Clinical trials: Respiratory System
Stroke, Acute
Telestroke at Comprehensive Stroke Center During the COVID-19 Pandemic
TELEstroke to CAre for STroke Patients at a Comprehensive Stroke Center (TELECAST-CSC) during the COVID-19 pandemic is a pre-post study evaluating guideline-based acute ischemic stroke care following the implementation of…
- Trial name
- TELECAST-CSC (NCT04761874)
- Testing
- Telestroke
- Where
- United States
- Volunteers
- 296 people
- Sponsor
- University of Minnesota
Intubation; Difficult, Respiration Disorders
Use of Dexmedetomidine to Facilitate Extubation in Surgical ICU Patients Who Failed Previous Weaning Attempts
Mechanical ventilation commonly is associated with patient agitation requiring sedation to alleviate discomfort and reduce excessive central respiratory drive.
- Trial name
- NCT00464490
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Francisco
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
COVID19
Expanded Access to Convalescent Plasma for the Treatment of Patients With COVID-19
This expanded access program will provide access to investigational convalescent plasma for patients in acute care facilities infected with SARS-CoV-2 who have severe or life-threatening COVID-19, or who are judged by a…
- Trial name
- NCT04338360
- Testing
- COVID-19 convalescent plasma
- Where
- 12 sites in United States
- Sponsor
- Mayo Clinic
Non-small Cell Lung Cancer
Observational Retro-prospective Study on PD1/PDL1 Inhibitors Treatment Duration in Patients With NSCLC
Retrospective/ prospective, multicentre, international observational study on long-responders with non-small cell lung carcinoma patients treated with anti Programmed cell Death 1/ Programmed cell Death Ligand 1 (anti-PD1/PD-L1)…
- Trial name
- I-STOP (NCT05418660)
- Testing
- Immunotherapy
- Where
- 10 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of Milano Bicocca
Obstructive Sleep Apnea, Hypertension
Screening Using Portable Electronic Recorders for Sleep Apnea in Hypertensive At-Risk Populations (SUPER-SHARP Trial)
Uncontrolled hypertension is associated with an increased risk of heart disease, stroke, and mortality. Obstructive sleep apnea (OSA) is common in hypertension and treatment using continuous positive airway pressure (CPAP) has…
- Trial name
- SUPER-SHARP (NCT05918120)
- Testing
- Home Sleep Apnea Test, In-laboratory polysomnography
- Where
- 3 sites in Canada
- Volunteers
- 190 people
- Sponsor
- Sunnybrook Health Sciences Centre
Lung Cancer, Squamous Cell Carcinoma
An Exploratory, Open Label, Multi-Center, Non-Randomized Study of [F-18]VM4-037
Phase: Exploratory Study Objectives: To collect drug bio-distribution data, begin collection of baseline and tumor/background imaging data, acquire experience to improve study design and the conduct of future studies Design…
- Conditions
- Lung Cancer, Squamous Cell Carcinoma, Head and Neck Cancer, Hepatic Carcinoma
- Trial name
- VM4-037 (NCT00884520)
- Testing
- [F-18] VM4-037
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Siemens Molecular Imaging
Obstructive Sleep Apnea, Treatment Compliance
Impact of Automatic Positive Airway Pressure on Treatment Compliance in OSA Patients Awaiting Bariatric Surgery
Obstructive sleep apnea (OSA) is a syndrome characterized by intermittent dynamic obstruction of the upper airways that causes a fall in oxygen saturation, reflex sympathetic activation and sleep micro-arousals.
- Conditions
- Obstructive Sleep Apnea, Treatment Compliance, Automatic Positive Airway Pressure
- Trial name
- APAP-CPAP (NCT02209220)
- Testing
- Positive airway pressure for the treatment of OSA
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Laval University
Obstructive Sleep Apnea
Stimulation Therapy for Apnea Reduction (Www.theSTARtrial.Com)
The purpose of this clinical trial is to demonstrate long-term safety and efficacy of the Inspire system. The Inspire Upper Airway Stimulation (UAS) therapy is intended to treat moderate-to-severe obstructive sleep apnea by…
- Trial name
- STAR (NCT01161420)
- Testing
- Inspire Upper Airway Stimulation System
- Where
- 22 sites in United States, Belgium and 3 more
- Volunteers
- 929 people
- Sponsor
- Inspire Medical Systems, Inc.
Melanoma, Meningioma
T Cell Receptor Immunotherapy Targeting NY-ESO-1 for Patients With NY-ESO-1 Expressing Cancer
Background: The National Cancer Institute (NCI) Surgery Branch has developed an experimental therapy for treating patients with cancer that involves taking white blood cells from the patient, growing them in the laboratory in…
- Conditions
- Melanoma, Meningioma, Breast Cancer, Non-Small Cell Lung Cancer
- Trial name
- NCT01967823
- Testing
- Anti-NY ESO-1 mTCR PBL, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Lung Cancer
Study of 18F-Fluoro-PEG6-IPQA
The goal of this clinical research study is to learn if an imaging solution called 18F-PEG6-IPQA can help to find tumors when used in positron emission tomography (PET) scans.
- Trial name
- NCT01320059
- Testing
- 18F-PEG6-IPQA, Positron emission tomography (PET)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Rheumatoid Arthritis, Atherosclerotic Ischemic Disease
Coronary Computed Tomography Angiography In Rheumatoid Arthritis Study
The Coronary Computed Tomography Angiography in Rheumatoid Arthritis study is part of the multinational, prospective, observational Autoimmunity and Atherosclerosis in Rheumatic Diseases cohort (https://atacc-rd.com) that…
- Conditions
- Rheumatoid Arthritis, Atherosclerotic Ischemic Disease, Pulmonary Disease, Depressive Disorder
- Trial name
- COTIRA (NCT07363980)
- Where
- 4 sites in Denmark
- Volunteers
- 4,000 people
- Sponsor
- Ellen Margrethe Hauge
Carcinoma, Non-Small-Cell Lung
A Study of LY2875358 in Participants With Non-Small Cell Lung Cancer With Activating Epidermal Growth Factor Receptor Mutations
The primary purpose of this study is to compare the efficacy of the study drug LY2875358, given together with erlotinib, against erlotinib, alone.
- Trial name
- Balise (NCT01897480)
- Testing
- LY2875358, Erlotinib
- Where
- 45 sites in Denmark, France and 7 more
- Volunteers
- 168 people
- Sponsor
- Eli Lilly and Company
Unspecified Adult Solid Tumor, Protocol Specific
A Dose Escalation Trial of PR610 Treating Patients With Solid Tumors
The purpose of this study is to determine the Maximum Tolerated Dose and the Dose-Limiting Toxicity of the drug to further evaluate safety and antitumor activity.
- Trial name
- NCT01631279
- Testing
- PR610
- Where
- 6 sites in United States, New Zealand
- Volunteers
- 33 people
- Sponsor
- Proacta, Incorporated
Non Small Cell Lung Cancer, T790M
Osimertinib for Russian EGFR T790M Mutation-positive NSCLC Patients Who Progressed on or After EGFR TKI Therapy
The purpose of this study is to assess safety of Osimertinib in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with progression during or after therapy with a prior EGFR tyrosine kinase inhibitor…
- Conditions
- Non Small Cell Lung Cancer, T790M, EGFR Gene Mutation
- Trial name
- TRUST (NCT05314296)
- Where
- Russia
- Volunteers
- 70 people
- Sponsor
- N.N. Blokhin National Medical Research Center of Oncology
COPD
Theophylline in Chronic Obstructive Pulmonary Disease
This will be a prospective randomized double-blinded parallel group clinical trial evaluating the short-term effects of theophylline therapy on exercise duration and lung function in patients with chronic obstructive pulmonary…
- Trial name
- NCT00299858
- Testing
- Theophylline
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Ottawa Hospital Research Institute
Asthma
BI 671800 ED in Steroid-naive Asthmatic Patients
This is a 6 week study to investigate the effectiveness and safety of BI 671800 ED in patients with asthma who do not take inhaled corticosteroids.
- Trial name
- NCT01092143
- Testing
- BI 671800, Fluticasone propionate
- Where
- 92 sites in United States, Australia and 8 more
- Volunteers
- 389 people
- Sponsor
- Boehringer Ingelheim
Lung Cancer
Cutting-edge IMAGING Technologies to Improve the SAFEty and the Sustainability of LUNG Cancer Screening and the Accuracy of Non-invasive Lung Nodules Characterization
Low-dose computed tomography (LDCT) is used in individuals at high risk of developing lung cancer (smokers over 50 years of age), as it allows for the identification of pulmonary nodules, which, in a small percentage of cases…
- Trial name
- NCT06963515
- Testing
- Magnetic Resonance Imaging
- Volunteers
- 250 people
- Sponsor
- IRCCS San Raffaele
Lung Cancer, Lung Neoplasms
Liquid Biopsy-Based Pre-Screening to Streamline LDCT Lung Cancer Screening in High-Risk Individuals
This study evaluates the feasibility and cost-effectiveness of using a blood-based liquid biopsy assay as a pre-screening tool before low-dose CT (LDCT) for lung cancer screening.
- Conditions
- Lung Cancer, Lung Neoplasms, Early Lung Cancer Detection, Cancer Screening
- Trial name
- NCT07358715
- Testing
- Liquid Biopsy (SPOT-MAS Assay), Exosome-Based Liquid Biopsy Assay, Low-Dose CT Thorax (LDCT)
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
COPD Exacerbation
Using a Closed-loop System for Oxygen Delivery (FreeO2) to Optimize Oxygentherapy in Patients With COPD Exacerbation
Aim: The purpose of this study is to evaluate the use feasibility of FreeO2 so as to deliver automatically oxygen and to enable a remote medical monitoring with a homogeneous patient population hospitalize for Chronic obstructive…
- Trial name
- NCT01393015
- Testing
- Automated settings on the oxygen delivery device, Manual settings with FreeO2 system in collection mode
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
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