Versus Automated Bag-based Mechanical Ventilator to Support ARDS Patients
This study evaluates the extubation success and compares the survival rate in patients with signs of Covid-19 intubated with Masi, a novel type of mechanical ventilator, or with other conventional ventilators admitted in the ICU…
- Trial name
- Masi-ARDS (NCT06667375)
- Where
- Peru
- Volunteers
- 87 people
- Sponsor
- Fanny Lys Casado Pena
Lung Injury, Acute, Ultrasound Therapy; Complications
Features of Regional Perfusion of Lung Consolidation
The aim of this study is to evaluate the potential usefulness of lung ultrasound to assess the size and perfusion of consolidation and explore their relationships with clinical outcome.
- Trial name
- NCT05647967
- Testing
- Ultrasound
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT)
Comparison of Different PEEP Titration Strategies Using Electrical Impedance Tomography in Patients With ARDS
The aim of the this study is to assess the short term physiological effects of 3 ventilation strategies for adult patients with ARDS admitted to intensive care unit.
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT), Positive End Expiratory Pressure (PEEP), Acute Lung Injury
- Trial name
- DELTA (NCT04247477)
- Testing
- Ventilation strategy
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Angers
ARDS, Multi-organ Failure
Biomarker of Lung Injury in ARDS Patients Receiving ECMO Support
The goal of this project is to find a marker expression that the investigators can use to trace symptom progression and develop a more efficient therapy to enhance ARDS patient survival rate and better post-ICU life quality.
- Trial name
- ARDS (NCT01967602)
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS)
Effect of R-spondin3 on Sepsis Induced Endothelial Dysfunction
Sepsis is the most frequent risk factor for ALI/ARDS. Meanwhile, Pulmonary is the most vulnerable organ to fail in response to sepsis, vascular endothelial dysfunction is a central event in the pathophysiology of sepsis.
- Trial name
- NCT04546919
- Testing
- sepsis
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Acute Respiratory Distress Syndrome
KL₄Surfactant Treatment in Patients With ARDS
Lung wash with KL₄Surfactant of individual lung segments using a bronchoscope compared to usual care alone consisting primarily of assisted (mechanical) ventilation in patients with acute respiratory distress syndrome(ARDS).
- Trial name
- NCT00215553
- Testing
- A.1 Lucinactant, B.3 SoC, A.2 Lucinactant
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Windtree Therapeutics
Moderate to Severe Acute Respiratory Distress Syndrome Associated With COVID-19
Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19 Infection
The objectives of this intermediate-size expanded access protocol are to assess the safety and efficacy of remestemcel-L in participants with ARDS due to coronavirus infection 2019 (COVID-19).
- Trial name
- NCT04366830
- Testing
- Remestemcel-L
- Where
- United States
- Sponsor
- Mesoblast International Sàrl