Clinical trials: Respiratory System
Chronic Respiratory Disease, COPD
The Effect of Spontaneous Respiration on Pulse-oximetry Measurements
This is a study designed to measure, characterize and describe changes on pulse-oxymetry values produced as a result of deep breaths in patients with stable chronic hypoxemic respiratory failure.
- Conditions
- Chronic Respiratory Disease, COPD, Interstitial Lung Disease
- Trial name
- NCT04139356
- Testing
- Deep breaths
- Where
- Mexico
- Volunteers
- 45 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Pulmonary Nodule, Multiple, Pulmonary Nodule, Solitary
Comparative Study on the Efficacy and Safety of Microwave Ablation and Lobectomy in the Treatment of Ground Glass Nodules Located in the Pulmonary Hilar Region
GGO is a characteristic focus of early lung cancer. Due to the abundant peripheral blood vessels and bronchial tissues around the GGO lesions located in pulmonary hilar, only lobectomy could be used for the surgical treat of…
- Trial name
- NCT05477251
- Testing
- microwave ablation, lobectomy
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
ASA Class I/II Patients, General Anesthetic
PCV vs VCV in Low-Flow Anesthesia
The aim of this observational study is to investigate the effects of ventilation modes on intraoperative and postoperative lung functions in patients under general anesthesia.
- Conditions
- ASA Class I/II Patients, General Anesthetic, Low Flow Anesthesia
- Trial name
- NCT07305129
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- HULYA TOPCU, MD
Sore Throat
Preoperative Aspirin and Benzydamine Hydrochloride Gargles on Severity and Duration of Post-Operative Sore Throat
Post-operative sore throat (POST) following General Anesthesia with endotracheal is a common symptom and drains resources. The researchers will compare preoperative gargling of Asprine and Benzydamine HCL to study comparative…
- Trial name
- Postbenas (NCT05343429)
- Testing
- Benzydamine hydrochloride, Aspirin
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Pneumoconiosis
The Experience of Patients and Family Caregivers in Managing Pneumoconiosis in the Family Context
This is an exploratory qualitative study to understand the needs of patients with pneumoconiosis, and the care-giving experience of their family caregivers.
- Trial name
- NCT04022902
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 83 people
- Sponsor
- Chinese University of Hong Kong
Anal Squamous Cell Carcinoma, Colorectal Neoplasms
Regorafenib With Tislelizumab in Patients With Selected Mismatch Repair-Proficient/Microsatellite Stable Cancers
REFIT-MSS is a non-randomized, multicenter, open-label, multi-cohort, 2-stage, phase II trial to evaluate the efficacy and safety of regorafenib in combination with tislelizumab (referred as Rego-Tisle) in adult patients with…
- Conditions
- Anal Squamous Cell Carcinoma, Colorectal Neoplasms, Soft Tissue Sarcoma, Malignant Pleural Mesothelioma
- Trial name
- REFIT-MSS (NCT05582031)
- Testing
- Regorafenib in combination with Tislelizumab
- Sponsor
- Translational Research in Oncology
Carcinoma, Non-Small-Cell Lung
ADAM-Afatinib Diarrhea Assessment and Management
This is a non-randomized, open label, two-cohort, multi-institutional study to evaluate the use of diarrheal management tools intended to facilitate timely intervention and treatment modifications due to afatinib…
- Trial name
- NCT01814553
- Testing
- afatinib, loperamide
- Where
- 12 sites in United States
- Volunteers
- 40 people
- Sponsor
- Boehringer Ingelheim
Liquid Biopsy for Early Screening of Lung Cancer
A Prospective Interventional Study on Early Screening for Lung Cancer Using Liquid Biopsy
This project aims to establish the MERCURY pilot screening program as part of the "Love Lung Project," employing a novel concept of lung cancer screening with the assistance of low-dose computer tomography (LDCT).
- Trial name
- NCT06422637
- Testing
- Liquid Biopsy Early Screening
- Where
- China
- Volunteers
- 5,944 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Advanced Solid Tumor, Metastatic Solid Tumor
A Phase I Study of WM-S1-030 in Patients With Advanced Solid Tumors
This study evaluates the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of WM-S1-030 in patients with advanced solid tumors.
- Conditions
- Advanced Solid Tumor, Metastatic Solid Tumor, Colorectal Cancer, Lung Cancer
- Trial name
- NCT04801095
- Testing
- WM-S1-030
- Where
- 6 sites in Australia, South Korea
- Volunteers
- 100 people
- Sponsor
- Wellmarker Bio
Spontaneous Pneumothorax
Techniques for Lung Deflation With Arndt® Blocker
The use of wire-guided Arndt® endobronchial blocker does not gain widespread acceptance during video-assisted thoracoscopy (VATS) because it takes longer time to collapse the operative lung especially in patients with chronic…
- Trial name
- NCT02030795
- Testing
- Disconnection group, Bronchial Suction group
- Where
- Saudi Arabia
- Volunteers
- 58 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Extensive Stage Lung Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
Palliative Radiotherapy With Lurbinectedin in Patients With Extensive Stage Small Cell Lung Cancer
This phase I trial aims to determine if it is safe to use palliative radiotherapy and lurbinectedin at the same time to treat small cell lung cancer that has spread outside of the chest and that has grown after being treated with…
- Trial name
- NCT05244239
- Testing
- Lurbinectedin, Palliative Radiation Therapy
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Emory University
Post COVID-19
Value of Montelukast as a Potential Treatment of Post COVID-19 Persistent Cough
As of September 2020, the COVID-19 pandemic has affected millions of people in 196 countries and left hundreds of thousands dead.
- Trial name
- NCT05447039
- Testing
- Montelukast Sodium Tablets
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Assiut University
COVID-19, Myocardial Reperfusion Injury
Myocardial Injury and Major Adverse Outcomes in Patients With COVID-19
The study will analyze the incidence, clinical outcomes and predictors of myocardial injury in a large patient population with COVID-19 treated in Mount Sinai Hospital (MSH) system.
- Conditions
- COVID-19, Myocardial Reperfusion Injury, Cardiovascular Diseases
- Trial name
- NCT04397939
- Where
- United States
- Volunteers
- 4,695 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Covid-19
Rehabilitation Needs After COVID-19 Hospital Treatment
The onset of Coronavirus Disease 2019 (COVID-19) in the first months of 2020 had a huge impact on Italian population and Healthcare System, with more than 150.000 total confirmed cases1.
- Trial name
- REACT (NCT04438239)
- Testing
- none, this study is observational
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Asthma
Efficacy and Safety of 2 Doses of Tiotropium Respimat® Compared to Placebo in Children With Moderate Persistent Asthma
The overall purpose of the trial is to evaluate efficacy and safety of tiotropium inhalation solution delivered via Respimat® inhaler (2.5 mcg and 5 mcg once daily in the evening) over 48 weeks, compared to placebo, in children…
- Trial name
- NCT01634139
- Testing
- Tiotropium low dose QD, Tiotropium high dose QD
- Where
- 79 sites in United States, Bulgaria and 14 more
- Volunteers
- 403 people
- Sponsor
- Boehringer Ingelheim
Non Small Cell Lung Cancer
Olmutinib Trial in T790M (+) NSCLC Patients Detected by Liquid Biopsy Using BALF Extracellular Vesicular DNA
The purpose of this study is to evaluate the efficacy of Olmutinib(Olita®) in patients with T790M-positive non-small cell lung cancer (NSCLC) confirmed using DNA extracted from extracellular vesicles of bronchoalveolar lavage…
- Trial name
- NCT03228277
- Testing
- Olmutinib
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Konkuk University Medical Center
Dyspnea
Diagnostic Performance of Chest Computed Tomography Scan in Patients Aged 65 and Over Presenting to Emergency Room With Acute Dyspnea
In acute dyspnea, the use of chest radiography is frequent and not very contributive, especially in the elderly patients. However, early diagnosis of the cause of dyspnea in the ED is associated with a better prognosis, in…
- Trial name
- CT-Dys (NCT06104475)
- Testing
- CT scan
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD
COPD Pal Phase 1: A Self-management App in COPD
Chronic Obstructive Pulmonary Disease (COPD) is a widespread condition which causes a poorer health status, reduced exercise, and lung function impairment.
- Trial name
- NCT04142957
- Testing
- COPD Pal
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Hywel Dda Health Board
Chronic Obstructive Pulmonary Disease (COPD)
Smartphone-based Self-Management Support Program to Enhance Quality of Life in Patients With COPD
The goal of this study is to find out if a smartphone-based program (called 3S-C) can help people with COPD live better, healthier lives. It will also look at how the program affects their knowledge, habits, and overall health.
- Trial name
- NCT06888557
- Testing
- Smartphone-based self-management support program ( 3S-C)
- Where
- 3 sites in Hong Kong
- Volunteers
- 130 people
- Sponsor
- Hong Kong Metropolitan University
Acute Lung Injury
Thoracic Fluid Content and Acute Lung Injury
To study the association of the thoracic fluid content and acute lung injury during liver transplantation.
- Trial name
- NCT01922557
- Testing
- NICOM
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- National Taiwan University Hospital
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