Clinical trials: Respiratory Distress Syndrome, Adult
COVID-19 Acute Respiratory Distress Syndrome
Prognostic Value of PtcO2 in Patients With COVID-19
Five percent of patients with COVID-19 progressed to respiratory failure and required ICU admission, such patients often have abnormal oxygen tolerance.
- Trial name
- NCT05682612
- Testing
- outcome, Subtype of COVID-19
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
COVID-19, ARDS, Human
Curosurf® in Adult Acute Respiratory Distress Syndrome Due to COVID-19
Surfactant replacement therapy (SRT) improves oxygenation and survival in NRDS and some infant ARDS. SRT was tried in adult ARDS with conflicting results.
- Trial name
- Caards-1 (NCT04384731)
- Testing
- poractant alfa
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Dr Christophe LENCLUD
Respiratory Distress Syndrome, Adult, Ventricular Dysfunction, Right
The Value of Combined Critical Care Ultrasound and PAC Monitor Oriented Therapy Protocol to Patients of ARDS With ACP
We hypothesize that combined critical care ultrasound and PAC monitoring-oriented therapy protocol (CUP protocol), would improve prognosis of patients of ARDS with right ventricular dysfunction.
- Trial name
- NCT03971331
- Testing
- PAC catheter and critical care ultrasound examination
- Volunteers
- 236 people
- Sponsor
- Kang Yan
Burns Chest Left Lateral, Burns Chest Right Lateral
Virtual Reality Distraction Technique to Improve Chest Burns With Acute Respiratory Distress Syndrome
Inhalation of toxic gases and chemical irritants during the fire leads to damage to the respiratory tract or the alveolar tissue, which is known as smoke inhalation injury.
- Conditions
- Burns Chest Left Lateral, Burns Chest Right Lateral, Acute Respiratory Distress Syndrome
- Trial name
- NCT05692557
- Testing
- Virtual reality, Progressive muscle relaxation
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Acute Lung Injury, Acute Respiratory Distress Syndrome
Soluble Forms and Ligands of RAGE in ALI/ARDS (SoLiRAGE).
RAGE, the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury. Soluble RAGE (sRAGE) is elevated in the plasma and in the pulmonary edema fluid from patients with ALI/ARDS, but…
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Mechanical Ventilation
- Trial name
- SoLiRAGE (NCT01270295)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Respiratory Distress Syndrome, Adult
Establishment of a Biomarkers-based Early Warning System of Acute Respiratory Distress Syndrome (ARDS)
The aim of the investigators 'study is to investigate the relationship between the biomarkers (e.g. protein markers, genetic polymorphisms and epigenetic markers) and the onset of ARDS.
- Trial name
- NCT03236272
- Where
- China
- Volunteers
- 376 people
- Sponsor
- Mingdong Hu
Intensive Care Unit, Population at High Risk for ARDS Development
Predictive Values of Plasma Soluble RAGE Levels and RAGE Polymorphisms for the Onset of Acute Respiratory Distress Syndrome in Critically Ill Patients
Current clinical prediction scores for acute respiratory distress syndrome (ARDS) have limited positive predictive value. No studies have evaluated predictive kinetics of plasma biomarkers and receptor for advanced glycation end…
- Trial name
- PrediRAGE (NCT02070536)
- Testing
- sRAGE
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Clermont-Ferrand
ARDS, Human, Extracorporeal Membrane Oxygenation Complication
Effects of Induced Moderate Hypothermia on ARDS Patients Under Venovenous ExtraCorporeal Membrane Oxygenation
Acute respiratory distress syndrome (ARDS) is a lesional pulmonary edema that occurs as a result of direct or indirect lung injury.
- Conditions
- ARDS, Human, Extracorporeal Membrane Oxygenation Complication, Hypothermia
- Trial name
- HypoLungECMO (NCT05306392)
- Testing
- Moderate Hypothermia, Normothermia
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Acute Respiratory Distress Syndrome (ARDS), Post Intensive Care Syndrome (PICS)
An Observational Study to Identify New Health Problems Arising After an Intensive Care Unit Admission in People With Acute Respiratory Distress Syndrome in the United States
This is an observational study in which data already collected from people with acute respiratory distress syndrome (ARDS) admitted to an intensive care unit (ICU) are studied.
- Trial name
- SeeMe Tool (NCT06272942)
- Testing
- An ICU admission and a temporally related ARDS diagnosis
- Where
- United States
- Volunteers
- 640,058 people
- Sponsor
- Bayer
Respiratory Distress Syndrome, Adult
Evaluation of Safety & Efficacy of BIO-11006 Inhalation Solution in Patients With ARDS
This Phase IIa pilot study is a placebo controlled, multicenter study to evaluate safety and efficacy of aerosolized BIO-11006 Inhalation Solution in ARDS patients.
- Trial name
- NCT03202394
- Testing
- BIO-11006
- Where
- 5 sites in United States
- Volunteers
- 38 people
- Sponsor
- BioMarck Pharmaceuticals, Ltd.
Acute Respiratory Distress Syndrome
Mesenchymal Stem Cells for The Treatment of Acute Respiratory Distress Syndrome (ARDS)
The clinical study with UMC119-06 is designed to investigate the safety in patients with moderate acute respiratory distress syndrome ("ARDS"). This will be a dose escalation, open-label, single-center study in adult with ARDS.
- Trial name
- NCT04347967
- Testing
- UMC119-06
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- Meridigen Biotech Co., Ltd.
Respiratory Distress Syndrome, Adult
Mesenchymal Stem Cell in Patients With Acute Severe Respiratory Failure
Although the advent of advanced medical support for respiratory failure, the mortality rate of acute severe respiratory failure is still high and the life quality is frequently compromised from pulmonary fibrosis.
- Trial name
- STELLAR (NCT02112500)
- Testing
- Mesenchymal Stem Cell
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Asan Medical Center
Acute Respiratory Distress Syndrome, Mechanical Ventilation
Physiological Studies in the Prone Position in Patients With ARDS
The purpose of this study is to observe the changes of physiological indicators such as ventilation and oxygenation in the prone position of ARDS patients, to observe the change trend of each patient's indicators, and to observe…
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation, Prone Positioning
- Trial name
- NCT06586736
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Lung Diseases
Low Tidal Volume and EVLWI During OLV
The use of low tidal volume (TV) during one lung ventilation (OLV) for thoracic surgery decreases the incidence of postoperative acute lung injury (ALI).
- Trial name
- NCT01762709
- Testing
- The VT 4 ml/kg group, The VT 6 ml/kg group, The VT 8 ml/kg group
- Where
- Saudi Arabia
- Volunteers
- 39 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Transient Tachypnea of the Newborn
Dexamethasone in Prevention of Respiratory Morbidity in Elective Caesarean Section in Term Fetus
Introduction: Babies born at term by elective caesarean section (CS) and before onset of labor are more likely to develop respiratory complications than babies born vaginally.
- Trial name
- NCT01772381
- Testing
- Dexamethasone
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
ARDS
Mechanical Ventilation and Respiratory Muscle Work of Breathing in Acute Respiratory Distress Syndrome (ARDS) Patients
The purpose of this study is to demonstrate that mechanical ventilation guided by the diaphragm EMG signal (also know as neurally adjusted ventilatory assist [NAVA]) is superior compared to pressure support and pressure control…
- Trial name
- NCT01289600
- Testing
- Mechanical ventilation
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Nijmegen
Respiratory Distress Syndrome
Comparison of Curosurf and Infasurf in the Treatment of Preterm Infants With Respiratory Distress Syndrome
Premature infants frequently have trouble breathing after birth. If the respiratory disorder is caused by surfactant deficiency or dysfunction, the disease is treated with a medication called surfactant that is given to the…
- Trial name
- NEOSURF (NCT02834624)
- Testing
- Poractant alfa, calfactant
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Missouri-Columbia
Acute Respiratory Distress Syndrome
Fluid Responsiveness Prediction During Prone Position
Predicting fluid responsiveness is primordial when caring for patients with circulatory shock as it allows correction of preload-dependent low cardiac output states, while preserving patients of the deleterious effects of…
- Trial name
- PROLOAD (NCT05898269)
- Testing
- Trendelenburg maneuver, End-expiratory occlusion test (EE OCC), End-expiratory and end-inspiratory occlusion test (EI OCC)
- Where
- 4 sites in France
- Volunteers
- 96 people
- Sponsor
- Hospices Civils de Lyon
COVID-19 Acute Respiratory Distress Syndrome
Chest and Abdominal Compression Versus PROne Position
Acute respiratory distress syndrome (ARDS) is a severe pulmonary insult responsible for major, life-threatening hypoxemia. The alteration of hematosis is secondary to alveolar edema, following damage to the alveolocapillary…
- Trial name
- CA_C_PRO (NCT05327205)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Retained Fetal Lung Fluid
Accuracy of Amniotic Fluid Lamellar Body Counting for Evaluating of Fetal Lung Maturity
The purpose of this study is to determine the accuracy of Amniotic fluid Lamellar Body Counting for Evaluating of Fetal Lung Maturity.
- Trial name
- NCT01463722
- Testing
- Amniotic fluid Lamellar Body Counting
- Where
- Iran
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences