Clinical trials: Respiratory Insufficiency, open to volunteers
Brain Injuries, Respiratory Failure
Epidural Spinal Cord Stimulation for Respiratory Recovery in Brain Injury
Patients with severe brain injury may develop impaired respiratory drive, diaphragm dysfunction, prolonged mechanical ventilation, and difficulty recovering spontaneous breathing.
- Trial name
- BREATH (NCT07766681)
- Testing
- Epidural Electrode Implantation
- Where
- 3 sites in China
- Volunteers
- 10 people
- Sponsor
- Zhongda Hospital
CABG, Respiratory Insufficiency
Early Postoperative Physiotherapy to Prevent Respiratory Insufficiency After Elective Heart Surgery
This study aims to determine whether starting respiratory physiotherapy one hour after removal of the breathing tube following elective coronary artery bypass graft (CABG) surgery leads to better recovery than the current…
- Conditions
- CABG, Respiratory Insufficiency, Postoperative Pulmonary Complications (PPCs)
- Trial name
- EPP-CABG (NCT07730034)
- Testing
- Early postoperative physiotherapy, Standard postoperative care
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- Dijana Filipović
Obstructive Sleep Apnea, Postoperative Analgesia
Oliceridine Versus Sufentanil Analgesia for Postoperative Patients With Obstructive Sleep Apnea
Opioids are frequently used for postoperative analgesia but may induce side effects. Opioid-induced respiratory depression is the most dangerous side effect of opioids.
- Conditions
- Obstructive Sleep Apnea, Postoperative Analgesia, Oliceridine, Sufentanil
- Trial name
- OSA (NCT07753785)
- Testing
- Oliceridine, Sufentanil
- Where
- China
- Volunteers
- 851 people
- Sponsor
- Peking University First Hospital
Respiration Failure, Cardio Vascular Disease
COMPARE-VENT Feasibility Pilot Study
Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20%…
- Conditions
- Respiration Failure, Cardio Vascular Disease, Cardiogenic Pulmonary Oedema, Critical Illness
- Trial name
- NCT07656259
- Testing
- Volume Controlled Mode, Pressure Controlled Mode
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Acute Hypoxemic Respiratory Failure
IntHyx : Intubation Strategies for Patients With Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure requires endotracheal intubation and invasive mechanical ventilation in approximately 30-40% of cases, due to severe hypoxemia and/or clinical signs of acute respiratory distress.
- Trial name
- IntHyx (NCT07189078)
- Testing
- Restrictive intubation strategy, Liberal intubation strategy
- Where
- 9 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Critical Illness, Mechanical Ventilation
Cost-Effectiveness of Inhaled Sedation Versus Intravenous Propofol in Mechanically Ventilated Critically Ill Adults
The goal of this observational study is to learn whether inhaled sedation is a cost-effective alternative to intravenous propofol in mechanically ventilated critically ill adults admitted to the intensive care unit.
- Conditions
- Critical Illness, Mechanical Ventilation, Respiratory Insufficiency
- Trial name
- NCT07734350
- Testing
- Isoflurane, Propofol (Astra-Zeneca)
- Volunteers
- 400 people
- Sponsor
- Hospital H+ Queretaro
Respiratory Failure, Extubation Failure
Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations
subjects on mechanical ventilator who are about to be extubated to Non invasive ventilation because the physician thinks they are high risk for failure will be approached and consented for our study.
- Trial name
- NCT07067502
- Testing
- Biphasic cuirass ventilator which is a type of negative pressure ventilator will be applied to patients on the intervention arm
- Volunteers
- 50 people
- Sponsor
- University of Missouri-Columbia
Acute Respiratory Distress Syndrome, Pneumonia in Children
AI-Guided Mechanical Ventilation in Children: A Randomized Controlled Trial
This prospective, randomized controlled trial aims to evaluate whether an AI-driven decision support system can improve clinical outcomes for mechanically ventilated pediatric patients (aged 1 month to 18 years) in the PICU…
- Conditions
- Acute Respiratory Distress Syndrome, Pneumonia in Children, Respiratory Failure (Pediatric Patients), Congenital Heart Disease in Children
- Trial name
- NCT07728136
- Testing
- AI-generated recommendations for ventilator parameters.
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wu Rongzhou
Lung Function Decreased, Surgery
Tubeless Surgery With Impaired Pulmonary Function
Some patients with impaired lung function require minimally invasive surgical treatment, including those with lung cancer, benign lung tumors, pneumothorax, or lung volume reduction surgery.
- Trial name
- NCT06848751
- Testing
- Non-intubated thoracoscopic surgery
- Where
- China
- Volunteers
- 45 people
- Sponsor
- The Second Hospital of Shandong University
Respiratory Insufficiency, Wounds and Injuries
Humidification Effects on Airway Complications and Clinical Outcomes in Trauma ICU Patients on Mechanical Ventilation
This study compares the effects of two primary airway humidification methods-active heated humidifiers (HHs) and passive heat-and-moisture exchangers (HMEs)-on trauma intensive care unit (ICU) patients requiring prolonged…
- Conditions
- Respiratory Insufficiency, Wounds and Injuries, Critical Illness
- Trial name
- NCT07713238
- Testing
- Airway Humidification Device
- Where
- Egypt
- Volunteers
- 162 people
- Sponsor
- Assiut University
Tracheostomy, Mechanical Ventilation
Trcheal High-flow for Weaning From Mechanical Ventilation
Multicentre randomized trial to determine whether tracheal high-flow nasal oxygen can improve weaning outcome vs. conventional oxygen therapy in critically ill tracheostomized patients who are hypoxemic.
- Conditions
- Tracheostomy, Mechanical Ventilation, Hypoxemic Respiratory Failure
- Trial name
- TRACFLOW (NCT07714564)
- Testing
- Oxygen therapy
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pediatric ALL, Respiratory Insufficiency
Multicenter HomeVENT: Home Values and Experiences Navigation Track
This is a multicenter study to test a decision-making support process for families and clinicians facing decisions about chronic home ventilation for a child.
- Conditions
- Pediatric ALL, Respiratory Insufficiency, Communication
- Trial name
- HomeVENT (NCT06102330)
- Testing
- HomeVENT decision support tool
- Where
- 4 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Respiratory Failure, Premature Neonates
Supraglottic Airway for Resuscitation in Preemies
The goal of this single-arm intervention trial is to learn whether using a supraglottic airway (SA) as the primary interface for positive pressure ventilation (PPV) is feasible during delivery room resuscitation of premature…
- Conditions
- Respiratory Failure, Premature Neonates, Delivery Room Resuscitation, Positive Pressure Ventilation
- Trial name
- SUPREEMIE (NCT07419438)
- Testing
- Supraglottic Airway
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Respiratory Failure, Dyspnea During Mechanical Ventilation
Mechanical Ventilator Adjustments and Patient Dyspnea
In the past 5 years, there are increasing data suggesting that patients treated with mechanical ventilation experience shortness of breath, despite appropriate sedation.
- Conditions
- Respiratory Failure, Dyspnea During Mechanical Ventilation, Mechanical Ventilation
- Trial name
- NCT07701850
- Testing
- Change to VC/AC, Change in Tidal Volume, Change in inspiratory flow
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Respiratory Insufficiency
Thoracoabdominal Asynchrony and Respiratory Distress
The investigators hypothesize that a simple 3-point tracking device that uses motion sensors attached to the abdomen and chest of a child will provide information regarding thoracoabdominal asynchrony (TAA), a major component of…
- Trial name
- NCT04626154
- Testing
- Objectively monitoring thoracoabdominal asynchrony
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
ARDS (Acute Respiratory Distress Syndrome), VILI (Ventilator-induced Lung Injury)
Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study)
The REALVENT trial is designed to evaluate whether a real-time, algorithm-driven ventilation feedback strategy can improve lung-protective ventilation (LPV) achievement rates in critically ill patients receiving invasive…
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), VILI (Ventilator-induced Lung Injury), Respiratory Failure, Critical Illness
- Trial name
- REALVENT (NCT07307066)
- Testing
- REal-time Algorithm-driven Ventilation feedback to improve lung-protective ventilation in critically, Standard ICU care
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Peking Union Medical College Hospital
Pulmonary Disease, Chronic Obstructive (COPD), Hypercapnia
Effectiveness and Efficiency of Home Telemonitoring and Non-invasive Ventilation in Patients With COPD and Hypercapnia (EVALECO)
The purpose of this study is to evaluate the effectiveness and clinical efficiency of combining home non-invasive ventilation (NIV) with a continuous remote telemonitoring (TM) system in patients with Chronic Obstructive…
- Trial name
- EVALECO (NCT07679646)
- Testing
- Home Non-Invasive Ventilation and Telemonitoring
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Air Liquide Healthcare Spain
Acute Respiratory Distress Syndrome, Respiratory Failure
Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome
The goal of this interventional study is to compare standard mechanical ventilation to a lung-stress oriented ventilation strategy in patients with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- PREVENT VILI (NCT06066502)
- Testing
- Precision ventilation, Guided usual care ventilation
- Where
- 33 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hypoxemic Respiratory Failure
Optimisation of High Flow Oxygen Therapy Settings During Hypoxaemic Respiratory Distress Based on Non-contact Measurement of Lung Volumes by Depth Camera
The goal of this clinical trial is to validate the interest of a strategy adjusting the flow rate delivered under high-flow oxygen (HFO) therapy according to the lung volumes measured by a new technique, in intensive care…
- Trial name
- DiStok (NCT06819644)
- Testing
- high flow oxygen therapy rate adjusted of lung volumes measured
- Where
- 8 sites in France
- Volunteers
- 406 people
- Sponsor
- University Hospital, Brest
Amyotrophic Lateral Sclerosis (ALS), Chronic Respiratory Failure
A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)
Amyotrophic lateral sclerosis (ALS) is a disease that causes weakness of the muscles of the body. The disease can eventually lead to severe breathing problems, which is the most common cause of death from ALS.
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Chronic Respiratory Failure, Neuromuscular Disease Patients, Neuromuscular Disease
- Trial name
- EVENT ALS (NCT07071935)
- Testing
- Non-invasive ventilation
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of Pennsylvania