Clinical trials: Respiratory Distress Syndrome, Newborn
Acute Respiratory Distress Syndrome, Acute Lung Injury
Study of the Economics of Pulmonary Artery Catheter Use in Patients With Acute Respiratory Distress Syndrome (ARDS)
Study of the long term outcomes and economic impact of the pulmonary artery catheter in acute respiratory distress syndrome (ARDS/ALI) patients.
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Lung Diseases
- Trial name
- NCT00234767
- Testing
- Pulmonary Artery Catheter, Protocolized Fluid Management
- Volunteers
- 650 people
- Sponsor
- University of Pittsburgh
Corona Virus Infection, ARDS
Use of UC-MSCs for COVID-19 Patients
The purpose of this research study is to learn about the safety and efficacy of human umbilical cord derived Mesenchymal Stem Cells (UC-MSC) for treatment of COVID-19 Patients with Severe Complications of Acute Lung Injury/Acute…
- Conditions
- Corona Virus Infection, ARDS, ARDS, Human, Acute Respiratory Distress Syndrome
- Trial name
- NCT04355728
- Testing
- Umbilical Cord Mesenchymal Stem Cells + Heparin along with best supportive care., Vehicle + Heparin along with best supportive care
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Camillo Ricordi
COVID, Acute Respiratory Distress Syndrome
COVID-19 : Transcutaneous pO2 and pCO2 as Predictive Factors for Acute Respiratory Destress Syndrome in Patients Affected With SARS-Cov-2
The first case of a person infected with SARS-Cov-2 virus can be tracked back on November the 17th, 2019, in China. On March 11, 2020, the World Health Organization (WHO) declared COVID-19 outbreak a pandemic.
- Conditions
- COVID, Acute Respiratory Distress Syndrome, Endothelial Dysfunction
- Trial name
- COVID-pO2-RAAS (NCT04524156)
- Testing
- Physiology
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Erasme University Hospital
Respiratory Distress Syndrome, Adult
Evaluating a Web-Based Ventilator Management Educational Program for Clinicians (The Lung Injury Knowledge Network [LINK] Study)
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a severe lung condition that causes respiratory failure. Individuals with ALI/ARDS often require the use of a respirator or artificial breathing machine, known…
- Trial name
- LINK (NCT00542737)
- Testing
- Web-Based Educational Program
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Preterm Infants, Neonatal Respiratory Distress Syndrome
Comparison of the Need Of Mechanical Ventilation Between Less Invasive Surfactant Administration (LISA) and Conventional INSURE (Intubation-Surfactant Administration-Extubation) Methods in Spontaneously Breathing Preterm Infants With Respiratory Distress Syndrome
Brief Summary of the Study This randomized controlled trial aims to compare the need for mechanical ventilation between Less Invasive Surfactant Administration (LISA) and the conventional INSURE (Intubation, Surfactant…
- Conditions
- Preterm Infants, Neonatal Respiratory Distress Syndrome, Need for Mechanical Ventilation
- Trial name
- NCT07910539
- Testing
- Intervention Name: Poractant alfa (surfactant) administered by the INSURE method
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Fatima Jinnah Medical University
Respiratory Distress Syndrome, Newborn
Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study
The primary objective of this study is to compare two methods of post-delivery stabilization and subsequent early respiratory care for reducing the need for MV and related secondary complications, such as BPD, in premature babies…
- Trial name
- Curpap (NCT00501982)
- Testing
- Poractant alfa (Curosurf®)
- Where
- 5 sites in Czechia, France and 3 more
- Volunteers
- 208 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
ARDS
MultiStem Administration for COVID-19 Induced ARDS (MACoVIA)
Multicenter investigation featuring an open-label lead-in followed by a double blinded, randomized, placebo-controlled Phase 2/3 part to evaluate the safety and efficacy of MultiStem therapy in subjects with moderate to severe…
- Trial name
- MACoVIA (NCT04367077)
- Testing
- MultiStem
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Healios K.K.
Respiratory Distress Syndrome, Adult
Mesenchymal Stem Cell in Patients With Acute Severe Respiratory Failure
Although the advent of advanced medical support for respiratory failure, the mortality rate of acute severe respiratory failure is still high and the life quality is frequently compromised from pulmonary fibrosis.
- Trial name
- STELLAR (NCT02112500)
- Testing
- Mesenchymal Stem Cell
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Asan Medical Center
Pediatric Acute Respiratory Distress Syndrome
Comparison of Oxygenation Index and Oxygen Stretch Index
Pediatric acute respiratory distress syndrome (pARDS) is a heterogeneous clinical syndrome that causes high rates of mortality and morbidity.
- Trial name
- NCT06586411
- Where
- 7 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Acute Respiratory Distress Syndrome (ARDS)
Conventional Versus Automated Bag-based Mechanical Ventilator to Support ARDS Patients
This study evaluates the extubation success and compares the survival rate in patients with signs of Covid-19 intubated with Masi, a novel type of mechanical ventilator, or with other conventional ventilators admitted in the ICU…
- Trial name
- Masi-ARDS (NCT06667375)
- Where
- Peru
- Volunteers
- 87 people
- Sponsor
- Fanny Lys Casado Pena
ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT)
Comparison of Different PEEP Titration Strategies Using Electrical Impedance Tomography in Patients With ARDS
The aim of the this study is to assess the short term physiological effects of 3 ventilation strategies for adult patients with ARDS admitted to intensive care unit.
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT), Positive End Expiratory Pressure (PEEP), Acute Lung Injury
- Trial name
- DELTA (NCT04247477)
- Testing
- Ventilation strategy
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Angers
ARDS, Multi-organ Failure
Biomarker of Lung Injury in ARDS Patients Receiving ECMO Support
The goal of this project is to find a marker expression that the investigators can use to trace symptom progression and develop a more efficient therapy to enhance ARDS patient survival rate and better post-ICU life quality.
- Trial name
- ARDS (NCT01967602)
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS)
Effect of R-spondin3 on Sepsis Induced Endothelial Dysfunction
Sepsis is the most frequent risk factor for ALI/ARDS. Meanwhile, Pulmonary is the most vulnerable organ to fail in response to sepsis, vascular endothelial dysfunction is a central event in the pathophysiology of sepsis.
- Trial name
- NCT04546919
- Testing
- sepsis
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Acute Respiratory Distress Syndrome
KL₄Surfactant Treatment in Patients With ARDS
Lung wash with KL₄Surfactant of individual lung segments using a bronchoscope compared to usual care alone consisting primarily of assisted (mechanical) ventilation in patients with acute respiratory distress syndrome(ARDS).
- Trial name
- NCT00215553
- Testing
- A.1 Lucinactant, B.3 SoC, A.2 Lucinactant
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Windtree Therapeutics
Moderate to Severe Acute Respiratory Distress Syndrome Associated With COVID-19
Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19 Infection
The objectives of this intermediate-size expanded access protocol are to assess the safety and efficacy of remestemcel-L in participants with ARDS due to coronavirus infection 2019 (COVID-19).
- Trial name
- NCT04366830
- Testing
- Remestemcel-L
- Where
- United States
- Sponsor
- Mesoblast International Sàrl
ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome)
Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) Patients
This study evaluates the safety and effectiveness of Ciprofol, a new sedative, in critically ill patients receiving Extracorporeal Membrane Oxygenation (ECMO), a life-support system for heart or lung failure.
- Conditions
- ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome), ECMO and Acute MI, Respiratory Failure Patients Treated With ECMO
- Trial name
- CIP-OXY (NCT06934811)
- Testing
- Ciprofol, Midazolam
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Acute Respiratory Distress Syndrome
ELASTANCE: Prospective Physiological Study of Lung Elastance in Recruitment and Derecruitment in Early Onset Mechanically Ventilated ARDS Patients
The recruitment strategy in Acute respiratory distress syndrome (ARDS) patients mechanically ventilated combines recruitment maneuvers and positive end expiratory pressure (PEEP).
- Trial name
- ELASTANCE (NCT01899560)
- Testing
- Measure lung and chest wall elastance with esophageal catheter, non-invasive method for measuring the lung elastance
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Preterm, Respiratory Distress Syndrome in Premature Infant
The Hemodynamic Impact of High-frequency Oscillatory Ventilation and Periodic Sighs in Preterm Infants
To evaluate the effectiveness of early lung recruitment using high-frequency oscillatory ventilation (HFOV) alone versus HFOV with superimposed sigh breaths in moderate-to-late preterm infants requiring invasive respiratory…
- Conditions
- Preterm, Respiratory Distress Syndrome in Premature Infant, Recruitment, Mechanical Ventilation
- Trial name
- NCT07896824
- Testing
- Superimposed sigh breaths, High frequency ventilation
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Respiratory Distress Syndrome
ECALMIST Versus InSurE in Preterm Infant < 32 Weeks,Multicenter, Multinational RCT
Minimally invasive surfactant therapy via a small vascular catheter - ECALMIST (Early CPAP And Large Volume Minimal Invasive Surfactant Therapy) versus InSurE (Intubate, Surfactant Extubate) in preterm infants with Respiratory…
- Trial name
- ECALMIST (NCT01848262)
- Testing
- ECALMIST, InSure
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University of Manitoba
Sepsis, Burn Injury
Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1
This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery.
- Conditions
- Sepsis, Burn Injury, Wound Healing, Critical Illness
- Trial name
- NCT07249762
- Testing
- Observational Cohort (No Intervention)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
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