Clinical trials: Respiratory Distress in Neonates
Respiratory Distress Syndrome
Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams
The purpose of this study is to compare two different treatment strategies for RDS in preterm infants > 1500 grams and evaluate whether a selective surfactant administration would reduce the need of intubation, mechanical…
- Trial name
- NCT00277030
- Testing
- Surfactant, Nasal CPAP
- Where
- 3 sites in Chile
- Volunteers
- 110 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Respiratory Distress Syndrome (RDS)
Comparison of Continuous Positive Airway Pressure (CPAP) and Non-Invasive Positive Pressure Ventilation (NIPPV) in Preterm Newborns With Respiratory Distress Syndrome.
Primary objective: to evaluate safety and efficacy of two different non-invasive respiratory support modalities in preterm neonatal patients with respiratory distress syndrome.
- Trial name
- NC3 (NCT06966752)
- Testing
- NIPPV, CPAP
- Where
- Lithuania
- Volunteers
- 150 people
- Sponsor
- Vilnius University
Fetal Membranes, Premature Rupture, Premature Birth
The Use of Cranberries in Women With Preterm Premature Rupture of Membranes
Cranberries have been proved to reduce the rate of urinary tract infections in a population of women with recurrent urinary tract infections in previous studies.
- Trial name
- NCT00247104
- Testing
- Cranberries - Vaccinium macrocarpon
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Neonatal Respiratory Distress Syndrome
Early Neonatal Respiratory Distress: Changes in Level IIb Hospital Over a Period of One Year
Respiratory distress is one of the first hospital grounds during the neonatal period. The clinical presentation and severity vary by gestational age and cause.
- Trial name
- DROPE (NCT02824497)
- Testing
- No intervention. It's a description study
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Transient Tachypnea of the Newborn
Role of Salbutamol and Furosemide in TTN
to see the effects of slabutamol and IV furosemide in the treatment of transient tachypnea of newborn
- Trial name
- NCT03208894
- Testing
- Furosemide Injection
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people
- Sponsor
- Armed Forces Hospital, Pakistan
Transient Tachypnoea of the Newborn
Study Protocol Evaluating Transient Tachypnoea of the Newborn in Term and Near Term Neonates
Transient tachypnoea of the newborn (TTN) is a common cause of hospitalisation in the neonatal period, complicating 1 to 1,5 per cent life birth.
- Trial name
- NCT00213941
- Testing
- Echocardiography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Premature Birth, Neonatal Hypoglycemia
Higher-Dose Dexamethasone Improves Breathing and Shortens NICU Stay in Preterm Babies
The goal of this observational study was to compare two doses of dexamethasone given to pregnant women at risk of preterm birth. Dexamethasone is a medicine used before birth to help a baby's lungs mature.
- Conditions
- Premature Birth, Neonatal Hypoglycemia, Maternal Infection During Pregnancy, Neurodevelopmental Disorder of Foetus
- Trial name
- NCT07765329
- Testing
- Dexamethasone 12 mg Every 12 Hours, Dexamethasone 6 mg Every 12 Hours
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Stella Maris Women and Children Hospital
Respiratory Distress, Newborn
Effectiveness of HVNI in Preterm Infants With Moderate Respiratory Distress
Neonatal respiratory distress is a common problem in preterm infants. The application of CPAP is widely used in neonatal units as a primary mode of respiratory support for respiratory distress.
- Trial name
- NCT06436222
- Testing
- HVNI
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Respiratory Distress Syndrome
Impact of Different Modes of Noninvasive Ventilation on Regional Oximetry and Hemodynamics in Premature Newborn
The purpose of this study is to examine the blood flow and the delivery of oxygen to the brain and gut in preterm babies while they are supported with two modes of breathing machine and compare these two methods to see if one…
- Trial name
- NCT01942967
- Testing
- Echocardiography, Near Infrared Spectroscopy Monitoring
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- University of Manitoba
Respiratory Distress Syndrome of Prematurity (Surfactant Dysfunction), Bronchopulmonary Dysplasia
Trial of Late Surfactant to Prevent BPD: A Pilot Study in Ventilated Preterm Neonates Receiving Inhaled Nitric Oxide
The purpose of this study is to determine if the combination of late doses of Infasurf with inhaled nitric oxide will interact to improve the surfactant function and thus the respiratory status and outcome of treated infants.
- Trial name
- TOLSURFPilot (NCT00569530)
- Testing
- Infasurf (ONY Inc.)
- Where
- 9 sites in United States
- Volunteers
- 85 people
- Sponsor
- Roberta Ballard
Respiratory Distress Syndrome, Preterm Birth
LISA vs INSURE in Extremely Low Birth Weight Infants. A Manikin Study
This is an unblinded, randomized, controlled, crossover (AB/BA) trial of surfactant treatment with LISA vs. INSURE in a manikin simulating an extremely low birth weight infant.
- Conditions
- Respiratory Distress Syndrome, Preterm Birth, Surfactant Deficiency Syndrome Neonatal
- Trial name
- NCT04944108
- Testing
- LISA approach, Insure approach
- Where
- 2 sites in Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital Padova
Respiratory Distress Syndrome, Newborn, Chronic Lung Disease of Newborn (Diagnosis)
Diaphragmatic Electrical Activity in Preterm Infants on Non-Invasive Ventilation
Preterm babies have immature lungs and frequent pauses in their breathing which often necessitates breathing support. Nasal Continuous Positive Airway Pressure (CPAP) is one of the most commonly used tools but does not always…
- Trial name
- NCT03422549
- Testing
- Drager VN500 Ventilator
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Inadequate; Pulmonary Ventilation, Newborn, Infant, Very Low Birth Weight
Nasal Noninvasive NAVA in the Very Low Birth Weight Infant
The purpose of this study is to determine if a new type of mechanical ventilation, or breathing machine (called neurally adjusted ventilatory assist or NAVA), will provide additional support to infants who were born prematurely.
- Trial name
- NCT01785563
- Testing
- Nasal NIV-NAVA
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Tarah T Colaizy
Neonatal Respiratory Distress
Effect of Antenatal Steroid on Pulmonary Artery Blood Flow
The aim of this study is to determine the effect of administering antenatal steroids in term fetuses on the blood flow in the fetal pulmonary artery, and to correlate these findings with clinical data obtained after birth…
- Trial name
- NCT02978976
- Testing
- Betamethasone, saline
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Respiratory Distress Syndrome, Newborn, Bronchopulmonary Dysplasia
Work of Breathing During Non-invasive Ventilation in Premature Neonates
Background: Non-invasive forms of respiratory support have been developed to manage respiratory distress and failure in premature newborns without exposing them to the risks associated with invasive mechanical ventilation.
- Trial name
- NCT02788110
- Testing
- Noninvasive neurally adjusted ventilatory assist (NIV NAVA), Nasal intermittent positive pressure ventilation (NIPPV)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Respiratory Distress Syndrome, Preterm Pregnancy
Less Invasive Surfactant Administration in Late Preterm or Early Term Born Infants
The aim of this study is to see if giving less invasive surfactant administration (LISA) during high-flow nasal cannula (HFNC) oxygen treatment reduces the need for invasive ventilation in babies with breathing problems born 2-6…
- Conditions
- Respiratory Distress Syndrome, Preterm Pregnancy, Surfactant Deficiency Syndrome Neonatal
- Trial name
- NCT06421506
- Testing
- Less invasive surfactant administration during high flow nasal cannula treatment
- Where
- United Kingdom
- Volunteers
- 245 people
- Sponsor
- King's College Hospital NHS Trust