Clinical trials: Respiratory Infections in Children
Pneumonia, Pneumonia, Viral
Diagnostic Accuracy of Pocket-size Lung Ultrasound in Pneumonia Etiology and Complications in Hospitalized Children
1. Background and study aims Pneumonia is the leading infectious cause of death in children worldwide. Although the diagnosis is clinical, a chest radiograph (CXR) is often necessary to clarify it, exposing the patient to…
- Conditions
- Pneumonia, Pneumonia, Viral, Pneumonia, Bacterial
- Trial name
- POCUS-L (NCT06296693)
- Testing
- Pocket-size lung ultrasound for etiological definition of pneumonia and surveillance of complications in children hospitalized
- Volunteers
- 76 people
- Sponsor
- Centro Hospitalar Universitário de Santo António
Pediatric Cancer, Chronic Sinusitis
Post-radiotherapy Rhinosinusitis in Children
Chronic rhinosinusitis (CRS) is a frequent complication of facial cancer treatment, mainly related to radiotherapy. However, while radiological involvement is frequent, clinical expression seems less important.
- Trial name
- PRRSC (NCT05454163)
- Testing
- SNOT 22 questionnaire
- Sponsor
- University Hospital, Lille
Bronchiolitis, Bronchodilator Agents
Characterization of Bronchodilator Response in Children With Bronchiolitis Using Phenotypic and Genotypic Features
Bronchiolitis is the leading cause of pediatric morbidity and healthcare costs. Despite the commonplace use of bronchodilator treatments, like albuterol, in conditions like asthma, their efficacy in bronchiolitis remains…
- Trial name
- NCT06946264
- Testing
- Albuterol Sulfate, 2.5 Mg/3 mL (0.083%) Inhalation Solution, Sodium Chloride 0.9% Inhl 3Ml
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Nemours Children's Clinic
Tonsillitis, Pharyngitis
TELI TON - Telithromycin in Tonsillitis
This is a multinational, randomized (1:1), double blind, double dummy, comparator-controlled, 2 parallel treatment group study in subjects from 6 months to < 13 years of age, with Streptococcus pyogenes tonsillitis/pharyngitis…
- Trial name
- NCT00315042
- Testing
- Telithromycin (HMR3647), Penicillin
- Where
- 5 sites in United States, Argentina and 3 more
- Volunteers
- 314 people
- Sponsor
- Sanofi
Cystic Fibrosis
The EPIC Observational Study
The purpose of this study is to better define risk factors preceding first isolation of Pseudomonas aeruginosa (Pa) from respiratory cultures in cystic fibrosis (CF) lung disease and to better define clinical outcomes associated…
- Trial name
- EPIC OBS (NCT00676169)
- Where
- 54 sites in United States
- Volunteers
- 1,248 people
- Sponsor
- CF Therapeutics Development Network Coordinating Center
Post-COVID-19 Syndrome, Anxiety
Connecting Breath and Mind for CYP With Long COVID
Recruitment target: Phase I: Co-design of intervention: 5 to 15 CYP aged between 12-18 years of age referred to the pan-London long COVID MDT.
- Conditions
- Post-COVID-19 Syndrome, Anxiety, Breathlessness
- Trial name
- NCT05705154
- Testing
- Psychology interventions
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Tuberculosis
BRIGHT-Child TB: Short-Course Treatment for Non-Severe Pulmonary Tuberculosis in Children
The goal of this Phase II, multicenter, open-label, randomized controlled trial is to evaluate the efficacy and safety of short-course treatment regimens for children with non-severe, drug-susceptible pulmonary tuberculosis.
- Trial name
- NCT07893444
- Testing
- 4-month FDC-based regimen, 3-month BDCZ regimen, Standard 6-month treatment regimen
- Where
- 13 sites in China
- Volunteers
- 90 people
- Sponsor
- Huashan Hospital
Dental Caries in Children, Dental Diseases
Information and Communication Technologies (ICTS) in Dentistry for SUS
At the time of the COVID-19 pandemic, thousands of children had their dental care interrupted or postponed, generating a pent-up demand for primary care.
- Trial name
- NCT04798599
- Testing
- Telemonitoring and teleorientation, Control Group - Waiting list
- Where
- Brazil
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Influenza
Safety and Immunogenicity of Three Influenza Vaccines in Children Aged 4 Years Old to Less Than 18 Years Old
Evaluate safety and immunogenicity of three influenza vaccines in children ages greater than 4 years old to less than 18 years old.
- Trial name
- NCT01992107
- Testing
- QIVc, TIV1c, TIV2c
- Where
- 88 sites in United States
- Volunteers
- 2,333 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Respiratory Tract Infections, Urinary Tract Infections in Children
PHase IV Clinical Trial of Ceftriaxone Sodium and Sulbactam Sodium for Injection (CRO-SBT)
To evaluate the safety and efficacy of treatment of children with acute bacterial infection disease with Ceftriaxone Sodium and Sulbactam Sodium for Injection in the condition of widely used, and provide the basis of adjusting…
- Trial name
- CRO-SBT (NCT04066621)
- Testing
- Ceftriaxone Sodium and Sulbactam Sodium for Injection
- Volunteers
- 30 people
- Sponsor
- Xiangbei Welman Pharmaceutical Co., Ltd
Vaccine Reaction, COVID-19
Determining Reactogenicity and Immunogenicity of Delayed COVID-19 Vaccine Schedule in Children
COVID-19 vaccine response data in children 5 to 11 years old remain scarce. Our understanding of the safety and immune responses including humoral and cellular responses generated in children remains limited.
- Conditions
- Vaccine Reaction, COVID-19, Children, Only
- Trial name
- NCT05329064
- Testing
- BNT162b2 Pfizer-BioNTech/Comirnaty
- Where
- Singapore
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Respiratory Syncytial Virus Infections, Severe Acute Respiratory Infection
Effectiveness of Immunization in Preventing Severe Acute Respiratory Infection RSV in Children Under 6 Months in Bogotá
This study aims to evaluate the real-world effectiveness of two preventive immunization strategies against Respiratory Syncytial Virus (RSV)-associated severe acute respiratory infection in infants less than six months of age in…
- Conditions
- Respiratory Syncytial Virus Infections, Severe Acute Respiratory Infection, Bronchiolitis, Viral, Viral Respiratory Tract Infection
- Trial name
- NCT07279298
- Testing
- RSVpreF vaccine (Abrysvo) and Nirsevimab (Beyfortus) or unexposed
- Where
- Colombia
- Volunteers
- 1,097 people
- Sponsor
- Bogotá District Health Secretariat
Influenza
A Clinical Trial of an Inactivated Quadrivalent Influenza Vaccine in Chinese Children Aged 3 to 8 Years
Routine annual influenza vaccination is recommended for all persons aged≥6 months who do not have contraindications. For those aged 6 monthsthrough 8 years who have previously received ≥2 total doses of trivalent orquadrivalent…
- Trial name
- NCT05313893
- Testing
- Quadrivalent influenza vaccine
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Covid19
Prevalence of SARS -Cov2 Carriage in Asymptomatic and Mildly-symptomatic Children
This study is expected to provide, for the first time, data on Cov2-SARS circulation in asymptomatic children and children with moderate respiratory symptoms in order to construct the severity pyramid of this novel pathogen.
- Trial name
- COVILLE (NCT04318431)
- Testing
- Data collection and rhinopharyngeal swab
- Where
- 22 sites in France
- Volunteers
- 605 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Upper Respiratory Tract Infections
Efficacy of Diclofenac Potassium vs Nimesulide in the Treatment of Fever and Pain in Children With Upper Respiratory Tract Infection
This is a local, phase IV, open-label, randomized, head to head study of children aged 3 to 7 years. The objective of the study is to compare the efficacy of a single dose of both diclofenac potassium and nimesulide in the…
- Trial name
- NCT01257126
- Testing
- diclofenac potassium, nimesulide
- Sponsor
- Novartis Pharmaceuticals
SARS-CoV-2, SARS-CoV Infection
Sero-prevalence COVID-19 Among Belgian Children
Based on studies in China, Iceland, the Netherlands and Italy it seems that children are less affected by SARS-CoV-2 infections and play a lesser role in the dissemination of the SARS-CoV-2 virus.
- Conditions
- SARS-CoV-2, SARS-CoV Infection, Covid19
- Trial name
- SeCoBelChild (NCT04613817)
- Where
- Belgium
- Volunteers
- 2,103 people, healthy volunteers welcome
- Sponsor
- Sciensano
Cystic Fibrosis (CF)
Antioxidant Supplements in Cystic Fibrosis Children
This randomized controlled clinical trial included 60 pediatric patients with cystic fibrosis (CF) assigned randomly into two arms; Arm 1(extra care arm):received a tailored dietary plan following Mediterranean diet to cover…
- Trial name
- NCT06875050
- Testing
- Mediterranean diet, Fat soluble vitamins supplementation, Antioxidant Supplement
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Novel 2009 Influenza H1N1, Influenza, Human
Tolerability and Immunogenicity Study of FLUVAL P H1N1 Flu Vaccine of Omninvest in Children and Adolescents
This is a single-blind, reference drug controlled study to assess safety and tolerability of FLUVAL P H1N1 monovalent influenza vaccine (whole virus, inactivated, adjuvanted with alumn phosphate gel) containing 6 mcgHA per 0.5mL…
- Trial name
- NCT01407978
- Testing
- Vaccination with Fluval P monovalent influenza vaccine, Vaccination with Fluval AB, Vaccination with Fluval AB Novo
- Where
- Hungary
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Fluart Innovative Vaccine Ltd, Hungary
Common Cold, Gastroenteritis
Echinacea, Propolis and Vitamin C for URI Prevention in Preschoolers
We hypothesize the herbal preparation will enhance the preschoolers' immune response and when taken prophylactically for 12 weeks will decrease episodes of upper respiratory infections and gastroenteritis in the active versus the…
- Trial name
- NCT00231218
- Testing
- dietary supplement--echinacea, propolis, and vitamin c
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Influenza
Study to Evaluate Safety and Immunogenicity of GSK Biologicals' Pandemic Influenza (H1N1) Candidate Vaccine in Children
The purpose of this study is to assess the safety and immunogenicity of two doses of the H1N1 candidate vaccine administered in children aged between 8 and 12 weeks at the time of first vaccination.
- Trial name
- NCT01003418
- Testing
- GSK2340272A GSK Biologicals' investigational influenza pandemic vaccine, Infanrix™-IPV/Hib, Prevenar
- Where
- 4 sites in Norway
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline