Clinical trials: Respiratory Distress Syndrome, Newborn
COVID-19, ARDS, Human
WeanINg From Mechanical Ventilation for ARDS CovId-19 Patients Guided by Combined Thoracic UltraSound.
The most feared complication of COVID-19 infection is the occurrence of an acute respiratory distress syndrome (ARDS) that requires ICU admission and prolonged mechanical ventilation in more than 2% of the affected patients.
- Conditions
- COVID-19, ARDS, Human, Mechanical Ventilation
- Trial name
- INVICTUS (NCT04372680)
- Testing
- CTUS examination
- Where
- 2 sites in France
- Volunteers
- 89 people
- Sponsor
- University Hospital, Toulouse
Respiratory Distress Syndrome in Premature Infant, Surfactant
Clinical RD (Respiratory Distress) Score for Objective Decision Making for Surfactant Therapy
To develop a comprehensive 'Clinical RD score' for decision making for administration of Surfactant in respiratory distress syndrome in preterm infants with gestation of 26 0/7 - 34 6/7 weeks and to assess the validity of this…
- Conditions
- Respiratory Distress Syndrome in Premature Infant, Surfactant, CPAP
- Trial name
- NCT03273764
- Where
- India
- Volunteers
- 209 people
- Sponsor
- Lady Hardinge Medical College
Neonatal Respiratory Distress Syndrome, Intubation, Intratracheal
Chest Physiotherapy Technique Increasing Inspiratory Flow on Weaning From Non Invasive Ventilation
The main objective is to show by a randomised controled therapeutic trial comparing in two parallel open arms ( 50 infants x 2 = 100 infants) that the technique IIF decreases the duration of non invasive respiratory support in…
- Trial name
- KVNI (NCT02041676)
- Testing
- Chest physiotherapy, Usual surveillance
- Where
- France
- Volunteers
- 101 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Injury, Acute
SB-681323 IV for Subjects at Risk of Acute Lung Injury or ARDS
This is an early phase (Phase IIa), randomized, double-blind, parallel group, multi-centre study for subjects with trauma (physical injury) who are at risk for developing Acute Lung Injury (ALI) or Acute Respiratory Distress…
- Trial name
- NCT00996840
- Testing
- SB-681323 Intravenous 3mg, SB-681323 Intravenous 7.5 mg, SB-681323 Intravenous 7.5mg
- Where
- 6 sites in United States
- Volunteers
- 77 people
- Sponsor
- GlaxoSmithKline
Respiratory Distress Syndrome, Adult
Evaluating Health Outcomes and QOL After ALI Among Participants of the ALTA, OMEGA, EDEN, and SAILS ARDS Network Trials
Acute lung injury (ALI) is a severe lung condition that causes respiratory failure. The ARDS Network (ARDSNet) is a National Heart, Lung, and Blood Institute-sponsored network that is focused on improving treatments for people…
- Trial name
- ALTOS (NCT00719446)
- Where
- 6 sites in United States
- Volunteers
- 922 people
- Sponsor
- Johns Hopkins University
COVID-19 Acute Respiratory Distress Syndrome
Prone Positioning and R/I Ratio in COVID-19 Patients With ARDS (SyDRAC-DV)
The purpose of this study is to determine the efects of prone positioning on the recruitment- to-inflation ratio in COVID-19 patients with acute respiratory distress syndrome.
- Trial name
- SyDRAC-DV (NCT05360862)
- Testing
- Prone positioning session
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
ARDS, ARDS, Human
Effects of Sevoflurane on Extravascular Lung Water and Pulmonary Vascular Permeability in Patients With ARDS
The study will investigate the effects of inhaled sedation with sevoflurane using the AnaConDa device on extravascular lung water index (EVLWi) and the pulmonary vascular permeability index (PVPI) in patients with moderate to…
- Trial name
- NCT04530188
- Testing
- Sevoflurane, Propofol
- Volunteers
- 68 people
- Sponsor
- Bicetre Hospital
Covid-19
Mesenchymal Stem Cell Therapy for SARS-CoV-2-related Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) is the major cause of death in the COVID-19 pandemic. In this trial, the safety and efficacy of Mesenchymal Stem Cells (MSC) for the treatment of ARDS in COVID-19 patients will be…
- Trial name
- NCT04366063
- Testing
- Cell therapy protocol 1, Cell therapy protocol 2
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Royan Institute
Acute Respiratory Distress Syndrome
Comparison of Different PEEP Strategies in Moderate-to-Severe ARDS Based on Various Bedside Assessment Tools
Many patients admitted to the intensive care unit (ICU) for a severe lung disease called acute respiratory distress syndrome (ARDS) require mechanical ventilation and positive end-expiratory pressure (PEEP) to improve their…
- Trial name
- OPTI-PEEP (NCT07741916)
- Testing
- Ventilation at different levels of PEP including a test involving a gradual decrease in PEP.
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Tourette Syndrome, Tic Disorders
Evaluating and Promoting Resilience in Adolescents With Tourette Syndrome
This study adapts and tests PRISM (Promoting Resilience in Stress Management), a short skills-based program that teaches resilience, for teens ages 12-18 with Tourette syndrome or persistent tic disorder.
- Conditions
- Tourette Syndrome, Tic Disorders, Persistent (Chronic) Motor or Vocal Tic Disorder
- Trial name
- PRISM-TS (NCT07905898)
- Testing
- PRISM Intervention, Usual care intervention
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Wake Forest University Health Sciences
Prematurity, Respiratory Distress Syndrome, Newborn
Infantile NO Replenishment as a New Therapeutic Possibility
Case-control study of inhaled Nitric Oxide (iNO) treatment of full-term and preterm infants. The main objective of this study is to investigate the association between premature birth and its later comorbidities (neuroendocrine…
- Trial name
- miniNO (NCT04914806)
- Where
- 3 sites in France, Greece and 1 more
- Volunteers
- 240 people
- Sponsor
- National and Kapodistrian University of Athens
Acute Lung Injury, Acute Respiratory Distress Syndrome
Epidemiologic Multicenter Study on Mechanical Ventilation Management in Children With Acute Lung Injury
PALIVE 1 is an observational multicenter study on mechanical ventilation strategies used in children with an acute lung injury (ALI).
- Trial name
- PALIVE1 (NCT00521625)
- Where
- 58 sites in United States, Austria and 10 more
- Sponsor
- St. Justine's Hospital
Acute Respiratory Distress Syndrome
Assessment of Occult Lung Stress During Lung Protective Mechanical Ventilation
The present study will utilize esophageal manometry to measure the presence and magnitude of persistent patient effort during lung protective ventilation, allowing identification and mitigation of occult lung stress.
- Trial name
- NCT05675696
- Testing
- Esophageal Catheter
- Where
- United States
- Sponsor
- NYU Langone Health
Respiratory Distress Syndrome
A Multicenter, Randomized, Open Label Trial of a New Animal Extracted Surfactant to Treat RDS in Preterm Infants
The purpose of this study is to determine the efficacy and safety of the new pulmonary surfactant produced by Butantan Institute among premature infants with gestational age below 34 weeks with RDS, comparing to the pulmonary…
- Trial name
- NCT02305160
- Testing
- Butantan, Control
- Where
- 30 sites in Brazil
- Volunteers
- 327 people
- Sponsor
- University of Sao Paulo
COVID, Acute Respiratory Distress Syndrome
Impact of Angiotensin II Receptor Blockers Treatment in Patients With COVID 19 (COVID-ARA2)
The actual pandemic infection related to SARS-CoV2 results in viral pneumonitis (COVID-19), that may, in the more severe cases, lead the patients to the intensive care unit (ICU).
- Trial name
- COVID-ARA2 (NCT04337190)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
ARDS (Moderate or Severe), Adult Patients
Role of Elastic Power in Acute Respiratory Distress Syndrome
Mechanical ventilation is essential for managing acute respiratory distress syndrome (ARDS), but it can also cause ventilator-induced lung injury (VILI) due to mechanical forces.
- Trial name
- NCT06878313
- Volunteers
- 20 people
- Sponsor
- Hospital El Cruce
Respiratory Failure, Acute Lung Injury (ALI)
Airway Pressure Release Ventilation (APRV) Versus AC/VC Conventional Ventilation
APRV mode of ventilation will result in an improved partial pressure of arterial oxygenation/ fraction of inspired oxygen (P/F ratio) on day 3 of mechanical ventilation.
- Conditions
- Respiratory Failure, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT01339533
- Testing
- Mechanical Ventilation
- Where
- 2 sites in United States
- Volunteers
- 246 people
- Sponsor
- Intermountain Health Care, Inc.
Acute Respiratory Distress Syndrome
Poractant Alfa (Curosurf®)) -- Effect in Adult Patients Diagnosed With 2019 Novel Coronavirus (SARS-COV-19; (Covid-19)) Acute Respiratory Distress Syndrome (ARDS)
The purpose of this study was to evaluate the efficacy and safety of poractant alfa (Curosurf®), administered by endotracheal (ET) instillation in hospitalized adult patients diagnosed with SARS-COV-19 acute respiratory distress…
- Trial name
- NCT04502433
- Testing
- CUROSURF® (poractant alfa)
- Where
- 6 sites in United States, Italy and 1 more
- Volunteers
- 22 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Respiratory Distress Syndrome, Newborn
ETCare: Safety and Preliminary Efficacy Trial
When babies are sick, or are born prematurely, they sometimes need an endotracheal (ET) tube to assist their breathing and/or a nasal canula.
- Trial name
- NCT01688440
- Testing
- #1 Respiratory Care Solution
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Intermountain Health Care, Inc.
Acute Lung Injury
Omics Sequencing of Exosomes in Body Fluids of Patients With Acute Lung Injury
The exosomes in the experimental group and the control group were sequenced to find the difference of the two groups, providing a basis for subsequent basic research.
- Trial name
- NCT05058768
- Testing
- The lungs causes and extrapulmonary factors
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
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