Clinical trials: Respiratory Distress Syndrome (RDS)
Respiratory Distress Syndrome
Respiratory Distress and Elective Cesarean Section at Term
Cesarean section is a life-saving surgical operation for women and their newborns. In Egypt, caesarean sections are over-utilized. The rate increased from 27.6 % in 2008 to 51.8 % in 2014, reaching 72.2 % in 2021.
- Trial name
- NCT06874478
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Assiut University
COVID-19 Acute Respiratory Distress Syndrome, COVID-19 Pneumonia
Effect of Prone Positioning on the Severity of COVID-19 Pneumonia and Acute Respiratory Distress Syndrome.
With this research, we are aiming at finding out the effectiveness of prone positioning in this region population affected by moderate pneumonia due to covid 19 infection so that the hospital staff and doctors may be encouraged…
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, COVID-19 Pneumonia, Prone Positioning
- Trial name
- COVID-19 (NCT05405335)
- Testing
- Prone Positioning Maneuver
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Ayub Medical College, Abbottabad
Coronavirus, Covid19
Impact of Aerosol Box Use on Healthcare Provider Contamination
Aerosol Generating Medical Procedures (AGMP) are procedures that have the potential to create tiny particles suspended in the air. These particles can contain germs such as viruses.
- Conditions
- Coronavirus, Covid19, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT04880668
- Testing
- Aerosol Box (Splashguard)
- Where
- 4 sites in United States, Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- KidSIM Simulation Program
COVID, ARDS
Prone Positioning and High-flow Nasal Cannula in COVID-19 Induced ARDS
Prone position (PP) has been proved to be effective in severe ARDS patients. On the other hand, High flow nasal cannula (HFNC) may prevent intubation in hypoxemic Acute respiratory failure (ARF) patients.
- Conditions
- COVID, ARDS, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- NCT04391140
- Testing
- Prone position
- Where
- Spain
- Volunteers
- 248 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
ARDS, Human, Nitric Oxyde
Exhaled Nitric Oxide : Biomarker of Acute Respiratory Distress Syndrome
The aim of the study is to see if endogenous exhaled Nitric Oxyde (eNO) concentrations measured are significantly higher in ARDS patients admitted in ICU ; compared to control subjects in good health with no lung disease or…
- Trial name
- ENOBARDS (NCT06250348)
- Testing
- Non invasive measure of endogenous exhaled Nitric Oxyde in exhaled gaz, by a laser spectrometer
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Grenoble
Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe)
Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)
This is a multi-center, randomized, placebo controlled, interventional phase 2A trial to evaluate the safety profile and potential efficacy of multi-dosing of mesenchymal stromal cells (MSC) for patients with SARS-CoV-2…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe), COVID-19 Pneumonia
- Trial name
- NCT04466098
- Testing
- Mesenchymal stromal cells
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Acute Respiratory Distress Syndrome
Thorathic Fluid Content as an Early Predictor of Weaning From Mechanical Ventilation in Acute Respiratory Distress Syndrome
Thorathic fluid content measurement using indirect cardiometry is required for prediction of Weaning from mechanical ventilation in cases of acute respiratory distress syndrome and its value in sucsess Weaning
- Trial name
- NCT06233448
- Testing
- Indirect cardiometry
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Respiratory Distress Syndrome in Premature Infant
nHFOV Versus Invasive Conventional Ventilation for Preterm Neonates With Respiratory Distress Syndrome
Preterm neonates usually develop respiratory distress syndrome (RDS) for which they need respiratory support, which may be invasive and non-invasive depend on the availability and individual need.
- Trial name
- nHFOV (NCT04914715)
- Testing
- Non-invasive High Frequency Oscillatory Ventilation, Conventional Invasive Ventilation
- Where
- Pakistan
- Sponsor
- Indus Hospital and Health Network
COVID-19
Decitabine for Coronavirus (COVID-19) Pneumonia- Acute Respiratory Distress Syndrome (ARDS) Treatment: DART Trial
This is a a randomized double blind placebo controlled Phase 2 trial with a 12 patient lead-in to evaluate safety, prior to full enrollment to an additional 28 patients (for a total of 40 patients) to assess efficacy of…
- Trial name
- DART (NCT04482621)
- Testing
- Decitabine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Johns Hopkins University
Surfactant Deficiency Syndrome Neonatal
Premedication for Less Invasive Surfactant Administration
Early respiratory management of preterm infants immediately after birth should be as gentle as possible. With this so-called developmental approach, unnecessary invasive methods can be avoided or at least postponed.
- Trial name
- LISA-Med (NCT03735563)
- Testing
- Ketamine, Fentanyl
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- University of Oulu
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Intratracheal Budesonide/Surfactant Prevents BPD
A double-blind study includes: 1) birth Wt 500-1499 gm, 2) respiratory distress shortly after birth and requires resuscitation 3) failure to NCPAP within 4 hrs after birth, defined as: a) FIO2 ≥ 0.30, pressure > 5cmH2O b) severe…
- Trial name
- NCT03275415
- Testing
- budesonide, Saline
- Where
- Taiwan
- Volunteers
- 310 people
- Sponsor
- Taipei Medical University
Cognitive Dysfunction
Electrophysiological Signatures of Cognitive Disorders Related to Intensive Care Unit (ICU) delirium_ BRAINSTORM-EEG
Early cognitive assessment of critically-ill acute respiratory distress syndrome (ARDS) patients with delirium using a multidimensional electrophysiological evaluation battery (mEEG) to identify and characterize the neural…
- Trial name
- B-EEG (NCT06089538)
- Testing
- mEEG battery
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Toulouse
Acute Respiratory Distress Syndrome
A Clinical Trial of Human Umbilical Cord Mesenchymal Stem Cell Injection for the Treatment of Severe Acute Respiratory Distress Syndrome
Primary Objective: To evaluate the safety and tolerability of human umbilical cord mesenchymal stem cell injection in the treatment of moderate/severe acute respiratory distress syndrome.Secondary Objectives: To explore the…
- Trial name
- ARDS (NCT07413978)
- Testing
- 1 vial containing a total of 5×10^7 cells, 2 vial containing a total of 1×10^8 cells, 3 vial containing a total of 1.5×10^8 cells
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Changchun Tuohua Pharmaceutical Co., Ltd.
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Study of the Pathobiology of Bronchopulmonary Dysplasia in Newborns
OBJECTIVES: I. Create a clinical sample bank of neonates with lung disease to test hypotheses regarding the pathogenesis of bronchopulmonary dysplasia (BPD). II.
- Trial name
- NCT00006058
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Center for Research Resources (NCRR)
Respiratory Distress Syndrome
Study of Antenatal Thyrotropin-Releasing Hormone in Women in Premature Labor to Prevent Lung Disease in Preterm Infants
OBJECTIVES: I. Assess the efficacy and safety of antenatal administration of thyrotropin-releasing hormone to women in premature labor to improve pulmonary outcomes in preterm infants.
- Trial name
- NCT00004840
- Testing
- thyrotropin-releasing hormone
- Volunteers
- 996 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Respiratory Infection, Pneumonia
Efficacy and Safety of Trimodulin (BT588) in Subjects With CAP Including COVID-19 Pneumonia
The main objectives of the trial are to assess the efficacy and safety of trimodulin as adjunctive treatment to standard of care (SoC) compared to placebo plus SoC in adult hospitalized subjects with non-severe community-acquired…
- Conditions
- Respiratory Infection, Pneumonia, Community-acquired Pneumonia, Acute Respiratory Distress Syndrome
- Trial name
- TRICOVID (NCT05531149)
- Testing
- Trimodulin
- Where
- 64 sites in Argentina, Austria and 12 more
- Volunteers
- 107 people
- Sponsor
- Biotest
Acute Respiratory Distress Syndrome
Quantitative Computed Tomography for Mortality Risk Stratification in ARDS
Acute respiratory distress syndrome remains a deadly disease with hospital mortality remaining between 40 to 50%. ARDS mortality risk factors have been identified from patient history, common clinical and biological variables in…
- Trial name
- CT4ARDS-2 (NCT06113276)
- Testing
- Low dose computed tomography to evaluate biomechanical parameters in the lung
- Where
- 4 sites in France
- Volunteers
- 210 people
- Sponsor
- Hospices Civils de Lyon
Critical Illness, Sepsis
ICU Admission Diagnoses and ICU Mortality
This retrospective cohort study will evaluate whether syndromic clinical diagnoses present at ICU admission are associated with ICU mortality, independent of physiologic severity scores.
- Conditions
- Critical Illness, Sepsis, Septic Shock, Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT07369206
- Where
- Turkey (Türkiye)
- Volunteers
- 1,248 people
- Sponsor
- Ataturk University
Transient Tachypnoea of the Newborn
Trial on Treatment With Inhaled Furosemide of Preterm and Term Neonates With Transient Tachypnoea
In this study we will prospectively analyze the benefit of inhaled furosemide for preterm and term neonates with Transient Tachypnoea.
- Trial name
- NCT01407848
- Testing
- Furosemide, Saline 0,9%
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Cologne
Respiratory Distress Syndrome, Newborn
A Double Blind, Randomized, Controlled Study to Evaluate CHF 5633 (Synthetic Surfactant) and Poractant Alfa in Neonates With Respiratory Distress Syndrome (RDS) (POC)
A multicenter, double blind, randomized, single dose, active-controlled study to investigate the efficacy and safety of synthetic surfactant (CHF 5633) in comparison to porcine surfactant (Poractant alfa, Curosurf ®) in the…
- Trial name
- NCT02452476
- Testing
- CHF5633, Poractant alfa
- Where
- 23 sites in United States
- Volunteers
- 123 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
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