Clinical trials: Respiratory Distress Syndrome (RDS)
Covid19, Ventilators, Mechanical
Efficacy of FES Cycling After a Severe Form of COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease 2019 (COVID-19) affect at late march 2021 more than 127 millions of persons worldwide (including more than 4.5 millions in France…
- Conditions
- Covid19, Ventilators, Mechanical, Respiratory Distress Syndrome
- Trial name
- FESrehabCoV (NCT04841746)
- Testing
- Physical therapy that include a standardized cycling training with functional electrical stimulation, Physical therapy that include a standardized cycling training with no additional functional electrical stimulation
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Hospices Civils de Lyon
Acute Respiratory Distress Syndrome (ARDS)
Assessment of the Reproducibility of the Recruitment-to-inflation Ratio (R/I Ratio) Measurement in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a severe lung condition that often requires invasive mechanical ventilation in the intensive care unit.
- Trial name
- RIRR (NCT07666503)
- Where
- 4 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19, SARS-CoV Infection
Glycine Supplement for Severe COVID-19
This study will explore whether a daily supplement of glycine, a substance that has antiinflammatory, cytoprotective, and endothelium-protecting effects, can improve mortality, as well as clinical and biochemical parameters, in…
- Conditions
- COVID-19, SARS-CoV Infection, SARS (Severe Acute Respiratory Syndrome), SARS Pneumonia
- Trial name
- NCT04443673
- Testing
- Glycine
- Where
- Mexico
- Volunteers
- 59 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
Acute Respiratory Distress Syndrome (ARDS), Ventilated Patient in Intensive Care
Comparison of Dynamic Mechanical Power Formula With Geometric Method in Pressure- and Volume-Controlled Ventilation: A Validation Study
This prospective observational study aims to validate the dynamic mechanical power (MPdyn) formula by comparing it with the gold-standard geometric method (MPgeo) in patients with acute respiratory distress syndrome (ARDS) who…
- Trial name
- NCT07099729
- Testing
- Volume-Controlled Ventilation (VCV) with inspiratory-to-expiratory (I:E) ratio of 1:2., Volume-Controlled Ventilation (VCV) with inspiratory-to-expiratory (I:E) ratio of 1:1., Pressure-Controlled Ventilation (PCV) with inspiratory-to-expiratory (I:E) ratio of 1:2.
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Cardiac Output, Hemodynamic Optimization
Hemodynamic Effects of Two Modalities of Alveolar Recruitment Maneuvers - ICU Patients
The objective of this study was to investigate the hemodynamic effects of two alveolar recruitment maneuver strategies in critical care patients with acute respiratory distress syndrome.
- Conditions
- Cardiac Output, Hemodynamic Optimization, Monitoring Blood Pressure, Stroke Volume
- Trial name
- CHARM-ICU (NCT05365854)
- Testing
- Alveolar Recruitment Maneuver (ARM)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Respiratory Distress Syndrome, Adult
Ultra-protective Pulmonary Ventilation Supported by Low Flow ECCO2R for Severe ARDS
This study evaluates the use of ultra-protective ventilation, where very low ventilation volumes are used, in patients with severe acute respiratory distress syndrome (ARDS) meeting criteria to nurse in the prone position.
- Trial name
- U-Protect (NCT02252094)
- Testing
- Prismalung, Ultra-protective ventilation, Conventional Lung Protective Ventilation
- Where
- 2 sites in Singapore
- Volunteers
- 8 people
- Sponsor
- National University Health System, Singapore
Acute Kidney Injury, COVID-19
Prediction of Acute Kidney Injury in Patients With COVID-19
The two biomarkers determined in urine, "Tissue Inhibitor of Metalloproteinases 2 (TIMP-2)" and "Insulin-like Growth Factor-Binding Protein 7 (IGFBP7)", can indicate the occurrence of Acute kidney injury (AKI) in cardiac surgery…
- Conditions
- Acute Kidney Injury, COVID-19, ARDS
- Trial name
- NCT04406688
- Where
- 13 sites in Germany, Italy and 3 more
- Volunteers
- 300 people
- Sponsor
- University Hospital Muenster
Ards, Covid19
FX06 to Rescue Acute Respiratory Distress Syndrome During Covid-19 Pneumonia
Vascular leakage following endothelial injury, responsible for interstitial and alveolar edema, is a major feature of pathogen induced acute lung injury.
- Conditions
- Ards, Covid19, Pneumonia
- Trial name
- FX-COVID (NCT04618042)
- Testing
- FX06
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Lung Injury, Acute Respiratory Distress Syndrome
The Specific Lung Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients in Supine and Prone Position
The investigators aim is to study the specific lung elastance in ALI/ARDS patients during invasive mechanical ventilation, in supine and prone position.
- Trial name
- NCT00568659
- Testing
- specific elastance
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Policlinico Hospital
COVID-19 Pneumonia
Efficacy and Safety of Tocilizumab in the Treatment of SARS-Cov-2 Related Pneumonia
The current spread of the COrona VIrus Disease-2019 (COVID-19) epidemic in Italy, and the current lack of effective and approved drugs for its treatment, poses the problem of Severe acute respiratory syndrome coronavirus-2…
- Trial name
- TOSCA (NCT04332913)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of L'Aquila
Pediatric Acute Respiratory Distress Syndrome
Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)
The goal of this clinical trial is to perform a PEEP titration protocol and use EIT to identify the optimal PEEP at which lung overdistention and collapse are most effectively balanced.
- Trial name
- NCT06684119
- Testing
- Electrical Impedance Tomography positive end-expiratory pressure titration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Los Angeles
Acute Respiratory Distress Syndrome (ARDS)
LIPS-B: Lung Injury Prevention Study With Budesonide and Beta
This study tested whether inhaled budesonide and formoterol were able to alleviate or prevent pulmonary injury when administered early in hospital course to the patients at risk for developing acute respiratory distress syndrome…
- Trial name
- LIPS-B (NCT01783821)
- Testing
- Budesonide, Formoterol
- Where
- 5 sites in United States
- Volunteers
- 61 people
- Sponsor
- Mayo Clinic
ARDS (Acute Respiratory Distress Syndrome)
Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT31-1 for Treating ARDS
This Phase 1/2A, randomized, double-blind study will evaluate the safety, tolerability, and pharmacokinetics (PK) of HT31-1 (hCitH3-mAb) in healthy adult volunteers and in patients with mild-to-moderate acute respiratory distress…
- Trial name
- NCT07449572
- Testing
- HT31-1, Saline (0.9%, sterile, for infusion)
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- HTIC, Inc
ARDS
MultiStem Administration for COVID-19 Induced ARDS (MACoVIA)
Multicenter investigation featuring an open-label lead-in followed by a double blinded, randomized, placebo-controlled Phase 2/3 part to evaluate the safety and efficacy of MultiStem therapy in subjects with moderate to severe…
- Trial name
- MACoVIA (NCT04367077)
- Testing
- MultiStem
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Healios K.K.
COVID-19 Pneumonia, COVID-19
Cardiac Magnetic Resonance Tissue Characterization in COVID-19 Survivors
The purpose of this study is to test if visualizing the heart with cardiac MRI/echo will be important in the understanding cardiac function and prediction of cardiopulmonary symptoms, physical effort tolerance, and outcomes in…
- Conditions
- COVID-19 Pneumonia, COVID-19, COVID-19 Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05164744
- Testing
- Cardiac MRI, Echocardiogram, 6-minute walk test
- Where
- 3 sites in United States
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Corona Virus Infection, Acute Respiratory Distress Syndrome
Losartan for Patients With COVID-19 Requiring Hospitalization
This is a multi-center, double-blinded study of COVID-19 infected patients requiring inpatient hospital admission randomized 1:1 to daily Losartan or placebo for 7 days or hospital discharge.
- Conditions
- Corona Virus Infection, Acute Respiratory Distress Syndrome, SARS-CoV Infection
- Trial name
- NCT04312009
- Testing
- Losartan
- Where
- 13 sites in United States
- Volunteers
- 205 people
- Sponsor
- University of Minnesota
Respiratory Distress Syndrome, Adult
Non-invasive Fluid Management
For patients with a condition called acute respiratory distress syndrome (ARDS), managing their fluid levels to achieve a negative balance helps to improve their outcomes.
- Trial name
- DECAF (NCT02892799)
- Testing
- NICOM-Guided Diuresis, Standard of Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Intermountain Health Care, Inc.
Acute Respiratory Distress Syndrome, Acute Respiratory Distress Syndrome in Adult or Child
Effects of Extravascular Lung Water on Prone Position Efficacy in Patients With ARDS
The study will investigate the influence that extravascular lung water index (EVLWi) could have on the efficacy and persistance of efficacy of prone position in patients with acute respiratory distress syndrome.
- Trial name
- NCT04635267
- Testing
- Prone position in patients with ARDS
- Volunteers
- 200 people
- Sponsor
- Bicetre Hospital
Extracorporeal CO2 Removal, Acute Respiratory Distress Syndrome
Effects of Blood Pulsatility on Von Willebrand Factor During ECCO2R
The primary objective of the study is to demonstrate that the ECCO2R pulsatile configuration prevents the Willebrand factor high molecular weight multimers decrease observed under continuous blood flow configurations.
- Conditions
- Extracorporeal CO2 Removal, Acute Respiratory Distress Syndrome, Chronic Obstructive Pulmonary Disease Exacerbation, Pulmonary Disease
- Trial name
- FLOW-ECCO2R (NCT05079009)
- Testing
- ECCO2R pulsatile configuration
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome
Clinical, Biological and Histological Pulmonary and Renal Damage Associated With the SARS-CoV-2 Syndrome in Patients Admitted in ICU
Renal damage in patients hospitalized for ARDS in the ICU can also be related to multiple causes including, but not limited to, the consequences of hemodynamic fluctuations in these patients or the use of nephrotoxic drugs…
- Trial name
- PR-Covid-19 (NCT04385004)
- Where
- France
- Volunteers
- 320 people
- Sponsor
- University Hospital, Strasbourg, France
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