Clinical trials: Respiratory Tract Disease
Chronic Obstructive Pulmonary Disease
Long Term Evaluation of Activity Levels Post Pulmonary Rehabilitation
Sustained improvement after pulmonary rehabilitation in activity levels as measured by an activity armband. Pulmonary rehabilitation is utilized to improve exercise capacity, quality of life and prognosis for patients who suffer…
- Trial name
- NCT01530412
- Testing
- Pulmonary Rehabilitation
- Where
- Ireland
- Volunteers
- 65 people
- Sponsor
- Beaumont Hospital
Post Covid-19 Condition
Functional Ability, Symptoms and Quality of Life in Patients With Post Covid-19 Condition
Up to 20% of patients with Covid-19 develop symptoms that last more than 3 months, which is known as long Covid or Post-Covid-19 condition.
- Trial name
- LC-cohort (NCT05699512)
- Testing
- Multiprofessional, tailored rehabilitation
- Where
- Finland
- Volunteers
- 400 people
- Sponsor
- Helsinki University Central Hospital
Asthma
Foster 100/6 mg NEXThaler Versus Foster 100/6mg Pressurized Metered-dose Inhaler (pMDI) in Patients With Controlled Asthma.
Primary Objective To demonstrate the non-inferiority of Foster® NEXThaler® 100/6 µg versus (vs.) Foster® pressurised metered dose inhaler (pMDI) 100/6 µg in terms of pulmonary function (change from baseline to the entire…
- Trial name
- FORTUNE (NCT03453112)
- Testing
- Foster 100/6µg NEXThaler, Foster 100/6µg pMDI
- Where
- 51 sites in China
- Volunteers
- 494 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Asthma
Effects of a Pedometer-based Unsupervised Exercise Program Upon Lifestyle Physical Activity of Asthmatic Adults
The purpose of this study is to determine whether a pedometer-based unsupervised exercise program is more effective than a general exercise recommendation to increase lifestyle physical activity in adult patients with asthma.
- Trial name
- NCT01984281
- Testing
- Pedometer-based physical activity prescription
- Where
- Brazil
- Volunteers
- 37 people
- Sponsor
- Federal University of Juiz de Fora
Cervical Cancer, Breast Cancer
Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors
A Phase 1 Open-Label, First-in-human, Dose Escalation and Expansion Study to Determine the Safety, Tolerability, Dosimetry, Pharmacokinetics, and Preliminary Efficacy of 212Pb-DOTAM-GRPR1 in Adult Participants with Recurrent or…
- Conditions
- Cervical Cancer, Breast Cancer, Colon Cancer, NSCLC
- Trial name
- NCT05283330
- Testing
- ²¹²Pb-DOTAM-GRPR1
- Where
- 8 sites in United States
- Volunteers
- 48 people
- Sponsor
- Orano Med Theranostics, SAS
Influenza
Immunogenicity and Safety of GSK Biologicals' FluLaval® TF
The present study is intended to assess a novel formulation of FluLaval. The idea is to obtain preliminary data on the safety and immune response to the FluLaval TF influenza vaccine in adults.
- Trial name
- NCT00727428
- Testing
- FluLaval® TF
- Where
- Belgium
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Thoracic Diseases
Dysphagia in Thoracic Surgical Patients
The proposed study seeks to determine the incidence of dysphagia and vocal fold mobility impairment (VFMI) in individuals undergoing throacic surgical procedures.
- Trial name
- NCT04487028
- Testing
- Fiberoptic Endoscopic Evaluation of Swallowing
- Where
- 3 sites in United States
- Volunteers
- 61 people
- Sponsor
- University of Florida
Nocturia, Insomnia
TUCSON Study: Tackling Underlying Causes of Sleep Related Nocturia Nocturia
The TUCSON study is a cross-sectional observational monocentric study. In order to provide a clinical helpful assessment for urologists for possible missed causes of nocturia, the aim is to investigate the voiding and sleep…
- Conditions
- Nocturia, Insomnia, OSA
- Trial name
- TUCSON (NCT05404828)
- Testing
- Polysomnography, Questionnaires, Blood and urine sample
- Where
- Belgium
- Volunteers
- 65 people
- Sponsor
- University Hospital, Ghent
COVID-19, Pneumonia
Study of the Efficacy and Safety of Ruxolitinib to Treat COVID-19 Pneumonia
The purpose of this study is to determine the safety and efficacy of the drug ruxolitinib in people diagnosed with COVID-19 pneumonia by determining the number of people whose conditions worsen (requiring machines to help with…
- Trial name
- NCT04331665
- Testing
- Ruxolitinib
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University Health Network, Toronto
Chronic Obstructive Pulmonary Disease, Chronic Heart Failure
Mindful Steps 2.0: Promoting Physical Activity in Patients With COPD and HF
The goal of this fully-remote randomized controlled trial is to test the efficacy of Mindful Steps in facilitating physical activity compared to usual standard of care among 136 patients with COPD and/or HF.
- Trial name
- NCT05934565
- Testing
- Mindful Steps
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Beth Israel Deaconess Medical Center
Postoperative Cough, Lung Cancer
Maekmoondong-tang on Post-operative Cough in Patients With Lung Cancer
The aim of the present study is to evaluate the efficacy and safety of Maekmoondong-tang on post-operative cough in patients with lung cancer. A randomized, double-blind, placebo-controlled trial will be conducted.
- Trial name
- NCT03384667
- Testing
- Maekmoondong-tang
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Seong-Gyu Ko
Asthma
Clinical Study on the Efficacy and Safety of SHR-4597 Inhalant in Adult Patients With Asthma
To evaluate the efficacy and safety of SHR-4597 inhalants in adults with asthma: a multicenter, randomized, open-label, positive-controlled Phase II clinical study
- Trial name
- NCT06940700
- Testing
- SHR4597, Budesonide inhalant
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Small Cell Lung Cancer (SCLC)
Tislelizumab Combined With Anlotinib and 2-cycles Irinotecan as Second Line Treatment of SCLC
SCLC has short doubling time, high proliferation rate and early widespread metastasis. Most patients with SCLC have hematogenous metastasis. SCLC is highly sensitive to initial chemoradiotherapy, but the recurrence rate is high.
- Trial name
- NCT05027100
- Testing
- Anlotinib Tislelizumab Irinotecan
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Haibo Zhang
Radiation Toxicity
Oligo-Fucoidan Decrease Lung Radiation Damage
Fucoidan is FDA approved and in common use for treatment of angina. These studies will advance that work to human use. Successful mitigation of lung radiation damage and heart toxicity will improve the quality of life in veterans…
- Trial name
- FIRILI (NCT05616507)
- Testing
- fucoidan
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University WanFang Hospital
Asthma
Aerosol Delivery in Different Types of Nebulizers
Background: Nebulizers design influences efficiency of aerosol delivery. Performance of nebulizers is commonly tested by breathing simulators with static parameters. However, breathing patterns vary in adults.
- Trial name
- NCT02764307
- Testing
- Constant jet nebulizer, Breath enhanced nebulizer, Manual-actuated nebulizer
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Non Small Cell Lung Cancer
Isotoxic Intensity Modulated Radiotherapy (IMRT) in Stage III Non Small Cell Lung Cancer (NSCLC) - A Feasibility Study
This study is for patients having a course of chest radiotherapy treatment after receiving chemotherapy for the treatment of non-small cell lung cancer.
- Trial name
- Isotoxic-IMRT (NCT01836692)
- Testing
- Intensity Modulated Radiotherapy treatment
- Where
- 7 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- Prof Corinne Faivre-Finn
Systemic Sclerosis
Hemodynamic Changes in Connective Tissue Disease
The study serves the identification of early forms of pulmonary arterial hypertension (PAH) in connective tissue disease and the hemodynamic follow-up of the investigated patients.
- Trial name
- NCT01468792
- Where
- Austria
- Volunteers
- 85 people
- Sponsor
- Medical University of Graz
Chronic Rhinosinusitis (CRS), Exacerbations
Effect of Pleuran on the Clinical Course of Patients With Chronic Rhinosinusitis
The goal of this clinical research is to learn if Imunoglukan P4H® as an add-on therapy to the standard of care treatment according to the EPOS guidelines (intranasal corticosteroids and saline irrigation) can help to prevent CRS…
- Conditions
- Chronic Rhinosinusitis (CRS), Exacerbations, Respiratory Tract Infections (RTI), Antibiotic Prophylaxis
- Trial name
- EPCCOR (NCT07460934)
- Testing
- Imunoglukan P4H® capsules
- Where
- 5 sites in Czechia, Slovakia
- Volunteers
- 85 people
- Sponsor
- Pleuran, s.r.o.
COVID 19
BromhexIne And Spironolactone For CoronаVirUs Infection Requiring HospiTalization
Patients with mild and severe COVID 19 will be randomized 1:1 into two groups: experimental, which will get bromhexine and spironolactone, and control. Patients will get investigated therapy for ten days.
- Trial name
- BISCUIT (NCT04424134)
- Testing
- Bromhexine and Spironolactone, Base therapy
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Lomonosov Moscow State University Medical Research and Educational Center
Acute Bronchitis
A Trial Of Azithromycin SR For The Treatment Of Acute Bronchitis And Secondary Infection Of Chronic Respiratory Diseases
To evaluate the clinical efficacy and safety in patients with Acute Bronchitis or Secondary Infection of Chronic Respiratory Diseases receiving a dose of 2 g of azithromycin in the SR formulation.
- Trial name
- NCT00360464
- Testing
- Azithromycin SR
- Where
- 19 sites in Japan
- Volunteers
- 64 people
- Sponsor
- Pfizer
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