Clinical trials: Respiratory Distress Syndrome of Newborn
Respiratory Distress Syndrome In Premature Infants, Bronchopulmonary Dysplasia
High Frequency Oscillatory Ventilation Combined With Intermittent Sigh Breaths: Effects on Lung Volume Monitored by Electric Tomography Impedance.
Background Ventilator induced lung injury (VILI) remains a problem in neonatology. High frequency oscillatory ventilation (HFOV) provides effective gas exchange with minimal pressure fluctuation around a continuous distending…
- Conditions
- Respiratory Distress Syndrome In Premature Infants, Bronchopulmonary Dysplasia, Ventilator-Induced Lung Injury, Functional Residual Capacity
- Trial name
- NCT01962818
- Testing
- HFOV combined with sigh breaths
- Where
- Australia
- Volunteers
- 16 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
ARDS (Acute Respiratory Distress Syndrome)
Influence of Lung Recruitment Potential on Positive End-Expiratory Pressure (PEEP) Titration Strategies in Acute Respiratory Distress Syndrome (ARDS) Patients.
Acute Respiratory Distress Syndrome (ARDS) is characterized by severe hypoxemia and diffuse alveolar collapse, often requiring invasive mechanical ventilation.
- Trial name
- RECRUIT-PEEP (NCT07603310)
- Testing
- Positive End-Expiratory Pressure (PEEP) Titration guided by Static Compliance, Positive End-Expiratory Pressure (PEEP) Titration guided by Transpulmonary Pressure
- Where
- Chile
- Volunteers
- 52 people
- Sponsor
- Hospital Dr. Franco Ravera Zunino
Acute Respiratory Distress Syndrome, ARDS
Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome
The acute respiratory distress syndrome (ARDS), characterized by alveolar flooding with protein-rich pulmonary edema fluid, is one of the most common disease in the intensive care unit (ICU) throughout the world.
- Trial name
- NCT02944279
- Volunteers
- 500 people
- Sponsor
- Peking University Third Hospital
ARDS (Acute Respiratory Distress Syndrome)
Comparison of 5% Nacl and 10% NaHCO3 As Contrast Agents for Lung Perfusion with EIT
Electrical impedance tomography (EIT) has enabled the bedside monitoring of lung perfusion measurement through the indicator-based contrast method.
- Trial name
- NCT06868810
- Testing
- Injection of hypertonic saline, Injection of 5% NaHCO3
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Peking Union Medical College Hospital
Acute Respiratory Distress Syndrome, Adult
Add-on Reparixin in Adult Patients With ARDS
Study objectives 1. To characterize the efficacy of reparixin in ameliorating lung injury and systemic inflammation and expediting clinical recovery and liberation from mechanical ventilation in adult patients with moderate to…
- Trial name
- NCT05496868
- Testing
- Reparixin 600mg
- Where
- 40 sites in United States, Germany and 1 more
- Volunteers
- 66 people
- Sponsor
- Dompé Farmaceutici S.p.A
Acute Respiratory Distress Syndrome
PEEP Recruitment-comparison Between Ultrasonographic Assessment and LIP Assessment
The purpose of this study is to compare lung recruitment in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) based on lower inflection point with transthoracic ultrasonographic assessment of lung recruitment.
- Trial name
- NCT01478217
- Where
- Croatia
- Volunteers
- 17 people
- Sponsor
- Sisters of Mercy University Hospital
Pediatric Acute Respiratory Distress Syndrome, Desflurane
Effect of Desflurane on Pediatric Acute Respiratory Distress Syndrome After Living Donor Liver Transplant Recipients
Biliary atresia is a serious congenital anomaly characterized by persistent and progressive cholestatic jaundice. The incidence of biliary atresia is more common in East Asia, especially China, with an incidence of 2 per 10,000…
- Conditions
- Pediatric Acute Respiratory Distress Syndrome, Desflurane, Biliary Atresia
- Trial name
- EDPARDSLDLTR (NCT05783518)
- Testing
- desflurane, propofol
- Where
- 2 sites in China
- Volunteers
- 165 people
- Sponsor
- Tianjin First Central Hospital
Respiratory Distress Syndrome, Adult
Significance of Biological Markers in Patients With Acute Lung Injury/Acute Respiratory Disease
The purpose of this study is to identify biological markers of disease in patients with acute lung injury (ALI) that are predictive of either disease susceptibility or prognosis, or that identify novel targets of therapeutic…
- Trial name
- NCT00217880
- Testing
- Bronchoscopy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Acute Respiratory Distress Syndrome
Safety and Efficacy Study of Acthar in Subjects With ARDS
This study is being performed to evaluate the potential efficacy and safety of Acthar as a treatment for moderate-severe Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- NCT02113735
- Testing
- H.P. Acthar® Gel (repository corticotropin injection)
- Sponsor
- Mallinckrodt
Acute Respiratory Distress Syndrome
Effect of Continuous Anterior Chest Compression on Ventilation/Perfusion Ratio and Hemodynamics
Intro: The mortality of acute respiratory distress syndrome (ARDS) remains high (40%), and may be aggravated by ventilation-induced lung injury (VILI), the main mechanisms of which are: 1. Anterior region overdistension, 2.
- Trial name
- HemodyCACC (NCT06699017)
- Testing
- Continuous anterior chest compression
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Distress Syndrome, Respiratory Insufficiency
Recruitment Manoeuvres in Critically Ill Patients
Diseases of the lungs can be life-threatening. When these organs fail to adequately work, treatments to support their function are offered, often in Intensive Care Units (ICU).
- Conditions
- Respiratory Distress Syndrome, Respiratory Insufficiency, Respiratory Failure, Shock Lung
- Trial name
- RMCIP (NCT05508724)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Oxford
ARDS, RDS
Surfactant for Neonate With Acute Respiratory Distress Syndrome (ARDS)
Acute respiratory distress syndrome (ARDS) in neonates has been defined, the role of surfactant is not clear. This study aimed to determine whether ARDS neonate would benefit from surfactant when oxygenation deteriorated on…
- Conditions
- ARDS, RDS, Surfactant
- Trial name
- NCT03217162
- Testing
- surfactant combined with mechanical ventilation (MV), mechanical ventilation (MV)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
COVID, Sars-CoV2
The Use of Tadalafil in Confirmed COVID-19 Pneumonia.
Our goal is to assess the effects of Tadalafil in the setting of confirmed COVID-19 pneumonia. In particular we plan to assess its effects on oxygen saturation, P:F ratio, and mixed central venous oxygen We plan to recruit all…
- Conditions
- COVID, Sars-CoV2, ARDS, Human
- Trial name
- NCT04946162
- Testing
- Tadalafil Pill
- Sponsor
- Santa Barbara Cottage Hospital
Transient Tachypnea of the Newborn
Role of Salbutamol and Furosemide in TTN
to see the effects of slabutamol and IV furosemide in the treatment of transient tachypnea of newborn
- Trial name
- NCT03208894
- Testing
- Furosemide Injection
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people
- Sponsor
- Armed Forces Hospital, Pakistan
Acute Respiratory Distress Syndrome, Right Ventricular Dysfunction
Ventilator-induced Right Ventricular Injury During EIT-based PEEP Titration in Patients With ARDS
Right ventricular failure may be associated with mortality in patients with acute respiratory distress syndrome (ARDS). Mechanical ventilation may promote right ventricular failure by inducing alveolar overdistention and…
- Trial name
- RIGHTENARDS (NCT05583461)
- Testing
- Positive end-expiratory pressure titration
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- University of Padova
Acute Respiratory Distress Syndrome
Efficacy and Safety of Anakinra in Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition characterized by acute respiratory failure with hypoxemia, noncardiogenic or non-fluid overload pulmonary edema, bilateral diffuse opacities on chest…
- Trial name
- ESKA (NCT05914454)
- Testing
- Anakinra 100Mg/0.67Ml Inj Syringe
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Respiratory Distress Syndrome
Comparison of Efficacy of Less Invasive Surfactant Treatment Under Nasal CPAP and Nasal IPPV
Non invasive ventilation is important in the care of preterm infants with respiratory failure, and surfactant treatment can be use with non invasive ventilation.
- Trial name
- NCT04698473
- Testing
- NCPAP, NIPPV
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Uludag University
Respiratory Distress Syndrome, Transient Tachypnea of Newborn
The Predictive Value of Amniotic Fluid pH and Electrolytes on Neonatal Respiratory Disorders
Amniotic fluid (AF) is a complex structure with a changing content by gestational time. AF pH can be affected by both maternal and fetal conditions such as preterm ruptures of membranes, prematurity and fetal distress.
- Trial name
- NCT02813954
- Testing
- Blood Gas Sampling
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Acute Respiratory Distress Syndrome, Acute Lung Injury
Efficacy and Safety of a Lung Recruitment Protocol in Children With Acute Lung Injury
Lung units which participate in gas exchange are known as 'recruited' lung. Patients with lung injury suffer from a proportion of units which do not participate in gas exchange (i.e.
- Trial name
- Recruitment (NCT00830284)
- Testing
- Recruitment maneuver
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Boston Children's Hospital
Respiratory Distress Syndrome, Pediatric, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
Continuous Infusion Versus Intermittent Boluses of Cisatracurium in the Early Management of Pediatric ARDS
The aim of this work is to compare continuous infusion vs on need intermittent boluses of Cisatracurium in the early management of pediatric acute respiratory distress syndrome
- Trial name
- NCT05153525
- Testing
- Intermittent boluses of Cisatracurium, Intravenous infusion of Cisatracurium for 24 hours
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
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