Clinical trials: Respiratory Infections in Children
Wheezing, Upper Respiratory Tract Infections
Nasal Resveratrol and Wheezing Episodes in Preschool Children
As most of the upper airways infections (UAI) leading to wheezing are secondary to viral triggers, the possible antinflammatory and antiviral role of resveratrol has been suggested in several studies, both in vitro and in vivo.
- Trial name
- RSVchild (NCT04689412)
- Testing
- Resveratrol
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Pneumonia, Atelectasis
Bronchoscopy Anesthesia and Neuropsychological Assessment in Children (BANACH) Study
Fiberoptic bronchoscopy plays a very important role in the diagnosis and treatment of respiratory diseases in children.In China,this procedure is mainly performed under two different anesthesia methods：sedation and general…
- Conditions
- Pneumonia, Atelectasis, Cough
- Trial name
- NCT03359044
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Bacterial Infections, Pneumonia, Pneumocystis Carinii
A Study to Compare Different Drugs Used to Prevent Serious Bacterial Infections in HIV-Positive Children
This study compares 2 different treatments administered to try to prevent serious bacterial infections (such as pneumonia) in HIV-positive children.
- Conditions
- Bacterial Infections, Pneumonia, Pneumocystis Carinii, HIV Infections
- Trial name
- NCT00000811
- Testing
- Azithromycin, Atovaquone, Sulfamethoxazole-Trimethoprim
- Where
- 75 sites in United States, Puerto Rico
- Volunteers
- 690 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bronchiolitis
Steroids Helping Albuterol Responders Exclusively
The purpose of the study is to determine whether corticosteroids are beneficial to children with bronchiolitis whose breathing gets better after being given a breathing treatment with albuterol.
- Trial name
- SHARE (NCT00798616)
- Testing
- prednisolone or methylprednisolone
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center
Community-acquired Pneumonia
Trial of Respiratory Infections in Children for Enhanced Diagnostics
The overall aim of the TREND study is to improve the differential diagnosis of bacterial and viral etiology in children below 5 years of age with clinical community acquired pneumonia.
- Trial name
- TREND (NCT03233516)
- Where
- Sweden
- Volunteers
- 376 people
- Sponsor
- Karolinska Institutet
Pneumonia
Can the Thoracic Replace the Conventional Radiography for the Diagnosis of Acute Pneumonia in Children?
The Thoracic ultrasound is a safer and sensitive technique than conventional radiography because it detects less than 1 cm pneumonic consolidations and minimal pleural effusions.
- Trial name
- NCT02781363
- Testing
- Thoracic ultrasound, CXR
- Where
- Spain
- Sponsor
- Hospital Universitari General de Catalunya
Influenza
Pharmacokinetic/Pharmacodynamic and Safety Evaluation of Intravenous Peramivir in Children With Influenza
The purposes of this study are to evaluate the pharmacokinetics (affect the body has on a drug), and pharmacodynamics (affect the drug has on the body) and safety of an experimental intravenous (within a vein) flu medication…
- Trial name
- NCT01063933
- Testing
- Peramivir
- Where
- 29 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID, Neurologic Manifestations
Neurologic Manifestations of COVID 19 in Children
The purpose of this study is to perform a secondary analysis of pre-existing de-identified limited datasets obtained from sites participating in Tier 1 (STUDY20040154: Neurologic Manifestations of COVID 19 in Children) and Tier 2…
- Trial name
- NCT04379089
- Testing
- Observational study only
- Where
- United States
- Volunteers
- 3,568 people
- Sponsor
- University of Pittsburgh
Diarrheal Illnesses, Respiratory Illness
A Trial of Zinc and Micronutrients in Tanzanian Children
A randomized clinical trial of multiple micronutrients, zinc, zinc + micronutrients, or placebo among 2400 children born to HIV-negative Tanzanian mothers.
- Conditions
- Diarrheal Illnesses, Respiratory Illness, Growth Faltering
- Trial name
- NCT00421668
- Testing
- Zinc, Multivitamins
- Where
- Tanzania
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Influenza Vaccination, Influenza
Assessment of Viral Shedding in Children Previously in Receipt of Multiple Doses of Live Attenuated Influenza Vaccine (LAIV) Compared to Influenza Vaccine-naïve Controls
LAIV shedding studies in children could be an important way to confirm whether impediments to viral replication do indeed explain these observed reductions in vaccine effectiveness(VE), whether prior vaccination has any influence…
- Conditions
- Influenza Vaccination, Influenza, Vaccination
- Trial name
- Flushed (NCT03104790)
- Testing
- Fluenz Tetra (The two groups are defined by immunisation history, all receive the same intervention in the study)
- Where
- 3 sites in United Kingdom
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- Public Health England
Influenza
Safety and Immunogenicity of H1N1 Vaccines in Children Aged 6 Months to Less Than 9 Years of Age
The purpose of this study is to characterize the safety and immune response of the H1N1 (swine) flu vaccines GSK2340274A and GSK2340273A in children 6 months to less than 9 years of age.
- Trial name
- NCT00976820
- Testing
- GSK2340274A, GSK2340273A
- Where
- 30 sites in United States, Canada
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COVID-19
Immunogenicity and Safety of the SpikoGen COVID-19 Vaccine in Children Aged 5 to <12 Years and 12 to <18 Years Compared With Adults Aged 18 to 40 Years
This was a non-randomized, three-armed, open-label, parallel-group, non-inferiority trial designed to compare the immunogenicity and safety of the SpikoGen COVID-19 vaccine in children aged 5 to <12 years and 12 to <18 years with…
- Trial name
- NCT05231590
- Testing
- Low-dose SARS-CoV-2 recombinant spike protein + Advax-SM adjuvant, SARS-CoV-2 recombinant spike protein + Advax-SM adjuvant
- Where
- Iran
- Volunteers
- 581 people, healthy volunteers welcome
- Sponsor
- Cinnagen
Sleep Disturbance
Sleep Quality During COVID-19 Containment in Children Whether or Not Usually Followed in Child Psychiatry
The purpose of this study is to determine whether sleep disturbances in children aged 7 to 12 during COVID-19 containment are more prevalent in children who received routine psychiatric care before containment compared to…
- Trial name
- CONFIDODO (NCT04370210)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Hôpital NOVO
Influenza
A Clinical Trial With Influenza A/H1N1 Vaccines
A single center, stratified, randomized and double-blind phase IV clinical trial is to be conducted in healthy elders (equal to or more than 61 years), adults (18-60 years), adolescents (12-17 years) and children (3-11 years) to…
- Trial name
- NCT00956111
- Testing
- split-virion, adjuvanted H1N1 vaccine of 7.5 μg per dose, split-virion, adjuvanted H1N1 vaccine of 15 μg per dose, split-virion, non-adjuvanted H1N1 vaccine of 15 μg per dose
- Where
- China
- Volunteers
- 1,614 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Upper Respiratory Tract Infection, Prevention
Clinical Trial to Evaluate the Efficacy of Lacticaseibacillus Rhamnosus CRL1505 in the Prevention of Upper Respiratory Tract Infections in Children
Randomized, double-blind, placebo-controlled, parallel-group, clinical trial to assess the efficacy of the intake of a probiotic product composed of Lacticaseibacillus rhamnosus CRL1505 strain in reducing or preventing upper…
- Trial name
- NCT07154992
- Testing
- Probiotic - Lacticaseibacillus rhamnosus CRL1505
- Where
- Spain
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Bioithas SL
Antibiotic Side Effect
Antibiotic Prescription for Children With Acute Upper Respiratory Tract Infections in Assiut District
Antibiotics are one of the most commonly prescribed drugs in pediatric care all over the world. Over prescription of antibiotics is a major public health problem and the most important factor in the emergence of antibiotic…
- Trial name
- NCT04127682
- Testing
- Antibiotic KAP questionnaire
- Where
- Egypt
- Volunteers
- 186 people
- Sponsor
- Assiut University
Cystic Fibrosis, Pseudomonas Aeruginosa
Cross Transmissions of Pseudomonas Aeruginosa Between Children From a Same Cystic Fibrosis Center.
Cystic fibrosis is the most common hereditary autosomal recessive disease in the Caucasian population. The diseases is caused by a mutation of the gene coding for the CFTR protein (Cystic fibrosis transmembrane conductance…
- Conditions
- Cystic Fibrosis, Pseudomonas Aeruginosa, Cross Infection
- Trial name
- PAPED (NCT03910920)
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Queen Fabiola Children's University Hospital
Cystic Fibrosis, Pneumonia
Population Pharmacokinetics of Prolonged Infusion Meropenem in Cystic Fibrosis (CF) Children
This study will determine the concentrations of the antibiotic meropenem when administered as a 3 hour prolonged infusion in children with cystic fibrosis who are hospitalized with an acute pulmonary exacerbation.
- Conditions
- Cystic Fibrosis, Pneumonia, Pseudomonas Aeruginosa Infection
- Trial name
- NCT01429259
- Testing
- meropenem
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Joseph Kuti
Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder
Brain Imaging in Babies Study
The aims of the BIBS Study The Brain Imaging in Babies study (BIBS) aims to improve understanding of how a baby's brain develops from before birth, up until 3-4 years of age.
- Conditions
- Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Neurodevelopmental Conditions, COVID-19
- Trial name
- BIBS (NCT04443179)
- Where
- United Kingdom
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- King's College London
Influenza, Human
Childhood Influenza Immunisation in General Practice Invitation Trial
This study will investigate whether behaviourally informed changes to the invitation process can improve uptake of childhood influenza vaccine by two and three year olds at primary care.
- Trial name
- NCT02921633
- Testing
- Intervention letter
- Volunteers
- 21,786 people, healthy volunteers welcome
- Sponsor
- Public Health England
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