Clinical trials: Respiratory Distress Syndrome (RDS)
ARDS, Human, Mechanical Ventilation Complication
Smartphone Application for Initiation of Protective Ventilation. Clinical Impact of Instrumental Dead Space Reduction
Clinical evaluation of a new educative tools (Smartphone application) based on impact of instrumental dead space reduction after initiation of protective ventilation during mechanical ventilation.
- Conditions
- ARDS, Human, Mechanical Ventilation Complication, Humidifier Lung
- Trial name
- Ventilo (NCT04390360)
- Testing
- Protective ventilation implementation, Protective ventilation with HME, Protective ventilation with Heated humidifier
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Laval University
Mechanical Ventilation, Respiratory Distress Syndrome, Adult
Practice of Ventilation in Middle-Income Countries
The purpose of this international, multicenter service review is to describe and compare ventilation management in patients at risk of acute respiratory distress syndrome (ARDS) versus patients not at risk and patients with…
- Conditions
- Mechanical Ventilation, Respiratory Distress Syndrome, Adult, Acute Respiratory Failure
- Trial name
- PRoVENT-iMIC (NCT03188770)
- Where
- 51 sites in Bangladesh, India and 8 more
- Volunteers
- 1,315 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
COVID, Corona Virus Infection
RIC as an Adjunct Therapy for Severe COVID-19 Disease: a Prospective Randomized Pilot Study
This research aims to assess the use of an experimental and non-invasive procedure, Remote Ischemic Conditioning (RIC), as an adjunct therapy in attenuating severe COVID-19 disease.
- Conditions
- COVID, Corona Virus Infection, Acute Lung Injury, Ischemia Limb
- Trial name
- NCT04659460
- Testing
- Remote Ischemic Conditioning
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Preterm Infants
NHFOV vs. NCPAP as a Primary Treatment to Neonatal Respiratory Distress Syndrome(NRDS)
The investigators compared advantages and disadvantages of two forms of noninvasive respiratory support -noninvasive high-frequency oscillatory ventilation (nHFOV) or nasal continuous positive airway pressure (nCPAP) -as a…
- Trial name
- NCT03099694
- Testing
- noninvasive high-frequency ventilation (nHFOV), nasal continuous positive airway pressure (nCPAP)
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Xingwang Zhu
Long Term Adverse Effects, Pneumonia
Long-term Follow Up of Adult Patients Treated With Extracorporeal Membrane Oxygenation for Respiratory Failure
Follow-up after treatment with Extracorporeal Membrane Oxygenation (ECMO) at the ECMO Center Karolinska. Patients: adult survivors treated with ECMO for severe refractory respiratory failure at least 5 years earlier.
- Conditions
- Long Term Adverse Effects, Pneumonia, Acute Respiratory Distress Syndrome, Sepsis
- Trial name
- NCT03031275
- Testing
- High-resolution computed tomography, Magnetic resonance imaging, Cognitive testing
- Where
- Sweden
- Volunteers
- 31 people
- Sponsor
- Karolinska University Hospital
ARDS (Acute Respiratory Distress Syndrome)
Physiological Effects of APRVplus and TCAV in ARDS
In previous studies, airway pressure release ventilation (APRV) has been proven to be an important respiratory support method for ARDS patients, and various APRV ventilation strategies have been proposed.
- Trial name
- NCT06748807
- Testing
- APRVplus, TCAV
- Where
- China
- Volunteers
- 20 people
- Sponsor
- West China Hospital
ARDS, Human, Obesity, Morbid
Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study.
The goal of this clinical trial is to test a personalized intervention aiming to optimize the mechanical ventilator settings in morbidly obese patients suffering from moderate to severe Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- TGV-MOA (NCT06119516)
- Testing
- Esophageal pressure-guided strategy,
- Where
- 5 sites in France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Virus Diseases, Pneumonia
Universal Anti-Viral Vaccine for Healthy Elderly Adults
This protocol tests the safety and efficacy of a novel universal vaccine concept called "allo-priming" which is designed to protect elderly adults from progression of any type of viral infection, including possible protection…
- Conditions
- Virus Diseases, Pneumonia, COVID-19 Respiratory Infection, RSV Pneumonia
- Trial name
- ALLOPRIME (NCT04441047)
- Testing
- AlloStim
- Where
- 4 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mirror Biologics, Inc.
Respiratory Distress Syndrome in Premature Infant, Bronchopulmonary Dysplasia
Safety, Pk and Anti-inflammatory Effects of CC10 Protein in Premature Infants With Respiratory Distress Syndrome (RDS)
Bronchopulmonary Dysplasia (BPD) is a multi-factorial disease process that is the end result of an immature, surfactant deficient lung that has been exposed to hyperoxia, mechanical ventilation and infection.
- Trial name
- NCT01473264
- Testing
- recombinant human CC10 (rhCC10)
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Clarassance, Inc.
COVID-19, Acute Respiratory Distress Syndrome
Efficacy and Safety of aerosolizedDornase Alfa Administration in Patients With COVID19 Induced ARDS (COVIDORNASE)
This study plans to learn more about the effects of Dornase Alfa in COVID19 (coronavirus disease of 2019) patients, the medical condition caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
- Trial name
- COVIDORNASE (NCT04355364)
- Testing
- Dornase Alfa Inhalation Solution [Pulmozyme], standard procedure
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Inadequate; Pulmonary Ventilation, Newborn, Infant, Very Low Birth Weight
Nasal Noninvasive NAVA in the Very Low Birth Weight Infant
The purpose of this study is to determine if a new type of mechanical ventilation, or breathing machine (called neurally adjusted ventilatory assist or NAVA), will provide additional support to infants who were born prematurely.
- Trial name
- NCT01785563
- Testing
- Nasal NIV-NAVA
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Tarah T Colaizy
Deep Vein Thrombosis, Covid19
Evaluation of Serial Ultrasound Screening in ICU COVID-19 Patients
This clinical trial is designed to evaluate if the periodic screening for deep venous thrombosis by ultrasound of lower extremity in patients with intensive care unit (ICU) patients with COVID 19 impacts on mortality, ICU stay…
- Conditions
- Deep Vein Thrombosis, Covid19, COVID-19 Pneumonia, COVID-19 Respiratory Infection
- Trial name
- NCT05028244
- Testing
- venous ultrasound of lower extremity
- Where
- Spain
- Volunteers
- 168 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pneumonia, Viral, Influenza in Humans
Low Doses Corticosteroids as Adjuvant Therapy for the Treatment of Severe H1N1 Flu
The H1N1 flu pandemic is one of the major infectious threat of the past half century. it is rapidly progressing worldwide and a substantial number of patients get severe H1N1 related pneumonia that requires mechanical ventilation…
- Trial name
- CORTIFLU (NCT01014364)
- Testing
- hydrocortisone, isotonic saline
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University of Versailles
ARDS (Acute Respiratory Distress Syndrome)
International Survey for EXTubation Evaluation and Respiratory Dynamics in Acute Respiratory Distress Syndrome
EXTEND ARDS study is an international survey for ventilator weaning and extubation among ARDS patients. This study will be conducted on behalf of the Japanese ARDS Clinical Practice Guideline 2024 Committee as well as endorsement…
- Trial name
- EXTEND ARDS (NCT06598709)
- Where
- Japan
- Volunteers
- 1,000 people
- Sponsor
- Hiroshima University
Severe Acute Respiratory Distress Syndrome / Severe ARDS, Invasive Mechanical Ventilation
Hemodynamic and Cardiac Effects of Individualized PEEP Titration Using Esophageal Pressure Measurements in ARDS Patients
The acute respiratory distress syndrome (ARDS) is common condition in critical ill patients affecting 7.2 people / 100,000 population / year and more than 7% of patients with invasive mechanical ventilation for more than 24…
- Conditions
- Severe Acute Respiratory Distress Syndrome / Severe ARDS, Invasive Mechanical Ventilation, Individualized PEEP Treatment Strategy
- Trial name
- ENCODE (NCT02617914)
- Testing
- individualized PEEP treatment, Invasive mechanical ventilation, ECMO,
- Sponsor
- RWTH Aachen University
Acute Respiratory Distress Syndrome
A Clinical Study of Mesenchymal Stem Cell Exosomes Nebulizer for the Treatment of ARDS
To evaluate allogeneic human mesenchymal stem cell exosomes (hMSC-Exos) in the treatment of acute respiratory distress syndrome (ARDS)
- Trial name
- NCT04602104
- Testing
- low dose hMSC-Exos, medium dose hMSC-Exos, high dose hMSC-Exos
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Ruijin Hospital
COVID-19 Acute Respiratory Distress Syndrome, Respiratory Distress Syndrome
Safety and Effectiveness of Placental Derived Exosomes and Umbilical Cord Mesenchymal Stem Cells in Moderate to Severe Acute Respiratory Distress Syndrome (ARDS) Associated With the Novel Corona Virus Infection (COVID-19)
Recent advances have been made in prevention of the viral infection via vaccines but there is still need for effective treatment options for patients. Novel therapies need to be developed to further improve clinical outcomes.
- Trial name
- NCT05387278
- Testing
- EV-Pure™ and WJ-Pure™
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vitti Labs, LLC
Intensive Care, Neonatal, Neonatal Respiratory Distress Syndrome
Breastfeeding Infants Receiving Respiratory Support Trial
The purpose of this study is to assess whether two methods of breathing support in babies called 'Humidified High-Flow Nasal Cannula' oxygen (HHFNC) and 'nasal Continuous Positive Airways Pressure' (nCPAP) are compatible with…
- Conditions
- Intensive Care, Neonatal, Neonatal Respiratory Distress Syndrome, Continuous Positive Airway Pressure, Breast Feeding
- Trial name
- BIRRST (NCT02999165)
- Testing
- Breast feeding, Nasogastric feeding
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Imperial College Healthcare NHS Trust
Neonatal Respiratory Distress Related Conditions
Oscillatory Versus Non-oscillatory Nasal Continuous Airway Pressure Neonatal Respiratory Support
Controlled randomized trial looking at Standard nasal continuous airway pressure (CPAP) respiratory support versus High Frequency CPAP in neonates who require respiratory support or who are being extubated and require support…
- Trial name
- NCT03711565
- Testing
- Regular Nasal CPAP using a conventional ventilator, High Frequency Nasal CPAP
- Where
- United States
- Sponsor
- University of California, Davis
Respiratory Distress Syndrome, Newborn
Amniotic Fluid Optical Density Determination as a Test for Assessment of Fetal Lung Maturity.
To determine the relationship between the result of amniotic fluid optical density between 26 and 36 6/7 weeks of pregnancy and the risk of developing neonatal respiratory distress syndrome.
- Trial name
- NCT02332304
- Testing
- Preterm fetus
- Where
- Panama
- Volunteers
- 200 people
- Sponsor
- Saint Thomas Hospital, Panama
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