Clinical trials: Respiratory Tract Disease
Hospital Stay
Effect of Incentive Spirometer and Pursed Lip Breathing After Whipple Procedure.
Whipple procedure is one of the most complex surgeries among hepatobiliary surgeries. It has named as Pancreaticoduodenectomy. It can cause many PPCs. Lung volumes are reduced due to atelectasis and pneumonia.
- Trial name
- NCT06460584
- Testing
- Pursed Lip Breathing, Incentive Spirometer
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Precapillary Pulmonary Hypertension, Pulmonary Arterial Hypertension
Evolution of Hypoxic Burden and Sympathetic/Parasympathetic Balance in Patients With Pulmonary Hypertension
Background and Rationale: Sleep-disordered breathing and nocturnal hypoxemia are highly prevalent in patients with precapillary pulmonary hypertension (PH), and current guidelines recommend systematic sleep assessment in this…
- Conditions
- Precapillary Pulmonary Hypertension, Pulmonary Arterial Hypertension, Sleep-disordered Breathing, Nocturnal Hypoxemia
- Trial name
- HRV&PH (NCT07464184)
- Testing
- Standard Clinical and Functional Assessment, Overnight Polysomnography
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Rouen
Dysphonia
Computational Cranial and Cervical Muscle Network in Normal and Disordered Voice
The long-term goal is to transform the diagnosis and treatment of dysphonia by elucidating cervical and cranial neuromuscular mechanisms underlying typical and disordered voicing.
- Trial name
- NCT04713033
- Testing
- surface electromyogram (sEMG), flexible laryngoscopy
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Respiratory Function Tests，Heart Function Tests, Cardiopulmonary Function
Xiangya Cardiopulmonary Health and Disease Cohort
Xiangya Cardiopulmonary Health and Disease Cohort (XY-CPHDC) is a non-intervention study grounded in real-world data. It is designed as a bidrectional clinical cohort combined retrospective and prospective design, in order to…
- Trial name
- XY-CPHDC (NCT06972784)
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Lung Carcinoma
The Rise in Robotic Atypical Segmentectomies
This study investigates the increased rate of robotic atypical segmentectomies. Segmentectomy refers to removing a section of a lobe of the lung.
- Trial name
- NCT04644952
- Testing
- Electronic Health Record Review
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Obstructive Pulmonary Disease
Disturbed Blood Flow Induces Endothelial Dysfunction in Severe Chronic Obstructive Pulmonary Disease
The aim of the study is to determine if increased retrograde shear would further deteriorate the already impaired vascular function in severe COPD patients.
- Trial name
- NCT03004352
- Testing
- retrograde flow, oxygen
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Brain and Central Nervous System Tumors, Childhood Langerhans Cell Histiocytosis
Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer
RATIONALE: Radiation therapy uses high-energy x-rays and other sources to damage tumor cells. Giving radiation therapy in different ways may kill more tumor cells.
- Conditions
- Brain and Central Nervous System Tumors, Childhood Langerhans Cell Histiocytosis, Gastrointestinal Carcinoid Tumor, Head and Neck Cancer
- Trial name
- NCT00002947
- Testing
- indium In 111 pentetreotide
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Yale University
Sleep Apnea
The Efficacy of the 4-channel Sequential NMES for the Treatment of Sleep Apnea
In the treatment of obstructive sleep apnea, by using sequential 4-channel electrical stimulation treatment, unlike conventional positive pressure devices, it can be done more effectively by improving the strength of the biceps…
- Trial name
- NCT05135611
- Testing
- 4 channel Electrical Stimulation Device
- Where
- South Korea
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Influenza
Safety of Synbiotics as Adjuvant to Influenza Vaccine in Elderly
Probiotics are viable commensal microorganisms that promote the establishment of beneficial microflora. Animal and human studies demonstrate that probiotics can enhance body's immune response to stimuli.
- Trial name
- NCT01304771
- Testing
- Synbiotic AKSB
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes, Diabetic Kidney Disease
Effect of Acute Hypoxia on Renal Hemodynamic in Healthy Volunteers, Patients With Diabetes and Patients With Diabetes and Kidney Disease
Diabetes mellitus is a non-transmissible disease whose incidence is growing worldwide . This pathology is defined by a chronic hyperglycaemia linked to a deficiency of either insulin secretion or its action or both.
- Conditions
- Diabetes, Diabetic Kidney Disease, Hypoxia, Healthy Volunteer
- Trial name
- DIAKIPOX (NCT06846034)
- Testing
- Hypoxia administration study group, Renal clairance study
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Dental Anxiety, Covid19
Music for Decreasing Dental Anxiety During Oral Surgery in Coronavirus Disease 2019 (COVID-19)
Approximately 100 patients undergoing oral surgery will be divided in 3 groups of musical audition to control anxiety: baroque (N=35), classicism (N=35) and control group (N=30).
- Trial name
- NCT05052034
- Testing
- Music
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- European University of Madrid
COVID-19, Quality of Life
COVID-19 - Quality of Life After Infection
This study aims to investigate the quality of life of COVID-19 patients after recovery and discharge from the hospital. Patients following-up at the PWH outpatient clinics will be enrolled for further evaluation via telephone…
- Trial name
- NCT04377464
- Testing
- SF12, EQ-5D-5L and work status standardized quantitative assessments
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Lung Cancer Metastatic, Nodes, Lung
Neck Ultrasound by Respiratory Physicians in Patients With Lung Cancer
This is a study of routine neck ultrasound performed by respiratory physicians in patients with mediastinal lymphadenopathy and suspected lung cancer
- Trial name
- NCT03970564
- Testing
- Neck ultrasound guide lymph node sampling
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- University College Hospital Galway
Pulmonary Arterial Hypertension
PET/MRI in PAH Patients
Aim of the study is to compare novel parameters of right ventricle (RV) function from right heart catheterization (RHC) and magnetic resonance imaging (MRI) with PET-derived RV FDG uptake.
- Trial name
- NCT03688698
- Testing
- PET/MRI
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
COVID-19
SAD Study of APR002 Investigating the Safety/Tolerability, Pharmacokinetics/Pharmacodynamics in Healthy Subjects
This study will investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of single ascending doses of APR002 in healthy subjects.
- Trial name
- NCT05268198
- Testing
- APR002
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Global Health Drug Discovery Institute
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Intersectoral Platform (SÜP) of the National Pandemic Cohort Network (NAPKON)
The intersectoral platform is part of the National Pandemic Cohort Network (NAPKON) and will be used to provide a comprehensive and harmonized collection of data and biomaterial for researchers from national consortia…
- Trial name
- SUEP-NAPKON (NCT04768998)
- Testing
- Observational of different courses of SARS-CoV-2 infection in different phases (acute vs. post-acute) and settings
- Where
- 34 sites in Germany
- Volunteers
- 6,550 people
- Sponsor
- Goethe University
Pulmonary Disease, Chronic Obstructive (COPD), Cognitive Impairment
COPD-Related Physiology and the Brain
COPD is the third leading cause of combined morbidity, disability, and mortality in the United States and is often associated with cognitive impairment.
- Trial name
- NCT03269721
- Testing
- Neuropsychological Assessment, Spirometry, Arterial Blood Gas
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Karin Hoth
Pulmonary Disease, Chronic Obstructive
Study of Relationship Between Changes in Inflammation, Lung Function, Symptoms and Medication Use in COPD Patients
The intention with the study is to have a better understanding of what happens to COPD patients' symptoms, lung function and markers of inflammation over 12 weeks.
- Trial name
- CORAL (NCT04168216)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- AstraZeneca
Non-small Cell Lung Cancer, Melanoma
PD-L1 Expression in Cancer (PECan Study).
Measurement of PD-L1 expression in cancer to monitor treatment response. A prospective non-blinded, single centre, single interventional arm diagnostic imaging study.
- Trial name
- PECan (NCT04436406)
- Testing
- [99mTc]-NM-01 SPECT/CT
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Lung Disease
Comparison of Propofol/Alfentanil With Propofol/Ketamine
A prospective, randomized, patient-blinded comparison of the safety and efficacy of conscious sedation by propofol/alfentanil with propofol/ketamine in patients undergoing flexible fiberoptic bronchoscopy.
- Trial name
- KET-001 (NCT02000206)
- Testing
- Propofol, Ketamine, Alfentanil
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rabin Medical Center
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