Clinical trials: Restless Leg Syndrome
Iron Deficiency Anemia of Pregnancy, Iron-deficiency
Non-invasive Detection of Iron Deficiency in Obstetrics
Validation of non-invasive measurement of zinc protoporphyrin for detection of iron deficiency in pregnancy. In addition, the impact of iron deficiency on the incidence of postpartum depression, restless legs syndrome, obstetric…
- Conditions
- Iron Deficiency Anemia of Pregnancy, Iron-deficiency, Restless Leg Syndrome in Pregnancy, Restless Leg Syndrome Due to Iron Deficiency Anaemia
- Trial name
- PICCOLINO (NCT07083492)
- Testing
- non-invasive measurement of zink protoporphyrin
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Restless Legs Syndrome
A Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome of Unknown Cause
The purpose of this study is to demonstrate the efficacy of rotigotine against placebo in adolescent subjects with idiopathic Restless Legs Syndrome (RLS) over a 12-week maintenance period and to investigate the safety and…
- Trial name
- NCT03728933
- Testing
- Rotigotine 1 milligram/24 hours, Rotigotine 2 milligram/24 hours
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- UCB Biopharma SRL
Restless Legs Syndrome
Efficacy and Safety of Pramipexole Compared to Placebo in the Treatment of Restless Legs Syndrome (RLS)
A 12 week clinical trial was conducted in the United States in order to compare pramipexole (Mirapex®) versus placebo for the ability to reduce the symptoms of restless legs syndrome in adult subjects.
- Trial name
- NCT00133198
- Testing
- Pramipexole
- Where
- 44 sites in United States
- Volunteers
- 345 people
- Sponsor
- Boehringer Ingelheim
Restless Legs Syndrome
Long-term Study Of Ropinirole In Restless Legs Syndrome
This is an initial placebo-controlled study followed by open treatment evaluating the effectiveness and tolerability of ropinirole long-term in patients with moderate to severe Restless Legs Syndrome.
- Trial name
- NCT00329602
- Testing
- Ropinirole
- Where
- 39 sites in Australia, Czechia and 9 more
- Volunteers
- 404 people
- Sponsor
- GlaxoSmithKline
Moderate to Severe Idiopathic RLS With Daytime Symptoms
Oxycodone/Naloxone Prolonged Release (OXN PR) Compared to Placebo to Demonstrate Improvement in Symptoms of Restless Legs Syndrome (RLS) in Subjects With Moderate to Severe Idiopathic RLS With Daytime Symptoms
The primary objective for the 12-week Titration-/Maintenance Period is: To demonstrate superior efficacy of OXN PR compared to PLA in the improvement of symptom severity of RLS.
- Trial name
- NCT01112644
- Testing
- Oxycodone naloxone prolonged release tablets (OXN PR)
- Where
- 3 sites in Germany, Spain and 1 more
- Volunteers
- 205 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Restless Legs Syndrome, Anxiety
Investigation of the Effects of Different Exercise Programs in Patients With Restless Legs Syndrome.
Restless leg syndrome (RLS) is a very common neurological condition characterized by an uncontrollable desire to move the legs. Due to the traumatic effect of RLS on morbidity, the patient is negatively affected in many different…
- Conditions
- Restless Legs Syndrome, Anxiety, Sleep
- Trial name
- NCT04711993
- Testing
- Aerobic exercise, Stretchin exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Gulhane School of Medicine
Hemodialysis, Restless Legs Syndrome
Exercise Training Versus Ropinirole in Treating Restless Legs Syndrome Among Hemodialysis Patients
This research aims to compare the efficacy of these two interventions, thereby addressing a critical gap in current therapeutic approaches.
- Conditions
- Hemodialysis, Restless Legs Syndrome, ESRD (End Stage Renal Disease), Diabetes Complications
- Trial name
- NCT06468371
- Testing
- Dopamine Agonist (Ropinirole), Excercise training
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Lahore General Hospital
Restless Legs Syndrome (RLS)
Intravenous Iron in the Management of Drug-resistant Restless Legs syndromeI
The pathophysiology of restless legs syndrome (RLS) is not well understood: it is thought to involve intracerebral iron deficiency and dopaminergic dysregulation.
- Trial name
- IRON-RLS (NCT07822607)
- Testing
- Ferric Carboxymaltose Injection [Ferinject], Randomization, Questionnaire and Physical Exam
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Montpellier
Neck Pain
The Effect of Dry Needling With Electrical Stimulation on Individuals With Restless Legs Syndrome
The purpose of this study is to examine the effects of dry needling with electrical stimulation (DNES) on sleep quality, symptom severity, and function in individuals with restless legs syndrome.
- Trial name
- NCT05860751
- Testing
- Dry Needling with electrical stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Restless Legs Syndrome
Three Different Transdermal Doses of Rotigotine in Subjects With Idiopathic Restless Leg Syndrome
The primary objective of this trial is to demonstrate that rotigotine (SPM 936) is efficacious in subjects with idiopathic restless leg syndrome (RLS).
- Trial name
- NCT00136045
- Testing
- Rotigotine
- Where
- Germany
- Volunteers
- 549 people
- Sponsor
- UCB Pharma
ADHD, Iron-deficiency
Impact of Iron Supplementation Treatment on Brain Iron Concentrations
The goal of the present study is to provide novel data to evaluate brain iron concentration as a mediator of the association between iron supplementation treatment and improvement in symptoms of ADHD and RLS in children…
- Conditions
- ADHD, Iron-deficiency, Restless Legs Syndrome, Periodic Limb Movement Sleep Disorder
- Trial name
- NCT04144790
- Testing
- ferrous sulfate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Restless Legs Syndrome
Yoga vs. Education for Restless Legs Syndrome: a Feasibility Study
The purpose of this study is to see whether adults with Restless Legs Syndrome (RLS) are willing to be in a 12-week study where they have a 50-50 chance of being placed in either a gentle yoga program or a film-based education…
- Trial name
- NCT03570515
- Testing
- Yoga, Educational film
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- West Virginia University
Stroke, Cramp
The Application of Wide Pulse High Frequency Neuromuscular Electrical Stimulation in Disorders Associated With Motoneuron Hyperexcitability
In the present project, the investigators aim at proposing innovative ways of investigating spinal motoneuron hyperexcitability to counteract the associated impairments by using wide pulse high frequency neuromuscular electrical…
- Conditions
- Stroke, Cramp, Restless Legs Syndrome, Healthy Volunteers
- Trial name
- MnHyperex (NCT05908214)
- Testing
- wide pulse high frequency neuromuscular electrical stimulation training
- Where
- Switzerland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Restless Legs Syndrome
The Effect of Progressive Muscle Relaxation Exercise Training Given to Pregnant Women With Restless Leg Syndrome
Restless Leg Syndrome (RLS) is a sensory-motor problem characterized by an uncomfortable and unpleasant feeling that causes a strong and overwhelming desire to move the legs, usually during periods of inactivity during sleep.It…
- Trial name
- NCT04853771
- Testing
- progressive muscle relaxation exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Gazi University
Restless Leg Syndrome
Blinded, Randomized Study of Gabapentin (Neurontin®) and Gabapentin Enacarbil (Horizant™) in Restless Leg Syndrome
The study will compare the safety, effectiveness and tolerability of gabapentin (Neurontin) versus gabapentin enacarbil (Horizant) as treatment restless leg syndrome.
- Trial name
- NCT02117076
- Testing
- Gabapentin immediate release, Gabapentin enacarbil extended release
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Theresa Zesiewicz, MD
Alzheimer's Disease, Dementia
Diagnosis and Natural History Study of Patients With Neurological Conditions
The purpose of this study is to improve understanding of neurological conditions. Patients participating in this study will continue receiving medical care, routine laboratory tests, and diagnostics tests (X-rays, CT-scans, and…
- Conditions
- Alzheimer's Disease, Dementia, Movement Disorder, Multiple System Atrophy
- Trial name
- NCT00001549
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Restless Leg Syndrome
Restless Legs Syndrome in Hemodialysis Patients
Restless legs syndrome (RLS) is defined as the spontaneous movement of the limbs (mainly legs) associated with unpleasant - painful sensation which is relieved by moving the affected limb.
- Trial name
- NCT03337529
- Testing
- Vitamin C
- Where
- Lebanon
- Volunteers
- 19 people
- Sponsor
- Makassed General Hospital
Restless Legs Syndrome, Stroke
Restless Legs Syndrome in Stroke Patients
Our study aimed to examine a possible association between Restless legs syndrome and cerebrovascular disease, by examining patients during hospitalization for acute stroke or transient ischemic attack, in a matched case-control…
- Conditions
- Restless Legs Syndrome, Stroke, Transient Ischemic Attack
- Trial name
- NCT01967303
- Volunteers
- 447 people
- Sponsor
- Rambam Health Care Campus
Restless Legs Syndrome
Safety and Efficacy of Rasagiline in Restless Legs Syndrome
The purpose of this study is to find out if rasagiline improves RLS symptoms. We also want to make sure rasagiline is safe to give people with RLS.
- Trial name
- RAS-RLS (NCT01192503)
- Testing
- rasagiline
- Where
- 8 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of Virginia
Sleep Disorders, Sleep Apnea, Obstructive
Comprehensive Police Fatigue Management Program
Police officers work some of the most demanding schedules known, which increases their risk of sleep deprivation and sleep disorders.
- Conditions
- Sleep Disorders, Sleep Apnea, Obstructive, Restless Legs Syndrome, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT00246051
- Testing
- Sleep Hygiene Education, Expert-Led Sleep Disorders Screening and Treatment, Online Sleep Disorders Screening
- Where
- United States
- Volunteers
- 683 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital