Clinical trials: Respiratory Morbidity
COVID-19 Infection
Extension Study in a Cohort of Adult Patients With COVID-19 Infection
The main objective of this study is to evaluate the incidence of post-COVID morbidity and characterize the complications profile in patients who participated in the APLICOV-PC study.
- Trial name
- E-APLICOV-PC (NCT05121740)
- Testing
- Plitidepsin 1.5 mg / day, Plitidepsin 2.0 mg / day, Plitidepsin 2.5 mg / day
- Where
- 10 sites in Spain
- Volunteers
- 34 people
- Sponsor
- PharmaMar
Chest Wall Tumor, Breast Cancer
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
Radiation therapy is an essential treatment for tumors in the chest area, including breast, lung, esophageal, mediastinal cancers, and spine metastases.
- Conditions
- Chest Wall Tumor, Breast Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- NCT07685938
- Testing
- Atorvastatin and Lisinopril
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Asthma
The Effect of Long Term Inhaled Corticosteroids on the Risk of Cardiovascular Morbidities
Cardiovascular disease is a major cause of morbidity and mortality worldwide. It is the second leading cause of death in Hong Kong. The disease burden is huge and effective control measures should target at prevention level.
- Trial name
- NCT00959257
- Where
- 4 sites in Hong Kong
- Volunteers
- 1,394 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Covid19, Non-specific Effects of Vaccines
Using BCG to Protect Senior Citizens During the COVID-19 Pandemic
Background: The virus SARS-CoV-2 has spread rapidly throughout the world. Seniors are at high risk of severe COVID-19 when infected.
- Conditions
- Covid19, Non-specific Effects of Vaccines, Heterologous Immunity, Morbidity
- Trial name
- NCT04542330
- Testing
- BCG-Denmark, Saline
- Where
- Denmark
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Multimorbidity, Cancer
The LifeMeds Cohort
The goal of this observational study is to investigate lifestyle behaviours, their determinants, and their associations with health outcomes in adults with multimorbidity, defined as the presence of at least two lifestyle-related…
- Conditions
- Multimorbidity, Cancer, Cardio Vascular Disease, Chronic Respiratory Conditions
- Trial name
- LifeMeds (NCT07846800)
- Volunteers
- 2,000 people
- Sponsor
- Tilburg University
Early-Onset Sepses, Neonatal, Periventricular Haemorrhage Neonatal
Zinc Supplementation on Very Low Birth Weight Infant
Premature birth is a major cause of neonatal death in addition to neonatal asphyxia and infections. Early in life, premature babies must get aggressive nutrition so that there is no extrauterine growth restriction (EUGR) in the…
- Conditions
- Early-Onset Sepses, Neonatal, Periventricular Haemorrhage Neonatal, Bronchopulmonary Dysplasia, Retinopathy of Prematurity
- Trial name
- NCT04050488
- Testing
- Zinc Sulfate
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Respiratory Morbidity
Dexmedetomidine Sedation in Children With Respiratory Morbidities
This study aimed to determine the feasibility of dexmedetomidine in children with respiratory morbidities who required deep sedation for magnetic resonance imaging (MRI) scans.
- Trial name
- NCT02555605
- Testing
- Dexmedetomidine
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- Universitair Ziekenhuis Brussel
Airway Morbidity, Airway Disease
Video Laryngoscopy in Pre-hospital Critical Care
Difficult conditions and critically ill and injured patients may complicate endotracheal intubation in the pre-hospital setting.
- Conditions
- Airway Morbidity, Airway Disease, Respiratory Insufficiency, Respiratory Failure
- Trial name
- NCT02035449
- Testing
- McGrath MAC
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University of Aarhus
Pulmonary Disease, Chronic Obstructive
Pulmonary Rehabilitation in Functional Outcomes and Its Relationship With Morbidity and Mortality in Patients With COPD
Background: The pulmonary rehabilitation effects on various outcomes of COPD are well known. However, they may be lost over time due to poor adherence to therapy with absence of regular exercise maintenance in long term, disease…
- Trial name
- NCT03692793
- Testing
- Pulmonary rehabilitation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of the State of Santa Catarina
Hypothermia
Plastic Hat Trial to Prevent Hypothermia in Preterm Newborns in the Delivery Room
The purpose of this research project is to ascertain the effectiveness of plastic head covering in prevention of hypothermia. Hypothermia is defined by body temperature <36.5º Celsius by the World Health Organization.
- Trial name
- NCT00904228
- Testing
- placement of plastic cap during delivery room stabilization, placement of routine cap during delivery room stabilization
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
Evaluation of Remote Patient Monitoring.
Nottingham Primary Care Trust has launched telemonitoring to support: independent living and self-management ability of people with congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) and co-morbidities…
- Trial name
- NCT00789100
- Where
- United Kingdom
- Sponsor
- Brunel University
Long COVID, COVID Long-Haul
Cardiopulmonary Exercise Tests in Patients With Long COVID
The value of clinical cardiopulmonary exercise testing (CPET) within healthcare settings has been established in the last decade.
- Trial name
- PREPP-19 (NCT06394921)
- Testing
- 2 day cardiopulmonary exercise test
- Where
- 5 sites in United States, India and 1 more
- Volunteers
- 146 people
- Sponsor
- Sheffield Hallam University
COVID-19, Corona Virus Infection
Enzalutamide Treatment in COVID-19
COVID-19 is a disease with high rate of morbidity if symptomatic. There is a great need of treatments to decrease the severity. The vast majority of patients needing intensive care are men, and this may be due to the androgens…
- Trial name
- COVIDENZA (NCT04475601)
- Testing
- Enzalutamide Pill
- Where
- 6 sites in Sweden
- Volunteers
- 42 people
- Sponsor
- Andreas Josefsson
Pneumonia, Diarrhea
Azithromycin to Prevent Post-discharge Morbidity and Mortality in Kenyan Children
Children hospitalized with severe illness in sub-Saharan Africa are at high risk of morbidity and mortality following discharge from hospital.
- Conditions
- Pneumonia, Diarrhea, Malaria, Co-infection
- Trial name
- Toto Bora (NCT02414399)
- Testing
- Azithromycin
- Where
- Kenya
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Washington
Covid19, Diabetes Mellitus
The Effect of Diabetes Mellitus on the Prognosis of Patients With COVID-19
All hospitalised patients with COVID-19 who have positive RT-PCR for SARS-COV-2 will be included in the study. The patients will be divided into two groups, as diabetics and non-diabetics.
- Trial name
- COVID-19-DM2 (NCT04591704)
- Testing
- hospitalisation, necessity of ICU, mortality rate, lung involvement
- Where
- Turkey (Türkiye)
- Volunteers
- 2,000 people
- Sponsor
- Uşak University
Mechanical Ventilation Complication, Tracheal Intubation Morbidity
Continuous Endotracheal Cuff Pressure Control to Prevent Ventilator Associated Respiratory Infections
The purpose of the study is to determine whether automated cuff pressure control results in a reduction in the proportion of patients developing ventilator associated respiratory infections during their stay in intensive care.
- Conditions
- Mechanical Ventilation Complication, Tracheal Intubation Morbidity, Ventilator-Associated Pneumonia, Hospital Acquired Infection
- Trial name
- VARI-prevent (NCT02966392)
- Testing
- Tracoe cuff pressure controller
- Where
- 3 sites in Vietnam
- Volunteers
- 600 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Measles, Diphtheria
Immunology of Non-specific Effects of Vaccine
OBJECTIVES General: To investigate the immunological background for the non-specific effects of diphtheria-tetanus-pertussis (DTP) and measles vaccines on child mortality Specific: Examine the cytokine responses and possible…
- Conditions
- Measles, Diphtheria, Tetanus, Pertussis
- Trial name
- NCT00168545
- Testing
- Measles vaccine
- Where
- Guinea-Bissau
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
COVID-19
Relation Between Atherogenic Index of COVID-19 and Upcoming Cardiac Morbidity and Mortality in Non-Cardiac Patients
Plasma lipids levels were estimated and the Atherogenic Index of Plasma (AIP) was computed in 302 COVID confirmed patients. Patients were evaluated using the COVID-GRAM (CG) critical illness score and during a hospital stay the…
- Trial name
- NCT05226377
- Testing
- Atherogenic Index of Plasma
- Where
- Egypt
- Volunteers
- 302 people
- Sponsor
- Tanta University
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh