Clinical trials: Respiratory Infections in Children
Community Acquired Pneumonia, Childhood Pneumonia
3 vs. 5 Days of Amoxicillin for Childhood Pneumonia: An RCT
Pneumonia is the most common infection in children and leading to most common cause of mortality and morbidity in in children globally. Bacterial cause is mostly streptococcus pneumonia in children of 3 months to 5 years of age.
- Trial name
- Pnemonia (NCT07647835)
- Testing
- Amoxicillin
- Where
- Pakistan
- Volunteers
- 250 people
- Sponsor
- Khyber Teaching Hospital
Influenza
A Study of Intravenous Tamiflu (Oseltamivir) in Children With Influenza
This open-label study will assess the pharmacokinetics/pharmacodynamics and safety of intravenous (iv) Tamiflu (oseltamivir) in 3 cohorts of children, aged 6-12, 3-5 and 1-2 years, with influenza infection.
- Trial name
- NCT01033734
- Testing
- oseltamivir [Tamiflu]
- Where
- 38 sites in United States, Israel and 1 more
- Volunteers
- 8 people
- Sponsor
- Hoffmann-La Roche
Influenza
Study on the Burden of Influenza-related Hospitalizations and Emergency Room (ER) Visits in Children in Spain
This study aims to quantify the inpatient and ER visits burden of laboratory-confirmed influenza, and compare the clinical features, severity, complications, risk factors and socioeconomic impact of influenza in children…
- Trial name
- NCT01592799
- Testing
- Throat swab and/or nasopharyngeal swab, Data collection
- Where
- Spain
- Volunteers
- 501 people
- Sponsor
- GlaxoSmithKline
Influenza
Open-Label Study of H5 Vaccine in Participants of Protocol 04-077
This study may provide safety information on a flu vaccine given to children and may provide immunogenicity information to add to what was collected in a previous flu vaccine study.
- Trial name
- NCT00402649
- Testing
- Inactivated Influenza A/H5N1 Vaccine (sanofi pasteur)
- Where
- 3 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19
Immunogenicity And Safety of COVID-19 Vaccine , Inactivated Co -Administration With EV71 Vaccine (Vero Cell)
This study is a randomized and controlled phase Ⅳ clinical trial of the COVID-19 vaccine (Vero cell), Inactivated manufactured by Sinovac Research \& Development Co., Ltd.
- Trial name
- NCT04993365
- Testing
- Experimental Group, Control Group
- Where
- 2 sites in China
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Sinovac Research and Development Co., Ltd.
Pertussis
Seroprevalence of Pertussis Among Healthy Children and Adolescents in Kazakhstan
Seroprevalence of pertussis among older children and adolescents in Kazakhstan: A cross sectional study. Justification: to describe the distribution of anti-pertussis toxin (PT) antibodies (IgA and IgG) in a population aged 10-18…
- Trial name
- NCT04779853
- Testing
- Blood samples for pertussis antibody testing
- Where
- Kazakhstan
- Volunteers
- 520 people
- Sponsor
- Scientific and practical center of sanitary and epidemiological expertise and monitoring
Asthma
Asthma in Families Facing Out-of-pocket Requirements Due to COVID-19
In addition to its impact on health, the COVID-19 pandemic led to increased unemployment and loss of employer-sponsored insurance coverage.
- Trial name
- AFFORD COVID (NCT04613739)
- Testing
- insurance navigation
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Harvard Pilgrim Health Care
Tuberculosis, Polio
Mobile Phone SMS Messages and Automated Calls in Improving Vaccine Coverage Among Children in Pakistan
Routine childhood immunization (RCI) in Pakistan is well below the recommended coverage of 90% with rates as low as 16% in certain regions (Pakistan DHS 2012-3).
- Conditions
- Tuberculosis, Polio, Diphtheria, Pertussis
- Trial name
- NCT03341195
- Testing
- SMS messages and automated calls
- Volunteers
- 3,850 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Diphtheria, Pertussis
Tdap Vaccine in Post-Partum Women
Monitoring immune response and longevity in serum and milk after Tdap administration to postpartum women. The clinical trial will involve women (aged 18 - 45 years) who have just delivered full-term infants (greater than or equal…
- Conditions
- Diphtheria, Pertussis, Tetanus
- Trial name
- NCT01711645
- Testing
- Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine adsorbed onto aluminum phosphate
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Influenza
Safety and Immunogenicity of a Monovalent Inactivated Influenza H3N2 Variant (H3N2v) Vaccine in Pediatric Populations
This is a Phase II open-label study in approximately 240, and up to 400, healthy males and non-pregnant females, aged 6 months to 17 years.
- Trial name
- NCT02100436
- Testing
- Influenza Virus Vaccine, Monovalent A/H3N2v A/Minnesota/11/2010 NYMC X-203
- Where
- 8 sites in United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Upper Respiratory Tract Infection
Probiotic S. Salivarius K12 for the Prevention of Upper Respiratory Tract Infection in Nursery-age Children
The purpose of this retrospective study is to assess the treatment benefits of probiotic Streptococcus salivarius K12 for the prevention of recurrent bacterial and viral infections of the pharynx, tonsils and ears in children…
- Trial name
- PUNK (NCT05840926)
- Testing
- Probiotic Streptococcus salivarius K12, No probiotic supplementation
- Where
- Pakistan
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- Liaquat University of Medical & Health Sciences
Bronchiolitis Acute Viral, Bronchiolitis
Nasal Bubble Continuous Positive Airway Pressure in Reducing Respiratory Distress in Children With Bronchiolitis
This study is designed to assess the effectiveness of nasal continuous positive airway pressure in reducing respiratory distress in children with bronchiolitis
- Conditions
- Bronchiolitis Acute Viral, Bronchiolitis, Bronchiolitis Acute, Bronchiolitis, Viral
- Trial name
- NCT04989114
- Testing
- nasal continuous positive airway pressure
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- ameer asadullah gull
COVID-19 Vaccines
A Study of COVID-19 Vaccine(s) in Children and Adults
The purpose of this study is to learn about the safety and effects of updated COVID-19 vaccines (called BNT162b2) in participants 5 Through 64 Years of Age with risk factors for Severe COVID-19, and Participants 65 Years of Age…
- Trial name
- NCT07798648
- Testing
- BNT162b2
- Where
- 14 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Influenza Immunity
Natural History of Systemic and Nasal Mucosal Immunity After Influenza Vaccination in a Pediatric Population
Background: The influenza (flu) virus infects millions around the world every year. Children are at increased risk of complications from the flu. The flu vaccine protects against influenza, but the vaccine can be improved.
- Trial name
- NCT04963166
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19 Pandemic
Retinal and Choroidal Microvascular Parameters in School-age Children in a COVID-19 Infection Pandemic Peak in China
We designed this study to examine whether COVID-19 infection could lead to retinal and choroidal microvascular involvement in school-age children (6-18 years) in a pandemic peak in China.
- Trial name
- NCT05952466
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangzhou First People's Hospital
Sleep-Disordered Breathing, Sleep Apnea Syndromes in Children
Lateral Pharyngoplasty Outcomes in Children Undergoing Tonsillectomy
The goal of this treatment study is to determine if doing lateral pharyngoplasty with tonsillectomy is better for children than doing tonsillectomy alone.
- Conditions
- Sleep-Disordered Breathing, Sleep Apnea Syndromes in Children, Sleep Apnea, Obstructive, Tonsillitis
- Trial name
- NCT05575401
- Testing
- Lateral pharyngoplasty, Tonsillectomy
- Where
- 4 sites in United States
- Volunteers
- 160 people
- Sponsor
- Loma Linda University
Influenza
Direct and Indirect Protection by Influenza Vaccine Given to Children in India
The study described here will immunize children with trivalent influenza vaccine (TIV) and determine whether this reduces influenza illness among the immunized children and their older family members.
- Trial name
- NCT00934245
- Testing
- Inactivated Trivalent Influenza Vaccine, Inactivated polio vaccine (IPV)
- Where
- India
- Volunteers
- 4,598 people, healthy volunteers welcome
- Sponsor
- Wayne Sullender, M.D.
Tonsillitis
Multicenter, Open, Randomized Comparative Trial To Compare The Efficacy Of Azithromycin Versus Amoxicillin In Children With Strep Throat
The primary objective was to compare the bacteriological efficacy at Day 10 of azithromycin pediatric suspension (20 mg/kg/day once daily for 3 consecutive days) versus amoxicillin pediatric suspension (50 mg/kg/day in 2 doses…
- Trial name
- NCT00643539
- Testing
- Zithromax, Clamoxyl
- Where
- 45 sites in France
- Volunteers
- 360 people
- Sponsor
- Pfizer
Influenza, Human
Immunogenicity and Safety of Butantan Quadrivalent Influenza Vaccine (Split Virion, Inactivated) in Infants and Children .
This is a Phase III Randomized Clinical Trial, blind, multicenter, with active controls, to evaluate the immunogenicity and safety of the Quadrivalent Influenza Vaccine (split virion, inactivated) from Instituto Butantan, in two…
- Trial name
- NCT05779020
- Testing
- Quadrivalent Influenza Vaccine (split virion, inactivated), Trivalent Influenza Vaccine (split virion, inactivated) containing Influenza B virus - Victoria lineage, Trivalent Influenza Vaccine (split virion, inactivated) containing Influenza B virus - Yamagata lineage
- Where
- 10 sites in Brazil
- Volunteers
- 1,373 people, healthy volunteers welcome
- Sponsor
- Butantan Institute
Common Cold
Study Comparing 3 Formulations to Evaluate the Efficacy and Safety of the Inflammatory Symptoms of the Upper Respiratory Tract, in Children Between 2 and 6 Years Old
The primary outcome of this study is to evaluate the clinical efficacy of the dose fixed combination and each drug, that composes it, isolated, regarding the respiratory symptoms improvement in superior air passages acute…
- Trial name
- NCT00967759
- Testing
- Bronpheniramine and fenilefrine (Decongex Plus), Bronpheniramine isolated, Fenilefrine isolated
- Where
- Brazil
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
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