Clinical trials: Respiratory Insufficiency, open to volunteers
Acute Hypoxemic Respiratory Failure
Bag CPAP vs Standard Oxygen Therapy in Acute Hypoxemic Respiratory Failure
Acute Hypoxemic Respiratory Failure (AHRF) is one of the prevalent causes of admission around the world and is associated with high mortality in resource-limited settings.
- Trial name
- BAGCPAP-R (NCT07460427)
- Testing
- Bag CPAP, Standard oxygen
- Where
- Rwanda
- Volunteers
- 250 people
- Sponsor
- Prof RWABIHAMA Jean Paul
Respiratory Insufficiency in Children
Comparison of Transcutaneous and Blood CO₂ Measurement in Critically Ill Children
Transcutaneous capnometry (tPCO₂) is a non-invasive method for continuous monitoring of ventilation status. In pediatric intensive care patients, it may reduce the need for repeated arterial or arterialized blood sampling.
- Trial name
- NCT07468006
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Brno University Hospital
Lung Edema
Heparin-binding Protein and Lungedema in ICU Patients.
The goal of this single center observational cohort study is to investigate the relationship between physiological measures of lung oedema, and the biomarker Heparin-binding Protein (HBP).
- Trial name
- NCT07434908
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Umeå University
Oxygen Delivery, Acute Respiratory Failure
Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy
Several factors can influence oxygenation monitoring and respiratory support through oxygen therapy: the type of oximeter used, skin pigmentation, and the oxygenation target.
- Conditions
- Oxygen Delivery, Acute Respiratory Failure, High Flow Oxygen Therapy, Hypoxemic Acute Respiratory Failure
- Trial name
- NCT07168213
- Testing
- Manual FiO2 titration with Philips oximeter (SpO2 target 90%), Manual FiO2 titration with Nonin oximeter (SpO2 target 90%), Manual FiO2 titration with Philips oximeter (SpO2 target 94%)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Colonic Polyp, Sedation Complication
A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy
The goal of this prospective, randomized, controlled study is to compare remimazolam besilat/sufentanyl and propofol/sufentanyl in patients during colonoscopic polypectomies procedures.
- Trial name
- Bypro (NCT07456111)
- Testing
- Remimazolam besylate, Propofol
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- Clinical Hospital Centre Zagreb
Acute Respiratory Insufficiency
Ultrasound Scoring Methods to Monitor Breathing Problems in Intensive Care Patients
The goal of this observational study is to compare two lung ultrasound protocols for assessing lung function in patients with acute respiratory insufficiency treated in intensive care units.
- Trial name
- UMBPI (NCT07446803)
- Testing
- Abbreviated Lung Ultrasound Protocol
- Where
- Croatia
- Volunteers
- 20 people
- Sponsor
- Clinical Hospital Center Rijeka
Respiratory Depression
ENA-001 for Post Operative Respiratory Depression (PORD)
This study is a Phase II, randomized, placebo-controlled, double-blind trial in 200 subjects having general anesthesia for major elective surgery with postoperative pain management to evaluate the efficacy, safety and…
- Trial name
- NCT06137638
- Testing
- ENA-001
- Volunteers
- 200 people
- Sponsor
- Enalare Therapeutics Inc.
Mechanical Ventilation, Respiratory Failure
Impact of PEEP on Respiratory Effort During Assisted Ventilation
Assisted mechanical ventilation is widely used to preserve diaphragmatic activity and improve lung aeration in patients with acute respiratory failure.
- Conditions
- Mechanical Ventilation, Respiratory Failure, Effort
- Trial name
- PEEP-EFFORT (NCT07437846)
- Testing
- PEEP Level Adjustment
- Where
- Chile
- Volunteers
- 12 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Lung Cancer, Radiation-Induced Disorder
Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer
Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy.
- Conditions
- Lung Cancer, Radiation-Induced Disorder, Radiation Pneumonitis, Pulmonary Disease
- Trial name
- ASPECT (NCT04676828)
- Testing
- Single-photon-emission CT scan
- Where
- 2 sites in Australia, Denmark
- Volunteers
- 90 people
- Sponsor
- University of Aarhus
Respiratory Insufficiency, Fasting
Non-inferiority of Continuing Oral Intake Versus Fasting in Patients With Acute Respiratory Failure
Fasting in intensive care is mainly studied in mechanically ventilated patients or those in the weaning phase. Recent research challenge the common assumption of fasting and suggests that continuing enteral nutrition before…
- Conditions
- Respiratory Insufficiency, Fasting, Dysphagia, Swallowing Disorder
- Trial name
- JEUN-TUBE (NCT06510972)
- Testing
- Oral intake continuation strategy, Fasting strategy
- Where
- 14 sites in France
- Volunteers
- 754 people
- Sponsor
- University Hospital, Tours
COPD, COPD (Chronic Obstructive Pulmonary Disease)
How Nocturnal Hypoventilation Predicts Long-term Response to Non-invasive Ventilation in Hypercapnic COPD Patients
The study is an observational, single-center, prospective cohort study aiming to evaluate respiratory mechanics data, as well as clinical and functional parameters commonly used in clinical practice in patients with COPD and…
- Conditions
- COPD, COPD (Chronic Obstructive Pulmonary Disease), Hypercapnia, Hypercapnic Respiratory Failure, COPD
- Trial name
- HYPONIV (NCT07414108)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Trauma, Rib Fractures
Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures
The goal of this double blinded randomized control trial is to learn if percutaneous cryoablation of traumatic rib fractures improves outcomes.
- Conditions
- Trauma, Rib Fractures, Chest Wall Disorder, Respiratory Insufficiency
- Trial name
- NCT06533904
- Testing
- Percutaneous Cryoablation of Intercostal Nerves, Multi-modal pain regimen
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Respiration Disorders
Respiratory Monitoring System That Detects & Predicts OIRD
This study is being conducted to evaluate the ability of the Respiratory Monitoring System (RMS) to detect and predict opioid induced respiratory depression (OIRD) in post-operative surgical patients managed with opioid…
- Trial name
- RTM-NIH-SBIR-2 (NCT07217197)
- Testing
- Study to evaluate a Respiratory Monitoring System (RMS) with a Tracheal Sound Sensor (TSS) for detecting and predicting opioid induced respiratory Depression (OIRD).
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Thomas Jefferson University
ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure
Prone Position Assessed by 3D EIT
To investigate global and regional changes in lung ventilation and perfusion induced by prone position in ARDS patients assessed by 3D-EIT. And to investigate the difference between 2D-EIT and 3D-EIT in prone position monitoring.
- Trial name
- NCT07083973
- Testing
- Prone position
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Respiratory Failure, Mechanical Ventilation Complication
Ventilator-based Inspiratory Muscle Training for Patients With Respiratory Failure
This study will be conducted to compare the effectiveness of progressive inspiratory flow trigger sensitivity rising versus stepwise pressure support reduction as ventilator-based inspiratory muscle training methods on weaning…
- Trial name
- NCT07353814
- Testing
- adjustment of parameters on mechanical ventilation device, routine plan of weaning and Conventional Chest Physiotherapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Respiratory Insufficiency Requiring Mechanical Ventilation
Registry for Automated Mechanical VEntilation in Adults
The aim of the here proposed study is to assess safety, performance and provide real world evidence (RWE) of the Hamilton Medical AG automated mechanical ventilation software packages in consecutive critically ill patients…
- Trial name
- RAVE (NCT06655805)
- Testing
- Non-invasive ventilation, Invasive mechanical ventilation, high-flow nasal oxygen
- Where
- 4 sites in Switzerland
- Volunteers
- 1,000 people
- Sponsor
- Hamilton Medical AG
Cardiac Failure, Respiratory Failure
Study of Platelet Population Changes Under Circulatory Support With ECMO
Advances in flow cytometry techniques have led to a better understanding of platelet phenotypes and have revealed the existence of four major platelet populations with distinct functional properties (native, proaggregating…
- Trial name
- ECMO-POP (NCT07334457)
- Where
- France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Respiratory Failure, Acute Respiratory Failure
Validation Study of the EMILY AI Device in Acute and Chronic Respiratory Failure
Currently, there is no holistic solution for patients with respiratory diseases that includes oxygenation and management of a patient with respiratory disease, combining dynamic and automatic O2 administration and the detection…
- Trial name
- NCT06952816
- Testing
- Emily.AI
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Aether Tech S.L.
Intensive Care Unit Syndrome, Intensive Care Neuropathy
Recovery From ICUAW Following Severe Respiratory and Cardiac Failure
To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO).
- Conditions
- Intensive Care Unit Syndrome, Intensive Care Neuropathy, Intensive Care (ICU) Myopathy, Acute Respiratory Distress Syndrome
- Trial name
- CLEVERER (NCT03753412)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Barts & The London NHS Trust