Clinical trials: Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Adult
Early Use of Prone Position in ECMO for Severe ARDS
Venovenous extracorporeal membrane oxygenation (VV-ECMO) is widely used in the salvage treatment of critical acute respiratory distress syndrome (ARDS).
- Trial name
- NCT04139733
- Testing
- Prone positon, Supine positon
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Beijing Chao Yang Hospital
Acute Respiratory Distress Syndrome
Pulmonary and Ventilatory Effects of Bed Verticalization in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is defined using the clinical criteria of bilateral pulmonary opacities on a chest radiograph, arterial hypoxemia (partial pressure of arterial oxygen [PaO2] to fraction of inspired…
- Trial name
- ERECTION (NCT04371016)
- Testing
- Verticalization (bed)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Respiratory Distress Syndrome, Acute Lung Injury
Pressure Opening With Electrical Impedance Tomography
Acute lung injury and ARDS (acute respiratory distress syndrome) are characterized by lung inhomogeneity, leading to a different distribution of the tidal volume (and pressure) within the lung.
- Trial name
- POET (NCT05825534)
- Testing
- EIT monitoring
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Lung Injury, Acute Respiratory Distress Syndrome
Strategies to Optimize Positive End-expiratory Pressure (PEEP) in Patients With Acute Lung Injury
The purpose of this study in patients suffering from acute lung injury is to determine whether positive end-expiratory pressure (PEEP) setting guided by electrical impedance tomography (EIT) influences pulmonary gas exchange…
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Respiratory Failure
- Trial name
- EIT-PEEP (NCT01326208)
- Testing
- PEEP titration
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bonn
ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT)
Cyclic On-off Switching of Pulmonary Blood Flow in Moderate to Severe ARDS
Although the theoretical model of "cyclic on-off switching of pulmonary blood flow" provides a crucial perspective for understanding VILI, its clinical validation and real-time intervention face significant obstacles.
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT), Pulmonary Perfusion
- Trial name
- NCT07327268
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Acute Respiratory Distress Syndrome, Prone Position
Early Verticalization of the Patient With Acute Respiratory Distress Syndrome: Assessment of Feasibility and Safety.
Acute Respiratory Distress Syndrome (ARDS) is defined according to the Berlin definition (1) as diffuse lung damage occurring in patients with a predisposing risk factor.
- Trial name
- STAND_ARDS1 (NCT04472260)
- Testing
- Verticalization and Prone position
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Acute Lung Injury (ALI), ARDS
Electrical Impedance Tomography (EIT) Monitoring in Adults With ALI or ARDS
Electrical impedance tomography (EIT) monitoring has been researched as a method to determine the spatial impedance distribution in a body cross section, but has yet to become an established clinical tool.
- Trial name
- NCT01272882
- Testing
- Electrical Impedance Tomography monitoring
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Christiana Care Health Services
Acute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
WorldwidE AssessmeNt of Separation of pAtients From Ventilatory assistancE
WEAN SAFE (WorldwidE AssessmeNt of Separation of pAtients From ventilatory assistancE) is a multi-centre, prospective, observational, 4-week inception cohort study being carried out by the Acute Respiratory Failure section of…
- Trial name
- WEAN SAFE (NCT03255109)
- Where
- Belgium
- Volunteers
- 11,000 people
- Sponsor
- European Society of Intensive Care Medicine
Mild to Moderate Acute Respiratory Distress Syndrome
Post-Market Study of Low-flow ECCO2R Using PrismaLung+
PrismaLung+ is intended to provide extracorporeal carbon dioxide removal (ECCO2R) as a standalone therapy or in combination with continuous renal replacement therapy (CRRT).
- Trial name
- NCT04617093
- Testing
- PrismaLung+
- Where
- 10 sites in France
- Volunteers
- 63 people
- Sponsor
- Vantive Health LLC
COVID-19, Respiratory Distress Syndrome
Comparison of Two Respiratory Physiotherapy Treatments in Postcovid-19 Patients.
To test the effectiveness of a respiratory physiotherapy treatment plan in patients who have passed COVID-19, comparing two randomized groups, for the performance of different respiratory musculature training protocols.
- Trial name
- NCT05435443
- Testing
- PowerBreathe and PEP Therosold tools
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Universidad Católica de Ávila
Hyalinosis, Hyaline Membrane Disease
Biomarker for Hyaline Fibromatosis Syndrome (BioHFS)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Hyaline fibromatosis syndrome from the blood
- Conditions
- Hyalinosis, Hyaline Membrane Disease, Juvenile Hyaline Fibromatosis, Fibromatosis Hyalinica Multiplex Juvenilis
- Trial name
- BioHFS (NCT03196115)
- Where
- 3 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Development, Infant, Respiratory Distress Syndrome in Premature Infant
Effect of Chest Physiotherapy on the Development of Preterm Infants.
The aim of this study is to investigate the effect of the stimulation of "reflex rolling" from the Vojta method and the effect of the expiratory flow increase technique on the development of the preterm infants.
- Trial name
- NCT04689386
- Testing
- Group I (GE-I) - Stimulation of "reflex rolling" from the Vojta method, Group II (GE-II) - expiratory flow increase technique
- Where
- 3 sites in Spain
- Volunteers
- 51 people
- Sponsor
- Universidad de Murcia
Acute Lung Injury, Adult Respiratory Distress Syndrome
Acute Lung Injury Ventilator Evaluation (ALIVE)
This study will compare two ventilator modes in mechanically ventilated patients with acute lung injury. Acute lung injury (ALI) is a condition in which the lungs are badly injured and are not able to absorb oxygen the way…
- Trial name
- ALIVE (NCT01901354)
- Testing
- Low-tidal-volume ventilation, Airway Pressure Release Ventilation (APRV)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Wisconsin, Madison
Acute Respiratory Distress Syndrome
Clinical Study to Assess the Safety and Preliminary Efficacy of HCR040 in Acute Respiratory Distress Syndrome
The main objective of the study is to assess the feasibility, safety, and tolerability of the administration of HCR040, a drug whose active substance is HC016, allogeneic adipose-derived adult mesenchymal stem cells expanded and…
- Trial name
- NCT04289194
- Testing
- HCR040 (Phase 1), HCR040 (Phase 2)
- Where
- 2 sites in Spain
- Volunteers
- 26 people
- Sponsor
- Histocell, S.L.
COVID-19, Pneumonia
Extra Vascular Lung Water and Pulmonary Permeability in Critically Ill Patients With SARS-CoV-2 (COVID-19)
Acute respiratory distress syndrome (ARDS) is a syndromic definition of an acute lung injury with alteration of biomechanics (lower respiratory system compliance) mostly associated with increased lesional edema.
- Conditions
- COVID-19, Pneumonia, Acute Respiratory Distress Syndrome
- Trial name
- PiCCOVID (NCT04376905)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
RDS of Prematurity, Prematurity
Fast Assessment of Surfactant Deficiency to Speed up Treatment
The aim is to validate a FTIR spectroscopy test for measuring lung maturity/Respiratory Distress Syndrome (RDS) in terms of safety, usability, and efficacy.
- Trial name
- FAST (NCT03235882)
- Testing
- LS-ratio
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Patients With Acute Respiratory Distress Syndrome
Registry on the EXperience of Extracorporeal CO2 Removal in Intensive Care Units
Investigators will aim to conduct an observational study in order to assess very thoroughly all patients implanted by Extracorporeal carbon dioxide removal (ECCO2R) in 10 critical care units of Paris and its surburb (APHP…
- Trial name
- REXECOR (NCT02965079)
- Testing
- ECCO2R
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rexecor
Acute Lung Injury, Acute Respiratory Distress Syndrome
The Role of Circulating Soluble CD74 in Acute Lung Injury
Efforts to identify circulating factors that predict severity of acute lung injury/acute respiratory distress syndrome（ALI/ARDS） patients is unrevealing.
- Trial name
- NCT02201446
- Where
- China
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
ARDS
Assessment of Blood Viscosity in ARDS (Acute Respiratory Distress Syndrome)
Acute respiratory distress syndrome (ARDS) is characterized by damage to the alveolar-capillary membrane, resulting in hypoxemia, decreased pulmonary compliance, and hemodynamic changes.
- Trial name
- VISC-ARDS (NCT07823296)
- Testing
- Blood draws (peripheral venous puncture), Blood draws (arterial catheter, central venous line, or Swan-Ganz catheter)
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Hospices Civils de Lyon
Acute Respiratory Failure, Acute Hypoxemic Respiratory Failure
Comparing Closed-loop FiO2 Controller With Conventional Control of FiO2
During mechanical ventilation (MV) hypoxemic or hyperoxemic events should be carefully monitored and a quick response should be provided by the caregiver at the bedside.
- Conditions
- Acute Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxemic and Hypercapnic Respiratory Failure
- Trial name
- NCT04568642
- Testing
- Activate FiO2 controller, Deactivate FiO2 controller
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
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