Clinical trials: Respiratory Infections in Children
Influenza
Live Versus Inactivated Influenza Vaccine Study in Hutterite Children
There is uncertainty about whether a live attenuated vaccine (LAIV) offers additional benefit over inactivated trivalent influenza vaccine (TIV) in providing indirect benefit to those who are unvaccinated through herd immunity.
- Trial name
- NCT01653015
- Testing
- Trivalent Inactivated Vaccine, Live Attenuated Influenza Vaccine
- Where
- Canada
- Volunteers
- 4,611 people, healthy volunteers welcome
- Sponsor
- McMaster University
Severe Pneumonia
Randomized Controlled Trial (RCT) in Children With Severe Pneumonia
Pneumonia is the leading cause of childhood morbidity and death in many developing countries including Bangladesh, causing about 2 million deaths worldwide each year.
- Trial name
- NCT00455468
- Testing
- Day-care treatment vs. hospital care
- Where
- Bangladesh
- Volunteers
- 368 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Pneumonia
Assesment of the Effectiveness of High Frequency Oral Oscillation and Mask of PEP in Children With Pneumonia
The hypothesis of this study is that the physiologic effects of these (PEP/ HFOO) resources may have positive effects in this population of children with acute respiratory illness.
- Trial name
- PEP/HFOO (NCT02192268)
- Testing
- PEP, HFOO, Assisted Coughing
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital Sirio-Libanes
Influenza, Orthomyxoviridae Infections
Annual Study for Serum Collection for Immunogenicity and Safety Evaluation in Healthy Children Receiving Fluzone®
Primary Objective: To provide the Center for Biologics Evaluation and Research (CBER) with sera collected from healthy children receiving the 2008-2009 formulation of the inactivated, split-virion influenza vaccine Fluzone® for…
- Trial name
- NCT00755274
- Testing
- Influenza Virus Vaccine No Preservative: Pediatric Dose
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Pneumonia
Accuracy of Clinical and Diagnostic Studies for Pneumonia in Children
Pneumonia continues to be a leading cause of death in children under five years of age worldwide. Many studies have evaluated clinical signs and symptoms that may predict pneumonia.
- Trial name
- NCT03630380
- Testing
- Clinical History, Physical Exam Findings, Laboratory Findings
- Where
- Nepal
- Volunteers
- 1,000 people
- Sponsor
- Patan Academy of Health Sciences
Lower Respiratory Tract Infection (LRTI), Pneumonia
Optimising Antibiotic Use for Paediatric Lower Respiratory Tract Infections in Africa
Lower respiratory tract infections (LRTIs) remain a leading cause of hospitalisation and death among young children in Africa. Although viral infections account for a substantial proportion of LRTIs, antibiotics are frequently…
- Conditions
- Lower Respiratory Tract Infection (LRTI), Pneumonia, Bronchopneumonia, Bronchiolitis
- Trial name
- BEACON (NCT07841691)
- Testing
- CRP- and PREPARE-guided Antibiotic Prescription
- Where
- South Africa
- Volunteers
- 400 people
- Sponsor
- University of Witwatersrand, South Africa
Multiple Osteochondroma, Osteogenesis Imperfecta
Resilience and Coping in a Rare Skeletal Disease Population to Face Coronavirus (COVID-19) Outbreak Distress: a Longitudinal Study
In the COVID-19 outbreak context, people living with rare diseases have been highly troubled with anxiety, loneliness, and depression.
- Conditions
- Multiple Osteochondroma, Osteogenesis Imperfecta, Ollier Disease, Maffucci Syndrome
- Trial name
- RELOAD (NCT04844697)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Streptococcus Group A
Mol Epi GrAS in Nicaragua
The purpose of this study is to determine the epidemiology of throat isolates of group A streptococci among 3-15 year-old children with pharyngitis (sore throat) living in Leon, Nicaragua.
- Trial name
- NCT00170521
- Where
- Nicaragua
- Volunteers
- 13,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumonia, Pneumococcal
Dynamics of the Immune Response in Children to the 23-valent Pneumococcal Capsular Polysaccharide Vaccine (Pneumovax)
To explore a further dimension of susceptibility to disease, the investigators tested the hypothesis that natural variation exists in the rapidity of IgG responses following exposure to pneumococcal polysaccharides, and that…
- Trial name
- NCT03460730
- Testing
- Pneumovax
- Where
- Kenya
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KEMRI-Wellcome Trust Collaborative Research Program
Influenza
Effect of Age and Prior Immunity to Response to Seasonal Influenza Vaccines in Children
A total of 88 children between 2 and 9 years of age will be randomized to receive a two dose schedule of either licensed live attenuated trivalent seasonal influenza vaccine (LAIV) or licensed inactivated seasonal influenza…
- Trial name
- NCT01246999
- Testing
- Live attenuated Influenza vaccine, Trivalent Influenza Vaccine, TIV followed by LAIV
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Rochester
SARS-CoV2 Infection, COVID-19
BinaxNOW for Evaluating Children for Infection With SARS-CoV-2 (COVID-19)
This is a study of the BinaxNOW Covid-19 Ag Card as a method to rapidly identify SARS-CoV-2 infection in asymptomatic children, teachers, and other school staff for exclusion.
- Trial name
- NCT05087524
- Testing
- BinaxNOW Ag Card
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
SARS-CoV2 Infection, COVID-19
Viral Dynamics of Omicron in Children
SARS-CoV-2 transmission is dependent on multiple factors, which may be related to either host-virus interaction or the environment.
- Trial name
- NCT05240183
- Testing
- Daily SARS-CoV-2 PCR Testing for 10 days
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- The Hospital for Sick Children
Tuberculosis, Severe Pneumonia
Impact of Systematic Early Tuberculosis Detection Using Xpert MTB/RIF Ultra in Children With Severe Pneumonia in High Tuberculosis Burden Countries (TB-Speed Pneumonia)
Despite progress in reducing tuberculosis (TB) incidence and mortality in the past 20 years, TB is a top ten cause of death in children under 5 years worldwide.
- Conditions
- Tuberculosis, Severe Pneumonia, Covid19
- Trial name
- NCT03831906
- Testing
- Xpert MTB/RIF Ultra (Ultra)
- Where
- 16 sites in Cambodia, Cameroon and 4 more
- Volunteers
- 2,570 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Influenza
Seasonal Influenza DNA Vaccine & Seasonal Influenza Trivalent Inactivated Vaccine (TIV) in Children & Adolescents
This is a Phase I, dose escalation study in healthy adolescents and children (6-17 years) to evaluate the safety, tolerability, and immunogenicity of a prime-boost regimen of the 2012/2013 seasonal influenza DNA vaccine (HA DNA)…
- Trial name
- NCT01609998
- Testing
- Seasonal Influenza DNA vaccine, TIV
- Where
- 5 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Respiratory Tract Infections, Coinfection
Virus Interactions in the Respiratory Tract; a Cohort Study With Children
Rationale: Prevention of virus induced acute respiratory infection (ARI) is a public health priority. As different respiratory virus infections can interact with each other, occurrence of one virus may influence occurrence of…
- Trial name
- VIOOL (NCT05318235)
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Influenza
Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children
The present study is designed to evaluate in children (aged between 3 and 9 years) the immunogenicity and safety of different antigen doses of the candidate vaccine (GSK1562902A) administered following a two-administration…
- Trial name
- NCT00502593
- Testing
- Pandemic Influenza Vaccine (GSK1562902A), Fluarix™
- Where
- 7 sites in Spain
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Asthma in Children
High-dose Vitamin D Supplement for the Prevention of Acute Asthma-like Symptoms in Preschool Children
To investigate whether high-dose vitamin D supplementation may have a beneficial effect on secondary prevention in preschool children (1-5 years of age), with respiratory infections being the primary cause of acute exacerbations…
- Trial name
- COPSACvitd (NCT05043116)
- Testing
- Cholecalciferol D3
- Where
- Denmark
- Volunteers
- 320 people
- Sponsor
- Copenhagen Studies on Asthma in Childhood
HIV, Cancer
Immunogenicity of Fluzone HD,A High Dose Influenza Vaccine, In Children With Cancer or HIV
This is an open label-study of Fluzone HD, a high-dose form of trivalent, inactivated influenza vaccine (TIV), vs. Fluzone, a standard-dose form of TIV.
- Trial name
- NCT01205581
- Testing
- Fluzone High Dose Vaccine, Fluzone Standard Dose Vaccine
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- St. Jude Children's Research Hospital
Influenza
Study to Evaluate Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Quadrivalent Influenza Vaccine GSK2282512A When Administered to Children 6 to 35 Months of Age
The purpose of this study is to investigate the immunogenicity, reactogenicity and safety of the new influenza vaccine GSK2282512A (FLU-Q-QIV) and compare its activity to the marketed vaccine Fluarix® (TIV) in young children 6 to…
- Trial name
- NCT01711736
- Testing
- Quadrivalent influenza GSK2282512A vaccine, Fluarix
- Where
- 8 sites in Canada, Dominican Republic and 1 more
- Volunteers
- 606 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Perioperative Respiratory Adverse Events, Anesthesia Outcomes
Nasal Decongestant to Reduce Perioperative Adverse Events in Children With Upper Respiratory Track Infections Having Anesthesia.
The goal of this multicentre, double-blind, randomised controlled trial study is to learn if the use of a nasal spray to open the nasal passages and increase airflow before surgery can reduce the occurrence of perioperative…
- Trial name
- NARWHAL (NCT07000877)
- Testing
- Decongestant nasal spray (oxymetazoline hydrochloride (0.05%))
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- Telethon Kids Institute
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