Clinical trials: Respiratory Tract Disease
Rheumatoid Arthritis, Interstitial Lung Disease
Interstitial Lung Disease in Early Rheumatoid Arthritis
The purpose of this study is to determine how interstitial lung disease can be predicted over time in early rheumatoid arthritis.
- Trial name
- ILD-Early RA (NCT03977415)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- National Jewish Health
Covid19
Bacterial Surinfections in COVID-19 ICU Patients
The aim of this study is to assess the incidence of bacterial surinfections (sepsis, VAP and catheter infections) in COVID-19 patients admitted to the ICU from 13th of March 2020 until 17h of October 2020.
- Trial name
- NCT04877808
- Where
- Belgium
- Volunteers
- 116 people
- Sponsor
- Jessa Hospital
Advanced Lung Non-Squamous Non-Small Cell Carcinoma, Metastatic Lung Non-Squamous Non-Small Cell Carcinoma
Aurora Kinase Inhibitor LY3295668 in Combination With Osimertinib for the Treatment of Advanced or Metastatic EGFR-Mutant Non-squamous Non-small Cell Lung Cancer
This phase Ib/II trial studies the side effects and best dose of aurora A kinase inhibitor LY3295668 when given together with osimertinib in patients with EGFR-mutant non-squamous non-small cell lung cancer that has spread to…
- Conditions
- Advanced Lung Non-Squamous Non-Small Cell Carcinoma, Metastatic Lung Non-Squamous Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8
- Trial name
- NCT05017025
- Testing
- Aurora A Kinase Inhibitor LY3295668, Osimertinib
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- M.D. Anderson Cancer Center
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Lung Cancer (Diagnosis), Hypoxemia
The Effect of Semi-recumbent Position on Hypoxemia After Lung Segment/Lobe Surgery
Thoracoscopic surgery is the most common surgical approach in thoracic surgery, which reduces surgical trauma and postoperative pain compared with open thoracotomy, but postoperative complications should not be overlooked, with…
- Trial name
- NCT07060625
- Testing
- Semi-reclining position
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Neurological Diseases or Conditions, Stroke, Acute
COVID-19 Prevalence and Cognitive Deficits in Neurological Patients
The purpose is to investigate the COVID-19 prevalence, associated morbidity and long-term cognitive deficits in consecutive patients presenting with acute neurological symptoms
- Conditions
- Neurological Diseases or Conditions, Stroke, Acute, Seizure Disorder
- Trial name
- Neuro-Covid (NCT04377425)
- Testing
- COVID-19 swap test PCR
- Where
- 4 sites in Denmark
- Sponsor
- Aarhus University Hospital
Late-onset Pompe Disease
A Study of Respiratory Muscle Strength in Patients With Late-onset Pompe Disease (LOPD)
Study 701-201 is a study in patients with late-onset Pompe disease (LOPD). The study will test respiratory muscle strength initially and again after 24 weeks in subjects treated or not treated with BMN 701 .
- Trial name
- NCT02191917
- Testing
- Respiratory muscle strength measurements by different techniques.
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 8 people
- Sponsor
- BioMarin Pharmaceutical
Critical Illness, Sedation Complication
Sedation, ANalgesia and Delirium MANagement in Intensive Care Unit
Patients with acute severe health problems often need to be admitted to specialised hospital wards called Intensive Care Units (ICUs) where they can receive emergency treatment such as mechanical ventilation to support their…
- Conditions
- Critical Illness, Sedation Complication, Intensive Care Unit Delirium, Analgesia
- Trial name
- SAnDMAN (NCT05027217)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 3,421 people
- Sponsor
- University of Oxford
Hypertension, Pulmonary
Piloting Mindfulness Meditation Program for Underserved Racial Minority Adults With Pulmonary Hypertension
The MMPH program will include two Zoom-delivered sessions (Weeks #1 \& #4), six video-recorded sessions (Weeks #2, #3, #5, #6, #7, #8), and daily mindfulness meditation practice using a mobile APP during an eight-week study…
- Trial name
- MMPH (NCT05387889)
- Testing
- Mindfulness Meditation for Pulmonary Hypertension (MMPH)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- State University of New York at Buffalo
Lung Cancers
⁶⁸Ga-DPA in the Lung Cancer Diagnosis
In previous studies, we synthesized a PD-L1-targeted molecular probe, ⁶⁸Ga-DPA, and developed a ⁶⁸Ga-DPA injection for clinical research.
- Trial name
- NCT07023068
- Testing
- 68Ga-DPA PET/CT
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Interstitial Lung Disease
Pursed Lip Breathing in Interstitial Lung Disease
This randomized, cross-over study aims at describing the effect of pursed lip breathing on exercise-induced dyspnea and exercise capacity in patients with interstitial lung disease.
- Trial name
- NCT02934750
- Testing
- Pursed lip breathing
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Neuromuscular Diseases, Respiratory Failure
Volontary Inspiratory Muscles Measures Compared With Phrenic Nerves Magnetic Stimulations Measures
Respiratory failure is the main death cause in neuromuscular diseases. Non-invasive and volitional measures of inspiratory muscles strength include the nasal pressure with an occluded nostril (Psnip) and the maximal inspiratory…
- Trial name
- NCT02078050
- Testing
- Phrenic nerves magnetic stimulations
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Lung Carcinoma
Three-Dimensional Fluoroscopic Guidance During Transbronchial Cryobiopsy
This study assesses the effectiveness of transbronchial cryobiopsy guided by 3-dimensional fluoroscopy. Transbronchial cryobiopsy is a procedure to collect lung tissue.
- Trial name
- NCT05059691
- Testing
- Electronic Health Record Review, Transbronchial Cryobiopsy Guided by Three-Dimensional Fluoroscopy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- M.D. Anderson Cancer Center
Cystic Fibrosis, Infection
Anti-pseudomonas IgY to Prevent Infections in Cystic Fibrosis
Hypothesis: Daily gargling with specific avian antibodies against Pseudomonas aeruginosa will prevent infections with this bacteria in patients with Cystic fibrosis (CF).
- Conditions
- Cystic Fibrosis, Infection, Pseudomonas Aeruginosa
- Trial name
- PseudIgY (NCT00633191)
- Testing
- Anti-pseudomonas IgY gargle
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Immunsystem AB
Severe Community-acquired Pneumonia
Diagnosis and Treatment Strategy Optimization of Severe Pneumonia Based on Multi-omics Data Integration
Severe community-acquired pneumonia still has a high incidence and mortality, but the molecular mechanism and prognostic biomarkers of severe community-acquired pneumonia caused by different pathogens are still unclear, and the…
- Trial name
- NCT06288074
- Testing
- Multi-omics tests
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Influenza, Healthy
Study of a Parenterally Administered H5N1 Influenza Vaccine in Healthy Adults
The safety and tolerability of the pandemic A/H5N1 virosomal vaccine formulated with or without the 3rd generation ISCOM™ adjuvant for parenteral administration will be investigated locally and systemically and by using…
- Trial name
- PANFLUVAC (NCT00868218)
- Testing
- Influenza vaccine
- Where
- Norway
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rebecca Cox
Severe Pulmonary Arterial Hypertension
Open-label, Multi-center Protocol to Provide QTI571 to PAH Patients Who Participated in the Extension Study (A2301E1) in Japan
To provide continued treatment to Pulmonary Arterial Hypertension (PAH) patients who are benefitting from treatment with QTI571.
- Trial name
- NCT02042014
- Testing
- QTI571
- Where
- 3 sites in Japan
- Volunteers
- 8 people
- Sponsor
- Novartis Pharmaceuticals
Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT)
Decision Aid for Anticoagulation Duration After Unprovoked Venous Thromboembolism
Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a common condition that is typically treated with blood thinners (anticoagulants).
- Conditions
- Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT), Pulmonary Embolism
- Trial name
- DECIDE-VTE (NCT07659106)
- Testing
- DECIDE-VTE Patient Decision Aid
- Where
- 5 sites in Canada
- Volunteers
- 850 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Carcinoma, Non-Small-Cell Lung (NSCLC)
Trial Of AG-013736, Cisplatin, And Gemcitabine For Patients With Squamous Non-Small Cell Lung Cancer
This study will evaluate whether AG-013736 when combined with cisplatin and gemcitabine shows activity and is safe in patients with squamous type of non-small cell lung cancer
- Trial name
- NCT00735904
- Testing
- AG-013736, gemcitabine, cisplatin
- Where
- 10 sites in Poland, Romania and 2 more
- Volunteers
- 38 people
- Sponsor
- Pfizer
NSCLC
Clinical Efficacy and Safety of Dendritic Cytotoxic Lymphocyte(DC-CTL) Cell Infusion in NSCLC Patients
Patients in group A will receive DC-CTL treatment and chemotherapy. Patients in group B will receive only chemotherapy.
- Trial name
- NCT02766348
- Testing
- gemcitabine, DC-CTL, cisplatinum
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
The first 5,000 results can be paged through. Add a filter or change the sort order to reach the rest.