Clinical trials: Respiratory Tract Disease
Upper Respiratory Tract Infections
The Association of Hand Hygiene Practice on Primary Schoolgirls Absence Due to URIs in Riyadh City, 2017-2018.
Research Problem: Upper respiratory infections (URIs) are a common reason for absence from schools as it is estimated that children get six to eight episodes every year.
- Trial name
- NCT03535064
- Testing
- Hand Hygiene Workshop
- Where
- Saudi Arabia
- Volunteers
- 496 people
- Sponsor
- Abrar Alzaher
Cystic Fibrosis
PREDICT Trial: PRospective Evaluation of NTM Disease In CysTic Fibrosis
Isolation of nontuberculous mycobacteria (NTM) from the sputum of individuals with CF is an increasingly common finding, and the lack of an evidenced-based approach to the diagnosis of NTM disease has been identified as one of…
- Trial name
- PREDICT (NCT02073409)
- Where
- 19 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Jewish Health
COPD, Healthy Volunteers
Airvo 3 Respiratory Rate Validation Study
This is a clinical performance testing to validate the accuracy of the Airvo 3 device with respiratory rate algorithm manufactured by Fisher \& Paykel Healthcare for continuous respiratory rate monitoring.
- Trial name
- NCT06329609
- Testing
- Airvo 3 with respiratory rate algorithm
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Education Programme on Continuous Positive Airway Pressure Treatment
The purpose of this study is to examine whether an education programme would enhance continuous positive airway pressure (CPAP) adherence.
- Trial name
- NCT01173406
- Testing
- CPAP education
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Pulmonary Embolism, Pulmonary Embolism and Thrombosis
Influence of Diagnostic Errors on the Prognosis of Acute Pulmonary Embolism
Diagnostic errors have been reported frequently in patient with pulmonary embolism since symptoms are not specific. However, there is only scarce evidence that the delay associated with diagnostic errors may impact patient…
- Conditions
- Pulmonary Embolism, Pulmonary Embolism and Thrombosis, Diagnostic Errors, Embolism
- Trial name
- IDEA-PE (NCT03101384)
- Testing
- Diagnostic error
- Where
- France
- Volunteers
- 302 people
- Sponsor
- European Georges Pompidou Hospital
Asthma
TQC2731 Clinical Trial for the Treatment of Severe Asthma With Injection
This study is a multicenter, randomized, double-blind, parallel-group, placebo-controlled Phase III clinical trial designed to evaluate the efficacy and safety of TQC2731 injection (420 mg Q4W) in adult subjects with inadequately…
- Trial name
- NCT06829784
- Testing
- TQC2731 injection
- Where
- 101 sites in China
- Volunteers
- 660 people
- Sponsor
- Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.
Acute Respiratory Distress
the Effect of High Dose Ascorbic Acid on Critically Ill Patients With ARDS
1. To access role of vitamin C supplementation in ARDS patients on the following: Oxidants/ antioxidants imbalance Length of hospital stay Mortality rate Weaning from mechanical ventilator Incidence of adverse drug reaction 2.
- Trial name
- NCT03780933
- Testing
- vitamin c
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Misr International University
Neoplasms
A Study of the Safety and Effects of ADH-1 Given Intravenously as a Single Agent
N-cadherin, a protein involved in blood vessel cell binding, is increased as cancer progresses, and is on the surface of many tumor cells. ADH-1 blocks N-cadherin.
- Trial name
- NCT00264433
- Testing
- ADH -1 (Exherin™)
- Where
- 11 sites in United States, Canada
- Sponsor
- Adherex Technologies, Inc.
Asthma
Evaluation of Dupilumab's Effects on Airway Inflammation in Patients With Asthma
Primary Objective: To evaluate the effect of dupilumab, compared to placebo, on airway inflammation in participants with persistent asthma.
- Trial name
- EXPEDITION (NCT02573233)
- Testing
- Dupilumab SAR231893/REGN668, fluticasone propionate and salmeterol, budesonide and formoterol
- Where
- 16 sites in United States, Canada and 4 more
- Volunteers
- 42 people
- Sponsor
- Sanofi
Melioidosis Pneumonia
Causes of Pneumonia in Yangon
This study will evaluate a new point of care diagnostic test for the diagnosis of melioidosis pneumonia in patients attending outpatient clinics in Yangon, Myanmar
- Trial name
- NCT03578133
- Testing
- InBios® Active Melioidosis DetectTM-Lateral Flow Assay
- Where
- Burma
- Volunteers
- 300 people
- Sponsor
- Myanmar Oxford Clinical Research Unit
Cancer, Dyspnea, Paroxysmal
Fentanyl Buccal Tablet for the Relief of Episodic Breathlessness in Cancer Patients
"Episodic breathlessness (or dyspnea) is one form of chronic refractory breathlessness characterized by a severe worsening of breathlessness intensity or unpleasantness beyond usual fluctuations in the patient's perception.
- Trial name
- EFFENDYS (NCT04635852)
- Testing
- Fentanyl, Immediate release morphine
- Where
- 3 sites in Germany
- Volunteers
- 10 people
- Sponsor
- University of Cologne
COPD
Management of Patients With Chronic Obstructive Pulmonary Disease in Granada: a Clinical Audit
It is actually unknown how are the COPD clinical guidelines followed in primary care in Andalusia, specially for diagnosis and follow up of patients with this diseases.
- Trial name
- Epocap (NCT04691752)
- Testing
- Audit
- Volunteers
- 2,280 people
- Sponsor
- Andalusian School of Public Health
Asthma
Markers of Airway Inflammation in BAL Fluid From Children With Asthma
The study compares the biochemical markers in bronchoalveolar lavage samples from asthmatic children to those markers found in non-asthmatic children with other respiratory diseases.
- Trial name
- NCT00838552
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- National Jewish Health
Respiratory Distress Syndrome
Spinal Cord Stimulation to Shorten Ventilator Dependence in ARDS Patients
This is an early phase, proof-of-concept clinical trial assessing the safety and feasibility of non-invasive spinal cord stimulation to prevent respiratory muscle atrophy in mechanically ventilated ARDS patients.
- Trial name
- NCT05928052
- Testing
- Transcutaneous Biopac Electrical Stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Covid19
Sofosbuvir Containing Regimens in Treatment of COVID 19 Patients
efficacy and safety of Sofosbuvir containing regimens in treatment of COVID-19 Egyptian patients,
- Trial name
- NCT04497649
- Testing
- Sofosbuvir, Daclatasvir
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
COVID-19, Children, Only
Water and Land-based Exercise for Children With Post COVID-19 Condition
The latest data indicate that post COVID-19 condition is frequent in children and adolescents, with the most common symptoms being fatigue, shortness of breath, exercise intolerance and weakness.
- Conditions
- COVID-19, Children, Only, Lung Function Decreased, Quality of Life
- Trial name
- postcovidkids (NCT05216549)
- Testing
- Water-based exercise, Land-based exercise
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- Józef Piłsudski University of Physical Education
Asthma, Status Asthmaticus
Study Evaluating the Safety and Effects of MN-221 in Subjects Experiencing an Acute Exacerbation of Asthma
The objective of this clinical study is to examine the safety and effectiveness of intravenous MN-221 compared to placebo when administered as an adjunct to standard therapy in subjects experiencing an acute exacerbation of…
- Trial name
- NCT00683449
- Testing
- Dose Group 1, Dose Group 2, Dose Group 3
- Where
- 9 sites in United States
- Volunteers
- 29 people
- Sponsor
- MediciNova
Pulmonary Sarcomatoid Carcinoma, Non-small Cell Lung Cancer
Toripalimab Combined With Bevacizumab, Nab-paclitaxel and Carboplatin for Untreated Metastatic Pulmonary Sarcomatoid Carcinoma
This study aimed to evaluate the efficacy and safety of first-line Toripalimab combined with bevacizumab, nab-paclitaxel and carboplatin in the treatment of patients with advanced pulmonary sarcomatoid carcinoma.
- Conditions
- Pulmonary Sarcomatoid Carcinoma, Non-small Cell Lung Cancer, Lung Diseases, Thoracic Neoplasms
- Trial name
- NCT04725448
- Testing
- Toripalimab, Bevacizumab, Nab-paclitaxel
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Pneumonia, Radiography
Change in the Proportion of Correct Interpretations of Pulmonary Opacities
This randomized crossover clinical trial will evaluate whether an artificial intelligence-based expert system improves the interpretation of chest radiographs by final-year medical students, rural physicians, and general…
- Trial name
- INTERPRET (NCT07744555)
- Testing
- Artificial intelligence expert system
- Where
- Colombia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de la Sabana
Community-acquired Pneumonia, COPD Exacerbation Acute
Neuromuscular Electrical Stimulation in COPD/Community Acquired Pneumonia
In older adults hospitalized for acute medical conditions, immobility, clinical treatments, and the illness itself contribute to physical deconditioning and delirium, hospital-acquired impairments that increase risk for long-term…
- Trial name
- NCT05452226
- Testing
- neuromuscular electrical stimulation (NMES)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Vermont
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