Clinical trials: Respiratory Functions
Lung Cancer
Effects of Positive End-Expiratory Pressure on Biventricular Function During One-Lung Ventilation
One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Wang et al measured intrapulmonary shunt by transesophageal echocardiography.
- Trial name
- NCT02483806
- Testing
- PEEP
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Yonsei University
Oxygen Toxicity, Oxidative Stress
Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity
The goal of this trial is to investigate whether adding a small fraction of hydrogen gas to an oxygen-enriched breathing mixture can reduce pulmonary oxygen toxicity (POT) in healthy and active divers from the Swedish Armed…
- Conditions
- Oxygen Toxicity, Oxidative Stress, Hyperoxia, Hyperbaric Oxygen
- Trial name
- NCT07263399
- Testing
- Inhaled Hydrogen-Enriched Oxygen Gas, Inhaled Nitrogen-Enriched Oxygen Gas
- Where
- 2 sites in Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Blekinge Institute of Technology
Exposure to Man-made Visible Light
Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 6 of 7)
NOTE: This is the sixth of in total 7 sub-studies related to the Ethics Committee of the Canton of Bern Ref. No. KEK-BE 2016-00674.
- Trial name
- NCT02919163
- Testing
- Visible light exposure
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bern
Non-small Cell Lung Cancer
Hyperpolarized Xenon Gas MR Imaging in NSCLC Radiotherapy
Lung cancer is the second most commonly diagnosed cancer in the United Kingdom, accounting for 22% of cancer deaths. The main treatments for lung cancer are surgery, radiotherapy or chemoradiotherapy.
- Trial name
- NCT02151604
- Testing
- Inhalation of hyperpolarized xenon gas
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Oxford University Hospitals NHS Trust
Asthma
Fenzian Asthma Multicenter Outcomes Study
The purpose of this study is to investigate the effects of Fenzian™ treatment on symptoms (such as shortness of breath), lung function (how well the lungs work), and albuterol/salbutamol (rescue medication) use in people with…
- Trial name
- FAMOUS (NCT00784758)
- Testing
- Fenzian Device
- Where
- 6 sites in United States, South Africa and 1 more
- Volunteers
- 81 people
- Sponsor
- University of California, Los Angeles
Obstructive Sleep Apnea (OSA), Snoring
Effects of Frequency Adjustment in Functional Electrical Stimulation on Genioglossus Muscle Activity
This single-group interventional study investigates the safety and physiologic effects of functional electrical stimulation (FES) applied to the tongue and submental muscles in adults at high risk for sleep apnea.
- Trial name
- NCT07466888
- Testing
- Functional Electrical Stimulation Device
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Pulmonary Function; Newborn, Abnormal, Infant Wheeze
Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function
Vitamin C supplementation (500 mg per day) given to pregnant women who can not quit smoking will improve the pulmonary function tests in their offspring measured at 3 months of age.
- Conditions
- Pulmonary Function; Newborn, Abnormal, Infant Wheeze, In-utero Nicotine, Second Hand Smoke
- Trial name
- VCSIP (NCT01723696)
- Testing
- Vitamin C +prenatal vitamin
- Where
- 2 sites in United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Glottic Carcinoma, Supraglottic Carcinoma
Clinical Treatments in Specialized Diseases of Laryngeal Carcinoma (LC) and Hypopharyngeal Carcinoma (HPC)
For early stage laryngeal carcinoma and hypohparyngeal carcinoma (T1 and T2), transoral laser microsurgery, open partial laryngectomy, radiotherapy, and transoral robotic surgery were performed according to NCCN guidelines…
- Conditions
- Glottic Carcinoma, Supraglottic Carcinoma, Subglottic Carcinoma, Pyriform Sinus Carcinoma
- Trial name
- NCT04908696
- Testing
- routines
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Menopause
Relationship Between Genitourinary and Respiratory Symptoms in Postmanopause
The aim of this study is to evaluate the relationship between genitourinary system symptoms and respiratory function and respiratory muscle strength in postmenopausal women.
- Trial name
- NCT07651566
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Halic University
Acute Lung Injury
The Impact of Automatic Lung Recruitment Postoperative Pulmonary Complications
Study Background and Purpose As society ages, an increasing number of elderly patients undergo surgery. Following surgery, particularly abdominal procedures, patients are susceptible to lung-related issues such as atelectasis…
- Trial name
- lung (NCT07477951)
- Testing
- Automated recruitment maneuver (Auto-RM)
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Yongtao Sun
Bronchiectasis, Functional Inspiratory Muscle Training
Functional Inspiratory Training in Bronchiectasis
Bronchiectasis is a chronic respiratory disease clinically characterized by recurrent pulmonary exacerbations, chronic cough, and sputum production, and is associated with an increase in the airway-artery ratio and permanent…
- Trial name
- NCT07188675
- Testing
- Functional Inspiratory Muscle Training (FIMT), Inspiratory Muscle Training (IMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Elif Kabasakal
Stem Cell Transplantation
Physical Deteriorations in Allo-HSCT.
Limited number of studies reported impairments in physical activity, exercise capacity and quality of life of allogeneic hematopoietic stem cell transplantation (allogeneic-HSCT) recipients.
- Trial name
- NCT03606005
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Gazi University
Premature Birth
Preterm Functional Early Enteral Development (FEED) Trial on Respiratory Support
The purpose of this study is to demonstrate that allowing infants that require high flow nasal cannula (HFNC)/Continuous positive airway pressure (CPAP) to orally feed if demonstrating oral cues will achieve full oral feeds…
- Trial name
- NCT04531566
- Testing
- Oral Feed, Usual care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pulmonary Arterial Hypertension PAH, Pulmonary Arterial Hypertension WHO Group I
Right Ventricular Compensation With Sotatercept: A Prospective Single Arm Open Label Phase 4 Study to Evaluate the Effects of Sotatercept on Right Ventricular Function in Pulmonary Arterial Hypertension (RECOMPENSE)
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by vascular remodelling resulting in elevated pressures in the pulmonary artery (PA).
- Conditions
- Pulmonary Arterial Hypertension PAH, Pulmonary Arterial Hypertension WHO Group I, Pulmonary Arterial Hypertension
- Trial name
- RECOMPENSE (NCT06658522)
- Testing
- Sotatercept
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Thyroid Dysfunction, Hypothyroidism
Fetal and Neonatal Thyroid in Pregnancies With Severe Acute Respiratory Syndrome Coronavirus 2 ( SARS- COV2 ) COVID-19
The thyroid gland has been shown to be a common target for COVID 19 virus. Babies born to mothers positive for COVID 19 infections were noticed to have elevated thyroid stimulating hormone ( TSH ) levels on screening.
- Conditions
- Thyroid Dysfunction, Hypothyroidism, Hyperthyroidism
- Trial name
- COVID-19 (NCT05385029)
- Testing
- Thyroxine
- Where
- Saudi Arabia
- Volunteers
- 95 people
- Sponsor
- OMER B ABDELBASIT
COVID-19, ARDS (Acute Respiratory Distress Syndrome)
Long-Term Outcomes After ICU-Treated COVID-19 ARDS
This observational cohort study describes long-term survival and patient-reported health after intensive care unit (ICU) treatment for COVID-19-related acute respiratory distress syndrome (ARDS) in adults treated in a single…
- Trial name
- NCT07397156
- Where
- Poland
- Volunteers
- 283 people
- Sponsor
- University in Zielona Góra
COVID-19 Pneumonia, Impaired Respiratory Function
Study of Efficacy and Safety of MAS825 in Patients With COVID-19
This clinical study was designed to assess the efficacy and safety of MAS825 for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infected patients with coronavirus disease 2019 (COVID-19) pneumonia…
- Trial name
- MAS-COVID (NCT04382651)
- Testing
- MAS825, Standard of Care (SoC)
- Where
- 21 sites in United States
- Volunteers
- 140 people
- Sponsor
- Novartis Pharmaceuticals
Obstructive Sleep Apnea of Adult
A Pilot Study of Antioxidant Therapy in Obstructive Sleep Apnea Patients
Sleep apnea is a common under-diagnosed medical disorder, and moderate to severe disease is found in approximately 9% of men and 4% of women.
- Trial name
- NCT05009901
- Testing
- Alpha Lipoic Acid 600 MG Oral Tablet
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Cystic Fibrosis, Cystic Fibrosis in Children
The PROMISE Pediatric Study 6 to 11 Years Old
This is a prospective, multi-center observational study. The study is designed to measure the clinical effectiveness of elexacaftor, tezacaftor and ivacaftor (ETI) triple combination therapy in children (6-11 years of old) with…
- Trial name
- NCT04613128
- Where
- 20 sites in United States
- Volunteers
- 125 people
- Sponsor
- Nicole Hamblett
Stroke, Chest Wall Disorder
Addition of Proprioceptive Neuromuscular Facilitation to Cardio Respiratory Training Post Stroke
Post-stroke hemiparesis causes sequelae in the limbs and also in the trunk and abdomen structures. The level of physical activity decreases and cardiorespiratory training(CRT) is indicated to this population to improve the…
- Conditions
- Stroke, Chest Wall Disorder, Quality of Life
- Trial name
- NCT03171012
- Testing
- Lower limbs CRT, Upper limbs CRT, Proprioceptive Neuromuscular Facilitation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Rio Grande do Norte