Clinical trials: Respiratory System
MSI-H Colorectal Cancer, Melanoma
Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors
This is an open-label, parallel group, non-randomized, multicenter phase II study to evaluate the efficacy of spartalizumab (cohorts 1 and 2) and tislelizumab (cohort 3) in monotherapy in patients with PD1-high-expressing tumors.
- Conditions
- MSI-H Colorectal Cancer, Melanoma, Anal Carcinoma, Mesothelioma
- Trial name
- ACROPOLI (NCT04802876)
- Testing
- Spartalizumab, Tislelizumab
- Where
- Spain
- Volunteers
- 184 people
- Sponsor
- SOLTI Breast Cancer Research Group
Chronic Obstructive Pulmonary Disease
An Evaluation of Post Discharge Utilization Among Patients With an Acute Exacerbation of COPD
Patients who are hospitalized at select Carolinas Healthcare System (CHS) sites with Chronic Obstructive Pulmonary Disorder (COPD) acute exacerbation symptoms will be treated per the CHS COPD Clinical Pathway.
- Trial name
- NCT03207776
- Testing
- Usual Care, COPD Clinical Pathway
- Where
- 8 sites in United States
- Volunteers
- 4,832 people
- Sponsor
- Wake Forest University Health Sciences
Bronchiolitis
High Flow in Infants With Bronchiolitis
In this multi-centre randomized controlled trial the investigators compare the effect on dyspnoea severity of oxgen delivery through High Flow Nasal cannula with Low Flow Nasal Prongs in children < 2 years of age hospitalised for…
- Trial name
- NCT02913040
- Testing
- High Flow Nasal Cannula, Low Flow Nasal Prongs
- Where
- 7 sites in Netherlands
- Volunteers
- 111 people
- Sponsor
- Princess Amalia Children's Clinic
Chronic Disease, Covid-19 Pandemic
Effect of Hand-Washing Training in Covid-19
This study was conducted in order to inform, the women with chronic disease in rural areas, about hand-washing and nutrition, and to evaluate the efficiency of the training program.
- Trial name
- NCT04957017
- Testing
- Training
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mehmet Akif Ersoy University
Long COVID
VSL#3® vs Placebo in the Treatment of Fatigue and Other Symptoms in Long Covid (DELong#3)
This study aims to evaluate the effectiveness of VSL#3® in reducing Fatigue and other symptoms in Long Covid Syndrome compared to placebo.
- Trial name
- DELong#3 (NCT05874089)
- Testing
- VSL#3®
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Chronic Obstructive Pulmonary Disease
A Study to Evaluate the Efficacy of MEDI8968 in Chronic Obstructive Pulmonary Disease
The purpose of this study is to evaluate the effect of MEDI8968 on the rate of moderate or severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in adult subjects with symptomatic, moderate to very severe…
- Trial name
- SPRING (NCT01448850)
- Testing
- MEDI8968 600 mg IV, 300 mg SC
- Where
- 60 sites in United States, Bulgaria and 8 more
- Volunteers
- 464 people
- Sponsor
- MedImmune LLC
Severe Persistent Asthma
Identification of Serum Biomarkers for CD15+ Hypodense Neutrophils in Severe Asthma
The goal of this study is to identify a serum biomarker(s) that can detect increased levels of a population of CD15+ hypodense neutrophils termed low-density granulocytes (LDG) in the blood of patients with severe persistent…
- Trial name
- NCT02659618
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Rush University Medical Center
Locally Advanced or Metastatic Non-Small Cell Lung Cancer
A Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations
DESTINY-Lung04 will investigate the efficacy and safety of Trastuzumab Deruxtecan (T-DXd) versus Standard of Care (SoC) as first-line treatment of Non-Small Cell Lung Cancer (NSCLC) with HER2 Exon 19 or 20 mutations
- Trial name
- NCT05048797
- Testing
- Trastuzumab Deruxtecan, Cisplatin, Carboplatin
- Where
- 130 sites in United States, Austria and 18 more
- Volunteers
- 454 people
- Sponsor
- AstraZeneca
COPD, Asthma
Perception of the Benefits and Effectiveness of Inhalation Therapy in Patients With Obstructive Dyspnea
Obstructive ventilatory disorders, including chronic obstructive pulmonary disease (COPD), asthma, and pulmonary emphysema, are chronic conditions characterized by progressive airflow limitation and worsening dyspnea, leading to…
- Trial name
- NCT07903597
- Testing
- Survey
- Where
- Italy
- Volunteers
- 101 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
SARS-CoV-2, COVID19
CORIMUNO19-ECU: Trial Evaluating Efficacy and Safety of Eculizumab (Soliris) in Patients With COVID-19 Infection, Nested in the CORIMUNO-19 Cohort
The overall objective of the study is to determine the therapeutic effect and tolerance of Eculizumab in patients with moderate, severe pneumonia or critical pneumonia associated with Coronavirus disease 2019 (COVID-19).
- Trial name
- CORIMUNO19-ECU (NCT04346797)
- Testing
- Eculizumab
- Where
- 3 sites in France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Down Syndrome, Obstructive Sleep Apnea
Using Personal Mobile Technology to Identify Obstructive Sleep Apnea in Children With Down Syndrome (UPLOAD)
This study aims to see if mobile video clips (smartphone recordings) can be used to screen children with Down syndrome to identify those at highest risk of obstructive sleep apnea (OSA), so they can be prioritized for an earlier…
- Conditions
- Down Syndrome, Obstructive Sleep Apnea, Child
- Trial name
- UPLOAD (NCT04022460)
- Testing
- Video clip assessment, Polysomnography (sleep study), Educational webinar
- Where
- Canada
- Volunteers
- 141 people
- Sponsor
- Children's Hospital of Eastern Ontario
Asthma
Safety, Tolerability, and Efficacy of AIN457 in Patients With Uncontrolled Asthma
This study is a preliminary proof of efficacy study of AIN457 in patients with bronchial asthma that is poorly controlled with the current standard of care.
- Trial name
- NCT01478360
- Testing
- AIN457 (secukinumab)
- Where
- 9 sites in Germany, United Kingdom
- Volunteers
- 46 people
- Sponsor
- Novartis Pharmaceuticals
Non-Small Cell Lung Cancer
PharmacoEconomic Assessment IRESSA® in the Treatment of Non-Small-Cell Lung Cancer (NSCLC)
The objective of this pharmacoeconomics (PE) study is to evaluate the cost- effectiveness analysis and cost-utility analysis of IRESSA® as first line treatment of NSCLC from the society perspective, based on resources and…
- Trial name
- NCT00173524
- Testing
- PharmacoEconomic Assessment
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Multiple Sclerosis
Applications of Nanotechnology in Multiple Sclerosis by Respiratory Samples
Multiple Sclerosis (MS) is a complex multi-factorial disease, with underlying both genetic and environmental factors. Different populations have different susceptibility.
- Trial name
- MS-NANOSE (NCT01206023)
- Testing
- NA-NOSE artificial olfactory system
- Where
- 2 sites in Israel
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Lung Cancer
Fluorine F 18 FEQA in Patients With Stage III or Stage IV Non-Small Cell Lung Cancer and in Healthy Participants
RATIONALE: Fluorine F 18 FEQA may be an effective radioactive drug to use with positron emission tomography (PET) scans. PURPOSE: This clinical trial is studying the use of fluorine F 18 FEQA in patients with stage III or stage…
- Trial name
- NCT00444223
- Testing
- fluorine F 18 FEQA + positron emission tomography
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Cystic Fibrosis, Cystic Fibrosis in Children
Program Of Exercises During The Hospitalization Of Children And Adolescents With Cystic Fibrosis
The objective of this study was to evaluate the effect of a physical exercise program on the functional capacity of children and adolescents with cystic fibrosis hospitalized at the Hospital de Clínicas of Porto Alegre (HCPA)…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis in Children, Cystic Fibrosis Pulmonary Exacerbation, Cystic Fibrosis With Exacerbation
- Trial name
- NCT03273959
- Testing
- Exercise protocol
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Bronchial Asthma
A Comparative Study of an Integrated Pharmaceutical Care Plan and a Routine Care in Bronchial Asthma
The aim of the study is to compare the effect of asthma care by clinical pharmacist intervention versus routine care on asthma control.
- Trial name
- NCT02046759
- Testing
- Pharmacist- Intervention, Routine Care
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Croup
Management of Recurrent Croup
Presently children who experience recurring croup symptoms receive a variety of treatments. This is because it is not clear which treatments may be best.
- Trial name
- NCT01748162
- Testing
- Fluticasone, Prednisolone IF needed
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan
Head and Neck Cancer
Prediction of Outcome After Chemoradiotherapy for Head and Neck Cancer Using Functional Imaging and Tumor Biology
Despite uniform histopathological definition the response of locally advanced squamous cell carcinomas of the head and neck (HNSCC) to ionizing radiation differs greatly with locoregional recurrences burdening this patient…
- Trial name
- NCT01829646
- Testing
- functional MRI, Hypoxia gene expression profile., Functional MRI before start of treatment.
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Severe Asthma
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)
The objective of this study is to assess the potential for GB-0895 to improve the health of adolescents and adults with severe asthma that is uncontrolled by inhaled corticosteroids (ICS) and conventional asthma controllers.
- Trial name
- NCT07359846
- Testing
- GB-0895
- Where
- 158 sites in United States, Argentina and 17 more
- Volunteers
- 786 people
- Sponsor
- Generate Biomedicines
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