Clinical trials: Respiratory System
Influenza, Human
Vaccine Pandemic Preparedness Through Airway Immunology Characterization
The study aims to compare the effectiveness of live attenuated influenza vaccines (LAIV) and intramuscular-inactivated vaccines (IIV) in healthy individuals aged 18-49.
- Trial name
- VAXXAIR (NCT05921448)
- Testing
- Vaxigripetra, Flumist
- Where
- 7 sites in Denmark, United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Copenhagen Respiratory Research
Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell
A Phase 1 Study of GNR-051 in Subjects With Advanced Malignancies
It is a Phase 1 Multicenter Open-Label Multi-Cohort Dose-Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Immunogenicity of GNR-051 in Subjects with Advanced Solid Malignancies.
- Conditions
- Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Melanoma
- Trial name
- NCT04544748
- Testing
- GNR-051
- Where
- 12 sites in Russia
- Volunteers
- 48 people
- Sponsor
- AO GENERIUM
Hypoxia Altitude Simulation Test, High Altitude
Hypoxia-altitude Testing to Predict Altitude Related Adverse Health Effects in Chronic Obstructive Pulmonary Disease (COPD) Patients
The predictive value of the hypoxia altitude simulation test (HAST) or other baseline values to predict altitude-related adverse health effects (ARAHE) is not established.
- Trial name
- NCT04915378
- Testing
- hypoxia altitude simulation test (HAST) at 760m, High Altitude (3100m)
- Where
- Kyrgyzstan
- Volunteers
- 75 people
- Sponsor
- University of Zurich
Diaphragmatic Plication, Diaphragmatic Paralysis
Short- and Long-term Effects of Robot-assisted Plication in Diaphragmatic Paralysis
Diaphragmatic paralysis may lead to severe symptoms such as breathlessness and reduced physical capacity. Diaphragmatic plication using Robotic-Assisted Thoracic Surgery (RATS) is a minimally invasive surgical technique developed…
- Conditions
- Diaphragmatic Plication, Diaphragmatic Paralysis, Diaphragmatic Eventration
- Trial name
- RAPIDLY (NCT06919185)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala County Council, Sweden
Covid19
RCT of Modified Qing Fei Pai Du Tang (mQFPD) for COVID-19
This is a multi-center, randomized, double-blind, placebo-controlled clinical trial to evaluate a 21-herb formula named modified Qing Fei Pai Du Tang (mQFPD) to treat COVID-19-positive outpatients with mild-to-moderate symptoms…
- Trial name
- MACH19 (NCT04939415)
- Testing
- mQFPD, organic brown rice
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Lung Cancer (Non-Small Cell), Sarcopenia
Multimodal Nutritional and Sarcopenia Assessment for Risk Stratification in Lung Cancer Surgery
This prospective observational cohort study aims to evaluate the prognostic value of multimodal nutritional status and sarcopenia assessment in patients undergoing lung cancer surgery.
- Conditions
- Lung Cancer (Non-Small Cell), Sarcopenia, Malnutrition Severe
- Trial name
- NCT07500376
- Testing
- Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Ondokuz Mayıs University
Cancer of the Larynx
Phase II Trial Evaluating Elimination of Radiation Therapy
The purpose of this study is to determine if reducing or eliminating radiation treatment to one or both sides of the neck where there is no evidence of cancer can help spare the side effects of radiation treatment for head and…
- Trial name
- NCT00593840
- Testing
- Intensity modulated radiation therapy
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Washington University School of Medicine
COVID-19
Probe-based Confocal Laser Endomicroscopy in Critically Ill COVID-19 Patients
The study is devoted to the comparative analysis of the data received in patients with COVID-19 lung pathology using the method of probe-based confocal laser endomicroscopy of distal airways and two reference methods: high…
- Trial name
- NCT04451889
- Testing
- miniprobe Alveoflex
- Where
- Russia
- Volunteers
- 15 people
- Sponsor
- Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
Staphylococcus Aureus
Aurexis® in Cystic Fibrosis Subjects Chronically Colonized With Staphylococcus Aureus in Their Lungs
Patients who are at least 7 years old with stable Cystic Fibrosis who have Staphylococcus aureus in their Lungs will be enrolled into the study and receive one dose of Aurexis® intravenously on Study Day 1, and will be followed…
- Trial name
- NCT00198289
- Testing
- Aurexis® (tefibazumab)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Bristol-Myers Squibb
Long Covid, Covid19
Clinical and Haematological Phenotypes in Long COVID
Analysis of the relationship between clinical characteristics and haematological parameters in long COVID. The novel coronavirus (Covid19) pandemic declared by the World Health Organisation in March 2020 has had an enormous huge…
- Trial name
- NCT04659889
- Testing
- Blood sampling (venesection)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- HCA International Limited
Low Back Pain, Mechanical, Complementary Therapies
Craniosacral Therapy as a Self-help Strategy for Patients With Chronic Non-specific Back Pain
Craniosacral Therapy (CST) is a non-manipulative, very gentle manual treatment method. Although the mechanisms of action have not yet been investigated sufficiently, initial clinical trials support CST efficacy/effectiveness in…
- Conditions
- Low Back Pain, Mechanical, Complementary Therapies, Progressive Muscle Relaxation
- Trial name
- CRANIO4ME (NCT04199091)
- Testing
- Craniosacral Therapy (CST) self-help techniques, Progressive Muscle Relaxation (PMR)
- Where
- Germany
- Volunteers
- 76 people
- Sponsor
- Universität Duisburg-Essen
Cystic Fibrosis, Bronchiectasis
Prevention of Bronchiectasis in Infants With Cystic Fibrosis
The general aim of this project is to conduct a randomized, double-blind, placebo-controlled clinical trial of azithromycin to determine whether treatment from infancy is safe and will prevent the onset of bronchiectasis.
- Trial name
- COMBATCF (NCT01270074)
- Testing
- Azithromycin
- Where
- 10 sites in Australia, New Zealand
- Volunteers
- 130 people
- Sponsor
- The University of Queensland
Neuromuscular Diseases (NMD), Pneumothorax
Incidence and Risk Factors of Pneumothorax in Patients With Neuromuscular Diseases
Neuromuscular diseases can cause weakness of the respiratory muscles, leading to respiratory pump failure and respiratory insufficiency.
- Trial name
- MYOPNEUMO (NCT07909018)
- Testing
- Cough assistance device and/or thoracic mobilization and/or mechanical ventilation
- Where
- France
- Volunteers
- 31,202 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Influenza Virus Infection, Influenza-like Illness
Direct and Indirect Benefits of Influenza Vaccination in Schools and Households
The purpose of this study is to determine the degree of indirect benefits to family members and classmates resulting from administration of influenza vaccine to children.
- Conditions
- Influenza Virus Infection, Influenza-like Illness, Acute Respiratory Infection
- Trial name
- NCT00981513
- Testing
- Trivalent live attenuated seasonal influenza vaccine, Monovalent live attenuated pandemic influenza vaccine, Saline
- Where
- Hong Kong
- Volunteers
- 6,300 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Heart Failure, Hypertension, Pulmonary
Measurement of Endothelial Function and Cardiac Output: New Methods
The main purpose of this study is to analyse test-retest-reliability of functional quantification of endothelial dysfunction through puls-amplitude-tonometry in patients with heart failure with preserved/reduced ejection…
- Conditions
- Heart Failure, Hypertension, Pulmonary, Hypertension, Diabetic Nephropathies
- Trial name
- NCT02299960
- Testing
- Endo-PAT, NICOM
- Where
- Germany
- Volunteers
- 101 people
- Sponsor
- Charite University, Berlin, Germany
Sepsis, Acute Respiratory Distress Syndrome
Corticosteroids in Hyperinflammatory Phenotype of Critical Illness
The goal of this clinical trial is to learn whether methylprednisolone improves outcomes in critically ill patients with a hyperinflammatory phenotype. It will also evaluate the safety of methylprednisolone at different doses.
- Trial name
- CHIP (NCT07511582)
- Testing
- Methylprednisolone (MP)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Bin Du
Trauma, Covid19
The Impact of COVID-19 Pandemic to Trauma Patients in Emergency Department: A Multicenter Experience of Istanbul
COVID-19, which emerged in China in December 2019, has become a pandemic with its spread to many countries of the world. The aim of this multi-centered study is to guide for the approach, organization, diagnosis and treatment of…
- Trial name
- NCT04479124
- Testing
- COVID-19 PCR
- Where
- Turkey (Türkiye)
- Volunteers
- 2,000 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Acute Respiratory Failure, Pediatric Respiratory Distress Syndrome
Closed-loop Synchronization Versus Conventional Synchronization
A prior research indicated that asynchrony between the patient and ventilator occurred in 33 percent of 19,175 breaths, and was seen in every patient.
- Trial name
- CHESTSIPP (NCT05731024)
- Testing
- close-loop synchronization controller with SPONT mode, Conventional synchronization settings with SPONT mode
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
COVID-19
Impact of COVID-19 Outbreak on Non-COVID-19 Patients
The Geneva Canton organized the health crisis of the COVID-19 epidemic around the care of COVID patients at the University Hospital (HUG), by moving the care of non-COVID patients to private hospitals of the canton.
- Trial name
- NoCOVImpact (NCT04537559)
- Where
- Switzerland
- Volunteers
- 240,000 people
- Sponsor
- University Hospital, Geneva
Chronic Obstructive Pulmonary Disease, Lung Diseases, Obstructive
TCM Daoyin Therapy in Individuals At-risk for COPD
Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable disease. The aim of prospective randomized study is to evaluate the effects of TCM Daoyin training on Individuals at-risk for COPD.
- Trial name
- NCT05940480
- Testing
- TCM Daoyin, Health education
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
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