Clinical trials: Retina; Detachment, Rhegmatogenous
Retinal Detachment
Comparison High-density Silicone Oils in Retinal Detachment
The purpose of the study is to compare the safety, intraocular adverse effects and the anatomic and functional outcome with two endotamponade silicone oil after a 3-month in complex inferior retinal re-detachments.
- Trial name
- NCT00403702
- Testing
- Oxane HD [oil-RMN3-mixture], Densiron [(F6H8)
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Rhegmatogenous Retinal Detachment
Dropless Pars Plana Vitrectomy Study
To demonstrate that intraoperative use of subtenon triamcinolone acetonide at the time of surgery without postoperative eye drops is non-inferior to the regimen of postoperative eye drops following primary pars plana vitrectomy…
- Trial name
- DVS (NCT05331664)
- Testing
- Pars plana vitrectomy, Triamcinolone Acetonide 40mg/mL, Moxifloxacin 0.5% or Polymyxin/Trimethoprim if patient is allergic to moxifloxacin
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Retinal Detachment
Duration of Silicone Oil Tamponade on Foveal and Parafoveal Thickness in Rhegmatogenous Retinal Detachment
Our study observes and analyses the influence of the duration of tamponade with silicone oil on the foveal and parafoveal thickness.
- Trial name
- siliconeoil (NCT05817630)
- Testing
- Silicone oil Tamponade for Retinal Detachment
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Dar El Oyoun Hospital
Rhegmatogenous Retinal Detachment
Foldable Capsular Scleral Buckling Versus Vitrectomy in Medium-complex Rhegmatogenous Retinal Detachment Treatment
The objective of the study is to evaluate: 1. Safety and efficacy of a novel foldable capsular scleral buckle (FCSB) in scleral buckling for primary rhegmatogenous retinal detachment (RRD) of medium complexity. 2.
- Trial name
- FCSB (NCT06610786)
- Testing
- foldable capsular scleral buckling, vitrectomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Rhegmatogenous Retinal Detachment, High-risk for Proliferative Vitreoretinopathy (PVR)
Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment.
This study investigates the effectiveness of a simple treatment to prevent proliferative vitreoretinopathy (PVR). Intraoperative intravitreal 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH) is used as a prophylactic…
- Trial name
- PRIVENT (NCT02834559)
- Testing
- 5-fluorouracil and low molecular weight heparin
- Where
- 13 sites in Germany
- Volunteers
- 326 people
- Sponsor
- Universitätsklinikum Köln
Stress Disorders, Post-Traumatic, Retinal Detachment
Diagnosis of Posttraumatic Stress Disorder Following Primary Rhegmatogenous Retinal Detachment
To investigate the prevalence of posttraumatic stress disorder (PTSD) in patients that underwent surgery for primary rhegmatogenous retinal detachment (RRD) and to determine variables associated with the disorder.
- Trial name
- NCT01233908
- Where
- Israel
- Volunteers
- 547 people
- Sponsor
- Sheba Medical Center
Retinal Detachment Rhegmatogenous
Use of Preoperative Gas in Eyes With Macula-off Rhegmatogenous Retinal Detachment (RRD)
The purpose of this study is to evaluate whether a preoperative intraocular gas injection improves visual outcomes in patients with a macula-off rhegmatogenous retinal detachment (RRD).
- Trial name
- NCT07855770
- Testing
- Intravitreal 100% C3F8 Injection, Pars plana vitrectomy or pars plana vitrectomy with scleral buckle
- Where
- 2 sites in United States
- Volunteers
- 190 people
- Sponsor
- Wills Eye
Rhegmatogenous Retinal Detachment, Proliferative Vitreoretinopathy
Topical Netarsudil for the Prevention of Proliferative Vitreoretinopathy in Patients With Retinal Detachment
This study has two main objectives. The first objective is to study the pharmacokinetics of topical netarsudil administration in the posterior segment of the eye, where netarsudil must exert its effect in order to prevent…
- Trial name
- NCT06033703
- Testing
- Netarsudil Ophthalmic
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Rhegmatogenous Retinal Detachment
Healaflow Patch for the Treatment of Rhegmatogenous Retinal Detachment
To report the surgical results of primary rhegmatogenous retinal detachment (RRD) repaired by 27G pars plana vitrectomy (PPV) combined with Healaflow patch and air tamponade, and do not need prone position postoperation.
- Trial name
- NCT03542162
- Testing
- Healaflow
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Eye Hospital
Rhegmatogenous Retinal Detachment of Both Eyes (Diagnosis)
Characters of Epiretinal Membranes in Patients With Previous Vitrectomy for Retinal Detachment
31 patients were included in the study,15 cases with ERM in silicone filled eyes and 16 eyes with idiopathic ERM
- Trial name
- RD (NCT04288440)
- Testing
- Surgery, Vitrectomy machine
- Where
- Egypt
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Tanta University
Retinal Detachment, Full Thickness Macular Hole
Inflammasomes in Cell Death in FTMH, ERM, and RRD
Prospective study evaluating the role of inflammasomes in cell death in retinal detachment, full thickness macular hole, and epiretinal membrane.
- Conditions
- Retinal Detachment, Full Thickness Macular Hole, Epiretinal Membrane
- Trial name
- NCT03332758
- Testing
- Pars plana vitrectomy, External drainage
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Allen C. Ho, MD
Rhegmatogenous Retinal Detachment
Ursodeoxycholic Acid for Rhegmatogenous Retinal Detachment
26 patients presenting a rhegmatogenous retinal detachment with more than 4 days of duration will be prospectively included. A single dose of ursodeoxycholic acid will be administered orally before surgery at different…
- Trial name
- UDCA-RD (NCT02841306)
- Testing
- Ursodeoxycholic Acid
- Where
- Switzerland
- Volunteers
- 26 people
- Sponsor
- Francine Behar-Cohen
Rhegmatogenous Retinal Detachment, Surgery
Treating Rhegmatogenous Retinal Detachment by Foldable Capsular Buckle
To evaluate the efficacy and safety of treating rhegmatogenous retinal detachment (RRD) using foldable capsular buckle (FCB). It is a multi-center clinical ,randomized, controlled, and single-blind clinical study.
- Trial name
- NCT04571788
- Testing
- Foldable Capsular Buckle, Silicone scleral padding
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Aier School of Ophthalmology, Central South University
Epiretinal Membrane, Macular Hole
UNITY VCS Vitreoretinal Surgery
This purpose of this study is to compare the safety and effectiveness of two eye surgery systems-UNITY VCS and CONSTELLATION-in treating adults with vitreoretinal diseases or disorders.
- Conditions
- Epiretinal Membrane, Macular Hole, Visually Significant Vitreous Floater, Vitreomacular Traction
- Trial name
- NCT07054281
- Testing
- UNITY Vitreoretinal Cataract System (VCS), CONSTELLATION Vision System, Vitreoretinal ophthalmic surgery
- Where
- 8 sites in United States
- Sponsor
- Alcon Research
Rhegmatogenous Retinal Detachment With Grade C Proliferative Vitreoretinopathy
Comparison of Visual Outcomes of Pars Plana Vitrectomy With and Without Injection Clexane for Rhegmatogenous Retinal Detachment Proliferative Vitreoretinopathy
This interventional prospective study was conducted in the Department of Ophthalmology at Lahore General Hospital, Lahore. The study included 60 male and female patients aged 18-65 years who had rhegmatogenous retinal detachment…
- Trial name
- NCT07787377
- Testing
- Enoxaparin Sodium, Pars Plana Vitrectomy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Lahore General Hospital
Retinal Detachment With Break
Suprachoroidal Visco-buckling for the Treatment of Rhegmatogenous Retinal Detachment
The study compares standard surgery for retinal detachment (RD) (vitrectomy, cryotherapy and gas) with a surgical variation that replaces the intraocular gas tamponade with suprachoroidal injection of viscoelastic underneath the…
- Trial name
- VIKING (NCT04557527)
- Testing
- Pars plana vitrectomy, laser or cryo retinopexy and intraocular gas tamponade, Suprachoroidal viscobuckle with 2.3% Sodium hyaluronate (Healon 5 Ophthalmic viscoelastic device)
- Where
- 6 sites in United Kingdom
- Volunteers
- 36 people
- Sponsor
- King's College Hospital NHS Trust
Rhegmatogenous Retinal Detachment
Macular Function After Scleral Buckle
Assess recovery of macula function after successful scleral buckling surgery for rhegmatogenous retinal detachment by using the multifocal ERG in the postoperative period i.e. recovery of functional integrity 2.
- Trial name
- NCT00345007
- Testing
- Scleral buckling
- Where
- Singapore
- Volunteers
- 27 people
- Sponsor
- Singapore National Eye Centre
Retinal Displacement After Retinal Detachment Surgery
Influence of Perfluorocarbon Liquid (LIQUID) During Pars Plana Vitrectomy on Retinal Vessel Displacement in Primary Macula-involving Rhegmatogenous Retinal Detachment
Rhegmatogenous retinal detachment (RRD) is an acute, sight threatening condition, with an incidence of approximately 10 per 100,000 people.
- Trial name
- LIQUID (NCT07027098)
- Testing
- Perflurocarbon liquid, Without Perflurocarbon liquid
- Where
- United Kingdom
- Volunteers
- 292 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Rhegmatogenous Retinal Detachment, Toxic Effect of Silicone
The Influence of Silicone Oil on Nerve Fiber Layer Thickness After Pars Plana Vitrectomy
The aim of the study is to evaluate the influence of silicone oil on thickness of the retinal nerve fiber layer by using optical coherence tomography (OCT) in patients following pars plana vitrectomy.
- Conditions
- Rhegmatogenous Retinal Detachment, Toxic Effect of Silicone, Glaucoma Due to Silicon Oil
- Trial name
- NCT01255306
- Testing
- Optical coherence tomography, Local medical treatment of raised intraocular pressure
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- University Hospital Sestre Milosrdnice
Rhegmatogenous Retinal Detachment - Macula Off
Acute Retinal Detachment Repair With the iSeelr™ Retinal Detachment Repair System
This study is a first-in-human clinical trial testing a new treatment for rhegmatogenous retinal detachments. The new treatment called retinal thermofusion uses a special laser device called iSeelr™ during surgery.
- Trial name
- NCT06468397
- Testing
- iSeelr™
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Photofuse Pty Ltd