Clinical trials: Respiratory System
Traumatic Brain Injury
Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
The global objective of this study is to establish the safety and investigate the potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences adipose-derived mesenchymal stem cells) on brain structure…
- Trial name
- NCT05951777
- Testing
- Autologous HB-adMSCs, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Hope Biosciences LLC
Vitamin D Deficiency, Covid19
The Relationship Between Vitamin D Levels, Inflammatory Parameters and Disease Severity of COVID-19 Infection
Vitamin D deficiency increases the susceptibility to respiratory virus infections and the severity of infections. Inflammation plays a key role in pathogenesis in COVID19 while identifying clinical course and prognosis…
- Trial name
- NCT04945577
- Testing
- Inflammatory Parameters, 25 OH Vitamin D Level
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Androgen Independent Prostate Cancer (AIPC), Non Small Cell Lung Cancer (NSCLC)
Study of DN-101 (Calcitriol) and Docetaxel in Subjects Previously Enrolled in Studies DN101-002 or DN101-004
The purpose of this study is to monitor the safety of continued DN-101 and docetaxel treatment for subjects previously enrolled in DN101-002 (ASCENT) or DN101-004 (NSCLC) Studies.
- Trial name
- NCT00285675
- Testing
- DN-101 (calcitriol) - Drug
- Where
- 13 sites in United States, Canada
- Volunteers
- 25 people
- Sponsor
- Novacea
Probiotics Infant Formula, Infants Health
The Impact of Infant Formula With Probiotics on Infants Health
The trial will be divided into three groups, the experimental group: (I) probiotic A formula, (II) probiotic B formula; control group: (III) regular formula (Youluck infant formula).
- Trial name
- NCT03993301
- Testing
- Probiotic A formula, Probiotic B formula, Regular formula
- Where
- Taiwan
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Obstructive Sleep Apnea (OSA)
Prevalence of Obstructive Sleep Apnoea (OSA) Among 4-8 Years Old Children in the General Population
The purpose of this study is to estimated prevalence of obstructive sleep apnea (OSA) in 4-8 year old children. To date, most studies estimating prevalence of sleep apnea in young children are based on utilizing subjective…
- Trial name
- NCT05479201
- Testing
- Home based sleep test
- Where
- Iceland
- Volunteers
- 386 people
- Sponsor
- Akureyri Hospital
Non-small Cell Lung Cancer
Tissue Eosinophils in Non-Small Cell Lung Cancer (the TEN Study)
The primary objective is to describe eosinophil infiltration in resected (early stage) NSCLC. Secondary objectives are: to investigate the correlation of T-Eos and B-Eos in the aforementioned patient population; to investigate…
- Trial name
- TEN (NCT05537701)
- Where
- Belgium
- Volunteers
- 316 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Respiratory Syncytial Virus
A Study to Assess EDP-938 for the Treatment of Acute Upper Respiratory Tract Infection With Respiratory Syncytial Virus in Adult Subjects
This was a randomized, double-blind, placebo-controlled, multicentre, phase 2 study to evaluate the efficacy, safety and tolerability of orally administered EDP-938 in adults with RSV infection.
- Trial name
- RSVP (NCT04196101)
- Testing
- EDP-938
- Where
- 29 sites in United States, Argentina and 5 more
- Volunteers
- 82 people
- Sponsor
- Enanta Pharmaceuticals, Inc
Lung Diseases
Image - Navigated Resection of Lung Nodules
This is an open label study lung nodules that are either cancer or non-cancer and who are eligible for surgical resection. Patients will undergo their surgery with the help of the Lung Resection Marker Locator Kit which will…
- Trial name
- NCT04702165
- Testing
- lung resection with Lung Resection Marker Locator Kit
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Navigation Sciences, Inc.
Covid19
Povidone-Iodine Rinses in the Management of COVID-19
The aim of this study is to determine if Povidone iodine (PVP-I) rinses and throat gargles or a PVP-I gel forming nasal spray compared to a placebo (a treatment that has no physical effect to a person) is an effective treatment…
- Trial name
- NCT04449965
- Testing
- Povidone-iodine
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- St. Paul's Hospital, Canada
Obstructive Sleep Apnea, Metabolic Syndrome X
Obstructive Sleep Apnea (OSA) and Metabolic Syndrome: Role of Oxidative Stress
The purpose of this study is to define the mechanism(s) through which Obstructive Sleep Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic syndrome.
- Trial name
- NCT00177892
- Testing
- sleep disruption, sleep with and without positive pressure
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Open Heart Surgery
Comparison of the Effects of Different Physiotherapy and Rehabilitation Methods on Open Heart Surgery
The aim of this study is to compare the effects of different physiotherapy and rehabilitation methods in hospitalization after Open Heart Surgery (OHS).
- Trial name
- NCT03955536
- Testing
- Group A: Group routine cardiac rehabilitation program (RCRP), Group B: Group RCRP and inspiratory muscle training, Group C: Group RCRP and virtual reality application
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- University of Beykent
Lung Adenocarcinoma, Stage III Lung Cancer
Firmonertinib Plus Chemotherapy for Unresectable EGFR PACC-Mutant Stage III Lung Cancer: A Phase II Study
This is a prospective, single-arm, multicenter Phase II clinical study. It aims to evaluate the efficacy and safety of Firmonertinib combined with chemotherapy in patients with unresectable Stage III lung adenocarcinoma harboring…
- Conditions
- Lung Adenocarcinoma, Stage III Lung Cancer, EGFR Positive Non-small Cell Lung Cancer
- Trial name
- NCT07878871
- Testing
- Firmonertinib, Platinum-based chemotherapy
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Hunan Province Tumor Hospital
Sleep Apnea
Non-Inferiority Study of the FRESCA Airbox Positive Airway Pressure System
Prospective, open-label, randomized crossover assignment, multi-center non-inferiority study conducted in the United States
- Trial name
- NCT03999944
- Testing
- positive airway pressure system
- Where
- 6 sites in United States
- Volunteers
- 52 people
- Sponsor
- FRESCA Medical
Carcinoma, Non-Small -Cell Lung
Analysis of Brain Metastasis in Patients With Lung Cancer
This study will examine patients with non-small cell lung cancer metastasis, that is, the distant spreading of tumors to the brain, and compare them with patients without brain metastasis.
- Trial name
- NCT00071344
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cystic Fibrosis
Safety, Tolerability and Pharmacokinetics of Tiotropium in Cystic Fibrosis Patients
Study to obtain information about the safety and tolerability of tiotropium bromide administered via the Respimat® inhalation device in pediatric (≤11 y.o.) and adolescent/adult (≥12 y.o.) cystic fibrosis (CF) patients after…
- Trial name
- NCT02172534
- Testing
- Tiotropium bromide low, Tiotropium bromide medium, Tiotropium bromide high
- Volunteers
- 113 people
- Sponsor
- Boehringer Ingelheim
COPD
Study to Evaluate the Efficacy and Safety of Glycopyrronium or Indacaterol Maleate and Glycopyrronium Bromide Fixed-dose Combination Regarding Symptoms and Health Status in Patients With Moderate COPD Switching From Treatment With Any Standard COPD Regimen
The main goal of this study is to evaluate the efficacy and safety of glycopyrronium bromide and indacaterol maleate and glycopyrronium bromide fixed dose combination (FDC) in patients with moderate COPD who switch from their…
- Trial name
- NCT01985334
- Testing
- Glycopyrronium, SABA, LABA
- Where
- 542 sites in Austria, Belgium and 21 more
- Volunteers
- 4,389 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Respiratory Disease, Cystic Fibrosis
The Effect of Proprioceptive Neuromuscular Facilitation (PNF) Technique for Children With Chronic Pulmonary Diseases.
Cystic fibrosis and bronchiectasis are the most seen problems in children with chronic pulmonary diseases. İt is a genetic, chronic system disease that reduces life expectancy, and life quality as well.
- Conditions
- Chronic Respiratory Disease, Cystic Fibrosis, Bronchiectasis
- Trial name
- NCT03420209
- Testing
- Group applying PNF technique
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Asthma
Evaluation of Tiotropium 2.5 and 5 µg Once Daily Delivered Via the Respimat Inhaler Compared to Placebo in Patient With Moderate to Severe Persistent Asthma
The aim of this trial is to evaluate the safety and efficacy of 2.5 and 5 µg tiotropium over a 52-week treatment period as compared to placebo.
- Trial name
- NCT01340209
- Testing
- Tiotropium Respimat
- Where
- 55 sites in Japan
- Volunteers
- 285 people
- Sponsor
- Boehringer Ingelheim
Hypoxia
Accuracy of CardioWatch 287-2 During Profound Hypoxia
In an individual's SpO2 range from 100 to 73 %, this study calibrates and evaluates the accuracy of SpO2 measurement by CW2 in comparison to reference pulse oximeter (Nellcor PM10) or CO-oximetry, Pulse rate (PR) and respiratory…
- Trial name
- ACW2 (NCT05542732)
- Testing
- CardioWatch 287-2
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Corsano Health B.V.
Small Cell Lung Cancer
DS-3201b and Irinotecan for Patients With Recurrent Small Cell Lung Cancer
This study will test the safety of the study drug, DS-3201b, given in combination with irinotecan to people who have recurrent small cell lung cancer (SCLC).
- Trial name
- NCT03879798
- Testing
- DS-3201b, irinotecan
- Where
- 7 sites in United States
- Volunteers
- 22 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
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