Clinical trials: Response Inhibition
Metastatic Melanoma
PD-1 Antibody Therapy + Infliximab for Metastatic Melanoma
The purpose of this research is to test the safety and effectiveness of the investigational combination of anti-Programmed Death (PD)-1 antibody therapy with or without LAG-3 inhibition (pembrolizumab or nivolumab+relatlimab) and…
- Trial name
- NCT05034536
- Testing
- Pembrolizumab, Infliximab, Relatlimab
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
Rheumatoid Arthritis, Coronary Artery Disease
Effects of Interleukin-1 Inhibition on Vascular and Left Ventricular Function in Rheumatoid Arthritis Patients With Coronary Artery Disease
Inhibition of interleukin-1 (IL-1) activity in patients with RA without CAD ameliorates vascular and LV function. Moreover, data from species shows beneficial effect of this treatment on LV function after experimental myocardial…
- Conditions
- Rheumatoid Arthritis, Coronary Artery Disease, Inflammation
- Trial name
- NCT01566201
- Testing
- anakinra
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Athens
Ovarian Cancer
ROCKIF Trial: Re-sensitization of Carboplatin-resistant Ovarian Cancer With Kinase Inhibition of FAK
The purpose of the study is to investigate the combination VS-6063, carboplatin, and paclitaxel. in the treatment of patients with ovarian cancer.
- Trial name
- NCT03287271
- Testing
- VS-6063, Paclitaxel, Carboplatin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Michael McHale
Multiple Trauma, Sepsis
The Role of Post-traumatic Inhibition of the Innate and Adaptive Immune System in the Development of Infectious Complications in Severely Injured Patients
Patients admitted to the Intensive Care Unit after severe injury are prone to suffer from infectious complications and even sepsis.
- Conditions
- Multiple Trauma, Sepsis, Innate Immune Response, Disorder of Neutrophils
- Trial name
- POSEIDON (NCT03489577)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- UMC Utrecht
Influenza A, Influenza B
Evaluating the Safety and Efficacy of Anti-Influenza Intravenous Hyperimmune Immunoglobulin (IVIG) in Adults Hospitalized With Influenza
Influenza (the flu) is a common illness that usually occurs in autumn and winter. The flu is usually mild, but can cause serious illness or death.
- Trial name
- NCT02287467
- Testing
- Intravenous hyperimmune immunoglobulin (IVIG)
- Where
- 21 sites in United States, Australia and 2 more
- Volunteers
- 329 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Muscle Inhibition, Knee Injury Simulation
Quadriceps Motor Unit Adaptation to Simulated Knee Injury
This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults.
- Trial name
- NCT06999057
- Testing
- Joint Effusion via 60 mL Sterile Saline, Intra-articular Lidocaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Healthy Volunteers
A Pharmacokinetic (PK) Study Of PF-00299804 And Dextromethorphan In Healthy Volunteers
A study to study the potential effect of PF-00299804 inhibition of CYP2D6 on dextromethorphan.
- Trial name
- NCT00999817
- Testing
- reference [dextromethorphan], test [PF-00299804 + dextromethorphan]
- Where
- Belgium
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Pfizer
PCOS
Insulin and Polycystic Ovary Syndrome
Increased insulin levels leads to increased secretion of D-chiro inositol(DCI) from the kidneys in women with PCOS, but not in normal women.
- Trial name
- NCT00683774
- Testing
- diazoxide
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Psoriasis
Exploring the Effects of IL-23 Inhibition by Risankizumab on Psoriasis Autoimmunity
Approximately 80 patients affected by moderate to severe psoriasis will be screened for the presence of LL37( and ADAMTSL5 autoreactive T-cells in their blood at Day 0.
- Trial name
- PSORIASI_RISA (NCT04722640)
- Testing
- SKYRIZI
- Volunteers
- 240 people
- Sponsor
- Istituto Clinico Humanitas
Cardiovascular Diseases, Heart Diseases
ACE Inhibition and Novel Cardiovascular Risk Factors
To determine the effects of an angiotensin converting enzyme inhibitor (ACE inhibitor), fosinopril, on multiple blood markers in 286 adults at high risk for cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00051389
- Testing
- Fosinopril
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity
Effect of PDE5 Inhibition on Adipose Metabolism in Humans
This is a randomized, double-blinded, placebo-controlled study of the effects of PDE5 inhibition with tadalafil on adipose tissue in obese individuals.
- Trial name
- NCT04684589
- Testing
- Tadalafil 20 MG
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Hyperlipidemia
Reduction of LDL-C With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study-2
The primary objective was to evaluate the effect of 12 weeks of evolocumab subcutaneously once every 2 weeks (Q2W) and once monthly (QM), compared with placebo, on percent change from baseline in low-density lipoprotein…
- Trial name
- RUTHERFORD-2 (NCT01763918)
- Testing
- Evolocumab
- Where
- 39 sites in United States, Australia and 12 more
- Volunteers
- 331 people
- Sponsor
- Amgen
Obsessive-Compulsive Disorder
TMS for Improving Response Inhibition in Adolescents With OCD
The study will examine whether inhibition of the pre-supplementary motor area (pSMA) using transcranial magnetic stimulation (TMS) normalizes activity in pSMA-connected circuits, improves response inhibition, and reduces…
- Trial name
- NCT05104697
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Bradley Hospital
Estrogen Receptor Positive Breast Cancer
Fulvestrant +/- Akt Inhibition in Advanced Aromatase Inhibitor Resistant Breast Cancer
This is a two stage study, with an initial dose escalation phase I study and subsequent double blind randomised phase II controlled trial.
- Trial name
- FAKTION (NCT01992952)
- Testing
- AZD5363, Fulvestrant
- Where
- 21 sites in United Kingdom
- Volunteers
- 149 people
- Sponsor
- Velindre NHS Trust
Renal Function
Direct Renin Inhibition and the Kidney
The objective of the study is to determine the magnitude of the effect of direct renin inhibition by VTP-27999 on renal plasma flow and kidney function.
- Trial name
- NCT01217736
- Testing
- aliskiren, VTP-27999
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Vitae Pharmaceuticals, Inc.
Small-cell Lung Cancer, Small Cell Lung Carcinoma
Small Cell Lung Cancer Irinotecan and CDC2-like Kinase Inhibition Trial (SLICK Trial)
Although small cell lung cancer (SCLC) responds dramatically to initial platinum-based chemotherapy, recurrences are nearly universal.
- Conditions
- Small-cell Lung Cancer, Small Cell Lung Carcinoma, Small Cell Lung Cancer
- Trial name
- NCT07155200
- Testing
- Cirtuvivint, Irinotecan
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Heart Defects, Congenital, Heart Septal Defects, Ventricular
Angiotensin Converting Enzyme Inhibition in Children With Mitral Regurgitation
This study will evaluate the efficacy and safety of angiotensin converting enzyme inhibition (ACE-I) therapy for the treatment of mitral regurgitation (MR).
- Conditions
- Heart Defects, Congenital, Heart Septal Defects, Ventricular, Heart Failure, Congestive
- Trial name
- AceiMR (NCT00113698)
- Testing
- Enalapril
- Where
- 7 sites in United States, Canada
- Volunteers
- 5 people
- Sponsor
- University of Utah
Metabolic Diseases, Diabetes Mellitus
Aldosterone and the Metabolic Syndrome
The purpose of this study is to determine the effects of mineralocorticoid receptor (MR) antagonism and renin inhibition on glucose metabolism in humans.
- Conditions
- Metabolic Diseases, Diabetes Mellitus, Endocrine System Diseases, Glucose Metabolism Disorders
- Trial name
- NCT01103245
- Testing
- Hydrochlorothiazide (HCTZ), Aliskiren 150 mg (ALI 150), Spironolactone (SPL 25)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Vanderbilt University Medical Center
CBD, Fear
Effects of Cannabidiol (CBD) on the Brain
Cannabidiol (CBD) is a phytocannabinoid that is one of 113 identified cannabinoids in the cannabis plant. It is derived from the hemp plant, and may treat conditions like pain, insomnia, and anxiety.
- Conditions
- CBD, Fear, Inhibition
- Trial name
- CBD (NCT04831294)
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Auburn University
Hypertension and Coronary Artery Disease
Effect of Celecoxib on Markers of Vascular Inflammation
This study involves a drug called celecoxib, which is commonly prescribed for people with arthritis. Arthritis is caused by inflammation of the joints or tissues.
- Trial name
- NCT00471341
- Testing
- Celecoxib
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of Florida