Clinical trials: Respiratory Insufficiency, open to volunteers
Exacerbation Copd, Acute Respiratory Distress
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide.
- Conditions
- Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
- Trial name
- HiFOLD (NCT03033251)
- Testing
- Non Invasive Ventilation, High Flow Oxygen Cannula 50, High Flow Oxygen Cannula 30
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Acute Hypercapnic Respiratory Failure
The Simplify Project
The high frequency of unplanned hospital visits of patients with chronic hypercapnic respiratory failure (e.g., chronic obstructive pulmonary disease, obesity-related hypoventilation) constitutes a major public health problem.
- Trial name
- SIMPLIFY (NCT05011877)
- Testing
- High-flow nasal cannula therapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Ventilatory Failure, Hypoxemic Respiratory Failure
PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study
The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal…
- Conditions
- Ventilatory Failure, Hypoxemic Respiratory Failure, Weaning Failure, Respiratory
- Trial name
- PREVISION (NCT06716463)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Unity Health Toronto
Respiration Disorders, Respiratory Failure
Investigating the Impact of Sepsis Phenotypes on Antibiotic Treatment in Patients With Severe Pneumonia and Sepsis
Aim of the research: To find out why antibiotics work differently in certain patients with severe pneumonia and sepsis. Background: Individuals can become very unwell from pneumonia, sometimes requiring admission to hospital or…
- Conditions
- Respiration Disorders, Respiratory Failure, Sepsis, Infection in ICU
- Trial name
- SIPRES (NCT06977165)
- Testing
- Antibiotic quantification
- Where
- United Kingdom
- Volunteers
- 119 people
- Sponsor
- University of Manchester
Postoperative Complications, Respiratory Depression
Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments
This study aims to evaluate the efficacy and safety of Remimazolam, either used alone or in combination with Propofol, for moderate sedation anesthesia during endoscopic therapies or examinations.
- Conditions
- Postoperative Complications, Respiratory Depression, Postoperative Nausea, Vomiting
- Trial name
- Remimazolam (NCT06777758)
- Testing
- Remimazolam, Propofol
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
EIT-Guided Ventilator Settings in AHRF
This exploratory study aims to investigate the effect of Electrical Impedance Tomography (EIT)-guided ventilator settings on mechanical power in patients with acute hypoxemic respiratory failure (AHRF), including both ARDS and…
- Conditions
- Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Mechanical Power, Ventilator Induced Lung Injury
- Trial name
- NCT06936618
- Testing
- Electrical Impedance Tomography (EIT), Enlight 2100
- Where
- Thailand
- Volunteers
- 17 people
- Sponsor
- Mahidol University
Respiratory Failure
Quantification of Inspiratory Effort Through Nasal Pressure in Patients Undergoing Weaning From Invasive Mechanical Ventilation and Correlation With Clinical Outcomes
Weaning from invasive mechanical ventilation (MV) constitutes a fundamental procedure in intensive care, covering up to 50% of time spent on ventilation (1).
- Trial name
- NAIVE (NCT05282238)
- Testing
- Nasal pressure assessment
- Where
- Italy
- Volunteers
- 175 people
- Sponsor
- University of Modena and Reggio Emilia
COPD, Interstitial Pneumonia
Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study
This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results.
- Conditions
- COPD, Interstitial Pneumonia, Bronchiectasis, Respiratory Failure
- Trial name
- NCT06922916
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Zhejiang University
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation
Safety and Efficacy of Low-Flow ECMO in a Multi-modal Cohort of Adults in Respiratory Failure
The current standard of care (SOC) for treatment of patients with acute respiratory distress syndrome (ARDS), inhalation injury, volume overload, and/or pulmonary dysfunction is mechanical ventilation (MV).
- Conditions
- Acute Hypoxemic Respiratory Failure, Mechanical Ventilation, Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT06938217
- Testing
- Low-flow ECMO
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Institute for Extracorporeal Life Support
Pulmonary Disease, Respiratory System Abnormalities
Distribution of Ventilation, Respiratory Drive and Gas Exchange: Measurements and Monitoring
Respiratory physiology involves a complex interplay of elements including control of breathing, respiratory drive, pulmonary mechanics, distribution of ventilation and gas exchange.
- Conditions
- Pulmonary Disease, Respiratory System Abnormalities, OSA, Respiratory Failure
- Trial name
- NCT05462600
- Testing
- Position change
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Critical Illness, Respiratory Failure
High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Intubation in the intensive care unit is a standard procedure with a high risk of adverse events such as hypoxaemia and cardiovascular instability.
- Conditions
- Critical Illness, Respiratory Failure, Multi Organ Failure, Hypoxia
- Trial name
- HiPOXIC (NCT05883137)
- Testing
- Optiflow Switch
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Pleural Effusions, Respiratory Failure
Drainage Of Pleural Effusions in the Intensive Care Unit (DOPE-ICU) - Feasibility Trial
This trial evaluates the feasibility of ultrasound-guided pleural drainage versus no drainage in adult ICU patients with pleural effusions (fluid buildup around the lungs) and respiratory failure.
- Trial name
- NCT06709456
- Testing
- Ultrasonography-guided pleural drainage
- Where
- 6 sites in Denmark
- Volunteers
- 88 people
- Sponsor
- Olav Schjørring
Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure
The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU
While most studies in the medical literature that indicate "music" as an intervention may recognize its impact and capacity to decrease pain perception, anxiety, and/or its role in the regulation of cardiac and respiratory…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
- Trial name
- NCT03642002
- Testing
- Toning, Ocean drum & SOK melody, SOK
- Where
- 3 sites in United States
- Volunteers
- 178 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Spinal Cord Injuries, Cervical Spinal Cord Injury
Neurostimulation for Respiratory Function After Spinal Cord Injury
The purpose of this research study is to learn more about the connections between the brain, nerves, and diaphragm after experiencing a cervical spinal cord injury (SCI).The main question it aims to answer is: Changes in…
- Conditions
- Spinal Cord Injuries, Cervical Spinal Cord Injury, Respiratory Function Impaired
- Trial name
- NCT05756894
- Testing
- Neurostimulation, Repiratory training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
ARDS (Moderate or Severe)
FAPI PET/CT to Detect Fibroblast Activity in Non-resolving ARDS
Of patients requiring mechanical ventilation in the ICU 23% meet criteria of the Acute Respiratory Distress Syndrome (ARDS). Mortality of this syndrome remains high (35-46%) in moderate and severe ARDS.
- Trial name
- FAPI ARDS (NCT06691464)
- Testing
- PET
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Critical Illness, Respiratory Failure
Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation
Tracheal intubation (TI) is associated with a high risk of adverse events in critically ill patients and peri-intubation hemodynamic collapse is the most commonly observed.
- Trial name
- PREVENTION (NCT05014581)
- Testing
- Noradrenaline
- Where
- 6 sites in France, Ireland and 1 more
- Volunteers
- 420 people
- Sponsor
- University of Turin, Italy
COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD
Survey on NIV Settings in the Intensive Care Unit for Acute Exacerbation of COPD
Introduction Chronic obstructive pulmonary disease (COPD) is a common condition and the fourth leading cause of death worldwide.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD, Hypercapnic Respiratory Failure, COPD
- Trial name
- NIV-ICU (NCT06888180)
- Testing
- Non interventional study
- Volunteers
- 976 people
- Sponsor
- University Hospital, Caen
Respiratory Failure, Osteopathy in Diseases Classified Elsewhere
The Utility of Osteopathic Manipulative Medicine in Weaning Patients from the Ventilator Pilot Trial
The objectives of this research are to determine the treatment effect size of OMM to wean patients off of the ventilator, determine the number of patients needed for a larger study (power), determine the willingness of…
- Trial name
- NCT06891248
- Testing
- Osteopathic Manipulative Treatment
- Volunteers
- 20 people
- Sponsor
- Oklahoma State University Center for Health Sciences
Respiratory Distress Syndrome (RDS), Respiratory Failure
SerpinB3 Expression, PAR2 and SCCA-PD Polymorphism in Acute Respiratory Distress Syndrome
The Acute Respiratory Distress Syndrome (ARDS) is a systemic syndrome characterized by severe respiratory failure, inflammation, loss of aerated tissue and high mortality.
- Trial name
- Serpin-ARDS (NCT06774534)
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Padova
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Oxygen Therapy
Effects of Face Mask Continuous Positive Airway Pressure Vs. Noninvasive Ventilation Vs. High-flow Nasal Oxygen on Intubation-free Survival in Acute Hypoxemic Respiratory Failure: the TRIPOD Randomized Clinical Trial
Acute hypoxemic respiratory failure (AHRF) is a common indication for admission to an intensive care unit (ICU), with mortality exceeding 50% in cases where invasive mechanical ventilation is needed.
- Conditions
- Acute Hypoxemic Respiratory Failure, High-Flow Nasal Oxygen Therapy, Noninvasive Ventilation, Continuous Positive Airway Pressure (CPAP)
- Trial name
- TRIPOD (NCT06795971)
- Testing
- Continuous Positive Airway Pressure, High-flow nasal oxygen, Non-invasive ventilation
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- Southeast University, China