Clinical trials: Respiratory Tract Disease
Pulmonary Arterial Hypertension
Resynchronisation Therapy of Right Ventricle in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension is a disease characterised by pathological changes in the pulmonary arteries leading to a progressive increase in pulmonary vascular resistance and pulmonary artery pressure.
- Trial name
- RETRIEVE (NCT01905189)
- Testing
- Resynchronization therapy of right ventricle
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Caen
Non-Small Cell Lung Cancer (NSCLC)
A Clinical Study in Three-arm of Lurbinectedin (PM01183) Alone or in Combination With Gemcitabine and a Control Arm With Docetaxel as Second Line Treatment in Non-Small Cell Lung Cancer (NSCLC) Patients
A clinical study of lurbinectedin(PM01183) alone or in combination with gemcitabine in comparison to docetaxel for the treatment of unresectable non-small cell lung cancer (NSCLC)patients
- Trial name
- NCT01951157
- Testing
- Docetaxel, Gemcitabine, Lurbinectedin (PM01183)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- PharmaMar
HIV Infections, Emphysema
Prevalence and Pathogenesis of Lung Disease in a Large HIV Cohort-coordinating Center
Despite the availability of highly active antiretroviral therapy (HAART), lung diseases remain a leading cause of morbidity and mortality in those with HIV infection.
- Conditions
- HIV Infections, Emphysema, Chronic Obstructive Pulmonary Disease, Pneumocystis
- Trial name
- MACS (NCT00870857)
- Where
- 2 sites in United States
- Volunteers
- 407 people
- Sponsor
- University of Pittsburgh
COPD, Education
Efficacy of an Education Protocol in the Correction of Inhalation Techniques in COPD
This study evaluates the implementation of an education protocol and its impact on the correct inhalation technique in COPD patients presenting errors or mistakes.
- Trial name
- NCT03144557
- Testing
- Education
- Where
- Argentina
- Volunteers
- 61 people
- Sponsor
- Hospital Italiano de Buenos Aires
Post Covid-19 Respiratory, Dyspnea
The Effects of a Music Therapy Respiratory Protocol on Post-Covid-19 Respiratory Symptoms
The effects of a tested and published music therapy respiratory protocol shown to be efficacious with pediatric asthma and adult COPD is being studied with individuals living with post-Covid-19 respiratory symptoms.
- Conditions
- Post Covid-19 Respiratory, Dyspnea, SARS-CoV 2
- Trial name
- NCT05231512
- Testing
- Respiratory Music Therapy Protocol
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Allergic Asthma
Cobra (Severe Asthma)Medical-economic
The severe asthma is a major source of expenses in term of public health, while it concerns no more than 5 % of the asthmatics. The expenses is direct (medicines, hospitalizations, care) but especially indirect (absenteeisms…
- Trial name
- Cobra (NCT01669681)
- Where
- France
- Volunteers
- 81 people
- Sponsor
- University Hospital, Montpellier
COVID-19
Homologous vs Heterologous Third Vaccination in Kidney Transplant Recipients Kidney Transplant Recipients
Randomized-controlled trial comparing homologous (mRNA vaccine) vs. heterologous (vector vaccine) for third SARS-CoV-2 vaccine dose in kidney transplant recipients not responding to initial prime-boost vaccination with an mRNA…
- Trial name
- BOOST_TX (NCT05324319)
- Testing
- Ad26COVS1, ChAdOx1 SARS2 Vaccine, BNT162B2
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Vienna
Bronchiolitis
HFNC Versus NCPAP/ NPPV in Infants With Severe Bronchiolitis
The purpose of the study was to test the null hypothesis that there is no difference between nasal continuous positive airway pressure / nasal positive pressure ventilation (NCPAP/NPPV) and high flow nasal cannula (HFNC) devices…
- Trial name
- NCT04650230
- Testing
- nasal continuous positive airway pressure / nasal positive pressure ventilation (NCPAP/NPPV) and high flow nasal cannula (HFNC) devices
- Volunteers
- 268 people
- Sponsor
- Children's Hospital of Tunis
Traumatic Brain Injury, Fatigue
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
Patients with a history of mild traumatic brain injury (mTBI) or post acute sequelae of SARS-CoV-2 (PASC) and abnormal growth hormone secretion, as measured by glucagon stimulation test, will be treated with replacement growth…
- Conditions
- Traumatic Brain Injury, Fatigue, Cognitive Impairment, COVID-19
- Trial name
- NCT03554265
- Testing
- Somatropin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
COPD (Chronic Obstructive Pulmonary Disease), Intersitital Lung Disease
MoblO2 to Maintain Oxygenation
Many patients with chronic lung disease (e.g., chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD)) require supplemental oxygen (O2) at some point during their disease course.
- Trial name
- SSeifert (NCT07704567)
- Testing
- MoblO2 controls O2 flow, MoblO2 does not control flow
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Minnesota HealthSolutions
Non-small Cell Lung Cancer, Non-small Cell Lung Cancer Metastatic
ALEctinib for the Treatment of Pretreated RET-rearranged Advanced Non-small Cell Lung Cancer
A research study to evaluate the activity of alectinib for the Treatment of pretreated patients with advanced NSCLC that have confirmed RETrearrangement.
- Conditions
- Non-small Cell Lung Cancer, Non-small Cell Lung Cancer Metastatic, Non-small Cell Lung Cancer Recurrent
- Trial name
- ALERT-lung (NCT03445000)
- Testing
- Alectinib
- Where
- 19 sites in Belgium, Ireland and 4 more
- Volunteers
- 14 people
- Sponsor
- ETOP IBCSG Partners Foundation
Rhinitis, Allergic, Asthma
Study on the Correlation Between Intestinal Microecology and Allergic Diseases in Children
Allergic diseases, including allergic reactions of respiratory tract and skin, are often triggered by mast cell degranulation mediated by allergen-specific IgE and chronic inflammation of target organs, which are involved in a…
- Conditions
- Rhinitis, Allergic, Asthma, Dermatitis, Atopic, Urticaria
- Trial name
- NCT04938700
- Testing
- probiotics, conventional medical treatment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Carcinoma, Non-Small-Cell Lung
Study to Assess Safety/Tolerability/Efficacy of Gefitinib Versus Docetaxel in Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
This is a randomized, open- label, parallel group, phase IV, multicentre study. The total number of patients expected to be recruited is 40.
- Trial name
- NCT00536107
- Testing
- Gefitinib, CT or MRI, Docetaxel
- Where
- Taiwan
- Volunteers
- 14 people
- Sponsor
- AstraZeneca
Healthy Participants
A Phase 1 Trial of AMG 691 in Healthy Chinese and Japanese Volunteers
The trial is designed to evaluate the pharmacokinetics, safety, tolerability, and immunogenicity of AMG 691 in healthy Chinese and Japanese participants
- Trial name
- NCT07745907
- Testing
- AMG 691
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Amgen
Carcinoma, Non-Small-Cell Lung
High-dose Icotinib Treatment Beyond Progression in EGFR Mutant NSCLC
The purpose of this study is to investigate whether high-dose icotinib treatment beyond disease progression is beneficial for NSCLC patients who have EGFR mutation and who have responded to EGFR TKI.
- Trial name
- NCT02960607
- Testing
- Icotinib
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Chinese Academy of Medical Sciences
Bronchiolitis Obliterans Syndrome
Imaging and Understanding BOS in Lung Transplantation
This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years.
- Trial name
- NCT02316392
- Testing
- Hyperpolarized Helium-3 MRI
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Idiopathic Pulmonary Fibrosis
Responsiveness and MID of 4 Metre Gait Speed in Idiopathic Pulmonary Fibrosis
This study measures the 4 metre gait speed (4MGS) test in patients with Idiopathic Pulmonary Fibrosis (IPF). The investigators are interested to see whether usual walking speed in IPF patients changes following pulmonary…
- Trial name
- IPFRESP (NCT02530736)
- Testing
- 4 metre gait speed
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Heart Diseases, Lung Diseases
The Usefulness of Patients Receiving Their Own Letter After an Outpatient Attendance
As part of the NHS plan it has been proposed to extend some consultants' usual practices and to send all patients copies of the letters sent to their general practitioners (GPs) following outpatient consultations.
- Trial name
- NCT00129636
- Testing
- Additional specific letter written to patient
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Sleep Apnea, Obstructive, Respiratory Insufficiency
Monitored Saturation Post-ICU
The overall aim with this project is to describe the correlation between measured and charted saturation after intensive care and also describe the saturation-pattern in these patients.
- Trial name
- NCT02290236
- Testing
- Pulseoximetry
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Karolinska University Hospital
COVID-19
Prospective Quality Register of Patients With Confirmed Covid-19 at Oslo University Hospital
Covid-19 is a recently emerging infectious disease with a very large impact on health care world-wide. The disease is still poorly described. It is an urgent need for better clinical characteristics.
- Trial name
- CovidRegOUH (NCT04345536)
- Where
- Norway
- Volunteers
- 2,519 people
- Sponsor
- Oslo University Hospital
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