Clinical trials: Respiratory Infections in Children
Influenza
Study of GSK Biologicals' Pandemic Influenza (H1N1) Candidate Vaccine in Children Aged 10 to Less Than 18 Years
The purpose of this study is to show that vaccination with a single dose of GSK Biologicals' pandemic H1N1 vaccine results in an immune response that meets or exceeds European Medicines Agency (EMEA) Committee for Medicinal…
- Trial name
- NCT01035749
- Testing
- GSK Biologicals' Influenza investigational vaccine GSK2340274A, GSK Biologicals' Influenza investigational vaccine GSK2340273A
- Where
- 9 sites in Estonia, Slovakia
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bronchiolitis
Utility of Severity Scales in Clinical Practice in Children Hospitalized Due to Bronchiolitis.
Prospective observational study of patients hospitalized with bronchiolitis. The objective of our study is to compare the accuracy of commonly used clinical scales for bronchiolitis to predict relevant outcomes.
- Trial name
- NCT06737159
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Szpital im. Św. Jadwigi Śląskiej
Respiratory Infections, Acute
Zinc and Pneumonia Protocol
Undernutrition in children less than five years of age is common throughout sub-Saharan Africa. Nutritional deficiencies may lead to less ability to fight infectious diseases.
- Trial name
- NCT00133432
- Testing
- Zinc
- Where
- Tanzania
- Volunteers
- 600 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Down Syndrome
Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis
Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured.
- Trial name
- NCT07366593
- Testing
- Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Badr University
Coronavirus, Coronavirus Infection
COVID-19 Infection and Transmission in Exposed, Confined and Community-based Infants
According to epidemiological models, the seroprevalence of SARS-CoV-2 infection in Île-de-France as of 11 May was between 10 and 15%.
- Conditions
- Coronavirus, Coronavirus Infection, Covid19, Sars-CoV2
- Trial name
- COVIDOCRECHE (NCT04413968)
- Testing
- Rapid detection test, Nasopharyngeal swab, Stool collection
- Where
- 11 sites in France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prophylaxis of Avian Influenza
Immunogenicity, Safety and Tolerability of Two Doses of a Pre-pandemic Influenza Vaccine in Participants Aged 6 Months to 17 Years
Evaluate the immune response and reactogenicity of H5N1 vaccination in subjects aged 6 months to 17 years compared to seasonal flu vaccination
- Trial name
- NCT00537524
- Testing
- H5N1 Influenza Vaccine
- Where
- Finland
- Volunteers
- 471 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
SARS-CoV2
Study of Seroprevalence of Anti-SARS-CoV2 Among Children of Hospital Workers in AP-HP
The purpose of this study is to define seroprevalence of anti-SARS-CoV2 among children of Hospital Workers in APHP, particularly exposed population, according to parents' SARS-CoV2 serological status.
- Trial name
- FamilyPEDCOVID (NCT04442087)
- Testing
- Serology SARS-CoV2, Data collection
- Where
- France
- Volunteers
- 563 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Tract Infection, Children
The Prevalence and Clinical Manifestations of Human Metapneumovirus Among Children With Bronchiolitis.
Sputum specimens will be obtained from children < 2 years of age and processed by different mode for the HMPV, RSV, Pertussis, Influenza A, B, Parainfluenza 1,2,3, Adenovirus.
- Trial name
- NCT00265187
- Where
- 3 sites in Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Pneumonia Childhood, Pneumonia
Lung Ultrasound for Guiding Antibiotic Use in Pediatric Pneumonia
Pneumonia is a major cause of illness and death in children, with an annual incidence of about 3.3 per 1,000 in those under five years old, many requiring hospitalization.
- Conditions
- Pneumonia Childhood, Pneumonia, Lung Ultrasound, Antibiotic Stewardship
- Trial name
- LUSCAP (NCT06921993)
- Testing
- LUNG ULTRASOUND
- Where
- 18 sites in United States, Israel and 1 more
- Volunteers
- 659 people
- Sponsor
- Meyer Children's Hospital IRCCS
COVID19
Part 2 on the Study Prevalence of SARS -Cov2 Carriage in Asymptomatic and Mildly-symptomatic Children (COVILLE2) (WHO)
France and in particular the paris area was one of the countries most affected by the pandemic Covid19. School closures and a generalized lockdown of the population were instituted in France from 17 March 2020 to 10 May 2020.
- Trial name
- COVILLE2 (NCT04416893)
- Testing
- RT-PCR SARS-Cov2, Sars-Cov2 serology
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Bronchiolitis Acute, Wheezing
The Role of Vitamin D and Vitamin D Receptor in Recurrent Wheezing in Children With Bronchiolitis: Immunological Association With T-lymphocyte Mitochondrial Mass
A prospective study will be conducted involving children under 2 years of age hospitalized for bronchiolitis during the period 2025-2026.
- Conditions
- Bronchiolitis Acute, Wheezing, RSV
- Trial name
- NCT07700134
- Testing
- No Intervention: Observational Cohort
- Where
- Greece
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Sinusitis
Efficacy of Azithromycin Prophylaxis in Preventing Recurrent Acute Sinusitis in Children
The purpose of this study is to evaluate efficacy of azithromycin prophylaxis in preventing recurrent acute sinusitis in children.
- Trial name
- NCT00944515
- Testing
- azithromycin
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Influenza
Study to Evaluate the Immunogenicity and Safety of an Investigational Influenza Vaccine (H1N1) in Children
The objective of this study is to evaluate the immunogenicity and safety of GSK Biologicals' investigational vaccine GSK2340272A in children aged between 3 and 17 years.
- Trial name
- NCT00972517
- Testing
- GSK investigational vaccine GSK2340272A
- Where
- 8 sites in Germany
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Influenza Vaccines
Vaccine Chatbot for Improving Influenza Vaccination Uptake
This study aims to assess the impact of a vaccine chatbot on improving influenza vaccination uptake among children aged between 6 and 59 months through a cluster randomized trial.
- Trial name
- NCT06657573
- Testing
- An AI-enabled chatbot tailored for influenza vaccine consultation
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Fudan University
Influenza A Virus Infection
Antiviral Therapy for Influenza A H1N1
The aims of this study are to characterise the clinical efficacy and virological clearance dynamics of orally administered oseltamivir in patients with influenza caused by novel influenza A(H1N1).
- Trial name
- SEA032 (NCT00985582)
- Where
- Vietnam
- Volunteers
- 181 people
- Sponsor
- South East Asia Infectious Disease Clinical Research Network
Tonsillitis Streptococcal
Comparison of Intravenous Co-amoxiclav Versus Benzyl Penicillin
To compare intravenous Co-amoxiclav versus Benzyl penicillin in children with severe streptococcal tonsillitis in terms of efficacy, safety and cost effectiveness.
- Trial name
- NCT04215770
- Testing
- inj co-amoxiclav 50 units/kg/day vs inj Benzyl Penicillin 25000 units/kg/day
- Where
- Pakistan
- Volunteers
- 310 people
- Sponsor
- Combined Military Hospital, Pakistan
Acute Respiratory Infection, Diarrheal Disease
Efficacy and Tolerance of a Follow-On Formula Fed to Children From 12-48 Months of Age in Salvador, Bahia, Brazil
The purpose is to determine if the consumption of study product has an effect on acute respiratory infections and/or diarrheal disease.
- Trial name
- NCT01431469
- Testing
- Cow's milk, Follow-On Formula
- Where
- Brazil
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Antibiotic Resistance, Respiratory Tract Infections
CRP for Respiratory Diagnosis in Kyrgyz Pediatric Practice
Rationale: Overuse of antibiotics globally is leading to increasing rates of antibiotic resistance and may lead to a 'post-antibiotic' era.
- Conditions
- Antibiotic Resistance, Respiratory Tract Infections, Pediatric Infectious Disease, CRP
- Trial name
- COORDINATE (NCT05195866)
- Testing
- CRP POCT (C-reactive protein point of care test)
- Where
- Kyrgyzstan
- Volunteers
- 1,204 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
SARS-CoV-2
Virus and Bronchial Epithelium in Children and the Elderly
The objective of the VIRCHILLD project is to identify age-related modifications of the bronchial epithelium physiology that account for differences in the response and susceptibility to respiratory viruses.
- Trial name
- VIRCHILLD (NCT06224062)
- Testing
- SARS-CoV-2, Adenovirus (AdV), Rhinovirus
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bordeaux
Asthma, Asthma in Children
Prospective Multicentre Study on Symptoms in First-onset Bronchial Asthma in Children and Adolescents
Bronchial asthma may present with symptoms other than the commonly reported complaints (cough, chest tightness, shortness of breath and wheezing).
- Conditions
- Asthma, Asthma in Children, Dyspnea, Cough
- Trial name
- NCT06201494
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- Charles University, Czech Republic
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