Clinical trials: Respiratory Function Impaired
Lung Transplantation
Impact of Inspiratory Muscle Training (IMT) With Intermittent Variable Resistance (IVR) Versus Constant Resistance (CR) on Functional Capacity in Lung Transplantation (LTx) Patients (I-TRAIN-LTx Study)
Objectives: Primary Objective: To compare Maximum Inspiratory Pressure (MIP) in lung transplant (LT) patients between the use of inspiratory muscle training (IMT) with intermittent variable resistance (IVR) or constant resistance…
- Trial name
- I-TRAIN-LTx (NCT06963190)
- Testing
- Constant Resistance (CR), Intermittent Variable Resistance (IVR)
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Hospital Universitario Marqués de Valdecilla
Respiratory Failure, Tracheostomy Complication
Ventilation Weaning Strategies and Correlation to Outcomes in Tracheostomized Patients in the Lausanne ICU
This retrospective study aims to study characteristics of patients tracheotomized in the Lausanne ICU, both overall and by primary reasons of intubation.
- Trial name
- NCT04987398
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Piquilloud Imboden Lise
Right Ventricular Dysfunction
Right Ventricular Contractility Reserve Following Repair of Tetralogy of Fallot
Background: Residual pulmonary regurgitation following repair of tetralogy of Fallot, in particular the use of a transannular patch, has been shown to correlate with the development of right ventricular dysfunction.
- Trial name
- TOF-Cond (NCT00557934)
- Testing
- dobutamine
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- University Hospital Tuebingen
Airway Obstruction, Asthma
Effects of Combined Respiratory Muscle Training and Steam Inhalation
The purpose of this investigation is to obtain more information on the efficacy and safety of respiratory training methods with WellO2 in patients with asthma and COPD.
- Conditions
- Airway Obstruction, Asthma, COPD
- Trial name
- NCT04584398
- Testing
- Respiratory muscle training with steam inhalation
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- WellO2 Oy
Asthma, Airway Obstruction
Single-dose Crossover Study to Investigate Pharmacodynamics of AZD3199
The purpose of this study is to investigate the pharmacodynamics of single doses of AZD3199 in asthmatic patients.
- Trial name
- NCT00736489
- Testing
- AZD3199, Formoterol
- Where
- 4 sites in Denmark, Sweden
- Volunteers
- 37 people
- Sponsor
- AstraZeneca
Respiratory Insufficiency
Effect of Non-invasive Ventilation (NIV) on Cerebral Oxygenation
SUMMARY AND AIM Background: The proper management of brain oxygenation is an essential component of all anaesthesiologic procedures.
- Trial name
- NCT02454582
- Testing
- Somanetics INVOS Cerebral Oxymeter 5100C
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ass.-Prof. PD Dr. Klaus Ulrich Klein
Surgery, Anaesthesia
Local Assessment of Ventilatory Management During General Anesthesia for Surgery
Objectives 1. To characterize mechanical ventilation practices during general anesthesia for surgery 2. To assess the dependence of intra-operative and post-operative pulmonary complications on intra-operative Mechanical…
- Conditions
- Surgery, Anaesthesia, Ventilator-Induced Lung Injury, Lung Injury
- Trial name
- LAS VEGAS (NCT01601223)
- Where
- 19 sites in United States, Estonia and 6 more
- Volunteers
- 10,690 people
- Sponsor
- European Society of Anaesthesiology
COVID-19, Lung Function Decreased
Pulmonary Function and CT Scan Finding in CKD Patients After COVID-19 Infection
COVID-19 is associated with increased morbidity and mortality in patients with chronic kidney disease (CKD) on dialysis. CKD requires particular emphasis during the pandemic due to concern for increased susceptibility to…
- Conditions
- COVID-19, Lung Function Decreased, Xray Complication
- Trial name
- NCT05348759
- Testing
- Pulmonary function test, Chest computer scan
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Hypoventilation
Capnography Monitoring in the Bronchoscopic Sedation
Procedure sedation of flexible bronchoscopy (FB) comforts patients undergoing FB. Hypoventilation during FB is a concern. The investigators investigate the feasibility of monitoring capnography in FB sedation.
- Trial name
- NCT02848118
- Testing
- A nasal-oral cannula of capnography, Observer Assessment of Alertness and Sedation scale
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- Chang Gung Memorial Hospital
Respiratory Failure, Weaning Failure
HVNI for Successful Weaning in Respiratory Failure
The goal of this randomized active-controlled study is to investigate the role of high velocity nasal insufflation (HVNI) in the immediate post-extubation period and compare it with non-invasive positive pressure ventilation…
- Trial name
- REVIVER (NCT05855213)
- Testing
- High Velocity Nasal Insufflation, Non-invasive positive pressure ventilation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Postoperative Pain
Personalizing Perioperative Analgesia in Children
In the United States alone, each year approximately 5 million children undergo painful surgery, many of them experience serious side-effects with opioids and inadequate pain relief.
- Trial name
- NCT01140724
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Senthil Sadhasivam
Respiratory Failure, Respiratory Insufficiency
Comparison of High-flow Oxygen vs. BiPAP in Type II (Hypercapnic) Respiratory Failure
A retrospective cohort study of all patients treated for type II (hypercapnic) respiratory failure with either High-Flow Oxygen Therapy or Non-Invasive Ventilation in a general adult hospital.
- Conditions
- Respiratory Failure, Respiratory Insufficiency, Respiratory Tract Diseases, COPD
- Trial name
- NCT03443479
- Testing
- Non-Invasive Ventilation, High-Flow Nasal Cannula
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- Hôpital de Verdun
Nasal Obstruction
Pain Relief for Submucosal Resection of Nasal Septum in Adults Does Ketamine Have a Pre-Emptive Effect?
Pain is an unpleasant sensory experience associated with actual or potential tissue damage. Acute pain management is an important aspect of perioperative anesthetic care.
- Trial name
- NCT02294162
- Testing
- Ketamine i.v
- Where
- Israel
- Sponsor
- Western Galilee Hospital-Nahariya
Lung Edema
Heparin-binding Protein and Lungedema in ICU Patients.
The goal of this single center observational cohort study is to investigate the relationship between physiological measures of lung oedema, and the biomarker Heparin-binding Protein (HBP).
- Trial name
- NCT07434908
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Umeå University
Epistaxis, Nasal Obstruction
The Effect of Packing in Post Operative Management of FESS
Chronic sinusitis is a very common problem. The functional endoscopic sinus surgery is a prevalent option to treat this disease.During usage of different techniques of surgery, the need for packing after surgery is debatable…
- Conditions
- Epistaxis, Nasal Obstruction, Pain
- Trial name
- NCT00793117
- Testing
- packing
- Where
- Iran
- Volunteers
- 66 people
- Sponsor
- Tehran University of Medical Sciences
Neuromuscular Diseases, Obesity Hypoventilation Syndrome
Effectiveness Monitoring of Home Non-invasive Mechanical Ventilation by Digital Diagnosis Platform
The main objective will be to determine the effectiveness of home non-invasive ventilation by flow-time and time-pressure curves analysis in a cohort of patients with this treatment by digital diagnosis platform.
- Conditions
- Neuromuscular Diseases, Obesity Hypoventilation Syndrome, Lung Disease, Restrictive
- Trial name
- PRE-HVNI (NCT03085537)
- Where
- 3 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Corporacion Parc Tauli
Respiratory Failure
Comparative Effects on Diaphragmatic Electrical Activity and Respiratory Pattern of Various Levels of Assistance
Exploration of the effects on diaphragmatic electrical activity (EMG) and on respiratory pattern of various level of assistance delivered by the ventilator in intubated spontaneously breathing patients in pressure support (PS)…
- Trial name
- NCT01248845
- Testing
- Titration of various level of assistance
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Prof. Philippe Jolliet
Gastrostomy, Ventilatory Failure
Concomitant Bedside Percutaneous Tracheostomy and Ultrasound Gastrostomy
The goal of this research study is to assess the FDA approved technique for inserting a feeding tube (gastrostomy) along with a breathing tube (tracheostomy) for patients that cannot breathe or eat on their own in the ICU…
- Conditions
- Gastrostomy, Ventilatory Failure, Respiratory Failure
- Trial name
- TPUG (NCT05955534)
- Testing
- TPUG, PEG, PRG
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Respiratory Failure, Botulism
Treatment of Survivors After Botulism Outbreak
Background. Northern Thailand's biggest botulism outbreak to date occurred on 14 March 2006 and affected 209 people. Of these, 42 developed respiratory failure, and 25 of those who developed respiratory failure were referred to 9…
- Trial name
- NCT00314080
- Testing
- Botulinum AntiToxin, neuro-electrophysiologic study, repetitive nerve stimulation, Protocol early weaning ventilator after recovery of repetitive nerve stimulation and stable negative inspiratory pressure
- Where
- Thailand
- Volunteers
- 18 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Respiratory Failure
Negative Pressure Ventilation Imapcts Weaning Ventilator In Medical Intensive Care Units (ICUs)
This is a Quasi-experimental research design. The subjects are limited in intensive care unit within north medical center hospital. All subjects depend on ventilator and receive weaning plans.
- Trial name
- NCT01155596
- Testing
- negative pressure ventilator use
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital