Clinical trials: Respiratory Failure With Hypercapnia
Respiratory Failure, Neuromuscular Disease
Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Acute Exacerbation of Respiratory Failure
The aim of the study is to compare the efficacy and tolerance of autotitrating non-invasive ventilation (NIV) versus standard NIV in patients admitted to hospital with acute exacerbation of chronic respiratory failure.
- Conditions
- Respiratory Failure, Neuromuscular Disease, Chest Wall Disorder, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01174316
- Testing
- AutoVPAP™, VPAPIIIST-A™
- Where
- United Kingdom
- Sponsor
- ResMed
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Helmet Ventilation in Acute Hypercapnic Respiratory Failure
Lack of tolerance to the treatment, makes the interface choice for non-invasive ventilation (NIV) one of the key factor. To date the helmet is rarely used in Acute Hypercapnic Respiratory Failure (AHRF), because of its large dead…
- Trial name
- NCT01645358
- Testing
- Helmet (Starmed), Total Face mask (Respironics)
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Type 2 Respiratory Failure
Efficiency of HFNC Vs NIV in Patient With Acute Type 2 RF
Background: In acute hypoxic respiratory failure, high-flow nasal cannula (HFNC) oxygen treatment is gaining popularity. However, there is just a small body of research to back up the use of HFNC in acute respiratory failure…
- Trial name
- NCT05698641
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Chronic Obstructive Pulmonary Disease Patients, Chronic Respiratory Failure
Effect of Extracorporeal CO2 Removal in Stable Hypercapnic COPD Patients
Chronic hypercapnic respiratory failure is common in stable COPD patients in a terminal phase of their disease In an attempt to correct or slow down the rate of rise of PaCO2, long-term noninvasive mechanical ventilation (NIV)…
- Trial name
- NCT02260583
- Testing
- extracorporeal CO2 device
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sleep Disordered Breathing, Heart Failure
The Effect of CRT on the Hypercapnic Ventilatory Response
Central Sleep Apnoea (CSA) affects up to half of patients with severe heart failure and is associated with a poor prognosis. CSA is manifest as episodes of deep breathing interspersed with very shallow or absent breathing and is…
- Trial name
- NCT02203383
- Testing
- CRT Implantation
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
COPD, Respiratory Failure
Inspiratory Muscle Training in Hypercapnic COPD
The trial intends to investigate, whether inspiratory muscle training in hypercapnic patients improves inspiratory muscle strength, inspiratory muscle endurance and endurance to walk within six minutes.
- Trial name
- NCT00291460
- Testing
- inspiratory muscle training
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Krankenhaus Kloster Grafschaft
Pressure Ulcer, Noninvasive Positive Pressure Ventilation
The ROTAtional-USE of Interface STUDY
In this trial investigators will explore if a protocolized rotational use of interfaces i.e., masks, during noninvasive positive pressure ventilation (NPPV) compared to standard care is clinically effective and cost-effective in…
- Conditions
- Pressure Ulcer, Noninvasive Positive Pressure Ventilation, Acute Hypercapnic Respiratory Failure
- Trial name
- ROTA-USE (NCT05513508)
- Testing
- Protocolized rotational use of interfaces, Standard of care
- Where
- Italy
- Volunteers
- 478 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Respiratory Failure With Hypercapnia
Extra-Corporeal Carbon Dioxide Removal in Exacerbations of Chronic Obstructive Pulmonary Disease
Around 20% of the patients requiring hospitalization for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) develop hypercapnia, which is associated with an increased risk of death.
- Trial name
- NCT03990155
- Testing
- HFNCOT+ECCO2R
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Policlinico Hospital
Respiratory Failure, Hypercapnic Acidosis
High Flow Oxygen Therapy in Patients Undergoing Bronchoscopy Under Sedation
A reduction of peripheral oxygen saturation (SpO2) commonly occurs during bronchoscopy and may be associated with both respiratory and cardiac adverse events.
- Trial name
- BroncHoFlow (NCT04728412)
- Testing
- High Flow Oxygen Therapy (HFOT)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Cardarelli Hospital
Acute Hypercapnic Respiratory Failure
Impact of Negative Pressure Ventilation in Patients Hospitalized With Acute Hypercapnic Respiratory Failure
The study aims to find if using a Biphasic Cuirass Ventilation is as effective as using a Non invasive Positive Pressure Ventilation in patients admitted with acute hypercapnic respiratory failure.
- Trial name
- NCT06108284
- Testing
- Intervention Arm (Biphasic cuirass ventilation)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Missouri-Columbia
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Telemedicine for Improving Outcome in Inner City Patient Population With Hypercapneic Respiratory Failure
The Hypercapnia Telemedicine Outreach Program (E-TOUCH Study) aims to utilize telemedicine technology, as well as emergency medical services (EMS) home visits to address the problem with poor follow-up and compliance among…
- Conditions
- Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome, Sleep Disordered Breathing
- Trial name
- ETOUCH (NCT03353064)
- Testing
- Vivify, EMS
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Albert Einstein Healthcare Network
Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome
Efficacy of Average Volume Assured Pressure Support With Bi-Level Pressure Support Nocturnal Ventilation
Patients with chronic hypercapnic respiratory failure can be successfully treated with home nocturnal non-invasive ventilation. Bi-level pressure support ventilators are at present the most frequently used ventilators for long…
- Conditions
- Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00479284
- Testing
- Average volume assured pressure support (AVAPS)
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- University Hospital, Geneva
Respiratory Failure, Respiratory Arrest
Postoperative Respiratory Abnormalities
The study aims to determine how historical cases of respiratory abnormalities are documented by clinicians in the electronic health records (EHR) of Memorial Hermann Healthcare System (MHHS) inpatient facilities.
- Conditions
- Respiratory Failure, Respiratory Arrest, Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- AI-ARF (NCT04079829)
- Testing
- Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Efficacy Care R&D Ltd
Respiratory Insufficiency, Sleep Disordered Breathing
Adjustment of Mask Pressure, for Bilevel Positive Airways Pressure Therapy, by Automated Algorithm
The aim of the study is to test the hypothesis that an automated algorithm for desired mask pressure improves breathing pattern and sleep quality in patients with hypercapnic ventilatory failure.
- Trial name
- NCT01403584
- Testing
- AutoVPAP with addition of AutoEPAP, AutoVPAP with EPAP manually selected
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- ResMed
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for Intubation
This study will evaluate whether adding extracorporeal carbon dioxide removal (ECCO2R) to noninvasive ventilation can improve breathing in adults hospitalized with a severe worsening of chronic obstructive pulmonary disease…
- Trial name
- NCT07785375
- Testing
- Extracorporeal Carbon Dioxide Removal, Noninvasive Ventilation
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome
Postoperative Complications in Patients With Obesity Hypoventilation Syndrome
Obstructive sleep apnea (OSA) and Obesity-Hypoventilation Syndrome (OHS) are common conditions in obesity, which may influence the prognosis in patients undergoing surgery.
- Conditions
- Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome, Hypercapnia, Post-Op Complication
- Trial name
- OHBE (NCT02980770)
- Where
- Turkey (Türkiye)
- Volunteers
- 999 people
- Sponsor
- Marmara University
Acute Respiratory Failure With Hypercapnia
High Flow Nasal Oxygen Therapy in Perioperative Period of the Adult With Hypercapnic and Hypoxemic Respiratory Faliure
The purpose of this study is to determine the impact of hign-flow nasal therapy on the adult with hypercapnia and hpoxemia respiratory faliure in comparison with standard oxygen therapy ang noninvasive ventilation.
- Trial name
- NCT03229460
- Testing
- standard low flow therapy, high flow nasal oxygen therapy, association of high flow nasal oxygen therapy and non invasive positive pressure ventilation
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Respiratory Failure, Respiratory Insufficiency
Comparison of High-flow Oxygen vs. BiPAP in Type II (Hypercapnic) Respiratory Failure
A retrospective cohort study of all patients treated for type II (hypercapnic) respiratory failure with either High-Flow Oxygen Therapy or Non-Invasive Ventilation in a general adult hospital.
- Conditions
- Respiratory Failure, Respiratory Insufficiency, Respiratory Tract Diseases, COPD
- Trial name
- NCT03443479
- Testing
- Non-Invasive Ventilation, High-Flow Nasal Cannula
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- Hôpital de Verdun
Type II Respiratory Failure, Hypercapnic Respiratory Failure
Post-Extubation High-Flow Nasal Cannula Versus Non-Invasive Ventilation in Type II Respiratory Failure
Acute hypercapnic respiratory failure is characterized by elevated arterial carbon dioxide levels and commonly occurs in patients with chronic respiratory diseases.
- Trial name
- NCT06918288
- Testing
- High-Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Benha University
Chronic Hypercapnic Respiratory Failure
Monitoring of Patients With Chronic Respiratory Failure Treated With Non-invasive Home Ventilation: Contribution of New Monitoring Tools
Single-center retrospective study conducted on a population of patients with chronic hypercapnic respiratory failure treated by non-invasive ventilation at home, followed at the CHRU of Nancy.
- Trial name
- NCT04872062
- Testing
- NIV cards, Medical file
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France