Clinical trials: Retention, open to volunteers
Speech
Speech Motor Learning and Retention (Aim 3)
The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and…
- Trial name
- NCT06492252
- Testing
- fMRI, Adaptation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Spinal Cord Injuries (SCI), Urinary Bladder, Neurogenic
Effect of Urethral Balloon Dilatation on Urinary Retention After Spinal Cord Injury
Trial Objectives: This clinical trial aims to explore whether ultrasound - guided urethral balloon dilation can effectively improve the micturition function of patients with urinary retention after spinal cord injury, and to…
- Conditions
- Spinal Cord Injuries (SCI), Urinary Bladder, Neurogenic, Urinary Retention
- Trial name
- NCT06978205
- Testing
- Urethral Balloon Dilation, intermittent catheterization, Acupuncture treatment
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Qilu Hospital of Shandong University
Acute Urinary Retention, Benign Prostate Hypertrophy(BPH)
Study of Teverelix DP on Prostate Volume, Urinary Function and Clinical Outcomes Following Acute Urinary Retention
This randomized, double-blind, placebo-controlled Phase 2 study is evaluating Teverelix DP in men following a first episode of acute urinary retention (AUR) associated with benign prostatic hyperplasia (BPH), a population at risk…
- Trial name
- NCT07733934
- Testing
- Teverelix DP
- Volunteers
- 126 people
- Sponsor
- Antev Ltd.
Opioid Use Disorder, Peer Recovery Supporters
Peer Recovery Support for Opioid Use Disorder Treatment Retention
The goal of this clinical trial is to learn whether adding peer recovery support services to standard opioid use disorder (OUD) treatment in primary care helps patients stay in treatment longer.
- Conditions
- Opioid Use Disorder, Peer Recovery Supporters, Peer Recovery Coaching, Primary Care
- Trial name
- NCT07620171
- Testing
- Peer Support
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Rectal Adenocarcinoma
The Efficacy and Safety of Short-course Radiation Combined With Adebrelimab and CAPEOX Neo-adjuvant Therapy for Organ-retention in Patients With MSS/pMMR Ultra Low Rectal Adenocarcinoma
To evaluate the efficacy, safety and organ retention rate of short-course radiation combined with Adebrelimab and CAPEOX neoadjuvant therapy in patients with MSS/pMMR ultra low rectal adenocarcinoma.
- Trial name
- NCT06266832
- Testing
- Adebrelimab, Oxaliplatin, Capecitabine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sir Run Run Shaw Hospital
Perinatal Mental Health, Gestational Weight Gain
Healthy Adaptation to Pregnancy, Postpartum and Parenthood
Healthy Adaptation to Pregnancy, Postpartum and Parenthood (HAP3) The HAP3 study is evaluating a new digital support program for pregnant women and their partners.
- Conditions
- Perinatal Mental Health, Gestational Weight Gain, Postpartum Weight Retention, Child Development
- Trial name
- HAP3 (NCT07837193)
- Testing
- HAP3 Family App
- Where
- Belgium
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Human Immunodeficiency Virus, Mental Disorder
Integrated Mental Health Care for Pregnant Women With HIV in Kenya: The Tunawiri Study
This study seeks to improve mental health, pregnancy, and HIV outcomes among pregnant and postpartum women living with HIV with common mental health disorders in Kenya.
- Trial name
- NCT06117163
- Testing
- Collaborative Care Model
- Where
- Kenya
- Volunteers
- 900 people
- Sponsor
- University of Colorado, Denver
Posttraumatic Stress Disorder
Family Involvement in Treatment for PTSD (FIT-PTSD): A Brief, Feasible Method for Enhancing Outcomes, Retention, and Engagement
Although effective treatments for PTSD exist, high rates of treatment dropout and sub-optimal response rates remain common. Incorporating family members in treatment represents one avenue for improving outcomes and providing…
- Trial name
- NCT05267665
- Testing
- Brief Family Intervention (BFI)
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Periprosthetic Joint Infection
Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression
The purpose of this research is to evaluate two different standard of care surgeries in treating periprosthetic joint infection (PJI) after total hip and knee arthroplasty.
- Trial name
- NCT05640336
- Testing
- Single Debridement, Antibiotics and Implant Retention, Planned Double Debridement, Antibiotics and Implant Retention
- Where
- 2 sites in United States
- Volunteers
- 490 people
- Sponsor
- Mayo Clinic
Professional Burnout, Moral Injury
Professional Contributions and Social Value in High-Acuity Medical Care Settings
This study will explore experiences in high-acuity medical care settings, such as emergency, trauma, intensive care, and related clinical areas.
- Trial name
- NCT07686666
- Testing
- Experience in high-acuity clinical care settings
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Glioma, High-Grade Glioma (HGG)
Feasibility Assessment of a Medical Device for Tumour Cell Retention and Radiotherapy Sensitization in Patients With Suspected High-grade Glioma
This is a prospective, multicenter, single-arm, pilot clinical investigation, aimed at evaluating the safety and preliminary efficacy of the GlioHook implant in patients with high-grade glioma undergoing surgical resection…
- Conditions
- Glioma, High-Grade Glioma (HGG), Surgical Resection
- Trial name
- CT-GlioHook (NCT07725640)
- Testing
- GlioHook device
- Where
- 3 sites in Spain
- Volunteers
- 15 people
- Sponsor
- Batea Oncology
Anal Fistula, Anal Fissure Chronic
Effect of Enhanced Recovery After Surgery for Benign Anorectal Conditions
This study aims to assess the role of Enhanced recovery after surgery(ERAS) protocol in reducing postoperative urine retention (POUR) after surgery for benign anorectal conditions.
- Conditions
- Anal Fistula, Anal Fissure Chronic, Haemorrhoid, Enhanced Recovery After Surgery (ERAS) Protocol
- Trial name
- NCT06803550
- Testing
- Enhanced recovery after surgery protocol, Routine pathway
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Opioid Use Disorder
Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.
The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid use disorder.
- Trial name
- NCT06323824
- Testing
- Methadone, Buprenorphine (BUP)
- Where
- 6 sites in United States
- Volunteers
- 600 people
- Sponsor
- Yale University
Opioid Use Disorder
Behavioral Optimization for Overcoming Suboptimal Treatment Retention (BUP-BOOSTeR)
Buprenorphine, a medication for opioid use disorder (MOUD), is associated with decreased opioid overdose and all-cause mortality.
- Trial name
- BUP-BOOSTeR (NCT07607743)
- Testing
- Behavioral Activation (BA), Attendance Reinforcement (AR), Peer-Delivered Motivational Interviewing (PDMI)
- Volunteers
- 240 people
- Sponsor
- Boston University
Problems Related to Social Environment
Leveraging Regulatory Flexibility for Methadone Take-Home Dosing to Improve Retention in Treatment for Opioid Use Disorder
Using a stepped-wedge randomized controlled trial, the study will test whether a clinic-level multidimensional intervention conducted in 36 opioid treatment programs (OTPs) will improve clinical decision making, regulatory…
- Trial name
- NCT05675735
- Testing
- Clinic-Level Multidimensional Intervention
- Where
- 4 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Opioid Use Disorder, Fentanyl
Comparing Outpatient Treatment Retention Among Individuals Using Fentanyl Randomized to Low-dose and Direct-to-inject Buprenorphine Initiation
The goal of this pragmatic randomized controlled trial is to compare treatment outcomes of two strategies for initiating buprenorphine treatment (low-dose initiation and direct-to-inject) in adults with opioid use disorder (OUD)…
- Trial name
- COPILOT (NCT07469501)
- Testing
- Injectable buprenorphine, Sublingual Buprenorphine (SUBOXONE, Zubsolv, or generic tablets)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Prostatic Hyperplasia, Urinary Retention
Comparing Clean Intermittent Self-catheterization and Indwelling Catheterization for the Management of Urinary Retention Before BPH Surgery.
The CATHETERS trial is a multicenter, randomized, open-label superiority study comparing two methods of managing urinary retention before surgery for benign prostatic hyperplasia (BPH): clean intermittent self-catheterization…
- Conditions
- Prostatic Hyperplasia, Urinary Retention, Urinary Catheterization, Intermittent Urethral Catheterization
- Trial name
- CATHETERS (NCT07555964)
- Testing
- ICSC, IDC
- Where
- 5 sites in France
- Volunteers
- 106 people
- Sponsor
- University Hospital, Bordeaux
Orthodontic Retention Appliance, Orthodontic Relapse
Effectiveness of Gold Fixed Retainers Compared to Conventional Stainless Steel Retainers
This randomized clinical trial will compare the effectiveness of a gold-plated multistranded mandibular fixed retainer versus a conventional multistranded stainless-steel fixed retainer in maintaining lower anterior tooth…
- Trial name
- NCT07280455
- Testing
- Gold-coated fixed retainer wire, Stainless steel fixed retainer wire
- Where
- Iraq
- Volunteers
- 40 people
- Sponsor
- Noor Sattar Raheem
Facelift Surgery, Fat Grafting
Ultrasound-Assessed Facial Macrofat Retention After Facelift
Facelift surgery repositions facial soft tissues but does not by itself restore all age-related volume loss. Autologous macrofat can be placed during the same operation to restore volume, yet the amount of grafted tissue that…
- Trial name
- NCT07805889
- Testing
- Facelift plus facial fat grafting
- Where
- Colombia
- Volunteers
- 400 people
- Sponsor
- Research Inc
Gastric Cancer Stage, Esophageal Cancer
Development and Validation of a Risk Prediction Model for Gastric Retention in Patients Undergoing Sedated Gastroscopy
Gastric retention not only compromises the quality of endoscopic examination but also significantly increases the risk of reflux and aspiration in sedated patients.
- Conditions
- Gastric Cancer Stage, Esophageal Cancer, Gastroparesis
- Trial name
- NCT07104214
- Where
- 3 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Zhejiang University