Clinical trials: Respiratory Tract Disease
Small Cell Lung Cancer
Cisplatin + Etoposide +/- Concurrent ZD6474 in Previously Untreated Extensive Stage Small Cell Lung Cancer
At this point in the treatment of extensive stage SCLC, we have reached a plateau in survival with conventional chemotherapy and newer regimens are greatly needed.
- Trial name
- NCT00613626
- Testing
- Cisplatin, Etoposide, ZD6474
- Where
- 19 sites in United States
- Volunteers
- 74 people
- Sponsor
- Hoosier Cancer Research Network
Stage III Non-small Cell Lung Cancer
Daily Adaptive Radiation Therapy: An Individualized Approach for Stage III Lung Cancer
This is a prospective multi-center randomized clinical trial designed to demonstrate that daily online adaptive radiotherapy with concomitant chemotherapy for stage III non-small cell lung cancer (NSCLC) will result in decreased…
- Trial name
- ARTIA-Lung (NCT05488626)
- Testing
- Adaptive Radiotherapy, Non-Adaptive Radiotherapy, Chemotherapy
- Where
- United States
- Sponsor
- Varian, a Siemens Healthineers Company
Leukemia, Leukemia, Myeloid
Breath Analysis for the Detection of Invasive Fungal Infections
Patients with leukemia and concomitant neutropenia are at high risk of developing invasive fungal infections (IFI) that are associated with high morbidity and mortality.
- Conditions
- Leukemia, Leukemia, Myeloid, Leukemia, Lymphoblastic, Neutropenia
- Trial name
- REDEFINE (NCT06537726)
- Testing
- Secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS)
- Where
- Switzerland
- Volunteers
- 130 people
- Sponsor
- University of Zurich
Pulmonary Disease, Chronic Obstructive
Long-term Use of Spiolto Respimat in Japanese Patients With Chronic Obstructive Pulmonary Disease
Study to assess the long-term safety and effectiveness of Spiolto in Japanese patients with Chronic Obstructive Pulmonary Disease (COPD) in real-world setting
- Trial name
- NCT02850978
- Testing
- Spiolto
- Where
- Japan
- Volunteers
- 1,335 people
- Sponsor
- Boehringer Ingelheim
Microbial Colonization, Atopic Dermatitis
Nationwide Research on the Rewilding of Kindergarten Yards
Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities that is associated with altered commensal microbiota and a rising burden of immunological disorders among urban children.
- Conditions
- Microbial Colonization, Atopic Dermatitis, Asthma in Children, Allergy
- Trial name
- Vahvistu (NCT06390878)
- Testing
- Biodiversity, Playground equipment
- Where
- 2 sites in Finland
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Natural Resources Institute Finland
Elderly, Pulmonary Embolism
Pharmacoepidemiology Treatment of Symptomatic Pulmonary Embolism in Hospitalized Patients Aged 75 Years or More: PEAGE
The treatment of the venous thromboembolic disease, including pulmonary embolism (PE), is based on anticoagulants. During the last decade, all the randomized clinical trials evaluating these anticoagulants have included PE…
- Conditions
- Elderly, Pulmonary Embolism, Anticoagulants
- Trial name
- PEAGE (NCT02360943)
- Testing
- 4 blood samples
- Where
- 20 sites in France
- Volunteers
- 1,500 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cystic Fibrosis
Video Game Exercise Effectiveness of a Domiciliary Pulmonary Rehabilitation Program in Cystic Fibrosis Patients
The aim of this study is to evaluate the efficacy of a long-term domiciliary exercise program using the Wii video game platform as a training modality in Cystic Fibrosis (CF) patients.
- Trial name
- NCT02552043
- Testing
- Nintendo Wii exercise program
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Universidad Autonoma de Madrid
Pulmonary Embolism, Thrombotic Disease
Study to Assess the Safety, Pharmacokinetics/Dynamics of DS-1040b in Subjects With Acute Submassive Pulmonary Embolism
This is a Phase 1b, double-blind (participants and Investigators), placebo-controlled, randomized, single-ascending dose, multi-center study to assess the safety, efficacy, tolerability, pharmacokinetics (PK), and…
- Trial name
- NCT02923115
- Testing
- DS-1040b, Enoxaparin
- Where
- 46 sites in United States, Austria and 6 more
- Volunteers
- 134 people
- Sponsor
- Daiichi Sankyo
Asthma
Pilot of Lifestyle and Asthma Intervention
This is to pilot test a weight loss intervention in obese patients with poorly controlled asthma. Obesity is a risk factor for the development of asthma (approximately 250,000 cases per year of asthma in the U.S.
- Trial name
- PLAN (NCT03291808)
- Testing
- Weight loss intervention
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Johns Hopkins University
Cystic Fibrosis
Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis
The purpose of this study is to determine the medium term efficacy and safety profile of inhaled mannitol, on its own and also as an additional therapy to rhDNase (pulmozyme).
- Trial name
- NCT00117208
- Testing
- mannitol, mannitol + pulmozyme, Dornase alpha
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Syntara
Heart Failure, Pulmonary Hypertension
Mechanisms of Pulmonary Vascular Dysfunction in Heart Failure
Heart failure (HF) patients often develop pulmonary hypertension (PH) that leads to transition into a biventricular HF with poor prognosis.
- Conditions
- Heart Failure, Pulmonary Hypertension, Pulmonary Vascular Resistance Abnormality
- Trial name
- LUNG-HF (NCT06331208)
- Testing
- non-contrast chest CT, spirometry with diffusing lung capacity for carbon monoxide (DLCO) analysis, Omics analysis of blood plasma obtained from pulmonary artery or peripheral blood
- Where
- Czechia
- Volunteers
- 230 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Asthma
A Study In Pediatric Subjects With Asthma Using ADVAIR HFA, ADVAIR HFA With Spacer, And ADVAIR DISKUS
Collect PK/PD data for this age group to compare ADVAIR DISKUS with ADVAIR HFA
- Trial name
- NCT00400608
- Testing
- ADVAIR HFA, ADVAIR DISKUS
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- GlaxoSmithKline
Lung Cancer
Retrospective Multi-Center Study to Compare Perioperative Outcomes for Robotic-assisted Lobectomy With Those Associated With VATS and Open Lobectomy for Lung Cancer
The main objective of this study is to evaluate and compare peri-operative outcomes of lobectomy compare with different approaches.
- Trial name
- PORTaL (NCT03347825)
- Testing
- Robotic-assisted lobectomy using da Vinci Surgical System, VATS (video assisted thoracic surgery), Open lobectomy
- Where
- United States
- Volunteers
- 7,000 people
- Sponsor
- Intuitive Surgical
Bronchiectasis
N- Acetylcysteine in Airway Clearance in Bronchiectasis
It has been deduced that reducing the production of mucus or improving the clearance of sputum in the airway is the key to enhance the therapeutic efficacy for bronchiectasis.
- Trial name
- NCT07293884
- Testing
- N Acetyle cysteine given by IV injection, Nebulized N Acetyle cysteine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Carcinoma, Non-Small Cell Lung, Carcinoma, Small-Cell Lung
Prospective Analysis of Genotypes in Adults Undergoing Therapy for Lung Cancer
Background: The Lung Cancer section of the National Cancer Institute s Medical Oncology Branch is running a study to better understand which genes might be important in patients who are undergoing therapy for lung cancer.
- Trial name
- NCT00923884
- Where
- United States
- Volunteers
- 546 people
- Sponsor
- National Cancer Institute (NCI)
Coronary Artery Disease, Exercise Addiction
Aerobic Exercise on Ventilatory Efficiency in CAD Patients
The purpose of the present study was to test the hypothesis that patients with coronary artery disease with lower aerobic fitness exhibit greater responsiveness on improving ventilatory efficiency after aerobic exercise training.
- Conditions
- Coronary Artery Disease, Exercise Addiction, Complication, Cardio-respiratory
- Trial name
- NCT02106533
- Testing
- Aerobic exercise training
- Volunteers
- 123 people
- Sponsor
- Hospital TotalCor
Coronary Artery Disease, Anesthesia
Myocardial Strain Analysis in Anaesthetized Coronary Artery Disease Patients During Hyperoxia and Normoxaemia
The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients with coronary artery disease.
- Trial name
- Strecho-O₂ (NCT04424433)
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 106 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Asthma
Educational Video for Improving Follow-up After an Emergency Department Visit for Asthma
The study will assess the efficacy of a three-part Emergency Department (ED)-based "Asthma Belief and Control" intervention on healthcare utilization, asthma controller medication use, symptoms, and quality of life during the 6…
- Trial name
- NCT00113633
- Testing
- Intervention Subjects
- Where
- United States
- Volunteers
- 439 people
- Sponsor
- Children's Hospital of Philadelphia
Chronic Obstructive Pulmonary Disease
Study in COPD Patients Evaluating the Quality of Life (TRISNOOZE)
This non-interventional study aims to collect information on the patient's quality of life, as well as the quality of sleep when stepping up to a fixed triple maintenance therapy (Trimbow®) as per physicians' decision…
- Trial name
- TRISNOOZE (NCT04611633)
- Testing
- Trimbow
- Where
- 11 sites in Belgium
- Volunteers
- 14 people
- Sponsor
- Chiesi SA/NV
Dysphagia, Covid19
Dysphagia Management During COVID-19 Pandemic
The current study is aimed to determine the procedures applied in the dysphagia clinics during the COVID-19 pandemic period. A questionnaire consisting of 30 questions will be implemented.
- Trial name
- NCT04509752
- Testing
- Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
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