Clinical trials: Resuscitations
Shock, Cardiovascular Diseases
Evaluation of Microcirculatory Function and Mitochondrial Respiration After Cardiovascular Surgery
This study will examine the differences in microcirculatory function and mitochondrial respiration in patients with shock after cardiovascular surgery.
- Conditions
- Shock, Cardiovascular Diseases, Critical Illness
- Trial name
- MicroRESUS (NCT05330676)
- Testing
- coronary artery bypass grafting, valve repair/replacement
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Pennsylvania
Intubation
Comparison Four Intubation Devices
Comparison of four laryngoscope blades (Miller, Macintosh, Phillips and Wis-Hipple) for infant intubation during resuscitation with and without chest compressions.
- Trial name
- NCT02280213
- Testing
- MIL, MAC, WIS
- Where
- Poland
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- International Institute of Rescue Research and Education
Intensive Care Unit Acquired Weakness, Shock, Septic
Hemodynamic Phenotype-Based,Capillary Refill Time-Targeted Resuscitation In Early Septic Shock:ANDROMEDA-SHOCK-2
Over-resuscitation including fluid overload has been associated with increased morbidity (prolonged duration of organ failure) and mortality in septic shock.
- Trial name
- ANDROMEDA-FR (NCT06062303)
- Testing
- Usual care (UC)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stillbirth, Neonatal Respiratory Depression
Newborn Heart Rate as a Catalyst for Improved Survival
Heart rate (HR) is not routinely assessed during newborn resuscitations in low- and lower-middle income countries (LMICs). Many non-breathing newborns classified as fresh stillbirths have a heartbeat and are live born.
- Conditions
- Stillbirth, Neonatal Respiratory Depression, Neonatal Bradycardia, Neonatal Resuscitation
- Trial name
- NCT03799861
- Testing
- Epoch 2: HBB with NeoBeat, Epoch 3: HR-guided HBB
- Where
- 3 sites in Democratic Republic of the Congo
- Volunteers
- 24,034 people, healthy volunteers welcome
- Sponsor
- American Academy of Pediatrics
Acute Coronary Syndrome
Effects and Plasma Concentration of Ticagrelor, After Crushed and Non-crushed Intake, After Acute Coronary Syndrome
The first aim of the study is to prove that after starting the therapy with crushed tablets, the platelet inhibition will be as expected after starting therapy with intact tablets. Gurbel et al.
- Trial name
- ticagrelor (NCT02341729)
- Testing
- ticagrelor
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Infant, Premature, Diseases, Continuous Positive Airway Pressure
Routine Or Selective Application of a Face Mask for Preterm Infants at Birth: the ROSA Trial
International guidelines recommend giving positive pressure ventilation (PPV) by face mask to newborns who do not breathe or have a slow heart rate at birth.
- Conditions
- Infant, Premature, Diseases, Continuous Positive Airway Pressure, Positive-Pressure Respiration, Resuscitation
- Trial name
- ROSA (NCT04500353)
- Testing
- Face mask application for CPAP and/or PPV delivery
- Where
- Ireland
- Volunteers
- 201 people
- Sponsor
- University College Dublin
Critically Ill, Acute Kidney Injury
Renal Resistive Index and Cardiac Output Changes During Resuscitation Predict the Occurrence of Acute Kidney Injury in Septic Shock Patients
Record the renal resistive index and hemodynamic parameters ( record the cardiac output and stroke volume if the patient's next to kin agree to undertake a PiCCO monitoring ) before and after resuscitation for severe sepsis or…
- Conditions
- Critically Ill, Acute Kidney Injury, Septic Shock
- Trial name
- CORRI (NCT01862588)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Basic Life Support (Simulation)
Supporting Tools and Cognitive Aids for BLS
Various studies have shown that rapid and correctly performed cardiopulmonary resuscitation (CPR) significantly increases the survival rate after cardiac arrest.
- Trial name
- NCT06601946
- Testing
- BLS Paper Based Cognitive App, First Aid App, Corpatch App
- Where
- Austria
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Heart Arrest, Coma
Pilot Clinical Study of the LRS ThermoSuit™ System in Post Arrest Patients
The purpose of this study is to determine if the Life Recovery Systems Thermosuit(R) System is able to quickly and conveniently cool patients who are comatose after resuscitation from cardiac arrest.
- Trial name
- NCT00410969
- Testing
- ThermoSuit(R) System
- Where
- 2 sites in Canada
- Volunteers
- 27 people
- Sponsor
- Life Recovery Systems
Cardiac Arrest, Sudden Cardiac Death
Hemodynamic Efficiency of an Hemodialysis Treatment With High Permeability in Post-resuscitation Shock
Rationale: Despite spontaneous cardiac activity recovery, a shock occurs in more than half of patients after resuscitation for cardiac arrest.
- Conditions
- Cardiac Arrest, Sudden Cardiac Death, Shock
- Trial name
- Hyperdia (NCT00780299)
- Testing
- hemodialysis with high permeability (HDHP), CVVH
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Blunt Trauma, Penetrating Wound
Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma
Primary Aim: To determine the feasibility and safety of hypotensive resuscitation for the early treatment of patients with traumatic shock compared to standard fluid resuscitation.
- Conditions
- Blunt Trauma, Penetrating Wound, Hemorrhagic Shock
- Trial name
- HypoResus (NCT01411852)
- Testing
- 0.9% Sodium Chloride 250 mL bolus, 0.9% Sodium Chloride 2000 mL bolus
- Where
- 6 sites in United States, Canada
- Volunteers
- 192 people
- Sponsor
- University of Washington
Critical Illness, Epidural Analgesia
Epidural Analgesia in Intensive Care Unit (APD-REA: Analgesie PeriDurale en REAnimation)
Epidural analgesia (EA) has been mainly investigated during the perioperative period. In the intensive care unit settings, EA should be proposed in critically ill patients, such as postoperative or trauma patients, typically.
- Trial name
- NCT01437358
- Testing
- Epidural analgesia
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Covid19, Cardiac Arrest
COVID-19 Resuscitation Plans and Decisions on Escalation and Limitation of Treatment
During the Corona Virus Pandemic health care resources have become scare, and the pandemic has brought forth the need for risk stratification of patients suffering from COVID19 in order to allocate resources appropriately.
- Trial name
- CORDEAL (NCT04743232)
- Testing
- Decision tool for clinicians
- Where
- 7 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Cardiopulmonary Resuscitation, Respiratory Physiology
Comparison of the Efficiency of Mouth-to-nose Breathing With Mouth-to-mouth Breathing
The purpose of this study is to find out the best way of providing artificial breathing during cardiopulmonary resuscitation (CPR). Current standard CPR involves giving mouth-to-mouth breathing to people requiring CPR.
- Trial name
- NCT00785447
- Testing
- Mouth-to-mouth or mouth-to-nose breathing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Septic Shock
SQUEEZE Trial: A Trial to Determine Whether Septic Shock Reversal is Quicker in Pediatric Patients Randomized to an Early Goal Directed Fluid Sparing Strategy vs. Usual Care
The purpose of the SQUEEZE Trial is to determine which fluid resuscitation strategy results in the best outcomes for children treated for suspected or confirmed septic shock.
- Trial name
- SQUEEZE (NCT03080038)
- Testing
- Fluid Sparing Resuscitation Strategy
- Where
- 8 sites in Canada
- Volunteers
- 406 people
- Sponsor
- McMaster University
Sudden Cardiac Arrest, Seizures
EEG in Resuscitated In-hospital Patients
In Kuopio University Hospital Department of Clinical Neurophysiology there have been designed a fast EEG electrode, that is suitable for acute emergency use.
- Trial name
- NCT02349087
- Testing
- Acute EEG with fast applicable EEG electrode
- Where
- Finland
- Volunteers
- 1 people
- Sponsor
- Kuopio University Hospital
Heart Arrest, Cardiac Arrest, Out-Of-Hospital
Synergy of Elevation of the Head and Thorax and REBOA During Out-of-Hospital Cardiac Arrest
Long-term neurological outcome after successful resuscitation of cardiac arrest remains poor, mainly due to cerebral hypoperfusion and severe hypoxic-ischemic brain injuries.
- Conditions
- Heart Arrest, Cardiac Arrest, Out-Of-Hospital, Cardiopulmonary Arrest, Cardiopulmonary Resuscitation
- Trial name
- GRAVITY2 (NCT06537492)
- Testing
- REBOA, Head-Up Cardiopulmonary Resuscitation (AHUP-CPR), Mechanical Chest Compression Device with Active Chest Decompression
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Grenoble
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.
The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition…
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Positive End-expiratory Pressure (PEEP), Ventilation During Resuscitation
- Trial name
- Lazarus-PEEP (NCT06939335)
- Testing
- Disposable PEEP Valve set at 5 cm H20., Controle
- Where
- 7 sites in Belgium, France
- Volunteers
- 132 people
- Sponsor
- University Hospital, Ghent
Rare Diseases, Congenital Diaphragmatic Hernia
Intact Cord Resuscitation in CDH
Isolated CDH is a rare disease (1/3500) and displays a wide range of severity and outcome. Despite attempts to standardize the management of this disease at birth and during the first months of life, the mortality varies from 20…
- Trial name
- CHIC (NCT04429750)
- Testing
- Immediate umbilical cord clamping, intact cord resuscitation
- Where
- 3 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Lille
Cardiac Arrest, Post-cardiac Arrest Care
Neuroprotection Bundles For Comatose Survivors Following Cardiac Arrest
The investigators designed LAPTOPS to determine the effectiveness of a goal-directed neuroprotection bundles of active management including body temperature,PaCO2,PaO2,position,Blood glucose ,blood sodium,Blood pressure and…
- Trial name
- LAPTOPS (NCT06992843)
- Testing
- Goal-directed care bundle for neuroprotection, Usual Care
- Where
- China
- Volunteers
- 1,008 people
- Sponsor
- Xiangya Hospital of Central South University
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