Clinical trials: Resuscitations
Heart Transplant
Donors After Circulatory Death Heart Trial
To evaluate the effectiveness of the OCS Heart System to resuscitate, preserve and assess hearts donated after circulatory death for transplantation to increase the pool of donor hearts available for transplantation.
- Trial name
- NCT03831048
- Testing
- OCS Heart System, Cold Storage
- Where
- 25 sites in United States
- Volunteers
- 180 people
- Sponsor
- TransMedics
Critical Illness, Trauma
Fluid Resuscitation Optimization in Surgical Trauma Patients (FROST)
The aim of this study is to determine if the incidence of post-operative complications can be decreased by the implementation of intra-operative, minimally invasive hemodynamic monitoring (MIHM) via FloTrac™ and EV1000™ in trauma…
- Trial name
- FROST (NCT02742974)
- Testing
- Device: FloTrac™ and EV1000™, Volume Challenge, Vasopressor Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- CAMC Health System
Intraosseus Access, Manikin
Intraosseous Access
The investigators will compare the success rates and time to successful IO access during simulated adult resuscitation.
- Conditions
- Intraosseus Access, Manikin, Resuscitation
- Trial name
- NIO (NCT02275520)
- Testing
- NIO Adult device, Bone Iniection Gun, EZ-IO
- Where
- Poland
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- International Institute of Rescue Research and Education
Resuscitation
Ambulance Crews' Experiences of Using a Mechanical Chest Compression Device.
Should a person have a cardiac arrest (where their heart stops beating) they require treatment of cardiopulmonary resuscitation (CPR). This includes providing chest compressions.
- Trial name
- NCT04478786
- Testing
- Focus group discussion
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Northumbria University
High-fidelity Simulation
High-Fidelity Simulation
This study explores the impact of high-fidelity simulation-based training on critical care nurses' emergency knowledge, skills, and teamwork in emergency and intensive care units.
- Trial name
- NCT06935773
- Testing
- High-Fidelity Simulated Emergency Training, No intervention (observational study)
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Pei Yu Huang
Hemorrhagic Shock, Trauma
Inferior Vena Cava Versus Subclavian Vein Collapsibility for Predicting Fluid Responsiveness in Trauma Hemorrhagic Shock
Hemorrhagic shock from severe bleeding is a leading cause of preventable death in trauma patients. Intravenous (IV) fluid resuscitation is essential for stabilizing blood pressure and organ perfusion, but administering too much…
- Conditions
- Hemorrhagic Shock, Trauma, Hypovolemia, Fluid Responsiveness
- Trial name
- NCT07817966
- Volunteers
- 120 people
- Sponsor
- Assiut University
Cardiac Arrest (CA)
PRECISION-CPR: PRecision-Controlled Ventilation in CPR
Cardiac arrest is a life-threatening emergency that requires immediate treatment with cardiopulmonary resuscitation (CPR). While chest compressions circulate blood, manual ventilation provides oxygen to the patient.
- Trial name
- NCT07088120
- Testing
- Precision-Controlled Ventilation with Real-Time Feedback, Standard Manual Ventilation During CPR
- Where
- 2 sites in United States, Mexico
- Volunteers
- 852 people
- Sponsor
- Rush University Medical Center
Shock
Consistency of Fluid Tolerance Evaluation Methods and Their Correlation With Clinical Outcomes in Patients With Shock
This study aims to explore the feasibility and scientific validity of carotid-jugular Doppler in evaluating volume tolerance in shock patients (with the VExUS score as an important reference standard), and to conduct an in-depth…
- Trial name
- NCT07373717
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Southeast University, China
Out-of-hospital Cardiac Arrest
The PulsePoint Randomized Controlled Trial
"Sudden cardiac arrest" occurs when someone's heart stops beating unexpectedly. Each year, more than 45,000 Canadians have a cardiac arrest.
- Trial name
- NCT01746290
- Testing
- PulsePoint notification
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen's University
Trauma and Emergency Care, Shock,Hemorrhagic
Delayed Fluids in Hemorrhagic Shock Due to Severe Injuries.
This study will provide information on the quality of care in hemorrhagic shock of severe injuries in a limited resource facility of Latin America, the strategies of fluid resuscitation, and outcomes.
- Conditions
- Trauma and Emergency Care, Shock,Hemorrhagic, Intravenous Fluid Therapy
- Trial name
- PERMIT-LATAM (NCT07530653)
- Testing
- Crystalloid below 1000 mL., IV fluids more than 1,000 mL
- Where
- Colombia
- Volunteers
- 716 people
- Sponsor
- Hospital Departamental de Villavicencio
Sepsis
Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock
Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock
- Trial name
- NCT05118646
- Testing
- sublingual microcirculation,, hemodynamic monitoring
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Xiangya Hospital of Central South University
Acute Kidney Injury
Isotonic Solution Administration Logistical Testing
The administration of intravenous crystalloids is ubiquitous in the care of the critically ill. Commonly available crystalloid solutions contain a broad spectrum of electrolyte compositions including a range of chloride…
- Trial name
- SALT (NCT02345486)
- Testing
- 0.9% sodium chloride, Physiologically balanced fluid
- Where
- United States
- Volunteers
- 974 people
- Sponsor
- Vanderbilt University
Prevention of Sudden Death
Training Mothers of Infants in Infant Cardiopulmonary Resuscitation (CPR)
This research will be a prospective, cohort study to determine if mothers of infants/newborns are more willing to complete CPR training using a 22-minute instructional DVD and infant manikin versus traditional four hour didactic…
- Trial name
- NCT00570869
- Testing
- CPR Anytime
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Lehigh Valley Hospital
Stress, Stress, Psychological
Simulation-based Stress Inoculation Training Study for UK Medical Professionals
This study is to assess for the effectiveness of a Simulation-Based Stress Inoculation Training (SIT) Programme for junior doctors and physicians associates.
- Conditions
- Stress, Stress, Psychological, Stress, Job
- Trial name
- SITS (NCT05182710)
- Testing
- Stress Inoculation Training, Alternative Training
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Royal Cornwall Hospitals Trust
Cardiac Arrest, Out of Hospital Cardiac Arrest
Compression Only-CPR Versus Standard-CPR
Out-of-hospital cardiac arrest (OHCA) is one of the leading causes of mortality in the industrialized world. Bystander CPR before arrival of the Emergency Medical Service (EMS) is a positive predictor of survival.
- Trial name
- TANGO2 (NCT02401633)
- Testing
- CO-CPR, S-CPR
- Where
- Sweden
- Volunteers
- 1,250 people
- Sponsor
- Karolinska Institutet
Unintubated Patients in ICU and Resuscitation Room
Measurement of Intravascular Volume Using USG of IVC Diameter Compared to VPW Chest X-ray
This study aimed to know the consistency of intravascular volume measurement using USG of IVC compared to VPW chest x-ray
- Trial name
- NCT03535038
- Testing
- Inferior vena cava (IVC) diameter using USG, Vascular pedicle width (VPW)
- Where
- Indonesia
- Volunteers
- 35 people
- Sponsor
- Universitas Indonesia
Cirrhosis With Sepsis
Comparison of Colloid (20% Albumin) Versus Crystalloid (Plasmalyte) for Fluid Resuscitation in Cirrhotics With Sepsis Induced Hypotension.
Consecutive cirrhotics who present to emergency department of Institute of Liver \& Biliary Sciences with documented or suspected sepsis induced hypotension will be randomized to receive either human albumin infusion over 3 hours…
- Trial name
- NCT02721238
- Testing
- 20% Albumin, Plasmalyte
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Status Epilepticus, Cardiac Arrest With Successful Resuscitation
VIGAB-BIOSTAT: Neuronal Injury Panel Substudy
The purpose of this substudy is to collect and analyze control data to characterize the degree of neuronal injury in PASE patients who have not received vigabatrin to later compare with patients who received this therapy and…
- Trial name
- NCT05000320
- Testing
- Neuronal Injury Panel
- Sponsor
- University of Florida
Coronary Artery Bypass Surgery
Starch or Saline After Cardiac Surgery
When people undergo major surgery, they require intravenous supplementation of fluids for a number of reasons: to compensate for no oral intake to support blood pressure and organ function during and after surgery to replace lost…
- Trial name
- SSACS (NCT00964015)
- Testing
- 6% Hydroxyethyl Starch 130/0.4, 0.9% Normal Saline
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- London Health Sciences Centre
Polytrauma, Resuscitation, Trauma Patients
Pv-aCO₂ Gap-Guided Resuscitation in Adult Polytrauma Patients: A Prospective Randomized Controlled Trial
dult patients with multiple traumatic injuries admitted to the ICU from the operating room, emergency department, or hospital wards who meet the study criteria will be included after obtaining informed consent from the patient or…
- Trial name
- NCT07480655
- Testing
- Veno-arterial Carbondioxide gap, Conventional resuscitation end points
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Pakistan Institute of Medical Sciences
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