Clinical trials: Respiratory Distress Syndrome, Newborn
Transient Tachypnea of the Newborn
PATET Ratio to Rule Out Transient Tachypnea of the Newborn
This study aims to find out whether diagnosis of Transient Tachypnea of the Newborn(TTN) can be predicted via evaluating pulmonary artery Doppler indices.
- Trial name
- PATET (NCT02965365)
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
COVID 19
Low Dose of IL-2 In Acute Respiratory DistrEss Syndrome Related to COVID-19
The purpose is to demonstrate the efficacy of low-dose interleukin 2 (Ld-IL2) administration in improving clinical course and oxygenation parameters in patients with SARS-CoV2-related ARDS.
- Trial name
- LILIADE-COVID (NCT04357444)
- Testing
- 1: ILT101
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome
Impact of Tissue Plasminogen Activator (tPA) Treatment for an Atypical Acute Respiratory Distress Syndrome (COVID-19)
At the beginning COVID-associated lung injury was considered as typical ARDS, hence respiratory and nonrespiratory treatments were delivered according to general principles for this kind of illness.
- Trial name
- AtTAC (NCT04453371)
- Testing
- Tissue plasminogen activator, Ringer solution
- Sponsor
- Negovsky Reanimatology Research Institute
Pulmonary Edema, Respiratory Distress Syndrome
Performance Evaluation of Clinical Ultrasound in Management of Acute Pulmonary Edema in Elderly Patient
The main objective is to assess the validation of the diagnosis early acute pulmonary edema in elderly patients with acute respiratory distress, admitted in a host of vital emergency services by lung ultrasound associated with…
- Trial name
- ECHOP (NCT02638350)
- Testing
- Strategy with lung ultrasound
- Where
- France
- Volunteers
- 123 people
- Sponsor
- University Hospital, Toulouse
COVID-19, Acute Respiratory Distress Syndrome
Safety and Efficacy of CAStem for Severe COVID-19 Associated With/Without ARDS
A phase1/2, open label, dose escalation, safety and early efficacy study of CAStem for the treatment of severe COVID-19 associated with or without ARDS.
- Conditions
- COVID-19, Acute Respiratory Distress Syndrome, Virus; Pneumonia, Acute Lung Injury
- Trial name
- NCT04331613
- Testing
- CAStem
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Chinese Academy of Sciences
ARDS, Human, Mechanical Ventilation Pressure High
Lung Protection in ARDS Using Neurally Adjusted Ventilatory Assist
The aim of this study is to investigate the use neurally adjusted ventilatory assist (NAVA) as lung protective strategy in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- NAVA (NCT03868982)
- Testing
- Neurally adjusted ventilatory assist
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Fu Jen Catholic University
COVID-19, COVID-19 Acute Respiratory Distress Syndrome
Study of Cysteamine-pantetheine Disulfide (TTI-0102) in Mild to Moderate COVID-19
This is multi-center, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, pharmacodynamics (PD) and efficacy of TTI-0102 for the treatment of patients with mild to moderate COVID-19.
- Trial name
- NCT05212662
- Testing
- TTI-0102
- Sponsor
- Thiogenesis Therapeutics, Inc.
Corona Virus Infection, Acute Respiratory Distress Syndrome
Losartan for Patients With COVID-19 Not Requiring Hospitalization
This is a multi-center, double-blinded study of COVID-19 infected patients randomized 1:1 to daily losartan or placebo for 10 days or treatment failure (hospital admission).
- Conditions
- Corona Virus Infection, Acute Respiratory Distress Syndrome, SARS-CoV Infection
- Trial name
- NCT04311177
- Testing
- Losartan
- Where
- 4 sites in United States
- Volunteers
- 117 people
- Sponsor
- University of Minnesota
Injuries, Acute Brain
Protective Ventilatory Strategy in Severe Acute Brain Injury
Acute respiratory distress syndrome (ARDS) occurs in almost 20% of patients with severe acute brain injury and is associated with increased morbidity and mortality.
- Trial name
- PROLABI (NCT01690819)
- Testing
- Conventional Ventilatory Strategy, Protective Ventilatory Strategy
- Where
- Italy
- Volunteers
- 524 people
- Sponsor
- University of Turin, Italy
ARDS, Human, Mechanical Ventilation Complication
Smartphone Application for Initiation of Protective Ventilation. Clinical Impact of Instrumental Dead Space Reduction
Clinical evaluation of a new educative tools (Smartphone application) based on impact of instrumental dead space reduction after initiation of protective ventilation during mechanical ventilation.
- Conditions
- ARDS, Human, Mechanical Ventilation Complication, Humidifier Lung
- Trial name
- Ventilo (NCT04390360)
- Testing
- Protective ventilation implementation, Protective ventilation with HME, Protective ventilation with Heated humidifier
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Laval University
Acute Respiratory Distress Syndrome in Children
Assessment of Airway Opening Pressure in Invasively Ventilated Children
Acute respiratory distress syndrome (ARDS) in children is associated with significant morbidity and mortality. Current studies seek to individualize the management of children by defining several phenotypes, based until now…
- Trial name
- AOP-KID (NCT07262541)
- Testing
- Measurement of airway opening pressure
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Distress Syndrome, Adult, Covid19
High-Dose Vitamin C Treatment in Critically Ill COVID-19 Patients
Acute respiratory failure due to COVİD-19 pneumonia has poor prognosis and high mortality . Both the lack of an effective antiviral treatment and the low level evidence of the recommendations presented in the guidelines on other…
- Trial name
- NCT04710329
- Testing
- Ascorbic acid
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Respiratory Distress Syndrome (RDS), Neonatal Diseases and Abnormalities
Nasal High Frequency in Preterm Neonates
One of the most commonly used non-invasive methods is nasal continuous positive airway pressure (nCPAP). Although high frequency ventilation (HFV) has been applied in many neonatal intensive care units, nasal high frequency…
- Trial name
- NCT06687083
- Testing
- nasal high frequency oscillatory ventilation mode, nasal continuous positive pressure ventilation mode
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Coronavirus, SARS-CoV-2
Hemodynamic Characteristics of Patients With SARS-CoV-2
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a public health emergency of international concern.
- Conditions
- Coronavirus, SARS-CoV-2, COVID-19, Acute Respiratory Distress Syndrome
- Trial name
- PiCCOVID (NCT04337983)
- Testing
- Transpulmonary thermodilution, Echocardiography
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Bicetre Hospital
ARDS (Acute Respiratory Distress Syndrome), VILI (Ventilator-induced Lung Injury)
Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study)
The REALVENT trial is designed to evaluate whether a real-time, algorithm-driven ventilation feedback strategy can improve lung-protective ventilation (LPV) achievement rates in critically ill patients receiving invasive…
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), VILI (Ventilator-induced Lung Injury), Respiratory Failure, Critical Illness
- Trial name
- REALVENT (NCT07307066)
- Testing
- REal-time Algorithm-driven Ventilation feedback to improve lung-protective ventilation in critically, Standard ICU care
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Peking Union Medical College Hospital
Deglutition Disorders, Respiratory Distress Syndrome In Premature Infants
Effect of Nasal Continuous Positive Airway Pressure on The Pharyngeal Swallow in Neonates
Oral feeding of neonates while on nasal continuous positive airway pressure (NCPAP) is a common practice in many neonatal intensive care units (NICU) all over the country.
- Conditions
- Deglutition Disorders, Respiratory Distress Syndrome In Premature Infants, Respiratory Aspiration, Newborn, Premature
- Trial name
- NCT02661256
- Testing
- NCPAP, Varibar® Thin Liquid Barium Sulfate for Suspension
- Volunteers
- 7 people
- Sponsor
- NYU Langone Health
Covid19, Acute Respiratory Distress Syndrome
The MEseNchymal coviD-19 Trial: MSCs in Adults With Respiratory Failure Due to COVID-19 or Another Underlying Cause
This is a pilot, multi-centre, open-label randomised controlled study to assess the early efficacy of intravenous (IV) administration of CYP-001 in adults admitted to an intensive care unit (ICU) with respiratory failure
- Trial name
- MEND (NCT04537351)
- Testing
- CYP-001
- Where
- 5 sites in Australia
- Volunteers
- 14 people
- Sponsor
- Cynata Therapeutics Limited
Respiratory Distress Syndrome, Adult, Septic Shock
Immunglobulin M Enriched Intra Venous Immunoglobulin (IVIG) Therapy in Adult Respiratory Distress Syndrom (ARDS) Patients
57 patients with Adult Respiratory Distress Syndrome (ARDS) requiring Extracorporeal membrane oxygenation (ECMO) therapy were analyzed retrospectively.
- Trial name
- IVIG (NCT02961166)
- Testing
- IgM enriched Immunoglobulins
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- University Hospital Tuebingen
Lung Injury, ARDS
Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19
This study seeks to define the ultrasound profile of patients with COVID-19, and document the progression of these ultrasound findings to develop prognostication and clinical decision instruments that can help guide management of…
- Conditions
- Lung Injury, ARDS, Acute Cardiac Event, Covid19
- Trial name
- PIOS-COVID (NCT05228717)
- Testing
- Point of Care Ultrasound
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Olive View-UCLA Education & Research Institute
Pregnant Women Receive Celesten
Betamethasone and Severity of Hyaline Membrane Disease
Primary purpose: to study the relationship between betamethasone placental transfer and the occurrence and severity of the Hyaline Membrane Disease.
- Trial name
- b-Mhyalines (NCT01854840)
- Where
- France
- Volunteers
- 127 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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