Clinical trials: Respiratory Infection Prevention
Healthy Participants
Influenza Virus Vaccine Plus Vitamin A and D Supplements for Prevention of Respiratory Virus Infections in Children
Children are particularly vulnerable to respiratory virus infections, especially influenza. Vitamin A \& D deficiencies are associated with vulnerability to infectious diseases of the respiratory tract.
- Trial name
- NCT02649192
- Testing
- Influenza virus vaccine, Vitamins A and D
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Intensive Critical Unit, Pneumonia
Evaluation of the Effectiveness and Safety of Supratube Device
Purpose of the trial: Trial design: Two-parallel arm, double-blind, individually randomized controlled trial. Primary endpoint: Clinical evaluation of sinus, oropharyngeal, tracheal, bronchial or pulmonary infections during…
- Conditions
- Intensive Critical Unit, Pneumonia, Aspiration, Prevention and Control
- Trial name
- SUPRANAV (NCT03573609)
- Testing
- Supranav
- Where
- Colombia
- Volunteers
- 108 people
- Sponsor
- Fundación Cardiovascular de Colombia
Pneumonia, Pneumococcal, Pneumococcal Infections
Study Evaluating the Effiacy of a 13-Valent Pneumococcal Conjugate Vaccine (13vPnC) in Adults
The purpose of this study is to assess the efficacy of 13-valent pneumococcal conjugate vaccine in the prevention of the first episode of vaccine-type pneumococcal community-acquired pneumonia in adults.
- Conditions
- Pneumonia, Pneumococcal, Pneumococcal Infections, 13-valent Pneumococcal Vaccine
- Trial name
- CAPITA (NCT00744263)
- Testing
- VACCINE: 13-valent pneumococcal conjugate vaccine
- Where
- 159 sites in Netherlands
- Volunteers
- 84,496 people, healthy volunteers welcome
- Sponsor
- Pfizer
RSV Infection
RSV Vaccination in Immunocompromised Patients.
Respiratory syncytial Virus (RSV) causes respiratory infections worldwide and typically presents with a seasonal pattern peaking in autumn/winter in temperate climate zones.
- Trial name
- NCT06597916
- Testing
- Arexvy powder and suspension for injection
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Covid19
Study of DS-5670a (COVID-19 Vaccine) in Japanese Healthy Adults and Elderly Subjects
This study will assess the safety, tolerability and immunogenicity of DS-5670a (COVID-19 Vaccine) and determine the recommended dose in Japanese healthy adults and elderly participants.
- Trial name
- NCT04821674
- Testing
- DS-5670a
- Where
- Japan
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Daiichi Sankyo Co., Ltd.
COVID 19
Oral 25-hydroxyvitamin D3 and COVID-19
The goal of this clinical trial is to investigate the therapeutic efficacy of rapidly correcting vitamin D deficiency in adults with the use of 25-hydroxyvitamin D3 [25(OH)D3] for reducing the risk of acquiring the SARS-CoV-2…
- Trial name
- NCT04386850
- Testing
- Oral 25-Hydroxyvitamin D3
- Where
- Iran
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Respiratory Tract Infections, Gastrointestinal Infections
Hand Hygiene Randomized Cluster Intervention to Reduce Infections
The purpose of this study is to determine if a simple intervention to improve hand hygiene, consisting of a 3-4 minute training video, on-site posters, and hand hygiene supplies, can reduce respiratory and GI illness among…
- Trial name
- NCT02131727
- Testing
- Hand Hygiene Improvement Intervention, Ask Me 3
- Where
- United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Kent State University
COVID-19
Study in Adults of AZD1222 and rAd26-S Administered as Heterologous Prime-Boost Regimen for the Prevention of COVID-19
The objective is to evaluate the safety and immunogenicity of AZD1222 given in combination with (either before or after) rAd26-S, for the prevention of COVID 19 in adults ≥ 18 years of age.
- Trial name
- NCT04684446
- Testing
- AZD1222, rAd26-S
- Where
- 4 sites in Russia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- R-Pharm
Pneumonia, Ventilator-Associated
The Efficacy of Adjuvant Oral Care in Prevention of Ventilator Associated Pneumonia.
A Randomized Controlled Trial (RCT) at Services Hospital, Lahore, aims to reduce Ventilator-Associated Pneumonia (VAP) incidence and mortality rates while shortening ICU stays in mechanically ventilated patients by adding…
- Trial name
- NCT06039995
- Testing
- Comprehensive Oral Care, Traditional Oral Care, Mechanical Tooth Brushing using 0.2% Chlorhexidine
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people
- Sponsor
- University of Health Sciences Lahore
COVID-19
Evaluation of Corfluvec Vaccine for the Prevention of COVID-19 in Healthy Volunteers
The aim of the study is to investigate the safety and immunogenicity of a two-component intranasal vaccine for the prevention of COVID-19 in healthy volunteers 18-60 years old
- Trial name
- NCT05696067
- Testing
- Corfluvec component 1 low dose, Corfluvec component 2 low dose, Corfluvec component 1 high dose
- Where
- 2 sites in Russia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tatyana Zubkova
Prevention of COVID-19
Assessing Immune Response of Different COVID-19 Vaccines in Older Adults
This is a randomised controlled, adaptive, multicentre Phase II protocol evaluating different booster strategies in individuals aged 75 years and older already vaccinated against SARS-CoV-2.
- Trial name
- EU-COVAT-1 (NCT05160766)
- Testing
- Comirnaty (BTN162b2), Spikevax (mRNA-1273)
- Where
- 9 sites in Germany, Lithuania and 2 more
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- Oliver Cornely, MD
Acute Respiratory Infection
Meditation and Exercise for Prevention of Acute Respiratory Infection
The overarching goal of this project is to determine whether mind-body practices such as meditation or exercise can reduce the public health burden of acute respiratory infection.
- Trial name
- MEPARI (NCT01057771)
- Testing
- Meditation, Exercise
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Influenza
Evaluation of Alternative Oseltamivir (Tamiflu) Dosing Strategies.
Objective 1: Determine the safety and toxicity profile of Tamiflu administered in combination with probenecid in healthy adults.Objective 2: Determine the pharmacokinetic profile of Tamiflu and probenecid in healthy adults.
- Trial name
- NCT00304434
- Testing
- Oseltamivir, Probenecid
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Asthma, Asthma Exacerbations
Vitamin D In the Prevention of Viral-induced Asthma in Preschoolers
In this 7-month randomized controlled trial, children aged 1 to less than 6 years, with recurrent asthma attacks triggered mostly by colds, will receive a high dose of vitamin D or a placebo every 3.5 months during their usual…
- Conditions
- Asthma, Asthma Exacerbations, Preschool Child, Vitamin D
- Trial name
- DIVA (NCT03365687)
- Testing
- Vitamin D
- Where
- 9 sites in Canada
- Volunteers
- 323 people
- Sponsor
- Professor Francine Ducharme
Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery
Our Aim is to identify patient risk factors and clinical practices associated with healthcare-acquired infections (HAIs) after cardiac surgery.
- Conditions
- Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection, Sepsis, Pneumonia
- Trial name
- HAI (NCT02068716)
- Where
- United States
- Volunteers
- 911,754 people
- Sponsor
- Dr. Donald Likosky
Influenza
Project to Investigate Ways to Reduce the Spread of Influenza in Schools and Households With Children
The purpose of this study is to understand the spread of influenza (flu) in schools and households with elementary (K-5) school children, and develop ways to reduce the flu using non-pharmaceutical means.
- Trial name
- PIPP (NCT00446628)
- Testing
- behaviors reducing spread of influenza
- Where
- United States
- Volunteers
- 3,360 people, healthy volunteers welcome
- Sponsor
- Kiren Mitruka
Influenza
Hutterite Influenza Prevention Study
The goal of this randomized clinical trial is to determine whether immunizing children in Hutterite colonies with inactivated influenza vaccine can prevent influenza and its complications in other colony members.
- Trial name
- NCT00877396
- Testing
- Influenza vaccination, Hepatitis A Vaccine
- Volunteers
- 4,771 people, healthy volunteers welcome
- Sponsor
- McMaster University
COVID19, Hydroxychloroquine
Protect: Study With Hydroxychloroquine for Prevention and Early Phase Treatment of Coronavirus Disease (COVID-19)
This is a Italian, superiority, open label cluster-randomised, interventional clinical trial aimed at assessing whether the treatment with Hydroxychloroquine can reduce the percentage of symptomatic subjects compared to…
- Conditions
- COVID19, Hydroxychloroquine, Prophylaxis, Treatment
- Trial name
- PROTECT (NCT04363827)
- Testing
- Hydroxychloroquine
- Where
- Italy
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
COVID-19
Safety and Immunogenicity of Recombinant SARS-CoV-2 Spike Protein Vaccine (CHO Cell) for the Prevention of COVID-19
The purpose of this double-blind, randomized, controlled study is to assess safety, reactogenicity, and immunogenicity of ZR-202-CoV, administered as 2 injections (i.m) at 28 days apart in adult subjects 60 years of age and above.
- Trial name
- NCT05313022
- Testing
- ZR-202-CoV
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Shanghai Zerun Biotechnology Co.,Ltd
Influenza
The Chloroquine for Influenza Prevention Trial
A randomised controlled trial to determine the efficacy of chloroquine for the prevention of influenza
- Trial name
- CHIP (NCT01078779)
- Testing
- Chloroquine
- Where
- Singapore
- Volunteers
- 1,516 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore