Clinical trials: Resuscitation
Polytrauma, Resuscitation, Trauma Patients
Pv-aCO₂ Gap-Guided Resuscitation in Adult Polytrauma Patients: A Prospective Randomized Controlled Trial
dult patients with multiple traumatic injuries admitted to the ICU from the operating room, emergency department, or hospital wards who meet the study criteria will be included after obtaining informed consent from the patient or…
- Trial name
- NCT07480655
- Testing
- Veno-arterial Carbondioxide gap, Conventional resuscitation end points
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Pakistan Institute of Medical Sciences
Neonatal Resuscitation, Neonatal Disease
Pedi-Cap CO2 Detector for Face-mask Ventilation in the Delivery Room
The goal of this study is to determine if using a Pedi-Cap (a type of colorimetric carbon dioxide detector) during face mask ventilation (PPV) for newborn infants in the delivery room will lower the time of PPV needed.
- Trial name
- CO2-Vent (NCT06258187)
- Testing
- Pedi-Cap
- Where
- United States
- Volunteers
- 632 people
- Sponsor
- University of Texas Southwestern Medical Center
Cardiac Arrest (CA), Cardiopulmonary Resuscitation
RescueDoppler- a Disruptive Ultrasound Solution for Improved Outcome After Cardiac Arrest.
RescueDoppler is an innovative, hands-free Doppler system designed for continuous monitoring of blood flow in the carotid artery, distinguishing between the presence and absence of a pulse.
- Conditions
- Cardiac Arrest (CA), Cardiopulmonary Resuscitation, Doppler Ultrasound
- Trial name
- RescueDoppler (NCT06599073)
- Testing
- RescueDoppler, Rescue
- Where
- 8 sites in Norway, Sweden
- Volunteers
- 285 people
- Sponsor
- Norwegian University of Science and Technology
Neonatal Resuscitation, Delivery Room Resuscitation
Supraglottic Airway for Resuscitation Trial
This is a hybrid type 3 effectiveness-implementation parallel cluster randomized superiority trial designed to compare two strategies to promote early supraglottic airway (SA) rescue during neonatal resuscitation, with a focus on…
- Conditions
- Neonatal Resuscitation, Delivery Room Resuscitation, Positive Pressure Ventilation, Infant, Newborn
- Trial name
- SUGAR (NCT07150923)
- Testing
- Enhanced Standard of Care ("Enhanced"), Enhanced Standard of Care ("Enhanced-Plus")
- Where
- 30 sites in United States
- Volunteers
- 36,503 people
- Sponsor
- Children's Hospital of Philadelphia
Resuscitation
Effect of Nalmefene on the Quality of Resuscitation in Patients Under General Anesthesia
Postoperative recovery is an important part of the patient's experience. A good recovery period is an important guarantee for the recovery of postoperative organs and functions after surgery.
- Trial name
- NCT04713358
- Testing
- Nalmefene, normal Saline
- Where
- 4 sites in China
- Volunteers
- 542 people
- Sponsor
- RenJi Hospital
Out-of-hospital Cardiac Arrest (OHCA), Cardiopulmonary Resuscitation (CPR)
The AIR-CPR Study: AI-Guided Chest Compressions
The AIR-CPR project aims to improve survival rates for patients with Out-of-Hospital Cardiac Arrest (OHCA) by utilizing Artificial Intelligence (AI) to optimize chest compression locations.
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), Cardiopulmonary Resuscitation (CPR), Aortic Valve Compression, Precision Resuscitation
- Trial name
- AIR-CPR (NCT07431710)
- Testing
- Device: AI-Enhanced Arterial Waveform Monitor (AIR-CPR App), AI-Guided Chest Compression Repositioning, Transesophageal Echocardiography (TEE)
- Where
- Taiwan
- Volunteers
- 255 people
- Sponsor
- Far Eastern Memorial Hospital
Severe Sepsis or Septic Shock, Fluid Resuscitation
COrporeal Compression at the ONset of Severe Sepsis and Septic Shock
Early and adequate fluid resuscitation (< 6 hours) in patients with circulatory failure is essential but may exacerbate oedema, which may itself: 1) aggravate pulmonary lesions and prolong mechanical ventilation, 2) aggravate…
- Trial name
- COCOON (NCT02656654)
- Testing
- Whole-body compression
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Medical Education, Cardiopulmonary Resuscitation (CPR)
Video-Based Versus Simulation-Based Basic Life Support Training in Medical Students
This randomized educational trial compared a structured video-based Basic Life Support (BLS) training program with simulation-based BLS training among fourth-year medical students.
- Conditions
- Medical Education, Cardiopulmonary Resuscitation (CPR), Basic Life Support (BLS) Training
- Trial name
- BLS-VIDEO-SIM (NCT07368452)
- Testing
- Video-based BLS training, Simulation-based BLS training
- Where
- Turkey (Türkiye)
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Adult Non-trauma Cardiac Arrest Resuscitation, Effectiveness of In-situ Simulation (ISS) Training
Effectiveness of In-Situ Simulation Training in Adult Non-Trauma Resuscitation: A Comparison of ISS and OSS Team Performance Using the A-C-L-S Model
This study employed a two-group non-randomized pre-post design to evaluate the effectiveness of interprofessional ISS training over one year at the National Taiwan University Hospital Yunlin Branch.
- Conditions
- Adult Non-trauma Cardiac Arrest Resuscitation, Effectiveness of In-situ Simulation (ISS) Training, Effectiveness of Off-site Simulation (OSS) Training, Improvement of Teamwork in Emergency Care Settings
- Trial name
- NCT07358793
- Testing
- In-situ Simulation (ISS) Training, Off-site Simulation (OSS) Training
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.
The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition…
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Positive End-expiratory Pressure (PEEP), Ventilation During Resuscitation
- Trial name
- Lazarus-PEEP (NCT06939335)
- Testing
- Disposable PEEP Valve set at 5 cm H20., Controle
- Where
- 7 sites in Belgium, France
- Volunteers
- 132 people
- Sponsor
- University Hospital, Ghent
Cardiopulmonary Resuscitation (CPR), ESCAPE ROOM
The Effect of Escape Room Simulation on Nursing Students' Clinical Decision-Making and Teamwork Attitudes Regarding Cardiopulmonary Resuscitation
The study was planned as a randomized controlled trial with a pre-test-post-test-follow-up design involving experimental and control groups.
- Trial name
- NCT07336511
- Testing
- Escape room
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Yildirim Beyazıt University
Pediatric Cardiac Arrest (Simulated), Cardiopulmonary Resuscitation, Simulation Training
Effect of Bed Height on Chest Compression Quality and Provider Biomechanics During Pediatric CPR Simulation
High-quality chest compressions are critical for outcomes after pediatric cardiac arrest, yet rescuer ergonomics and bed height may adversely affect compression quality and fatigue.
- Conditions
- Pediatric Cardiac Arrest (Simulated), Cardiopulmonary Resuscitation, Simulation Training, In-Hospital Cardiac Arrest, Rescuer Fatigue During CPR
- Trial name
- NCT07329842
- Testing
- Fixed Standard Bed Height (58 cm), Anthropometry-Based Bed Height (Patella Midpoint), Anthropometry-Based Bed Height (Lower One-Third Patella-ASIS)
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Cardiac Arrest (CA), Cardiac Arrest With Successful Resuscitation
A Study on the Impact of a New Canton-Wide First Responder System in Zug, Switzerland, on Survival After Adult Cardiac Arrest-Examining Early Life-Saving Organized Help, Fast Defibrillation, and Improved Outcomes for Out of Hospital Cardiac Arrest
REVIVE Zug: Improving Emergency Response for Out-of-Hospital Cardiac Arrest Out-of-hospital cardiac arrest (OHCA) represents one of the most time-critical medical emergencies, where rapid recognition and immediate intervention…
- Conditions
- Cardiac Arrest (CA), Cardiac Arrest With Successful Resuscitation, Resuscitation, Emergency Medical Services
- Trial name
- REVIVE Zug (NCT07323667)
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- Felix Brinkmann
Cardiopulmonary Resuscitation (CPR), Electrical Shock
Effect of Electrically Insulated Gloves on ROSC Time, End-tidal CO₂ Response, Survival and Morbidity in Uninterrupted CPR
Cardiopulmonary arrest is the sudden cessation of spontaneous breathing and circulation due to various causes. Cardiopulmonary resuscitation (CPR) is the set of decisions and procedures encompassing all efforts aimed at restoring…
- Conditions
- Cardiopulmonary Resuscitation (CPR), Electrical Shock, Defibrillation
- Trial name
- IG-CPR (NCT07299188)
- Testing
- HANDS ON BUT OFF DEFIBRILLATION
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Izmir Katip Celebi University
Resuscitation, Burn
Optimizing Fluid Resuscitation in Adults With Major Burns: A Randomized Trial of Burn Navigator™ Versus Parkland Formula
Burn injuries affecting ≥20% TBSA trigger major fluid shifts requiring aggressive fluid resuscitation to prevent burn shock. Traditional formulas such as the Parkland and Modified Brooke estimate initial 24-hour fluid needs, but…
- Trial name
- FLARE (NCT07307599)
- Testing
- Burn Navigator, Resuscitation (Voluven)
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Alnas Hospital
Coma, Heart Arrest
Predictive Outcome in Comatose Patients
Evaluating the prognosis of comatose patients after cardiac arrest (CA) in the intensive care unit (ICU) remains challenging. It requires a multimodal approach combining standardized clinical examination, serum biomarkers…
- Conditions
- Coma, Heart Arrest, Cardiopulmonary Resuscitation
- Trial name
- PRECOM (NCT05321459)
- Testing
- Neurological prognosis
- Where
- 7 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Shock
Fluid Management and Individualized Resuscitation in Sepsis
The goal of this clinical trial is to find out if a personalized treatment approach can improve care for people with sepsis in the emergency department (ED).
- Conditions
- Sepsis, Shock, Personalized Medicine, Emergency Medicine
- Trial name
- FLUIDS (NCT07009665)
- Testing
- Personalized SV-guided resuscitation, Standard Care Resuscitation
- Where
- Netherlands
- Volunteers
- 188 people
- Sponsor
- University Medical Center Groningen
Healthy Participants, Knowledge Acquisition
Learning Cardiopulmonary Resuscitation in the School Setting: RCP-KNOW Project.
Title: Out-of-hospital cardiorespiratory arrest and learning cardiopulmonary resuscitation in the school setting: evidence synthesis. CPR-KNOW PROYECT.
- Conditions
- Healthy Participants, Knowledge Acquisition, Cardiopulmonary Resuscitation (CPR), Children
- Trial name
- RCP-KNOW (NCT07292532)
- Testing
- Cardiopulmonary Resuscitation Teaching Intervention in Children
- Where
- 2 sites in Spain
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Basic Life Support Training Course, Cardiopulmonary Resuscitation (CPR)
Serious Game vs Traditional BLS Training in Adolescents
This randomized controlled trial aimed to compare the effects of a serious video game and traditional training on adolescents' basic life support (BLS) knowledge and skills.
- Trial name
- NCT07286708
- Testing
- Lifesaver Video Game CPR Training, Traditional Instructor-Led CPR Training
- Where
- Turkey (Türkiye)
- Volunteers
- 117 people
- Sponsor
- Burcu SELVI CALSIKAN
Cardiac Arrest, Heart Arrest
Rehabilitation for Survivors of Out-of-hospital Cardiac Arrest
This study is a parallel group multicentre investigator-initiated clinical randomised controlled superiority trial that will include a total of 214 survivors of OHCA.
- Conditions
- Cardiac Arrest, Heart Arrest, Cardiopulmonary Resuscitation, Return to Work
- Trial name
- NCT05173740
- Testing
- Individually tailored rehabilitation intervention, Usual care
- Where
- Denmark
- Volunteers
- 214 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet