Clinical trials: Respiratory Infections in Children
Otitis Media, Tonsillitis
Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections
This study was performed in children with upper respiratory tract infections (acute ear infection, infection of the tonsils or throat, or bacterial inflammation of the bronchi) who needed treatment with an antibiotic…
- Conditions
- Otitis Media, Tonsillitis, Pharyngitis, Bronchitis
- Trial name
- DoSe iT (NCT04016051)
- Testing
- Clarithromycin DST (125 mg), Clarithromycin DST (187.5 mg), Clarithromycin DST (250 mg)
- Where
- 20 sites in Germany, Poland
- Volunteers
- 265 people
- Sponsor
- Grünenthal GmbH
Upper Respiratory Tract Infections, Virus
Edinburgh and Lothian Virus Intervention Study in Kids
ELVIS Kids is a parallel, open label, randomised controlled trial (RCT) of Hypertonic Saline (HS) nose drops (~2.6% NaCl) vs. standard care in children <7 years of age with symptoms of an Upper Respiratory Tract Infection (URTI).
- Conditions
- Upper Respiratory Tract Infections, Virus, Virus Shedding, Pediatric ALL
- Trial name
- ELVIS Kids (NCT03463694)
- Testing
- Na Cl solution
- Where
- United Kingdom
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Dental Caries in Children
Pandemic-adapted Caries Care Multicentre Single-group Interventional Study
The current understanding of dental caries has not been completely transferred into the clinical practice to control caries lesion progression (severity / activity) and the individual risk of caries.
- Trial name
- NCT04666597
- Testing
- Modified CariesCare International management
- Where
- 21 sites in United States, Argentina and 11 more
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Universidad El Bosque, Bogotá
Infections, Streptococcal
Safety and Immunogenicity Study of a Booster Dose of GSK Biologicals' 10-valent Pneumococcal Conjugate Vaccine
This study will evaluate the safety, reactogenicity and immunogenicity of a booster dose of the pneumococcal conjugate vaccine, co-admin with a 1st dose or a 2nd dose of MMRV vaccine at 12-14 or respectively 14-16 months of age…
- Trial name
- NCT00370227
- Testing
- 10 valent pneumococcal conjugate (vaccine)
- Where
- 8 sites in Finland
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Common Cold, Nasal Mucosal Inflammation
Post Market Clinical Follow-Up Study - Medical Device KalobaNaso
The goal of this observational PMCF study is to confirm the efficacy and safety of the medical device KalobaNaso (a nasal spray) in children, adolescents and adults with common cold symptoms, such as runny nose, nasal congestion…
- Conditions
- Common Cold, Nasal Mucosal Inflammation, Rhinitis
- Trial name
- PMCF (NCT05960318)
- Testing
- KalobaNaso spray, KalobaNaso junior spray
- Where
- Italy
- Volunteers
- 131 people
- Sponsor
- Schwabe Pharma Italia
Rhinitis
Safety Study of Levocetirizine Oral Solution for Japanese Pediatrics
To evaluate the safety of treatment with levocetirizine oral solution in pediatric patients aged form 6 months to 2 years old with allergic rhinitis or pruritus associated with the skin diseases.
- Trial name
- NCT01563081
- Testing
- Levocetirizine
- Where
- 7 sites in Japan
- Volunteers
- 60 people
- Sponsor
- GlaxoSmithKline
Respiratory Infection
A Randomized Trial of Vitamin D to Reduce Respiratory Infection
The goal of this study is to assess the effectiveness of vitamin D in reducing laboratory-confirmed influenza and in reducing non-influenza viral respiratory tract infections.
- Trial name
- NCT01705314
- Testing
- vitamin D supplements
- Where
- Vietnam
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- McMaster University
Infections, Respiratory Tract
Probiotics in Respiratory Tract Infections in Children
The purpose of this study is to assess the potential of probiotics in prevention of respiratory tract infections and their complications in children
- Trial name
- NCT01510938
- Testing
- L. acidophilus DDS-1, B. lactis UABLA-12
- Where
- Ukraine
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Lviv National Medical University
SARS-CoV-2, COVID-19
Special Investigation for Booster Dose of Comirnaty in Children Ages 6 Months Though 4 Years
The purpose of this post-marketing study is to assess the safety of Comirnaty monovalent XBB.1.5. for booster vaccination children ages 6 months though 4 years under actual use medical practice.
- Trial name
- NCT06130410
- Testing
- COMIRNATY intramuscular injection
- Where
- Japan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Pfizer
Influenza, Orthomyxoviridae Infections
Safety and Immunogenicity of an Intramuscular A/H5N1 Inactivated, Split Virion Pandemic Influenza Vaccine in Children
This study is part of an effort to develop an effective vaccination program in children in the event of a pandemic. Study objectives: To describe the safety profiles in the periods following each vaccination in subjects receiving…
- Conditions
- Influenza, Orthomyxoviridae Infections, Orthomyxovirus Infections
- Trial name
- NCT00884182
- Testing
- A/H5N1 Inactivated, Split Virion Pandemic Influenza Vaccine
- Where
- 13 sites in Finland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Respiratory Syncytial Virus Bronchiolitis
Comparison of High Flow Oxygenation Therapy and CPAP in Children With Bronchiolitis.
Bronchiolitis in infants and young children often requires respiraty support. In Denmark Continous Positive Airway Pressure ( CPAP) are routinely used in children with moderate-severe bronchiolitis.
- Trial name
- NCT02618213
- Testing
- Optiflow Junior, Continous Positive Airway Pressure
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Tetanus, Diphtheria
Safety and Immunogenicity of Tdap Vaccine Compared to DTaP Vaccine in Children 4 to 6 Years of Age
Currently, there is no 5-component acellular pertussis vaccine licensed for the 5th dose in US children aged 4 to 6 years.This study is aimed at providing evidence of sero-protection, booster response and safety of this…
- Conditions
- Tetanus, Diphtheria, Pertussis
- Trial name
- NCT00467519
- Testing
- Tdap (Tetanus Toxoid Reduced Diphtheria Toxoid/Acellular Pertussis), DTaP (Diphtheria & Tetanus Toxoids & Acellular Pertussis Adsorbed)
- Where
- 43 sites in United States, Canada
- Volunteers
- 1,045 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Influenza Viral Infections
An Effectiveness Trial to Evaluate Protection of Children and Pregnant Women by Influenza Vaccine in Rural Bangladesh
Annually influenza is a leading cause of severe disease and mortality particularly in young children <5 years old and pregnant women in the low and middle-income countries (LMICs) and both groups are prioritised for vaccination…
- Trial name
- FluEffect (NCT04998344)
- Testing
- Inactivated influenza vaccine, Inactivated polio vaccine
- Where
- 2 sites in Bangladesh, Norway
- Volunteers
- 3,800 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Asthma, Asthma Exacerbations
Vitamin D In the Prevention of Viral-induced Asthma in Preschoolers
In this 7-month randomized controlled trial, children aged 1 to less than 6 years, with recurrent asthma attacks triggered mostly by colds, will receive a high dose of vitamin D or a placebo every 3.5 months during their usual…
- Conditions
- Asthma, Asthma Exacerbations, Preschool Child, Vitamin D
- Trial name
- DIVA (NCT03365687)
- Testing
- Vitamin D
- Where
- 9 sites in Canada
- Volunteers
- 323 people
- Sponsor
- Professor Francine Ducharme
Common Cold
A Trial of Echinacea in Children
This is a randomized trial to determine if echinacea is effective in shortening the length and/or lessening the severity of colds in children 2 through 11 years old.
- Trial name
- NCT00029211
- Testing
- Echinacea
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Community-Acquired Pneumonia
Comparison Between Amoxycillin/Clavulanic Acid and Oxacillin/Ceftriaxone for Community Acquired-pneumonia
Objective: To compare the clinical effectiveness and hospital costs, the initial empirical treatment, Oxacillin / Ceftriaxone and Amoxicillin / Clavulanate in children with Community Acquired Pneumonia (CAP) severe.
- Trial name
- NCT01166932
- Testing
- Amoxycillin/clavulanic acid, ceftriaxone/oxacillin
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Pneumonia, Bacterial, Community-Acquired Infections
A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia
The purpose of this study is to evaluate the safety and tolerability of doripenem compared to cefepime in children hospitalized with pneumonia.
- Conditions
- Pneumonia, Bacterial, Community-Acquired Infections, Nosocomial Infection, Pneumonia, Ventilator-Associated
- Trial name
- NCT01110421
- Testing
- Cefepime, Doripenem, Amoxicillin/clavulanate potassium
- Where
- 25 sites in United States, Argentina and 8 more
- Volunteers
- 7 people
- Sponsor
- Janssen Research & Development, LLC
Influenza
The Objectives of This Study Are Comparative Assessment of the Tolerability, Safety and Immunogenicity of the Flu-M Vaccine vs. the Ultrix® Vaccine by Single Vaccination of Children Aged 6 to 17 Years.
Comparative assessment of the tolerability, safety and immunogenicity of the Flu-M vaccine vs. the Ultrix® vaccine by single vaccination of children aged 6 to 17 years.
- Trial name
- NCT05317767
- Testing
- Flu-M [Inactivated split influenza vaccine], Inactivated Split Influenza Vaccine
- Where
- 2 sites in Russia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- St. Petersburg Research Institute of Vaccines and Sera
Severe Pneumonia
Research on the Treatment of Severe Community-acquired Pneumonia in Children
The need for glucocorticoid therapy in children with severe community-acquired pneumonia in the acute phase of the disease remains unclear.
- Trial name
- NCT05768204
- Testing
- Prednisolone Acetate
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Baoping XU
Bronchiolitis
Efficacy and Safety of 3% Hypertonic Saline Inhalation (24h vs 72h) to Treat Acute Bronchiolitis in Hospitalized Infants
Efficacy/Safety of 3% hypertonic saline inhalation (24H vs 72H) to treat acute bronchiolitis in infants.
- Trial name
- BRONDUSAL (NCT02538458)
- Testing
- 3 % hypertonic saline up to 72H, 3 % hypertonic saline up to 24H
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
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