Clinical trials: Respiratory Distress Syndrome of Newborn
Acute Respiratory Distress Syndrome (ARDS)
Application of Electrical Impedance Tomography in Evaluating Pulmonary Function Improvement After High Lateral Recumbent Position Therapy in ARDS Patients
This randomized controlled trial investigates the effects of prone positioning versus lateral positioning at different angles (30°, 90°, 120°) on pulmonary function improvement in patients with acute respiratory distress syndrome…
- Trial name
- NCT07375849
- Testing
- Place the patient in the 90-degree high lateral position., Place the patient in the 30-degree low lateral position., Place the patient in the 120-degree high lateral position.
- Volunteers
- 140 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Acue Respiratory Distress Syndrome
Use of Extracorporeal CO2 Removal in Case of Moderate to Severe ARDS to Apply an Ultraprotective Mechanical Ventilation Strategy
The extracorporeal CO2 removal (ECCO2R) has been recently proposed in case of Acute Respiratory Distress Syndrome (ARDS) in order to reduce pulmonary injuries induced by the mechanical ventilation.
- Trial name
- ECCO2R (NCT04556578)
- Testing
- High-flow extracorporeal CO2 removal
- Where
- France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Montpellier
ARDS, Human, Catheter Infection
Prone Position Impact in ARDS Patients on the Incidence of Central Venous Catheter Colonization
Catheter colonization, catheter-associated infection and catheter-associated bacteremia are a major challenge for resuscitation unit.
- Trial name
- ILCDV (NCT03405038)
- Where
- France
- Volunteers
- 202 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Respiratory Distress Syndrome, Newborn, Neonatal Respiratory Disorders
Non-Inferiority Test of Mixsafe® Compared to Neopuff® in Providing Respiratory Support to Neonates
The aim of the study is to compare the non-inferiority of the Mix-safe T-piece resuscitator (intervention group) to the Neopuff T-piece resuscitator (control group) in providing respiratory assistance during the resuscitation of…
- Trial name
- NCT07422116
- Testing
- Mixsafe T piece resucitator, Standardized T Piece resuscitator
- Where
- Indonesia
- Volunteers
- 107 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Acute Respiratory Distress Syndrome, Covid19
Cellular Immuno-Therapy for COVID-19 Acute Respiratory Distress Syndrome
The clinical picture of the novel corona virus 2 (SARS-CoV-2) disease (COVID-19) is rapidly evolving. Although infections may be mild, up to 25% of all patients admitted to hospital require admission to the intensive care unit…
- Trial name
- CIRCA-19 (NCT04400032)
- Testing
- Mesenchymal Stromal Cells
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Ottawa Hospital Research Institute
Nonintubated Acute Respiratory Distress Syndrome (ARDS), Pathogen-associated Lung Injury
Vadadustat for the Treatment of Nonintubated Acute Respiratory Distress Syndrome Due to Pathogen-Associated Lung Injury
The objective of this study is to assess the efficacy and safety of vadadustat for treating hospitalized patients with nonintubated Acute Respiratory Distress Syndrome (ARDS) secondary to pathogen-associated lung injury.
- Trial name
- NCT07086755
- Testing
- Vadadustat 900mg, Vadadustat 1200mg
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- Paul Potnuru
Transient Tachypnea of the Newborn
Positive End Expiratory Pressure With A T-piece Resuscitator For Near-Term and Term Infants With Respiratory Distress
Evaluating the effect of early application of Continuous positive airway pressure (CPAP) via Neopuff in cases of transient tachypnea of the newborn(TTN) and its role in decreasing the duration and complication of TTN.
- Trial name
- NCT01859533
- Testing
- Neopuff
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Congenital Pneumonia, Transient Tachypnea of the Newborn
Comparison of Congenital Pneumonia and Transient Tachypnea of the Newborn
Accurate and timely differentiation between transient tachypnea of the newborn (TTN) and congenital pneumonia is essential in neonatal care, as it facilitates prompt initiation of appropriate treatment, reduces the risk of…
- Trial name
- NCT06803355
- Testing
- complete blood count, CRP, blood smear test, blood culture, chest X- ray
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Infant, Premature, Diseases, Respiratory Distress Syndrome, Newborn
Exogenous Surfactant in Very Preterm Neonates in Prevention of Bronchopulmonary Dysplasia
Advances in perinatal care have made it possible to improve the survival of the most immature neonates, but at the cost of an increase in the population at risk of developing bronchopulmonary dysplasia (BPD).
- Conditions
- Infant, Premature, Diseases, Respiratory Distress Syndrome, Newborn, Bronchopulmonary Dysplasia
- Trial name
- CURDYS (NCT01039285)
- Testing
- Curosurf, Air
- Where
- 13 sites in France
- Volunteers
- 118 people
- Sponsor
- Jean Michel Hascoet
Respiratory Failure, Ventilatory Failure
Non-Invasive Monitoring of Respiratory Function in Spontaneously Breathing Patients With COVID-19 Infection
This study uses the AirGo band to monitor changes in tidal ventilation in spontaneously breathing patients with COVID-19 associated respiratory failure.
- Conditions
- Respiratory Failure, Ventilatory Failure, COVID-19, Pneumonia
- Trial name
- NCT04356443
- Testing
- AirGo Respiratory Monitor
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Covid19
Early Cognitive Assessment and Evolutionary Monitoring of Patients With Severe ARDS on COVID-19 Pneumonia Requiring Mechanical Ventilation
The new coronavirus pandemic responsible for the severe acute respiratory syndrome SARS-CoV2 requires, in its severe forms, the use of invasive ventilation in intensive care.
- Trial name
- CognitiVID (NCT04468035)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Infant Respiratory Distress Syndrome, Ventilator Lung; Newborn
Closed-loop Automatic Oxygen Control (CLAC-4) in Preterm Infants
Two-center, randomised controlled, cross-over clinical trial in preterm infants born at gestational age below 34+1/7 weeks receiving supplemental oxygen and respiratory support (Continous positive airway pressure (CPAP) or…
- Trial name
- CLAC-4 (NCT03163108)
- Testing
- Closed-loop automatic oxygen control (CLAC) fast in addition to RMC, Closed-loop automatic oxygen control (CLAC) slow in addition to RMC
- Where
- 2 sites in Germany
- Volunteers
- 19 people
- Sponsor
- University Hospital Tuebingen
Covid19, Corona Virus Infection
Expanded Access to Zofin for Patients With COVID-19
This expanded access protocol will provide access to the investigational product Zofin for patients in outpatient facilities infected with SARS-CoV-2 who have mild to moderate COVID-19, or who are judged by a healthcare provider…
- Conditions
- Covid19, Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome), Acute Respiratory Distress Syndrome
- Trial name
- NCT04657406
- Testing
- Zofin
- Sponsor
- ZEO ScientifiX, Inc.
Acute Respiratory Distress Syndrome
Expiratory Flow Limitation Assessment
This study intended to assess the expiratory flow limitation (EFL) during tidal breath in patients intubated in intensive care unit (ICU) for moderate or severe acute respiratory distress syndrome (ARDS).
- Trial name
- FLAIR (NCT03462849)
- Testing
- increase in positive end expiratory pressure
- Where
- 2 sites in France
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
COVID-19 Acute Respiratory Distress Syndrome
PRactice of Ventilation and Adjunctive Therapies in COVID-19 Patients.
PRactice of Ventilation and Adjunctive Therapies in COVID-19 Patients. An observational study of ventilation practice and adjunctive therapies in critically ill, invasively ventilated COVID-19 patients during the first and second…
- Trial name
- PRoVAcT-COVID (NCT05954351)
- Where
- Netherlands
- Volunteers
- 2,465 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Respiratory Distress Syndrome
Characterization of the Cord Blood Stem Cell in Situation of Neonatal Asphyxia
Neonatal anoxic-ischaemic enkephalopathy is a dramatic perinatal complication due to brain asphyxia. Neurological and neurosensory sequelae are frequent in survivors, due to neuronal damage and loss.
- Trial name
- NEOCORD (NCT01284673)
- Testing
- in vitro characterization of the cord blood stem cell
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Respiratory Distress Syndrome, Noninvasive Ventilation
Helmet vs Face Mask in Patients With Acute Respiratory Distress Syndrome
The objective of this study is to evaluate the efficacy of noninvasive ventilation with helmet in reducing endotracheal intubation rates in comparison with Noninvasive Ventilation (NIV) facemask among patients with Acute…
- Conditions
- Acute Respiratory Distress Syndrome, Noninvasive Ventilation, Corona Virus Disease, Acute Respiratory Failure
- Trial name
- NCT04507802
- Testing
- Non invasive ventilation via helmet
- Where
- Qatar
- Volunteers
- 60 people
- Sponsor
- Hamad Medical Corporation
Acute Respiratory Distress Syndrome (ARDS)
Clinical Trial With Aprotinin in the Acute Respiratory Distress Syndrome Treatment
This is a multicentre, double-blind, placebo-controlled Phase III randomized clinical trial designed to evaluate the efficacy and safety of inhaled aprotinin in adult patients with moderate or severe acute respiratory distress…
- Trial name
- NCT07317050
- Testing
- Aprotinin (inhaled)
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Fundacion del Hospital Nacional de Paraplejicos para la Investigacion y la Integracion
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Post-extubation Pressures in Preterm Neonates: A CER Study
The optimal post-extubation pressure level on non-invasive respiratory support modes - irrespective of the choice of the specific non-invasive mode - that optimizes extubation success and improves clinical outcomes remains…
- Conditions
- Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, Preterm Birth
- Trial name
- NCT06552455
- Volunteers
- 1,050 people
- Sponsor
- McMaster Children's Hospital
Acute Respiratory Distress Syndrome, Right Ventricular Dysfunction
Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS)
Acute respiratory distress syndrome (ARDS) and mechanical ventilation can lead to right ventricular dysfunction and ultimately right ventricular failure by increasing pulmonary vascular resistances and pressure load.
- Conditions
- Acute Respiratory Distress Syndrome, Right Ventricular Dysfunction, Right Heart Failure, Acute Cor Pulmonale
- Trial name
- STRAIN (NCT01757522)
- Where
- France
- Volunteers
- 47 people
- Sponsor
- University Hospital, Grenoble
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