Clinical trials: Restless Leg Syndrome, open to volunteers
Restless Leg Syndrome (RLS), Spinal Cord Stimulation (SCS)
Neuromodulation to Overcome Severe Restless Legs Syndrome
This prospective, single-center, first-in-indication feasibility study will evaluate the safety and preliminary effectiveness of spinal cord stimulation (SCS) for the treatment of severe, treatment-refractory primary Restless…
- Trial name
- NO RLS (NCT07780032)
- Testing
- Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Marshall Holland
Restless Leg Syndrome
Tolerability and Efficacy of CBD Extract for RLS Treatment
This study plans to learn more about the safety and tolerability of high Cannabidiol (CBD) cannabis extract (BRC-002) for use in Idiopathic Restless Legs Syndrome.
- Trial name
- NCT07224932
- Testing
- BRC-002, Placecbo
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Restless Leg Syndrome (RLS)
The Effect of Acupressure on Restless Legs Syndrome and Pruritus in Patients Undergoing Hemodialysis
This randomized controlled trial aims to evaluate the effect of combined traditional and paraspinal acupressure on restless legs syndrome and pruritus among patients undergoing hemodialysis.
- Trial name
- RLS/CKD-aP (NCT07814443)
- Testing
- Vibration Assisted Acupressure
- Where
- Iraq
- Volunteers
- 70 people
- Sponsor
- University of Baghdad
End Stage Renal Failure, Hemodialysis, Restless Leg Syndrome (RLS)
Efficacy and Safety of Super High-Flux Hemodialysis in Maintenance Dialysis Patients. SHINE-RLS (Super High-flux Dialysis Improves Neuro-symptoms and Efficacy in Restless Legs Syndrome)
Patients with end-stage kidney disease (ESKD) rely on maintenance hemodialysis. While high-flux hemodialysis improves small solute clearance, its removal of middle-molecule uremic toxins (e.g., α1-microglobulin [α1-MG]) remains…
- Trial name
- SHINE-RLS (NCT07794826)
- Testing
- Super High-Flux HD
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Far Eastern Memorial Hospital
Restless Leg Syndrome (RLS), Spinal Cord Stimulation (SCS)
The Effect of Spinal Cord Stimulators on Restless Leg Syndrome
This study aims to evaluate neurophysiological responses and symptom changes in individuals with Restless Legs Syndrome (RLS) and/or chronic pain.
- Trial name
- NCT07179406
- Testing
- H-Reflex, Somatosensory evoked potential (SSEP), Vibratory Electrophysiological Response Potential (ERP)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Restless Leg Syndrome
Effects of Static Stretching and Strength Training on Antenatal Restless Leg Syndrome
Restless Legs Syndrome (RLS) is a prevalent sensorimotor disorder affecting pregnant women, particularly in the third trimester, and is associated with sleep disturbances, fatigue and reduced quality of life.
- Trial name
- NCT07642089
- Testing
- Static Stretching, Static Stretching + Strength Training
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Restless Leg Syndrome in Pregnancy
Comparative Effects of Aerobic and Muscle Relaxation Exercises in Pregnant Women With Restless Leg Syndrome
This study will be a randomized controlled trial and will be conducted in the Gynecology and Physiotherapy departments of Valencia Health Clinic, Lahore. Non-probability purposive sampling will be used to collect data.
- Trial name
- NCT07628387
- Testing
- aerobic exercises, progressive muscle relaxation
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Restless Leg Syndrome (RLS)
Study on the Efficacy of Spinal Cord Stimulation in Patients With Severe Refractory Primary or Secondary RLS
A Double-Blind Randomized Controlled Crossover Study to compare the short-efficacy of Burst-SCS with Sham Stimulation, in patients with severe to very severe RLS refractory or intolerant to standard available treatments and/or…
- Trial name
- REST-SCS (NCT07571733)
- Testing
- Spinal cord stimulation (SCS)
- Where
- 2 sites in Switzerland
- Volunteers
- 15 people
- Sponsor
- Clinica ARS Medica
Restless Leg Syndrome (RLS)
Using Cannabis to Treat Restless Legs Syndrome
Restless Legs Syndrome (RLS) is a disorder that causes painful and uncomfortable sensations in the legs, and its symptoms have a significant impact on sleep and quality of life.
- Trial name
- NCT06863740
- Testing
- Cannabis oil
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Restless Leg Syndrome Due to Uraemia
A Self-Controlled Study on the Treatment of Restless Legs Syndrome in Uremia With Dipyridamole
The purpose of this clinical trial is to determine whether dipyridamole can treat restless legs syndrome in patients with uremia. In addition, the safety of dipyridamole will also be evaluated.
- Trial name
- NCT07199504
- Testing
- Dipyridamole 50mg tid
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Yunfeng Xia
Restless Leg Syndrome (RLS), Variant Restless Legs Syndrome
Novel Calcium Channel Modulators in RLS and Variants: Efficacy & Safety
The goal of this [study type: clinical trial] is to [primary purpose: evaluate the efficacy and safety of a novel calcium channel modulator in treating Restless Legs Syndrome (RLS) and its variant subtypes] in [describe…
- Trial name
- NCT07453862
- Testing
- Crisugabalin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Friendship Hospital
Restless Leg Syndrome
The Suggested Immobilization Test With Exploratory Heart Rate Variability Analysis for Diagnosis of Restless Legs Syndrome
Restless leg syndrome (RLS) is not uncommon and can also affect people's health and quality of life. Mainly, RLS is diagnosed based on clinical criteria subjectively.
- Trial name
- NCT07110961
- Testing
- A suggested immobilization test (SIT)
- Where
- Thailand
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Restless Leg Syndrome (RLS)
Combined Effects of Near-Infrared Light and Vibration on Diabetic Patients With Restless Leg Syndrome
This Randomized Clinical Trial, titled "Combined Effects of Near-Infrared Light and Vibration on Pain, Sleep Quality and Symptom Severity in Diabetic Patients with Restless Leg Syndrome," aims to evaluate a non-pharmacological…
- Trial name
- NCT07308080
- Testing
- Near-Infrared Light Therapy, Vibration, Conventional Physical Therapy
- Volunteers
- 42 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Hemodialysis Patient, Restless Leg Syndrome (RLS)
Effect of Autogenic Training on Hemodialysis Patients
goal of this interventional study to investigate the effect of autogenic training on sleep disturbance , restless leg syndrome and fatigue on hemodialysis patient Is there any significant effect of autogenic training on restless…
- Conditions
- Hemodialysis Patient, Restless Leg Syndrome (RLS), Fatigue, Sleep Disturbance
- Trial name
- NCT07276828
- Testing
- Autogenic training, conventional physical therapy and hemodialysis care
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Cairo University
Restless Leg Disorder, Restless Leg Syndrome (RLS)
Peroneal Electrical Nerve Stimulation in Pregnancy for Restless Legs Syndrome
The goal of this study is to evaluate whether peroneal electrical nerve stimulation (PNS) using the TOMAC™ device is a feasible, acceptable, and safe non-pharmacologic intervention for managing Restless Legs Syndrome (RLS) during…
- Conditions
- Restless Leg Disorder, Restless Leg Syndrome (RLS), Pregnancy, Sleep Disorder (Disorder)
- Trial name
- PENS-P (NCT07144631)
- Testing
- Peroneal Nerve Stimulation (PNS) Device
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Rhode Island Hospital
Restless Leg Syndrome With Knee OA, Sleep Disorder
Comparative Effectiveness of Myofacial Release vs Cupping Therapy on Quality of Life in Restless Leg Syndrome With Knee O.A.
The aim of this study is to determine effectiveness of Myofascial Release and Cupping Therapy on Quality of Life in Restless Leg Syndrome with knee Osteoarthritis.
- Trial name
- RCT (NCT06918847)
- Testing
- Myofacial release, Dynamic cupping therapy
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Dow University of Health Sciences
Restless Leg Syndrome (RLS)
Observe Change in Nasal Swab DRD2 Gene Expression in Restless Legs Syndrome (RLS) Patients on Prolonged Dopamine Agonist Treatment
The study aims to observe changes in dopaminergic genes expression in peripheral tissue upon prolonged dopamine agonist treatment on patients with Restless Legs Syndrome (RLS).
- Trial name
- RLS-DRD2gene (NCT06726785)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- HBC Immunology Inc
Iron Deficiency Anemia of Pregnancy, Iron-deficiency
Non-invasive Detection of Iron Deficiency in Obstetrics
Validation of non-invasive measurement of zinc protoporphyrin for detection of iron deficiency in pregnancy. In addition, the impact of iron deficiency on the incidence of postpartum depression, restless legs syndrome, obstetric…
- Conditions
- Iron Deficiency Anemia of Pregnancy, Iron-deficiency, Restless Leg Syndrome in Pregnancy, Restless Leg Syndrome Due to Iron Deficiency Anaemia
- Trial name
- PICCOLINO (NCT07083492)
- Testing
- non-invasive measurement of zink protoporphyrin
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Elderly, Restless Leg Syndrome (RLS)
Effects of PNF Stretching vs Conventional Physical Therapy on the Symptoms of Restless Leg Syndrome in Elderly Population.
Restless leg Syndrome (RLS) is a common condition in the elderly population,characterized byan uncontrollable urge to move the leg,often occuring in the evening or at night,which can significantly disturb sleep and daily…
- Conditions
- Elderly, Restless Leg Syndrome (RLS), Proprioceptive Neuromuscular Facilitation, Sleep Disturbance
- Trial name
- NCT06747741
- Testing
- PNF stretching(Contract relax with agonist contraction), Conventional physical therapy
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Foundation University Islamabad