Clinical trials: Respiratory Distress Syndrome (RDS)
Covid-19
Mesenchymal Stem Cell Therapy for SARS-CoV-2-related Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) is the major cause of death in the COVID-19 pandemic. In this trial, the safety and efficacy of Mesenchymal Stem Cells (MSC) for the treatment of ARDS in COVID-19 patients will be…
- Trial name
- NCT04366063
- Testing
- Cell therapy protocol 1, Cell therapy protocol 2
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Royan Institute
Acute Respiratory Distress Syndrome
Comparison of Different PEEP Strategies in Moderate-to-Severe ARDS Based on Various Bedside Assessment Tools
Many patients admitted to the intensive care unit (ICU) for a severe lung disease called acute respiratory distress syndrome (ARDS) require mechanical ventilation and positive end-expiratory pressure (PEEP) to improve their…
- Trial name
- OPTI-PEEP (NCT07741916)
- Testing
- Ventilation at different levels of PEP including a test involving a gradual decrease in PEP.
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Prematurity, Respiratory Distress Syndrome, Newborn
Infantile NO Replenishment as a New Therapeutic Possibility
Case-control study of inhaled Nitric Oxide (iNO) treatment of full-term and preterm infants. The main objective of this study is to investigate the association between premature birth and its later comorbidities (neuroendocrine…
- Trial name
- miniNO (NCT04914806)
- Where
- 3 sites in France, Greece and 1 more
- Volunteers
- 240 people
- Sponsor
- National and Kapodistrian University of Athens
Acute Lung Injury, Acute Respiratory Distress Syndrome
Epidemiologic Multicenter Study on Mechanical Ventilation Management in Children With Acute Lung Injury
PALIVE 1 is an observational multicenter study on mechanical ventilation strategies used in children with an acute lung injury (ALI).
- Trial name
- PALIVE1 (NCT00521625)
- Where
- 58 sites in United States, Austria and 10 more
- Sponsor
- St. Justine's Hospital
Acute Respiratory Distress Syndrome
Assessment of Occult Lung Stress During Lung Protective Mechanical Ventilation
The present study will utilize esophageal manometry to measure the presence and magnitude of persistent patient effort during lung protective ventilation, allowing identification and mitigation of occult lung stress.
- Trial name
- NCT05675696
- Testing
- Esophageal Catheter
- Where
- United States
- Sponsor
- NYU Langone Health
Respiratory Distress Syndrome
A Multicenter, Randomized, Open Label Trial of a New Animal Extracted Surfactant to Treat RDS in Preterm Infants
The purpose of this study is to determine the efficacy and safety of the new pulmonary surfactant produced by Butantan Institute among premature infants with gestational age below 34 weeks with RDS, comparing to the pulmonary…
- Trial name
- NCT02305160
- Testing
- Butantan, Control
- Where
- 30 sites in Brazil
- Volunteers
- 327 people
- Sponsor
- University of Sao Paulo
COVID, Acute Respiratory Distress Syndrome
Impact of Angiotensin II Receptor Blockers Treatment in Patients With COVID 19 (COVID-ARA2)
The actual pandemic infection related to SARS-CoV2 results in viral pneumonitis (COVID-19), that may, in the more severe cases, lead the patients to the intensive care unit (ICU).
- Trial name
- COVID-ARA2 (NCT04337190)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
ARDS (Moderate or Severe), Adult Patients
Role of Elastic Power in Acute Respiratory Distress Syndrome
Mechanical ventilation is essential for managing acute respiratory distress syndrome (ARDS), but it can also cause ventilator-induced lung injury (VILI) due to mechanical forces.
- Trial name
- NCT06878313
- Volunteers
- 20 people
- Sponsor
- Hospital El Cruce
Respiratory Failure, Acute Lung Injury (ALI)
Airway Pressure Release Ventilation (APRV) Versus AC/VC Conventional Ventilation
APRV mode of ventilation will result in an improved partial pressure of arterial oxygenation/ fraction of inspired oxygen (P/F ratio) on day 3 of mechanical ventilation.
- Conditions
- Respiratory Failure, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT01339533
- Testing
- Mechanical Ventilation
- Where
- 2 sites in United States
- Volunteers
- 246 people
- Sponsor
- Intermountain Health Care, Inc.
Acute Respiratory Distress Syndrome
Poractant Alfa (Curosurf®)) -- Effect in Adult Patients Diagnosed With 2019 Novel Coronavirus (SARS-COV-19; (Covid-19)) Acute Respiratory Distress Syndrome (ARDS)
The purpose of this study was to evaluate the efficacy and safety of poractant alfa (Curosurf®), administered by endotracheal (ET) instillation in hospitalized adult patients diagnosed with SARS-COV-19 acute respiratory distress…
- Trial name
- NCT04502433
- Testing
- CUROSURF® (poractant alfa)
- Where
- 6 sites in United States, Italy and 1 more
- Volunteers
- 22 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Respiratory Distress Syndrome, Newborn
ETCare: Safety and Preliminary Efficacy Trial
When babies are sick, or are born prematurely, they sometimes need an endotracheal (ET) tube to assist their breathing and/or a nasal canula.
- Trial name
- NCT01688440
- Testing
- #1 Respiratory Care Solution
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Intermountain Health Care, Inc.
Acute Lung Injury
Omics Sequencing of Exosomes in Body Fluids of Patients With Acute Lung Injury
The exosomes in the experimental group and the control group were sequenced to find the difference of the two groups, providing a basis for subsequent basic research.
- Trial name
- NCT05058768
- Testing
- The lungs causes and extrapulmonary factors
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
COVID-19, Pneumonia
Study to Assess Efficacy and Safety Relative to Standard of Care in Patients With COVID-19 Pneumonia
To assess the clinical efficacy of ANG-3777 relative to the standard of care in reducing the severity and progression of pulmonary and renal dysfunction and mortality in adult patients hospitalized with COVID-19 pneumonia
- Trial name
- NCT04459676
- Testing
- Standard of Care (SOC) + ANG-3777
- Where
- 10 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Angion Biomedica Corp
Respiratory Distress Syndrome of Prematurity
Cerebral and Renal Oximetry Study in Preterm Patients Who Require Surfactant Administration
Respiratory distress syndrome of prematurity (RDSP) is an acute respiratory condition that occurs in preterm infants due to pulmonary surfactant deficiency.
- Trial name
- NCT05091840
- Testing
- oximetry monitoring
- Volunteers
- 40 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Respiratory Distress Syndrome, Adult, Gastrointestinal Hemorrhage
INR-Triggered Transfusion In GI Bleeders From ER
Transfusion-related acute lung injury (TRALI) is the most common cause of transfusion-related morbidity and mortality in the United States.
- Conditions
- Respiratory Distress Syndrome, Adult, Gastrointestinal Hemorrhage, Liver Diseases, Transfusion Related Lung Injury
- Trial name
- I-TRIGER (NCT01461889)
- Testing
- Transfuse plasma to High INR target, Transfuse plasma to Low INR target
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
ARDS (Acute Respiratory Distress Syndrome)
Comparison of 5% Nacl and 10% NaHCO3 As Contrast Agents for Lung Perfusion with EIT
Electrical impedance tomography (EIT) has enabled the bedside monitoring of lung perfusion measurement through the indicator-based contrast method.
- Trial name
- NCT06868810
- Testing
- Injection of hypertonic saline, Injection of 5% NaHCO3
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Peking Union Medical College Hospital
Acute Respiratory Distress Syndrome
Influence of NEP Inhibition on Vascular Leak and Inflammation (NEPi-INFLAMMATION)
Acute Respiratory Distress Syndrome (ARDS) is a severe type of lung injury that affects 10% of patients admitted to Intensive Care Units worldwide, with an unacceptably high mortality of up to 48% in those with the most severe…
- Trial name
- NCT05600062
- Testing
- Racecadotril 100 milligram (MG) Oral Capsule
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Respiratory Distress Syndrome, Adult
Effects of Different Assisted Mechanical Ventilation in Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS) Patients
The aim of this study is to evaluate the effects in terms of gas exchange, respiratory mechanics and comfort of breathing, of different assisted mechanical ventilation in ALI/ARDS patients.
- Trial name
- NCT00267241
- Testing
- Mechanical Ventilation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Policlinico Hospital
Acute Respiratory Distress Syndrome, Lung Diseases
Corticosteroids as Rescue Therapy for the Late Phase of Acute Respiratory Distress Syndrome
The purpose of this study is to assess innovative treatment methods in patients with adult respiratory distress syndrome (ARDS) as well as those at risk of developing ARDS.
- Trial name
- NCT00295269
- Testing
- Mythylprednisolone
- Volunteers
- 200 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Respiratory Distress Syndrome, Positive-Pressure Respiration
Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability
This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung…
- Conditions
- Respiratory Distress Syndrome, Positive-Pressure Respiration, Mechanical Ventilation
- Trial name
- NCT06430554
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
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