Clinical trials: Respiratory Tract Infection Acute
Post-Acute COVID-19 Syndrome, Long COVID
QEEG-NEUROFEEDBACK FOR COGNITIVE REHABILITATION IN LONG COVID-19 SURVIVORS WITH BRAIN FOG
The pandemic has highlighted social, economic, educational, and political issues that have affected the health and quality of life of millions of Brazilians.
- Conditions
- Post-Acute COVID-19 Syndrome, Long COVID, Brain Fog
- Trial name
- QEEG-NFT (NCT07005921)
- Testing
- qEEG-neurofeedback
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jade Carvalho Da Silva
Covid19, Kidney Diseases
Michigan Medicine COVID-19 Cohort: Clinical Characteristics, Inflammatory Markers and Outcomes of Patients Hospitalized for COVID-19
To better understand the role of inflammation in COVID-19, we established the Michigan Medicine COVID-19 Cohort (M2C2). M2C2 is a funded and ongoing cohort which has currently enrolled over 1500 adult patients (≥18 years) with…
- Conditions
- Covid19, Kidney Diseases, Inflammation, SARS-CoV Infection
- Trial name
- M2C2 (NCT04706533)
- Testing
- Biomarkers of inflammation
- Where
- United States
- Volunteers
- 3,402 people
- Sponsor
- University of Michigan
Respiratory Tract Infections
Mycoplasma Infection Rate and Macrolides Resistance in Children With Acute Respiratory Tract Infection
In recent years, mycoplasma pneumoniae caused more than 30% of respiratory infections in children in China, among which the detection rate of drug-resistant mycoplasma pneumoniae was higher than 90%.
- Trial name
- NCT04126304
- Testing
- Azithromycin, non-macrolides antibiotics, Mycoplasma detection
- Volunteers
- 2,312 people
- Sponsor
- Shanghai Children's Medical Center
COVID-19, Severe Acute Respiratory Syndrome Coronavirus 2
Monocytes and NK Cells Activity in Covid-19 Patients
SARS-CoV-2 belong to beta-coronavirus family and its transmission route and symptoms follow those of all community-acquired coronaviruses.
- Conditions
- COVID-19, Severe Acute Respiratory Syndrome Coronavirus 2, Immunomodulation
- Trial name
- NCT04375176
- Testing
- Study of immune-mediated mechanisms in patients tested positive for SARS-CoV-2
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Università degli Studi dell'Insubria
COVID-19
A Study to Measure the Amount of Study Medicine in Blood in Adult Participants With COVID-19 and Severe Kidney Disease
The purpose of this study is to learn about the side effects (safety) of the study medicine PF-07321332 (nirmatrelvir)/ritonavir for the treatment of mild to moderate COVID-19 infection in adults with severe renal impairment.
- Trial name
- NCT05487040
- Testing
- PF-07321332 (nirmatrelvir)/ritonavir
- Where
- 52 sites in United States
- Volunteers
- 15 people
- Sponsor
- Pfizer
COVID-19, Long COVID
Study of Vascular Endothelial Glycocalyx and Ophthalmic Injury, Prospective Cohort of Patients With Prolonged Post-COVID-19 Symptoms
The glycocalyx is a membrane coat composed of glycoproteins attached to the surface of cell membranes. Recent publications have drawn attention to the potential role of a degradation of the endothelial glycocalyx (a kind of gel…
- Trial name
- GLYCOVLONG (NCT05235698)
- Testing
- Ophthalmological examinations, GlycoCheck
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Bronchiectasis, Lower Respiratory Infection
Safety, Efficacy and PK/PD of POL7080 in Patients With Exacerbation of Non-cystic Fibrosis Bronchiectasis.
To test whether POL7080 is effective in patients with exacerbation of non-cystic fibrosis bronchiectasis caused by Pseudomonas aeruginosa infection.
- Trial name
- NCT02096315
- Testing
- POL7080
- Where
- 4 sites in Spain, United Kingdom
- Volunteers
- 20 people
- Sponsor
- Polyphor Ltd.
Antibiotic Prescribing for Acute Respiratory-tract Infections
Effect of CRP and SAA Point-of-care Testing on Antibiotic Prescribing for Acute Respiratory-tract Infections
The study was a practical, cluster-randomized controlled trial to evaluate the impact of CRP and SAA point-of-care testing (CRP\&SAA POCT) on antibiotic prescribing in patients with acute respiratory-tract infections (ARI) at…
- Trial name
- NCT06568432
- Testing
- CRP+SAA POCT
- Where
- China
- Volunteers
- 35,108 people
- Sponsor
- Huazhong University of Science and Technology
COVID-19
Treatment of COVID-19 Patients With Anti-interleukin Drugs
The purpose of this study is to test the safety and effectiveness of individually or simultaneously blocking IL-6 and IL-1 versus standard of care on blood oxygenation and systemic cytokine release syndrome in patients with…
- Trial name
- COV-AID (NCT04330638)
- Testing
- Usual Care, Anakinra, Siltuximab
- Where
- 15 sites in Belgium
- Volunteers
- 342 people
- Sponsor
- University Hospital, Ghent
Acute Rhinosinusitis, Sore Throat
The Development and Testing of a Scaling Strategy for a Community-Based Primary Care Antimicrobial Stewardship Program
Antibiotic resistant infections are expected to cause 10 million deaths worldwide by 2050, and exceed cancer deaths. Reducing antibiotic use can reduce resistance levels.
- Conditions
- Acute Rhinosinusitis, Sore Throat, Acute Cystitis, Acute Bronchitis
- Trial name
- PC-ASP 2 (NCT03517215)
- Testing
- Enhanced CB-ASP, Standard CB-ASP
- Where
- 3 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Covid19, Post Traumatic Stress Disorder
Quality of Life After COVID-19 Related Acute respIratory Distress Syndrome Among ICU Survivors Patients in Italy: the ODISSEA Study.
Acute respiratory insufficiency is one of the principal causes of intensive care admission for COVID 19 positive patients. This may determine a variable mortality rate ranging from 25-30%.
- Conditions
- Covid19, Post Traumatic Stress Disorder, Quality of Life
- Trial name
- ODISSEA (NCT04860687)
- Where
- 8 sites in Italy
- Volunteers
- 309 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
COVID-19
Tocilizumab Versus Baricitinib in Patients With Severe COVID-19
The aim of this study is to investigate whether baricitinib is non-inferior to tocilizumab in severe COVID-19.
- Trial name
- NCT05082714
- Testing
- Tocilizumab, Baricitinib
- Where
- Greece
- Volunteers
- 251 people
- Sponsor
- University Hospital of Patras
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
COVID-19 (SARS-CoV-2)
Risk of Infection of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), COVID-19, in a Massive Musical Show With Transmission Prevention Measures
The coronavirus disease 2019 (COVID-19) outbreak, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan in December 2019 and has spread globally, representing a serious threat to public…
- Trial name
- NCT04668625
- Testing
- Participate in a massive musical event
- Where
- Spain
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Covid19, SARS-CoV Infection
A Registry Study of COVID-19 Serologic and Virologic Testing to Accelerate Recovery and Transition
The co-primary objectives of this study are to: 1. Determine and compare the COVID-19 antibody positivity rate in health care workers and patients without a known COVID-19 infection 2.
- Trial name
- START (NCT04573634)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jill M Kolesar
Patient Preference, COVID-19
Patients' Experiences in a Medicalized Hotel for COVID-19 Acute Care Support
The 11th March 2020, the World Health Organization (WHO) declared the novel coronavirus Covid-19 as a pandemic. Urgent reorganization was required to give answers to the needs of this new illness.
- Trial name
- NCT04503434
- Where
- Spain
- Volunteers
- 517 people
- Sponsor
- Hospital Clinic of Barcelona
Stroke, Mild Cognitive Impairment (MCI)
Telerehabilitation Decision Support System: Pilot Testing Protocol
This study follows the successfully completed HOLOBalance project which was funded by the EU Horizon 2020 scheme. TheHOLOBalance platform delivers exercises demonstrated via a hologram of the physiotherapist and corrected in real…
- Conditions
- Stroke, Mild Cognitive Impairment (MCI), Vestibular Disease, Long Covid-19
- Trial name
- TeleRehab DSS (NCT07079787)
- Testing
- TeleRehab DSS Pilot Test
- Where
- 5 sites in Germany, Greece and 3 more
- Volunteers
- 30 people
- Sponsor
- University College, London
Coronavirus Disease 2019 (COVID-19)
Increased Risk of Severe Coronavirus Disease 2019 in Patients With Vitamin D Deficiency
In this prospective observational study we aim to study the association of vitamin D deficiency with adverse clinical outcomes in patients infected with Coronavirus disease 2019
- Trial name
- COVIT-D (NCT04403932)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Hospital San Carlos, Madrid
Influenza
Evaluation of Efficacy and Safety of Peramivir in Adults With Acute Serious or Potentially Life-threatening Influenza
This study has been designed as a randomized, double-blind, controlled, study to evaluate the efficacy and safety of two once daily intravenous peramivir regimens (200 mg and 400 mg) versus oral oseltamivir phosphate (75 mg twice…
- Trial name
- NCT00453999
- Testing
- Peramivir 200 mg, Peramivir 400 mg, Oseltamivir
- Where
- 83 sites in United States, Australia and 5 more
- Volunteers
- 137 people
- Sponsor
- BioCryst Pharmaceuticals
SARS-CoV-2, Influenza
A Safety, Reactogenicity, and Immunogenicity Study of mRNA-1045 (Influenza and Respiratory Syncytial Virus [RSV]) or mRNA-1230 (Influenza, RSV, and Severe Acute Respiratory Syndrome Coronavirus 2 [SARS-CoV-2]) Vaccine in Adults 50 to 75 Years Old
The primary goal of this study is to evaluate the safety and reactogenicity of multi-component vaccines mRNA-1045 (Influenza and RSV) and mRNA-1230 (influenza, RSV, and SARS-CoV-2) compared with mRNA-1010 (influenza), mRNA-1345…
- Conditions
- SARS-CoV-2, Influenza, RSV
- Trial name
- NCT05585632
- Testing
- mRNA-1010, mRNA-1345, mRNA-1273.214
- Where
- 30 sites in United States, Australia and 1 more
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.