Clinical trials: Respiratory Infections in Children
Pneumonia Childhood
Acute Respiratory Infection Diagnostic Aids (ARIDA) Controlled Accuracy Evaluation Protocol
Pneumonia is the leading infectious cause of death among children under 5 years of age globally. Many pneumonia deaths result from late care seeking and inappropriate treatment due to misdiagnosis of symptoms.
- Trial name
- NCT03067558
- Testing
- Children's automated respiratory rate monitor, MK2 Acute Respiratory Infection (ARI) Timer
- Where
- Ethiopia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Malaria Consortium
Asthma, Bronchiolitis
WheezoMeter® Correlation Study
The primary goal of the study is to more firmly establish correlations between WheezeRate(Wz%) and other parameters used to assess wheezing and asthma including spirometry, provider's auscultation, and symptoms at the time of Wz%…
- Trial name
- NCT01556958
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- iSonea
Respiratory Syncytial Virus Infection, Acute Bronchiolitis Due to Respiratory Syncytial Virus
RSV-Positive Children <5 Years Presenting to Pediatric Emergency Departments in Türkiye: TRUST-RSV
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in infants and young children and contributes substantially to pediatric emergency department (ED) visits and hospitalizations.
- Conditions
- Respiratory Syncytial Virus Infection, Acute Bronchiolitis Due to Respiratory Syncytial Virus, Pneumonia, Upper Respiratory Tract Infection
- Trial name
- TRUST-RSV (NCT07346963)
- Volunteers
- 4,000 people
- Sponsor
- Eskisehir Osmangazi University
COVID-19
Safety of an Inactivated SARS-CoV-2 Vaccine (CoronaVac) in Children and Adolescents
This study is a randomized, double-blinded, placebo-controlled, phase Ⅱb clinical trial of an inactivated SARS-CoV-2 vaccine (CoronaVac) manufactured by Sinovac Life Sciences Co.
- Trial name
- NCT04884685
- Testing
- SARS-CoV-2 Inactivated Vaccine
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Sinovac Life Sciences Co., Ltd.
Ventilator Associated Pneumonia, Tracheobronchitis
A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children
The objective of this study is to evaluate implementation of diagnostic stewardship programs as a strategy to safely reduce antibiotic use, and to generate evidence and tools to support dissemination of diagnostic stewardship…
- Trial name
- BrighT STAR (NCT04987840)
- Where
- 8 sites in United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Adult Children
Investigation of Physical Impairments in Young Adults
Physical inactivity is widespread among young adults due to different disasters like the COVID-19 and earthquakes. On the other hand, it is unknown how physical activity level affects cough strength and balance in young adults.
- Trial name
- NCT06561776
- Testing
- Physical Evaluations of individuals
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Izmir Democracy University
Acellular Pertussis, Diphtheria
Post-marketing Surveillance to Assess the Safety of Infanrix-IPV Vaccine Among Infants and Children in Korea
The purpose of this study is to collect safety information following routine vaccination with Infanrix-IPV among infants and children in Korea.
- Conditions
- Acellular Pertussis, Diphtheria, Tetanus, Poliomyelitis
- Trial name
- NCT01568060
- Testing
- Infanrix-IPV data collection
- Where
- South Korea
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Ventilator Associated Pneumonia, Pneumonia, Bacterial
Cultures in PICU Patients Compared to Healthy Children
This study is being done to determine if the bacteria found in your mouth (oral flora bacteria) in children admitted to the intensive care unit who need to be on a breathing machine is different from the oral flora in healthy…
- Trial name
- NCT03418272
- Testing
- Culture/PCR Analysis
- Sponsor
- State University of New York at Buffalo
RESPIRATORY SYNCYTIAL VIRUS (RSV)
A Study to Learn About the Safety and Immune Activity of RSVpreF in Children 2 to <18 Years of Age
The purpose of this study is to learn about the safety and immune activity of the vaccine (called RSVpreF) in children 2 to <18 years of age.
- Trial name
- PICASSO (NCT05900154)
- Testing
- RSVpreF 120 µg, RSVpreF 60 µg
- Where
- 17 sites in United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Pfizer
Tonsillitis
Comparison of Dexmedetomidine and Midazolam for Prevention of Emergence Delirium in Children
Emergence delirium is a common complication in children after anesthesia. The incidence of emergence delirium is reported upto 50%.
- Trial name
- NCT03337672
- Testing
- Dexmedetomidine, Midazolam
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Eunah Cho, MD
Virus Diseases in Children
A Study to Investigate the Effect of Probiotics (L. Reuteri ATCC PTA 5289 and L. Reuteri DSM 17938) on Symptoms of Viral Upper Respiratory Tract Infections in Children
This study investigates the effect of Lactobacillus reuteri probiotic strains (ATCC PTA 5289 and DSM 17938) on symptoms of viral upper-respiratory tract infections in children.
- Trial name
- NCT06205966
- Testing
- BioGaia Pharax (L. reuteri PTA 5289 and DSM 17938)
- Where
- Hungary
- Volunteers
- 142 people
- Sponsor
- Milosevits Gergely
Influenza
Peds Sanofi H1N1 Influenza Vaccine Administered at Two Dose Levels
The purpose of this study is to assess the safety and the body's immune response (body's defense against disease) to an experimental H1N1 influenza vaccine.
- Trial name
- NCT00944073
- Testing
- Influenza Virus Vaccine, Monovalent A/H1N1 A/California/7/2009 NYMC X-179A
- Where
- 9 sites in United States
- Volunteers
- 583 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Wheezing, Bronchiolitis
Bedside Lung Ultrasound in Young Children Presenting to the Emergency Department (ED) With Wheezing
Young children presenting to the Emergency Department (ED) with wheezing often have prolonged stays in the ED or even get admitted to the hospital.
- Trial name
- NCT01452945
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's National Research Institute
Common Cold, Infections, Upper Respiratory Tract
Acute Cough Study In Children
15 mg dextromethorphan hydrobromide will be better than placebo with respect to reducing the number of coughs over 6 hours and reducing the subjective severity of cough over 6 hours.
- Trial name
- NCT01257542
- Testing
- Dextromethorphan
- Where
- 4 sites in United States
- Volunteers
- 140 people
- Sponsor
- Pfizer
Influenza, Healthy
Evaluate the Shedding and Immunogencity of Different Formulations of FluMist in Children 24 to <48 Months of Age
This study is being conducted to compare the immunogenicity, safety, and viral shedding of a new A/H1N1 strain that will be incorporated into the FluMist quadrivalent formulation for the 2017-2018 influenza season with the…
- Trial name
- FluMist (NCT03143101)
- Testing
- FluMist trivalent (2015-2016), FluMist Quadrivalent (2015-2016), FluMist Quadrivalent (2017-2018)
- Where
- 12 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Sinusitis
Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children
The investigators objective is to compare short course (5 days) to long course (14 days)antibiotics for the treatment of acute bacterial sinusitis in children.
- Trial name
- NCT01166945
- Testing
- Amoxicillin-Potassium Clavulanate Combination
- Where
- 2 sites in United States
- Volunteers
- 98 people
- Sponsor
- University of Wisconsin, Madison
Respiratory Syncytial Virus Lower Respiratory Tract Infection
Dose Ranging Study of ALX-0171 in Infants Hospitalized for Respiratory Syncytial Virus Lower Respiratory Tract Infection
The primary objective is to evaluate the anti-viral effect and safety of different doses of inhaled ALX-0171 in subjects hospitalized for Respiratory Syncytial Virus Lower Respiratory Tract Infection (RSV LRTI).
- Trial name
- Respire (NCT02979431)
- Testing
- ALX-0171 3.0 mg/kg, ALX-0171 6.0 mg/kg, ALX-0171 9.0 mg/kg
- Where
- 74 sites in Belgium, Bulgaria and 15 more
- Volunteers
- 180 people
- Sponsor
- Ablynx, a Sanofi company
Rhinitis, Allergic, Perennial and Seasonal
Safety Study To Assess Growth In Children With Seasonal Allergic And/Or Perennial Allergic Rhinitis Treated With GW685698X Aqueous Nasal Spray Or Placebo Nasal Spray
The purpose of this study is to assess any effect in children with seasonal and/or perennial allergic rhinitis by GW685698X aqueous nasal spray (versus vehicle placebo nasal spray) on growth using knemometry.
- Trial name
- NCT00109486
- Testing
- GW685698X
- Where
- Denmark
- Volunteers
- 56 people
- Sponsor
- GlaxoSmithKline
Sinusitis
Immunologic Aspects of the Pathogenesis of Chronic Sinusitis in Children
Chronic sinusitis is a common pediatric disease; it ranks among the top five infectious diseases of the upper respiratory tract. Its treatment is limited and may be due largely in part to a lack of understanding of its cause.
- Trial name
- NCT00004638
- Testing
- pathogenesis study
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Sleep Breathing Disorders, Tonsillitis
Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children
Postoperative pain following tonsillectomy or adeno-tonsillectomy in children is severe and sometimes last for days. Sufentanil is used by epidural route for postoperative analgesia in children.
- Conditions
- Sleep Breathing Disorders, Tonsillitis, Adenoid Hypertrophy
- Trial name
- NCT02205580
- Testing
- continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion, continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion, continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jin Ni
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